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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1438-1452页

作者： Shasha Qu Yingju Li Bingyu Lu Cuiping Wang Yuansheng Yang institute of Metal research Chinese Academy of SciencesShenyang 110016China guangdong institute of special equipment inspection and research Foshan 528251China College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China

The effects of B addition on microstructure and mechanical properties of aγ′-strengthened CoNi-base superalloy are *** addition of B leads to a substantial increase in the volume fraction of both the eutectic structure and *** CoNi-base alloy shows a high solubility limit for the element *** become noticeable in the area surrounding the eutectic structure after the B level exceeds 0.46 at.%.It is found that the compression property and stress rupture life of the 4W2Ta alloys exhibit an initial rise followed by a subsequent drop as the B content gradually increases from 0.08 to 0.78 at.%.The 4W2Ta0.46B alloy demonstrates the most excellent high-temperature strength and stress rupture life,revealing that a moderate amount of B in the alloy noticeably enhances its mechanical properties by enhancing the grain boundary cohesion.

关键词： CoNi-base superalloy Borides Grain boundary Microstructure Mechanical properties

Identification of Shell Color-Associated Genes Using Mantle branch-Specific RNA Sequencing of Yellow-Colored Line of Pearl Oyster Pinctada fucata martensii

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Journal of Ocean University of China 2024年第4期23卷 1076-1086页

作者： PENG Haiming LIAO Yongshan YANG Chuangye MKUYE Robert DENG Yuewen YUE Chenyang Fisheries College Guangdong Ocean UniversityZhanjiang 524088China Pearl research institute Guangdong Ocean UniversityZhanjiang 524088China guangdong Science and Innovation Center for Pearl Culture Zhanjiang 524088China Pearl Breeding and Processing Engineering Technology research Center of guangdong Province Zhanjiang 524088China guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture Zhanjiang 524088China

The yellow-colored line of pearl oyster Pinctada fucata martensii displays a yellow prismatic layer and a white nacreous layer that can be used as an ideal model for research on shell color ***-Raman spectroscopy and transcriptome analyses were performed to explore the potential molecular mechanism underlying the phenotype *** micro-Raman spectroscopy results indicate that the prismatic layer exhibits distinct characteristic peaks of carotenoids,while these peaks are not prominent in the nacreous *** the transcriptome comparison of the central zone of mantle and mantle edge tissue,which function in nacreous and prismatic layer formation,respectively,935 significantly differentially expressed genes(DEGs)were identified,with 385 genes upregulated and 227 genes downregulated(|log_(2)(Fold change)|>1 and false discovery rate<0.05)in the mantle edge *** these genes,some were associated with melanoma/melanogenesis,such as tyrosinase,zinc metalloprotease,glutathione S-transferase,and ATP-binding cassette sub-family;some were associated with the carotenoid-related pathway,including scavenger receptors,cytochrome P450 and lipoprotein *** associated with porphyrin metabolism,including porphobilinogen deaminase,and copper/zinc superoxide dismutase,and genes associated with shell matrix protein,including amorphous calcium carbonate binding protein,shematrin,PIF,and collagen,also exhibited significantly different *** is speculated that the different colours between prismatic layer and nacreous layer in the yellow-colored line of *** might be resulted from melanin,carotenoids and porphyrin metabolism,while genes related to shell structure and biomineralization might also affect *** results provide new insights to understand the mechanism of shell color formation in mollusca.

关键词： Pinctada fucata martensii shell coloration transcriptome

A novel copper metabolism-related signature model for predicting the prognosis,target drugs,and immunotherapy in stomach adenocarcinoma

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Genes & Diseases 2024年第5期11卷 21-24页

作者： Kai Zhuang Siqi Tang Haixin Feng Jinying Zhang Ying Liu Yong Liu Yongjian Su Jiaqi Yu Zunnan Huang Key Laboratory of Computer-Aided Drug Design of Dongguan City The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523710China Key Laboratory of Big Data Mining and Precision Drug Design of guangdong Medical University Key Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguanGuangdong 523808China School of Public Health Guangdong Medical UniversityDongguanGuangdong 523808China Marine Biomedical research institute of guangdong zhanjiang ZhanjiangGuangdong 524203China

Stomach adenocarcinoma(STAD)is one of the most common gastric neoplasms with a high death ***,there is an urgent need to propose an efficient therapy for *** plays key roles in regulating the distribution of immune cells and affecting the tumor immune escape,and may be a novel indicator of immunotherapy in ***,the specific impact of copper metabolism-related genes(CMRGs)on the patient’s prognosis,tumor microenvironment,and immunotherapeutic response remains unelucidated.

关键词： metabolism stomach adenocarcinoma

Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan Liangbin Zhou Chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical research institute of guangdong zhanjiang ZhanjiangGuangdongChina guangdong Provincial Key Laboratory of research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina Dongguan Key Laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM Medical Molecular Biology institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C19 transcription through the nuclear factor-􀇉B signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

Noise‐tolerant matched filter scheme supplemented with neural dynamics algorithm for sea island extraction

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 996-1013页

作者： Yiyu Chen Dongyang Fu Difeng Wang Haoen Huang Yang Si Shangfeng Du School of Electronics and Information Engineering Guangdong Ocean UniversityZhanjiangChina State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhouChina School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanChina

Achieving high‐precision extraction of sea islands from high‐resolution satellite remote sensing images is crucial for effective resource development and sustainable ***,achieving such accuracy for sea island extraction presents significant challenges due to the presence of extensive background interference.A more widely applicable noise‐tolerant matched filter(NTMF)scheme is proposed for sea island extraction based on the MF *** NTMF scheme effectively suppresses the background interference,leading to more accurate and robust sea island *** further enhance the accuracy and robustness of the NTMF scheme,a neural dynamics algorithm is supplemented that adds an error integration feedback term to counter noise interference during internal computer operations in practical *** comparative experiments were conducted on various remote sensing images of sea islands under different noisy working conditions to demonstrate the superiority of the proposed neural dynamics algorithm‐assisted NTMF *** experiments confirm the ad-vantages of using the NTMF scheme for sea island extraction with the assistance of neural dynamics algorithm.

关键词： edge detection image classification image recognition shape extraction

Detection of a mud volcano in the Weitan Banks area of the northern South China Sea

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Journal of Oceanology and Limnology 2024年第5期42卷 1450-1469页

作者： Wei LUO Pin YAN Yanlin WANG Junhui YU Qionghua WAN Zhenbo ZHANG Tao XUE Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering guangdong Laboratory(Guangzhou) Guangzhou 511458China CNOOC International Energy Services(Beijing)Co. Ltd.Beijing 100028China University of Chinese Academy of Sciences Beijing 100049China Oilfield Engineering research institute of Geophysics CNOOC Energy Technology and ServicesZhanjiang 524057China

Situated between the petroliferous Cenozoic Zhujiang(Pearl)River Mouth Basin and the mud volcano-rich Mesozoic Dongsha Basin in the middle sector of the northern South China Sea,the Weitan Banks area has been previously mapped as a basement high that is composed of Mesozoic magmatic *** this study,we present several favorable indicators for petroleum geology that were detected from geophysical profiling and benthic sampling in the area.A conspicuous hill was discovered,named“Zhongwei Hill”,~80 m high above the~340 m deep seafloor and~1 km broad,in a depression with more than 7 km thick sedimentary *** Zhongwei Hill was seismically imaged with a mushroom-shaped structure and containing a cake-like crown,fluid flow pipes,and an~10 km broad anticline at ***,the hill represents a source-plumbing-eruption *** gas zones linked to deep fracture were found at or near the *** correlation indicates that the deep strata comprise the Jurassic and Paleogene strata,the major hosts of hydrocarbon source *** addition to the hill,there are number of mounds from which three bottom water samples were collected and the samples are rich in dissolved methane with concentrations high up to~900 nmol/L,much higher than the background level(0.5–2 nmol/L).The benthic samples are rich in coarse sediment clastics,authigenic carbonate nodules,and deep-water habitats likely feeding on methanotrophic *** these observations and the context,we propose that the Zhongwei Hill represents a mud volcano,likely thermally driven,that seeps methane from Jurassic and Paleogene source layers,thus poses a favorable clue for significant hydrocarbon generation capacity in transitional zone of the Zhujiang River Mouth Basin and the Dongsha Basin.

关键词： South China Sea Zhongwei Hill deep-level anticline mud volcano Mesozoic source layer hydrocarbon generation

Functional microfluidics:theory,microfabrication,and applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 140-173页

作者： Mingzhu Xie Ziheng Zhan Yinfeng Li Junkai Zhao Ce Zhang Zhaolong Wang Zuankai Wang Interdisciplinary research Center of Low-carbon Technology and equipment College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082People’s Republic of China Energy research institute of Shandong Academy of Sciences Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014People’s Republic of China Qian Xuesen Laboratory of Space Technology China Academy of Space Technology(CAST)Beijing 100094People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of China 999077People’s Republic of China

Microfluidic devices are composed of microchannels with a diameter ranging from ten to a few hundred ***,quite a small(10-9–10-18l)amount of liquid can be manipulated by such a precise *** the past three decades,significant progress in materials science,microfabrication,and various applications has boosted the development of promising functional microfluidic *** this review,the recent progress on novel microfluidic devices with various functions and applications is ***,the theory and numerical methods for studying the performance of microfluidic devices are briefly ***,materials and fabrication methods of functional microfluidic devices are ***,the recent significant advances in applications of microfluidic devices are highlighted,including heat sinks,clean water production,chemical reactions,sensors,biomedicine,capillaric circuits,wearable electronic devices,and ***,perspectives on the challenges and future developments of functional microfluidic devices are *** review aims to inspire researchers from various fields engineering,materials,chemistry,mathematics,physics,and more—to collaborate and drive forward the development and applications of functional microfluidic devices,specifically for achieving carbon neutrality.

关键词： capillary theory functional devices functional microfluidics

Investigation of the segregation of a binary particle mixture in a square circulating fluidized bed with air staging

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Particuology 2019年第6期17卷 70-76页

作者： Mingkun Du Shuai Wang guangdong institute of special equipment inspection and research Zhuhai Inspection InstituteZhuhai 519002China School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China

To further understand the segregation characteristics of a binary particle mixture in a riser,the flow behaviors of particles with different sizes were experimentally and numerically investigated in a cold square circulating fluidized *** impact of the gas velocity,solid circulation rate,initial coarse particle fraction,and air staging on the coarse particle fraction and axial pressure drop were *** experimental results show that air staging can significantly promote the pressure drop of a binary mixture at the bottom of the bed compared with that of monosized ***,the segregation of the binary mixture at the bottom is *** was also found that there was clear radial segregation owing to a higher coarse particle fraction near the wall compared with the bed's center and its corner.

关键词： Circulating fluidized bed Binary mixture Segregation Air staging

Analysis of influence of heat exchangerfouling on heat transfer performancebased on thermal fluid coupling

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排灌机械工程学报 2023年第7期41卷 695-700页

作者： HUANG Si MURAD Tariq NIU Qifeng LIN Guangtang CHEN Jianxun School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhouGuangdong 510641China guangdong institute of special equipment inspection and research Zhuhai branch ZhuhaiGuangdong 519002China

A study on heat transfer performance by thermal fluid coupling simulation for the fouling in a shell-tube heat exchanger used in engineering was presented. The coupling simulation was performed in a fluid and solid domains under three different fouling conditions: fouling inside the tube, fouling outside the tube, and fouling inside the shell. The flow field, temperature, and pressure distributions in the heat exchanger were solved numerically to analyze the heat transfer performance parameters, such as thermal resistance. It is found that the pressure drop of the heat exchanger and the thermal resistance of the tube wall increase by nearly 30% and 20%, respectively, when the relative fouling thickness reaches 10%. The fouling inside the tube has more impact on the heat transfer performance of the heat exchanger, and the fouling inside the shell has less impact.

关键词： shell-tube heat exchanger thermal fluid coupling fouling thermal resistance heat transfer analysis

Microstructure evolution and mechanical properties of the Sip/Zn- Al composite joints by ultrasonic-assisted soldering in air

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China Welding 2018年第2期27卷 39-44页

作者： Kang Yuqing Shen Haoran Fu Yang Chen Yunru Xu Chang Li Xin Gu Keyun Li Xiaohai An Ledong Wang Qian guangdong institute of special equipment inspection and research zhanjiang branch Zhanjiang 524000 China Shanghai Aerospace equipments Manufacture Shanghai 200245 China School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 China

Hypereutectic Al -27Si alloys were joined without flux by ultrasonic-assisted soldering at 420 ℃ in air using Zn -5Al the filler alloys, and Si particulate-reinforced Zn - Al based composites filler joints were obtained. The ultrasonic vibration introduced into soldering could influence the migration of Si particles and the microstructure of solidified Zn - Al based alloys. Both the distribution of Si particles and microstructure of the solidified Zn - Al based alloys affected the shear strength of joints. The shear strength increased with the ultrasonic vibration time. The highest average shear strength of joints reached to -68.5 MPa. Transcrystalline rupture mode was observed on the fracture surface.

关键词： Hypereutectic Al - Si alloys ultrasonic soldering microstructure mechanical properties