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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Performance Development Target Setting of Passenger Car Diesel Engine

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 512-517页

作者： ZHENG Guangyong YU Xiumin LIU Jiangwei SONG Tao LI Wenxiang state Key Lab of Automotive Dynamic Simulation Jilin University research and Development Center FAW Group Corporation

Setting engine emission targets to meet diesel car requirements is particularly important in engine performance development phase. Many researches are focused on associating vehicle performance with engine targets, but most work is done by testing, which is time and cost consuming, furthermore, the relationship of vehicle and engine will change when either engine or vehicle changes. A GT-Drive model to simulate New European Driving Cycle (NEDC) for passenger car is developed and calibrated by testing data, model precision is controlled within 5%. Time distribution of engine operating conditions when car running NEDC cycle has been analyzed, 10 critical major engine operating points are summarized according to running time proportion. Emission of NOx and smoke control regions containing these 10 points for target engine are set. Vehicle emissions are simulated and evaluated during engine development after engine performance test data are got, and engine combustion system layout and calibration are adjusted until vehicle targets are met. Vehicle is tested in chassis dynamometer finally, the testing results show a good agreement with the simulated results with an error of less than 5%, which proves that the emission value exchange of vehicle and engine is reliable. Performance target decomposition method for passenger car diesel presented can greatly shorten the development cycle and save costs.

关键词： passenger car diesel engine emission target New European Driving Cycle simulation analysis

Effect of Direct Quenching on Microstructure and Mechanical Properties of a Wear-resistant Steel

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 390-398页

作者： Hongyu SONG Shunhu ZHANG Liangyun LAN Canming LI Haitao LIU Dewen ZHAO Guodong WANG state Key Laboratory of Rolling and Automation Northeastern University Technical research and Development Center Laiwu Steel Group

A wear-resistant steel was hot rolled at the same finish temperature, and subsequently treated with conventional reheat quenching and tempering process （RQ＆T） and direct quenching and tempering process （DQ＆T）, respectively. The effect of direct quenching on the microstructure and mechanical properties was investigated in detail by using optical microscope, transmission electron microscope and scanning electron microscope equipped with electron backscattered diffraction. The results showed that the microstructures of both the RQ and DQ specimens were complex constituents of lath martensite and lower bainite. Compared with the RQ specimen, the lower bainite content in DQ specimen was much higher. Furthermore, the bainite in the DQ specimen extended into and segmented the prior austenite grains, which can decrease martensite packet size. The proportion of high-angle boundary in the DQ specimen was higher than that in the RQ specimen, which may improve the impact toughness. The carbides in DQ＆_T specimen were much finer and distributed even dispersively because direct quenching can retain substantive defects which may provide more nucleation sites for carbide precipitation in the tempering process. Besides, the mechanical properties of DQ and DQ＆T specimens were superior than those subjected to RQ and RQ＆T processes, respectively.

关键词： Direct quenching Temper Lower bainite Martensite packet Mechanical properties

Cytotoxic, kinetics of inhibition of carbohydrate-hydrolysing enzymes and oxidative stress mitigation by flavonoids roots extract of Dicoma anomala(Sond.)

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 24-31页

作者： Fatai Oladunni Balogun Anofi Omotayo Tom Ashafa Phytomedicine and Phytopharmacology research group Department of Plant Sciences University of the Free StateQwaQwa Campus Phytomedicine and Phytopharmacology research group Department of Plant Sciences University of the Free State QwaQwa Campus

Objective: To investigate the free radical scavenging, antidiabetic, kinetics and cytotoxic potentials of flavonoids extract of Dicoma anomala root by using standard methods. Methods:Antioxidant activity of the flavonoids was investigated at scavenging free radicals such as 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, hydroxyl radical, reducing capabilities, 2,2-azinobis(3-ethylbenzothiazoline-6) sulfonic acid as well as metal chelating capability at different concentrations(0.125-1.000 mg/mL) while the antidiabetic activity was evaluated via the inhibition and kinetics of carbohydrate digestive enzymes including, alpha glucosidase, sucrase and maltase. Brine shrimp lethality assay was also employed to examine the cytotoxic effects of the extract by using different range of concentrations(0.125-2.000 mg/mL). Results: The study revealed the best antioxidant activity of the extract in 1,1-diphenyl-2-picrylhydrazyl,2,2-azino-bis(3-ethylbenzothiazoline-6) sulfonic acid and nitric oxide having IC_(50) values of(386.90±4.91),(736.00±38.12),(629.30±9.62) μg/mL respectively compared with quercetin(standard) with IC_(50) [(522.20±12.38),(1 021.00±15.61) and(1 075.00±29.35) μg/mL]respective values while it was insignificantly(P>0.05) at par with quercetin for reducing power. Similarly, the extract exhibited a moderate inhibition of alpha glucosidase(43.1%),sucrase(33.4%) and maltase(29.9%) activities which were significantly(P<0.05) better than acarbose(18.4%, 12.7% and 24.9% respectively) although acarbose(46.1%) inhibited the higher activity of alpha amylase than the extract(13.7%). The kinetics of mode of inhibition of alpha amylase, alpha glucosidase, sucrase and maltase by flavonoids extract of Dicoma anomala revealed an uncompetitive, non-competitive, competitive and non-competitive inhibition respectively. The result of the lethality assay showed a potent cytotoxic effect of the flavonoids with LC_(50) value 0.510 mg/mL. Conclusions: The results obtained from this stud

关键词： Antioxidative Antihyperglycaemic Cytotoxic Dicoma anomala Flavonoids Kinetics

Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 391-401页

作者： Yongxuan Shang Mingyu Fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University state Key Laboratory of Metal Material for Marine Equipment and Application Iron & Steel Research Institute of Ansteel Group Corporation

Carbon can change the phase components of low-density steels and influence the mechanical properties. In this study, a new method to control the carbon content and avoid the formation of δ-ferrite by decarburization treatment was proposed. The microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically examined. Crussard–Jaoul(C–J) analysis was employed to examine the work hardening characteristics during the tensile test. During decarburization by heat treatments, the carbon content within the austenite phase decreased, while Mn and Al were almost unchanged; this made the steel with full austenite transform into the austenite and ferrite dual phase. Meanwhile,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the same. In addition, the formation of other carbides restrained. Carbon loss induced a decrease in strength due to the weakening of the carbon solid solution. For the steel with the single austinite, the deformation mode of austenite was the dislocation planar glide, resulting in the formation of microbands. For the dual-phase steel, the deformation occurred by the dislocation planar glide of austenite first, with the increase in strain, the cross slip of ferrite took place, forming dislocation cells in ferrite. At the late stage of deformation, the work hardening of austinite increased rapidly, while that of ferrite increased slightly.

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Effect of Sulfur Precursor on Dimensions of One-dimensional CdS Nanocrystals

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Journal of Materials Science & Technology 2009年第4期25卷 462-464页

作者： M.Maleki Sh.Mirdamadi R.Ghasemzadeh M.Sasani Ghamsari Department of Metallurgy and Material Engineering Iran University of Science & Technology Solid state Lasers research group Laser & Optics Research School

One-dimensional CdS nanocrystals have been prepared by solvothermal method using cadmium acetate as a cadmium precursor, elemental sulfur and Na2S, as a sulfur precursor, and ethylenediamine as a solvent at 150℃ for 5 h. The nanocrystals were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM） and UV-Vis absorption spectroscopy. XRD patterns indicate that both Na2S and elemental sulfur as the sulfur precursor result in CdS nanorods with wutzite phase （hexagonal structure）. SEM and TEM images show that diameter of CdS nanorods can be decreased using Na2S instead of elemental sulfur. For the growth of CdS nanorods, a mechanism has been proposed. Uv-Vis absorption of CdS nanorods （sulfur precursor： Na2S） was shown blue shift to 485 nm due to the quantum size effect.

关键词： Nanomaterials Semiconductors CdS nanorods Na2S Solvothermal method

Guest Editorial:Special Section on Control Centers for the Evolving Power Grid:Architecture and Applications

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 I0001-I0002页

作者： Anjan Bose Patrick Panciatici Xin Shan Washington state university PullmanUSA RTE ParisFrance NARI group Corporation(state Grid Electric Power research Institute) NanjingChina

THE world-wide drive to decrease greenhouse gases in the atmosphere is rapidly changing the mix of fuel resources that are used to generate *** percentage of fossil fuels,especially coal,is declining while the percentage of renewable resources,like wind and solar,is *** generation mix has always depended on the avail-ability of different fuels in different regions,like the availability of hydro or the acceptability of nuclear power,and the recent changes also depend on this geography,like the radiance of the sun or the intensity of the *** these changes will lead to different architectures in the evolving power grid,some trends are already being felt.

关键词： Power gases fuels

Solution of the Schrodinger equation for a particular form of Morse potential using the Laplace transform

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Chinese Physics C 2013年第4期37卷 36-38页

作者： M.Zarezadeh M.K.Tavassoly Atomic and Molecular group Faculty of PhysicsYazd University Photonics research group Engineering Research CenterYazd University

In this paper, we have solved the Schrdinger equation for a particular kind of Morse potential and find its normalized eigenfunctions and eigenvalues, exactly. Our work is based on the Laplace transform technique wh... 详细信息

关键词： Schrdinger equation Laplace transform Morse potential bound state

Algorithm for source recovery in underdetermined blind source separation based on plane pursuit

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Journal of Systems Engineering and Electronics 2018年第2期29卷 223-228页

作者： FU Weihong WEI Juan LIU Naian CHEN Jiehu state Key Lab of Integrated Service Networks Xidian University No.10 research Institution China Electronics Technology Group Corporation

In order to achieve accurate recovery signals under the underdetermined circumstance in a comparatively short time,an algorithm based on plane pursuit(PP) is proposed. The proposed algorithm selects the atoms according to the correlation between received signals and hyper planes, which are composed by column vectors of the mixing matrix, and uses these atoms to recover source signals. Simulation results demonstrate that the PP algorithm has low complexity and higher accuracy as compared with basic pursuit(BP), orthogonal matching pursuit(OMP), and adaptive sparsity matching pursuit(ASMP) algorithms.

关键词： underdetermined blind source separation(UBSS) source recovery greedy algorithm plane pursuit