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Methods for Increasing Creditability of Anomaly Detection System

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 79-82页

作者： YANQiao graduateschoolatshenzhen TsinghuaUniversityShenzhen518055GuangdongChina

Based on Bayes' theorem we point out that the false positive rate must be lower than the intrusion base rate in order to make the Alarm Credibility Probability of the intrusion detection system exceed 50%. We present the methods that have been used in our developing intrusion detection system AIIDS (artificial immune intrusion detection systems) to increase the creditability of anomaly detection system. These methods include increasing the regularities of the system call trace by use of Hidden Markov Model (HMM), making every antibody or detector has finite lifetime, offering the detector a co-stimulate signal to illustrate whether there is damage in the system according to the integrity, confidentiality, or availability of the system resource.

关键词： Key words intrusion detection creditability false positive rate

Diffusion in Laser Gradient Field Studied by Fluorescence Correlation Spectroscopy

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Chinese Physics Letters 2004年第4期21卷 760-763页

作者：孟凡波陈波刘广马辉 MolecularandNanoScienceLaboratory DepartmentofPhysicsTsinghuaUniversityBeijing100084 graduateschoolatshenzhen TsinghuaUniversityShenzhen51805"7

We discuss the effects of a laser gradient field on particle diffusion in solvent. A tightly focused laser beam may change both the local concentration and the diffusion time obtained in fluorescence correlation spectroscopy (FCS). A quantitative relation between the gradient field strength and the local particle concentration has been derived. Using the data generated by Monte Carlo simulations, we demonstrate that the quantitative relation can be used to obtain number density and polarizability of the particles by FCS experiments in the laser gradient field. A nonlinear growth of diffusion time with laser power is also shown by both the theoretical analysis and the simulations.

关键词： Diffusion

Precise Determination of the MgAlON/(AlN+MgAlON) Phase Bound- ries in the MgO-AlN-Al_2O_3 Ternary System at 1600℃ and 1700℃

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Journal of Materials Science & Technology 2005年第2期21卷 277-280页

作者： HouxingZHANG YanruoHONG YongHUANG JialinSUN graduateschoolatshenzhen TsinghuaUniversityShenzhen518057China//UniversityofScienceandTechnologyBeijingBeijing100083China UniversityofScienceandTechnologyBeijing Beijing100083China DepartmentofMaterialScienceandEngineering TsinghuaUniversityBeijing100084China

The accurate phase boundary of MgAION/(AIN+MgAION) in MgO-AIN-Al2O3 ternary system, has not been determined precisely so far. In the present study, the lattice parameters of MgAION solid solution with various compositions were determined precisely with X-ray powder diffraction. According to the relationship between the lattice parameters of MgAION solid solution and the contents of AIN and MgO, the phase boundaries of MgAION/(AIN+MgAION) in MgO-AIN-AI2O3 ternary system at 1600℃ and 1700℃ were precisely determined.

关键词： Phase boundary MgAlON X-ray diffraction Lattice parameter

Inhibitors of protein kinase C

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Chinese Science Bulletin 2005年第13期50卷 1293-1304页

作者： LIUShiying JIANGYuyang CAOJiant LIUFeng ZHAOYufen KeyLaboratoryofBioorganicPhosphorusChemistry MinistryofEducationDepartmentofChemistrySchoolofLifeScienceandEngineeringTsinghuaUniversityBeijing100084China TheKeyLaboratoryofChemicalBiology GuangdongProvinceGraduateSchoolatShenzhenTsinghuaUniversityShenzhen518055China DepartmentofBiologicalEngineering HenanUniversityofTechnol-ogyZhengzhou450052China

Protein kinase catalyzes the transfer of the γ-phosphoryl group from ATP to the hydroxyl groups of protein side chains, which plays critical roles in signal transduction pathways by transmitting extracellular signals across the plasma membrane and nuclear membrane to the destination sites in the cytoplasm and the nucleus. Protein kinase C (PKC) is a superfamily of phospholipid-dependent Ser/Thr kinase. There are at least 12 isozymes in PKC family. They are distributed in different tissues and play different roles in physiological processes. On account of their concern with a variety of pathophysiologic states, such as cancer, inflammatory conditions, autoimmune disorder, and cardiac diseases, the inhibitors, which can inhibit the activity of PKC and the interaction of cytokine with receptor, and interfere signal transduction pathway, may be candidates of therapeu-tic drugs. Therefore, intense efforts have been made to de-velop specific protein kinase inhibitors as biological tools and therapeutic agents. This article reviews the recent develop-ment of some of PKC inhibitors based on their interaction with different conserved domains and different inhibition mechanisms.

关键词：蛋白质激活酶C 抑制剂信号转换免疫能力