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co.position,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions

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Journal of Animal Science and biotechnology 2024年第2期15卷 659-678页

作者： Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang co.lege of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhouGuangdongPeople’s Republic of China guangdong Provincial Key Laboratory of Agro‑Animal Genomics and Molecular Breeding South China Agricultural UniversityGuangzhouGuangdongChina Yunfu Subcenter of guangdong Laboratory for Lingnan Modern Agriculture YunfuGuangdongChina National Engineering Research Center for Breeding Swine Industry Wens Foodstuff Group Co.Ltd.YunfuGuangdongPeople’s Republic of China

Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous ***,the optimal timeframe for introducing probiotics to achieve this outco.e remains *** In the co.text of this investigation,we co.ducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time ***,we gathered vaginal and fecal samples from 23 *** 16S rRNA gene and metagenomic sequencing methodologies,we co.ducted a co.prehensive analysis of the fluctuation patterns in microbial co.position,functional capacity,interaction networks,and co.onization resistance within the gut microbiota of *** the piglets progressed in age,discernible modifications in intestinal microbial diversity,co.position,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal *** D21,the microbial interaction network displayed a more co.cise and efficient co.figuration,acco.panied by enhanced co.onization resistance relative to the other two time ***,we identified three strains of Ruminoco.cus *** D10 as potential candidates for improving piglets’weight gain during the weaning *** The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet *** investigation augments our co.prehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthco.ing probiotic interventions.

关键词： co.onization resistance Intestinal microbiota Piglet Weaning Weight gain

Advances in the Study of Anoectochilus Roxburghii Extracts and Prospects for co.metic Application Potentials

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China Detergent & co.metics 2024年第1期9卷 45-53页

作者： Liu Xiaochun Chen Laicheng Yang Zhanhong Zou Jie School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityChina Guangzhou Hemgathion biotechnology co. Ltd.China

co.metics made from natural ingredients are beco.ing more and more co.mon because they co.tain bioactive co.pounds that provide many health benefits,are more environmentally friendly and *** roxburghii(AR)is a precious Chinese herb in China,possessing bioactive co.ponents including flavonoids,polysaccharides,volatile oils,kinsenoside,*** to its unique bioactivity and high safety,the prospect of development and utilization is very *** this paper,the extraction,separation and purification techniques of AR’s flavonoid,polysaccharides,volatile oils and kinsenoside are briefly ***,we discusses their co.formational relationships in co.metics with antioxidant,whitening,antibacterial and soothing effect,and looks forward to the study of Anoectochilus roxburghii in the field of co.metics,with a view to providing references to the development and utilization of this resource in the field of co.metics.

关键词： Anoectochilus roxburghii extract Anoectochilus roxburghii polysaccharides Anoectochilus flavonoids co.metic efficacy

Research Progress on Application of Borneol As Permeation Enhancer in Functional co.metics

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China Detergent & co.metics 2024年第1期9卷 71-75页

作者： Xu Yuanyu Chen Yuxu Zhang Jingqing Zhao Zhimin Yang Depo Xu Xinjun Wang Shidong co.lege of Pharmacy Sun Yat-sen UniversityChina guangdong Yuansi South Pharmaceutical biotechnology co. Ltd.China

Borneol, as a traditional natural permeation enhancer, has been widely used to promote the transdermal absorption of active ingredients. In this review, the mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described. The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced. The application of borneol as a natural ingredient added to functional co.metics was summarized, and its effects on skin-spot treatment, acne skin care, eczema skin care, skin repair and anti-oxidation were introduced. Finally, the possible problems in the application of borneol in co.metics were put forward, and the application prospect of borneol in the development of co.metics was given.

关键词： borneol permeation enhancer co.metics

Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

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Journal of Animal Science and biotechnology 2024年第4期15卷 1466-1481页

作者： Di Zhao Ranran Liu Xiaodong Tan Huimin Kang Jie Wang Zheng Ma Haiquan Zhao Hai Xiang Zhengfen Zhang Hua Li Guiping Zhao guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanChina State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijingChina guangdong Tinoo’s Foods Group co. Ltd.QingyuanChina

Background Carcass traits are crucial indicators of meat production ***,the molecular regulatory mechanisms associated with these traits remain *** In this study,we co.ducted co.prehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory *** on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle ***6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co.expression network analysis and differential expression ***-level experiments co.firmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary *** expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 ***,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of *** co.lectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast ***,the downstream variant rs317934171 regulates SERPINB6 *** results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

关键词： Carcass traits Chicken Genome SERPINB6 Transcriptome

Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy

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Food Science and Human Wellness 2024年

作者： Hong-Yu Pan Na Wang Qian-Wang Zheng Yuan Zou Jing-Ru Zhong Guo-Zhao Luo Ming-Zhen Tu Li-Qiong Guo Jun-Fang Lin co.lege of Food Science South China Agricultural University.Guangzhou Research Center for Micro-Eco.ogical Agent Engineering and Technology of guangdong Province Faculty of Food Science and Engineering Kunming University of Science and Technology Guangzhou Alchemy biotechnology co. Ltd

Ergothioneine is a natural amino acid with powerful antioxidant activity. Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans， and enhance telomerase activity. In present study， the metagenomics sequencing and qRT-PCR analysis were employed to characterize the co.position and diversity of gut microbiome in aging flies. And the alterations in the gut barrier， gut morphology， and other gut physiological indicators of aging flies were evaluated. Here， the results showed that EGT induced little variations in gut microbiota co.position in flies at mid-life， and significant alterations in the gut microbiota populations were only observed in flies at late-life. And ergothioneine attenuated age-related gut injuries， including decreasing reactive oxygen species levels in intestinal enterocytes， reduction of intestinal cells death， and preservation of gut integrity in aging flies. Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy. And activation of intestinal autophagy also co.tributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.

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Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy

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Neural Regeneration Research 2024年第7期19卷 1489-1498页

作者： Jinwang Ye Huali Wan Sihua Chen Gong-Ping Liu Shenzhen Key Laboratory of Marine biotechnology and Eco.ogy College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong ProvinceChina Department of Laboratory Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina co.innovation Center of Neurodegeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older *** features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neurofibrillary tangles,fo rmed by tau protein,in the *** there are amyloid-β-ta rgeting therapies for the treatment of Alzheimer’s disease,these therapies are co.tly and exhibit potential negative side *** evidence suggests significant involvement of tau protein in Alzheimer’s disease-related *** an important microtubule-associated protein,tau plays an important role in maintaining the stability of neuronal microtubules and promoting axonal *** fact,clinical studies have shown that abnormal phosphorylation of tau protein occurs before accumulation of amyloid-βin the *** therapeutic strategies targeting tau protein have begun to emerge,and are co.sidered possible methods to prevent and treat Alzheimer’s ***,abnormalities in post-translational modifications of the tau protein,including aberrant phosphorylation,ubiquitination,small ubiquitin-like modifier(SUMO)ylation,acetylation,and truncation,co.tribute to its microtubule dissociation,misfolding,and subcellular *** causes mitochondrial damage,synaptic impairments,gliosis,and neuroinflammation,eventually leading to neurodegeneration and co.nitive *** review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer’s disease and discusses tau-targeted treatment of Alzheimer’s disease.

关键词： acetylation Alzheimer’s disease co.nitive deficits gliosis mitochondria damage neuroinflammation phosphorylation synaptic impairments tau tau immunotherapy

A Review of Lithospermi Erythrorhizon Root Extract for co.metic Additive Application Purpose

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China Detergent & co.metics 2022年第4期7卷 42-48页

作者： Kang Yunxiang Zhou Zhiming Zhang Anqi guangdong deyi shengmei biotechnology co. Ltd.China

Lithospermum erythrorhizon(LE)is a plant of which the root has a long medicinal use *** researches have co.firmed the positive effects of LE root extract on ***,many effective co.positions of this extract have been *** benefits brought by LE root extract,such as anti-oxidation and antiinflammation,on human makes it a great additive in co.metic *** co.position,benefits,and extracting method were reviewed in this work based on the co.sideration of applying LE root extract as a co.metic additive.

关键词： Lithospermi erythrorhizon root extract co.metic skin

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging

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Science China(Life Sciences) 2024年第4期67卷 745-764页

作者： Shujie Chen Liujing Huang Bingdong Liu Huimin Duan Ze Li Yifan Liu Hu Li Xiang Fu Jingchao Lin Yinlan Xu Li Liu Dan Wan Yulong Yin Liwei Xie Department of Endocrinology and Metabolism Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Public Health Xinxiang Medical UniversityXinxiang 453003China Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Metabo-Profile biotechnology(Shanghai)co.Ltd. Shanghai 201315China Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsSchool of Medical TechnologyGuangdong Medical UniversityDongguan 524023China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China

The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle ***,the interplay between gut microbiota/metabolites and the regulation of satellite cell(SC)homeostasis,particularly during aging,remains *** propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development,regeneration,and aging *** investigation reveals that microbial dysbiosis manipulated by either antibiotic treatment or fecal microbiota transplantation from aged to adult mice,leads to the activation of SCs or a significant reduction in the total ***,employing multi-omics(e.g.,RNA-seq,16S r RNA gene sequencing,and metabolomics)and bioinformatic analysis,we demonstrate that the reduced butyrate levels,alongside the gut microbial dysbiosis,co.ld be the primary factor co.tributing to the reduction in the number of SCs and subsequent impairments during skeletal muscle ***,butyrate supplementation can mitigate the antibiotics-induced SC activation irrespective of gut microbiota,potentially by inhibiting the proliferation and differentiation of SCs/*** butyrate effect is likely facilitated through the monocarboxylate transporter 1(Mct1),a lactate transporter enriched on membranes of SCs and *** a result,butyrate co.ld serve as an alternative strategy to enhance SC homeostasis and function during skeletal muscle *** findings shed light on the potential application of microbial metabolites in maintaining SC homeostasis and preventing skeletal muscle aging.

关键词： gut microbiota aging satellite cells butyrate Slc16a1(Mct1)

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Application of Sargassum fusiforme(Harv.)*** in Cigarettes

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Agricultural biotechnology 2024年第1期13卷 49-50,65页

作者： Juanjuan LI Jing SHAN Xianyan RAO Lina MA Weichuan WANG Mingyue ZHAO Youchi HU China Tobacco.guangdong Industrial co. Ltd.Guangzhou 510385China Zhengzhou Tobacco.Research Institute of CNTC Zhengzhou 450001China

[Objectives]This study was co.ducted to investigate the application of Sargassum fusiforme(Harv.)*** cigarettes.[Methods]Tobacco.specific nitrosamines in the smoke of cigarettes added with ethanol extract of *** were determined,and the co.pounds related to the aroma of *** were identified by flavor-smelling experiment.[Results]With the addition of the ethanol extract of ***,the decrease in the total amount of four tobacco.specific nitrosamines in mainstream cigarette smoke reached 16.42%.The results of the flavor-smelling experiment showed that the aroma of *** might be related to(R)-5,6,7,7A-tetrahydro-4,4,7A-trimethyl-2(4H)-benzofuranone,glycerol,ethyl palmitate,methyl palmitate,ethyl linoleate,methyl(Z,Z,Z)-9,12,15-octadecatrienoate,ethyl(Z,Z,Z)-9,12,15-octadecatrienoate,phytol,and tetradecanoic acid.[co.clusions]The ethanol extract of *** has the potential function of reducing the co.tent of tobacco.specific nitrosamines in smoke and improving the taste of cigarettes.

关键词： Sargassum fusiforme(Harv.)Setch. Tobacco.specific nitrosamines(TSNAs) Flavor smelling