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Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents

World Journal of Gastroenterology 2005年第3期11卷 389-392页

作者： Ya-YenChen Chiao-MingChen Pi-YuChao Tsan-JuChang Jen-FangLiu GraduateInstituteofNutrition&HealthSciences TaipeiMedicalUniversityTaipeiTaiwanChina graduateinstituteofpharmacy TaipeiMedicalUniversityTaipeiTaiwanChina DepartmentofFoodandNutrition ChineseCultureUniversityTaipeiTaiwanChina TaoyuanDistrict AgricultureImprovementStationTaipeiBranchTaiwanChina

AIM: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin 0-deethylase (EROD), pentoxyresorufin 0-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined. QR represented phase Ⅱ enzymes, the rest of the enzymes tested represented phase Ⅰ enzymes. RESULTS: The oxidized frying oil feeding produced a significant increase in phase Ⅰ and Ⅱ enzyme systems, including the content of CYP450 and microsomal protein, and the activities of NADPH reductase, EROD, PROD, ANH, AMD and QR in rats (P<0.05). In addition, the activities of EROD, ANH and AMD decreased and QR increased after feeding with H. cordata in OFO-fed group (P<0.05). The feeding with 2% H. cordata diet showed the most significant effect. CONCLUSION: The OFO diet induces phases I and II enzyme activity, and the 2% H. cordata diet resulted in a better regulation of the xenobiotic-metabolizing enzyme system.

关键词： Frying oil Houttuynia cordata thunb Xenobiotic metabolizing enzyme system

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Effects of long-term ethanol consumption on jejunal lipase and disaccharidase activities in male and female rats

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World Journal of Gastroenterology 2005年第17期11卷 2603-2608页

作者： Chi-ChangHuang Jiun-RongChen Chieh-ChungLiu Kung-TungChen Ming-JerShieh Suh-ChingYang SchoolofNutritionandHealthSciences TaipeiMedicalUniversityTaipei110TaiwanChina graduateinstituteofpharmacy SchoolofPharmacyTaipeiMedicalUniversityTaipei110TaiwanChina DepartmentofPhysicalEducation YuanpeiUniversityofScienceandTechnologyHsinChuTaiwanChina DepartmentofGeneralEducation MingHsinUniversityofScienceandTechnologyHsinChu304TaiwanChina

AIM: To study the effect of long-term ethanol consumption on jejunal lipase and disaccharidase (sucrase, maltase,and lactase) activities in rats and its gender difference. METHODS: Age-matched male and female Wistar rats were fed control or ethanol-containing liquid diets for 12 wk following the Lieber-DeCarli model. According to both theplasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, 40 rats were divided into four groups as follows: male control group (MC), male ethanol group (ME), female control group (FC), and female ethanol group (FE).RESULTS: After ethanol feeding for 12 wk, the results revealed that plasma AST and ALT activities of group MEwere significantly increased by 58% and 92%, respectively,than those of group MC (P＜0.05). Similarly, plasma AST and ALT activities of group FE were also significantly increased by 61% and 188%, respectively, than those of group FC (P＜0.05). Fat accumulation was observed in both ethanol treated groups, while fatty changes were more severe in group FE than those in group ME. The induction of hepatic microsomal cytochrome P450 2E1 (CYP2E1) was obviously seen in group ME and group FE, but was not detected in group MC and group FC. Jejunal lipase activity of group ME was significantly increased by 1.25-fold than that of group MC (P＜0.05). In contrast to, sucrase, maltase, and lactase activities of group ME were significantly decreased by 63%, 62% and 67%, respectively, than those of group MC (P＜0.05). Similarly, activities of these three enzymes of group FE were also significantly decreased by 43%, 46% and 52%, respectively, than those of group FC (P＜0.05).There were no significant epithelial changes of the duodenal mucosa in any ***: Long-term ethanol consumption significantly can increase jejunal lipase and decrease jejunal disaccharidase activities in both male and female rats.

关键词： Ethanol consumption Jejunal lipase Disaccharidase Gender difference Rats

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