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A Novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

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Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina Torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar Ramos-Martínez Iván Ramos-Martínez Quiroz-Mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México departamento de Investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de Investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de Investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio Nacional de ptica de la Visin-Centro de Investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular degeneration

Polarization conversion using customized subwavelength laser-induced periodic surface structures on stainless steel

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Photonics Research 2022年第9期10卷 2024-2031页

作者： MAHMOUD H.ELSHORBAGY LUIS MIGUEL SÁNCHEZ-BREA JERÓNIMO BUENCUERPO JESÚS deL HOYO ÁNGELA SORIA-GARCÍA VERÓNICA PASTOR-VILLARRUBIA ALEJANDRO SAN-BLAS AINARA RODRÍGUEZ SANTIAGO MIGUEL OLAIZOLA JAVIER ALDA grupo Complutense deÓptica Aplicada Departamento deÓpticaFacultad de Ciencias FıÂsicasUniversidad Complutense de MadridPlaza de las Ciencias S.N.28040 MadridSpain Physics department Faculty of ScienceMinia University61519 El-MinyaEgypt L’Institut Photovoltaïque d’Île-de-France(IPVF) 18 Bd Thomas Gobert91120 PalaiseauFrance Ceit-Basque Research and Technology Alliance(BRTA) Manuel Lardizabal 1520018 Donostia/San SebastiánSpain Universidad de Navarra TecnunManuel Lardizabal 1320018 Donostia/San SebastiánSpain

Stainless steel is a basic raw material used in many *** can be customized by generating laser-induced periodic surface structure(LIPSS)as subwavelength ***,we present the capabilities of an LIPSS on stainless steel to modify the polarization state of the reflected radiation at the IR *** structures have been modeled using the finite element method and fabricated by femtosecond laser *** Stokes parameters have been obtained experimentally and a model for the shape has been used to fit the simulated Stokes values to the experimental *** birefringence of the LIPSS is analyzed to explain how they modify the polarization state of the incoming *** find the geometry of the subwavelength grating that makes it work as an optical retarder that transforms a linearly polarized light into a circularly polarized *** addition,the geometrical parameters of the LIPSS are tuned to selectively absorb one of the components of the incoming light,becoming a linear axial *** selecting the geometrical parameters and orientation of the fabricated LIPSS makes it possible to obtain an arbitrary pure polarization state when illuminated by a pure linearly polarized state oriented at an azimuth of 45°.The overall reflectance of these transformations reaches values close to 60%with respect to the incident intensity,which is the same reflectivity obtained for non-nanostructured stainless steel flat surfaces.

关键词： steel laser polarization

Direct observation of longitudinal aberrated wavefields

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Photonics Research 2023年第6期11卷 1015-1020页

作者： J.P.TREVINO V.COELLO A.JAIMES-NÁJERA C.E.GARCIA-ORTIZ S.CHÁVEZ-CERDA J.E.GÓMEZ-CORREA Tecnológico de Monterrey School of Engineering and SciencesMonterrey NL 64849Mexico Universidad Politécnica de Puebla CuanaláPuebla 72640Mexico Centro de Investigación Científica y de Educación Superior de Ensenada Unidad MonterreyApodaca NL 66629Mexico Instituto Nacional de Astrofísica Óptica y ElectrónicaCoordinación deÓpticaTonantzintla Puebla 72840Mexico

Rather than focusing on a focal spot,aberrated wavefields spread out over a *** a wave phenomenon,optical aberrations are analyzed in terms of waves propagating in the 3D *** this work,we report the observation of 2D longitudinal aberrated *** observation can be visualized by mapping the intensity distributions of surface plasmon polaritons(SPPs)that propagate on a metal/air interface using leakage radiation *** orientation of the SPP beam is tweaked by tilting and translating the system to mimic aberrated beams,presenting known Seidel terms:defocus,spherical,coma,and tilt *** approach allows the examination of the longitudinal evolution of aberrated beams in a visual and rapid manner,in contrast to more complicated post-processing reconstructions.

关键词： space wave fields

A novel and stretchable carbon-nanotube/Ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of Environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael Perez-Gonzalez Christian Gomez-Solis Luis Armando Diaz-Torres Armando Encinas Jorge Oliva Vicente Rodriguez-Gonzalez Consejo Nacional de Ciencia y Tecnología-División de Materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de Ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México grupo de Espectroscopia de Materiales Avanzados y Nanoestructurados(GEMANA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CNTs),silicon rubber and Ni@TiO_(2):W nanoparticles(TiWNi NPs) with average size of 37±2 *** images showed that the TiWNi NPs decorated the surface of the CNT fibers,which are oriented in a preferential *** NPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWNi powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CNT composite (stretched at 0%),TiWNi powders,CNT+TiWNi(stretched at 0%),CNT+TiWNi (stretched at 50%) and CNT+TiWNi (stretched at 100%),***,stretching the CNT+TiWNi composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CNT/TiWNi-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

Topological protection of partially coherent light

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Photonics Research 2022年第5期10卷 1223-1231页

作者： KONRAD TSCHERNIG GABRIEL MARTINEZ-NICONOFF KURT BUSCH MIGUEL A.BANDRES ARMANDO PEREZ-LEIJA Max-Born-lnstitut 12489 BerlinGermany Humboldt-Universität zu Berlin Institut fur PhysikAG Theoretische Optik&Photonik12489 BerlinGermany Coordinacidn deÓptica Instituto Nacional de AstrofisicaÓpticay Electronica72840 TonantzintlaPueblaMexico CREOL The College of Optics and PhotonicsUniversity of Central FloridaOrlandoFlorida 32816USA

Topological physics exploits concepts from geometry and topology to implement systems capable of guiding waves in an unprecedented *** ideas have led to the development of photonic topological insulators,which are optical systems whose eigenspectral topology allows the creation of light states that propagate along the edge of the system without any coupling into the bulk or backscattering even in the presence of ***,topological protection is a fully coherent effect,and it is not clear to what extent topological effects endure when the wavefronts become partially ***,we study the interplay of topological protection and the degree of spatial coherence of classical light propagating in disordered photonic topological *** results reveal the existence of a well-defined spectral window in which partially coherent light is topologically *** opens up the design space to a wider selection of light sources,possibly yielding smaller,cheaper,and more robust devices based on the topological transport of light.

关键词： topological coherent topology

Retinal microglial activation in glaucoma:evolution over time in a unilateral ocular hypertension model

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Neural Regeneration Research 2022年第4期17卷 797-799页

作者： JoséA.Fernández-Albarral Ana I.Ramírez Rosa de Hoz Juan J.Salazar Instituto de Investigaciones Oftalmológicas Ramón Castroviejo Universidad Complutense de MadridMadridSpain Facultad deÓptica y Optometría Departamento de InmunologíaOftalmología y ORLUniversidad Complutense de MadridMadridSpain

Glaucoma is a neurodegenerative chronic pathology,characterized by the loss of retinal ganglion cells(RGC),which leads to an irreversible vision field *** increased intraocular pressure(IOP)constitutes its main risk ***,the main treatments for glaucoma are focused on decreasing IOP;nevertheless,the progression of the disease continues,despite IOP *** fact shows the existence of other factors that could contribute to the advance of glaucomatous *** early diagnostics,the use of neuroprotective therapies,and knowledge of the pathological processes are the major challenges associated with the management of this *** pathogenic mechanisms have been proposed to be responsible for RGC death,including oxidative stress,mitochondrial dysfunction,glutamate excitotoxicity,and neuroinflammation(Casson et al.,2012).

关键词： irreversible oxidative activation

A deep learning framework to emulate density functional theory

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npj Computational Materials 2023年第1期9卷 687-695页

作者： Beatriz G.del Rio Brandon Phan Rampi Ramprasad departamento de Física Teórica Atómica yÓpticaUniversidad de ValladolidPaseo de Belén 747011 ValladolidSpain School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive NWAtlantaGA 30332USA

density functional theory(DFT)has been a critical component of computational materials research and discovery for ***,the computational cost of solving the central Kohn–Sham equation remains a major obstacle for dynamical studies of complex phenomena ***,we propose an end-to-end machine learning(ML)model that emulates the essence of DFT by mapping the atomic structure of the system to its electronic charge density,followed by the prediction of other properties such as density of states,potential energy,atomic forces,and stress tensor,by using the atomic structure and charge density as *** deep learning model successfully bypasses the explicit solution of the Kohn-Sham equation with orders of magnitude speedup(linear scaling with system size with a small prefactor),while maintaining chemical *** demonstrate the capability of this ML-DFT concept for an extensive database of organic molecules,polymer chains,and polymer crystals.

关键词： functional theory system

Local characterization of the polarization state of 3D electromagnetic fields:an alternative approach

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光子学研究:英文版 2023年第7期11卷 1326-1338页

作者： ROSARIO MARTíNEZ-HERRERO DAVID MALUENDA MARCOS AVINOA ARTUR CARNICER IGNASI JUVELLS ANGEL S.SANZ departamento de Óptica Universidad Complutense de Madrid(UCM)Ciudad Universitaria28040 MadridSpain Facultat de Física Departament de Física aplicadaUniversitat de Barcelona(UB)Martíi Franquès 108028 BarcelonaSpain

A precise knowledge of the polarization state of light is crucial in technologies that involve the generation and application of structured light fields. The implementation of efficient methods to determine and characterize polarization states is mandatory;more importantly, these structured light fields must be at any spatial location at a low expense. Here, we introduce a new characterization method that relies on a rather convenient description of electric fields without neglecting their 3D nature. This method is particularly suitable for highly focused fields,which exhibit important polarization contributions along their propagation direction in the neighborhood of the focal region;i.e., the contributions out of the planes transverse to the optical axis, conventionally used to specify the polarization state of these fields. As shown, the method allows the extraction of information about the three field components at relatively low computational and experimental costs. Furthermore, it also allows characterization of the polarization state of a field in a rather simple manner. To check the feasibility and reliability of the method, we determined both analytically and experimentally the local polarization states for a series of benchmark input fields with it, finding excellent agreement between the theory and experiment.

关键词： polarization characterization state

Amyotrophic lateral sclerosis,a neurodegenerative motor neuron disease with retinal involvement

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Neural Regeneration Research 2022年第5期17卷 1011-1012页

作者： Ana I.Ramírez Rosa de Hoz Pilar Rojas Juan J.Salazar Instituto de Investigaciones Oftalmológicas Ramón Castroviejo.Universidad Complutense de Madrid MadridSpain Facultad deÓptica y Optometría.departamento de Inmunología Oftalmología y ORL.Universidad Complutense de MadridMadridSpain Hospital General Universitario Gregorio Marañón Instituto Oftálmico de MadridMadridSpain

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that damages the motor neurons,the spinal cord,the cerebellum,and some areas of the ***,more recent studies show that it can also affect the visual syst... 详细信息

关键词： visual problems involvement