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Nano-Micro Letters 2025年第2期17卷 387-400页

作者： Mengen Ma Cuiling Zhang Yujiao Ma Weile Li Yao Wang Shaohang Wu Chong Liu Yaohua Mai Institute of New Energy Technology College of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 510632People’s Republic of China Key Laboratory of New Semico.ductors and Devices of guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632People’s Republic of China guangdong Mellow Energy co. LimitedYuanming RoadZhuhai 519075GuangdongPeople’s Republic of China

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-co.ting *** this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive *** then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable co.tinuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.

关键词： Gas quenching Additive distribution Buried passivation Blade co.ting Crystallization dynamics

Engineering atomic Rb-N co.figurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis co.pled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang Pan Yihuang Chen Qiong Liu co.lege of Chemistry and Materials Engineering Wenzhou University guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and co.teffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise co.trol over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co.photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a reco.d photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alco.ol to furoic acid,achieving a remarkable solar-to-chemical co.version （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N co.figurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger co.nection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2co.pled with biomass valorization.

关键词： Atomic eco.omy Radical pathway regulation Rubidium atom co.rdination Biomass valorization

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal co.d injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Quality co.trol of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal co.d ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal co.d injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal co.d injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of co.tusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal co.d ***,we established a PC12-BV2 cell co.culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal co.d injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted reco.ery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal co.d injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal co.d injury

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico.approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive co.ponents and underlying mechanisms have not been *** objective of this study was to identify the active co.ponents and potential mechanisms of SMW by integrating pharmaco.ogical experimentation,serum pharmaco.hemistry,network pharmaco.ogy and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmaco.ynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive co.ponents present in SMW-co.taining *** pharmaco.ogy and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and gluco.e metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 co.pounds detected in SMW-co.taining serum were identified as potential active co.ponents,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 co.responding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active co.pounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated gluco.e transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).co.clusion:S

关键词： hyperuricemia network pharmaco.ogy serum pharmaco.hemistry Simiaowan UPLC-Q-Exactive-MS/MS

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu co.lege of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy co. LTD.

Hard carbon （HC） has been co.sidered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectrosco.y/electrochemical impedance spectrosco.y （FTIR/EIS） and X-ray photoelectron spectrosco.y （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping co.tent exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectrosco.y

Activation of adult endogenous neurogenesis by a hyaluronic acid co.lagen gel co.taining basic fibroblast growth factor promotes remodeling and functional reco.ery of the injured cerebral co.tex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and co.nitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina co.innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reco.struct co.tical layers II to VI in non-neurogenic regions,such as the co.tex,remains *** this study,we implanted a hyaluronic acid co.lagen gel loaded with basic fibroblast growth factor into the motor co.tex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reco.structed the architecture of co.tical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral co.tex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid co.lagen gel co.tical remodeling functional reco.ery migration motor co.tex injury neural circuits neural stem cells newborn neurons proliferation

Qualitative and quantitative assessment of related substances in the co.pound Ketoco.azole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC

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Journal of Pharmaceutical Analysis 2019年第3期9卷 156-162页

作者： Wenling Yang Xiaomei Yang Fanghua Shi Zhigang Liao Yongkun Liang Liangzhong Yu Ruixun Wang Qing Li Kaishun Bi School of pharmacy Shenyang Pharmaceutical University Shenyang 110016 China G.D China Resources Shunfeng Pharmaceutical co. Ltd Guangdong 528300 China

Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the co.pound Ketoco.azole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two co.pounds named ketoco.azole impurity B′ optical isomer and ketoco.azole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-co.ponents method was applied in the quantitative analysis, which was an effective way for reducing co.t and improving accuracy. This study can provide a creative idea for routine analysis of quality co.trol of the co.pound Ketoco.azole and Clobetasol Propionate Cream.

关键词： co.pound Ketoco.azole and Clobetasol Propionate Cream Ketoco.azole impurity B' optical isomer Ketoco.azole impurity E Quality co.trol HPLC-TOF-MS HPLC

Manufacturability and mechanical reliability study for heterogeneous integration system in display(HiSID)

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Advances in Manufacturing 2023年第2期11卷 191-202页

作者： Hao-Hui Long Hui-Cai Ma Jia-Ying Gao Li Zhang De-Ming Zhang Jian-Qiu Chen Huawei Device co. Ltd.Shenzhen518129GuangdongPeople's Republic of China

In this paper,the system on display panel(SoDP)architecture,the primary stage of heterogeneous integration system in display(HiSID),is introduced for the first *** this architecture,the driving co.ponents of display,which are supposed to be on the display flexible print circuit(FPC)in traditional architecture,are innovatively integrated onto the backside of display *** the SoDP architecture,the simulated impact strain in the panel fan-out region can decrease about 30%co.pared to the traditional architecture,and SoDP provides more the 10 mm extra space in the in-plane Y-direction for holding a larger ***,the SoDP is co.patible with the current organic laser emitted diode(OLED)and system in package(SiP)*** the primary stage,this paper also presents a co.prehensive and extensive analysis on the challenges of the manufacturability for the advanced stage of HiSID from four key technologies perspectives:device miniaturization,massive manufacturing,driving technology,and advanced heterogeneous integration.

关键词： Display Heterogeneous integration system in display(HiSID) Manufacturability Mechanical reliability System on display panel(SoDP)

Effects of dietary astaxanthin supplementation on growth performance, antioxidant status, immune response, and intestinal health of rainbow trout(Onco.hynchus mykiss)

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Animal Nutrition 2024年第2期17卷 387-396页

作者： Xiaoxue Meng Fumei Yang Lulu Zhu Lingli Zhan Toru Numasawa Junming Deng co.lege of Fisheries Guangdong Ocean University Kunming Biogenic co. Ltd.

A feeding trial was co.ducted to assess the impacts of dietary astaxanthin from wall-broken Haematoco.cus pluvialis(WBHPA) on the growth performance, antioxidant status, immune response, and intestinal health of rainbow trout(Onco.hynchus mykiss). Six experimental diets were formulated with various co.centrations of WBHPA, ranging from 0 to 8.4 g/kg(co.taining 0 to 125 mg/kg astaxanthin). Each diet was fed to triplicate groups of rainbow trout(mean initial weight of 561 g) twice daily for 9 co.secutive weeks. The survival rate and feed intake of fish exhibited no significant differences among the dietary groups(P > 0.05). Similarly, dietary inclusion of 25 to 100 mg/kg astaxanthin did not significantly affect the weight gain and daily growth co.fficient(P > 0.05), but excessive inclusion of astaxanthin(125 mg/kg) slightly depressed these parameters(P co.al barrier function and improved antioxidant activity,thereby promoting intestinal development. co.clusively, 25 to 75 mg/kg astaxanthin from WBHPA was reco.mended to be included in diets for rainbow trout.

关键词： Astaxanthin Growth Antioxidant Immune Intestinal health

Power Inco.plete Data Clustering Based on Fuzzy Fusion Algorithm

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Energy Engineering 2023年第1期120卷 245-261页

作者： Yutian Hong Yuping Yan guangdong Electric Power Information Technology co. Ltd.Guangzhou520000China guangdong Power Grid co. Ltd.Guangzhou520000China

With the rapid development of the eco.omy,the scale of the power grid is *** number of power equipment that co.stitutes the power grid has been very large,which makes the state data of power equipment grow *** multi-source heterogeneous data have data differences,which lead to data variation in the process of transmission and preservation,thus forming the bad information of inco.plete ***,the research on data integrity has beco.e an urgent *** paper is based on the characteristics of random chance and the Spatio-temporal difference of the *** to the characteristics and data sources of the massive data generated by power equipment,the fuzzy mining model of power equipment data is established,and the data is divided into numerical and non-numerical data based on numerical *** the text data of power equipment defects as the mining ***,the Apriori algorithm based on an array is used to mine *** strong association rules in inco.plete data of power equipment are obtained and *** the change trend of NRMSE metrics and classification accuracy,most of the filling methods co.bined with the two frameworks in this method usually show a relatively stable filling trend,and will not fluctuate greatly with the growth of the missing *** experimental results show that the proposed algorithm model can effectively improve the filling effect of the existing filling methods on most data sets,and the filling effect fluctuates greatly with the increase of the missing rate,that is,with the increase of the missing rate,the improvement effect of the model for the existing filling methods is higher than 4.3%.Through the inco.plete data clustering technology studied in this paper,a more innovative state assessment of smart grid reliability operation is carried out,which has good research value and reference significance.

关键词： Power system equipment parameter inco.plete data fuzzy analysis data clustering