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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of graduate student Chongqing Medical UniversityChongqingChina department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Glutamate and γ-aminobutyric acid receptors and their characteristics in retina

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Chinese science Bulletin 1999年第17期44卷 1548-1556页

作者： Xiongli Yang Ying Shen Minghu Han Shanghai Institute of Physiology and Key Laboratory of Neurobiology Chinese Academy of Sciences Shanghai China graduate student of department of biological science and technology Zhejiang University Hangzhou China

Glutamate and γ-aminobutyric acid (GABA) are important neurotransmitters in the retinal neuronal circuitry. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors in the retina have been extensively investigated. Results indicate that glutamate receptors on horizontal cells may be an AMPA preferring subtype,

关键词： retina glutamate γ-aminobutyric acid desensitization receptor patch clamp.

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Blue-light-induced rapid chloroplast de-anchoring in Vallisneria epidermal cells

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Journal of Integrative Plant Biology 2015年第1期57卷 93-105页

作者： Yuuki Sakai Shin-Ichiro Inoue Akiko Harada Ken-Ichiro Shimazaki Shingo Takagi department of biological sciences Graduate School of Science Osaka University Division of biological science Graduate School of Science Nagoya University department of Biology Osaka Medical College department of Biology Faculty of Science Kyushu University

In the outer periclinal cytoplasm of leaf epidermal cells of an aquatic angiosperm Vallisneria, blue light induces ＂chloroplast de-anchoring＂, a rapid decline in the resistance of chloroplasts against centrifugal force. Chloroplast de- anchoring is known induced within lmin of irradiation with high-fluence-rate blue light specifically, preceding the com- mencement of chloroplasts migration toward the anticlinal cytoplasm. However, its regulatory mechanism has remained elusive, although pharmacological analysis suggested that a calcium release from intracellular calcium stores is necessary for the response, in search of the responsible photoreceptors, immunoblotting analysis using antibodies against phototropins demonstrated that cross-reactive polypeptides of 120-kDa exist in the plasma-membrane fraction prepared from the leaves. In vitro phosphorylation analysis revealed that 120-kDa polypeptides were phosphorylated by exposure to blue light in a fluence-dependent manner. The blue-light-induced phosphorylation activity was sensitive to a Ser/Thr kinase inhibitor, staurosporine, and unusually was retained at a high level for a long time in darkness. Furthermore, phototropin gene homologs （Vallisneria PHOTOTROPINI and PHOTOTROPIN2） expressed in leaves were isolated. We propose that calcium- regulated chloroplast de-anchoring, possibly mediated by phototropins, is an initial process of the blue-light-induced avoidance response of chloroplasts in Vallisneria.

关键词： Avoidance response of chloroplasts blue-light response chloroplast de-anchoring cytoplasmic calcium phototropin

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Orientation of larval and juvenile horseshoe crabs Limulus polyphemus to visual cues: Effects of chemical odors

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Current Zoology 2010年第5期56卷 618-633页

作者： Julie M.MEDINA Richard A.TANKERSLEY department of biological sciences Florida Institute of Technology

Adult horseshoe crabs Limulus polyphemus have long served as models for the study of vision in marine arthropods. Yet, little is known about the ability of early life history stages to detect and respond to visual cues. We examined the visually directed movements of larvae and first stage juveniles to horizons containing dark visual targets of different sizes. The study tested the hypotheses that （1） larval and juvenile crabs can detect and respond to visual targets and （2） the direction of orientation varies with the presence of chemical cues associated with settlement habitats. Orientation of larval and juvenile crabs to rectangles subtending angles from 30--330~ was tested in a circular arena containing water that either lacked estuarine chemical cues （offshore water） or contained odors from aquatic vegetation or known predators. In the absence of chemical odors, larvae oriented toward and juveniles moved away from dark horizons subtending angles 〉 60~. When placed in water containing chemical odors from potential nursery habitats, including the seagrasses Halodule wrightii and Syringodium filiforme, crabs reversed their direction of orientation relative to their responses in offshore water. Odors from two known predators, the mummichug Fundulus grandis and blue crab Callinectes sapidus, had no affect on the orientation of larvae. Yet, juveniles responded to both odors by moving toward the visual target. Results support the hypothesis that the visual orientation of larval and juvenile horseshoe crabs changes upon exposure to habitat and predator cues and that the direction of the response undergoes an ontogenetic shift following metamorphosis

关键词： Orientation Visual cues Chemical odors

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Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

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Neural Regeneration Research 2016年第9期11卷 1394-1395页

作者： Misako Okumura Takahiro Chihara department for Evolutionary Biology Max-Planck Institute for Developmental Biology department of biological science Graduate School of ScienceHiroshima University

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

关键词： ORN Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

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Effect of berberine on activity and mRNA expression of N-acetyl transferase in human lung cancer cell line A549

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Journal of Traditional Chinese Medicine 2014年第3期34卷 302-308页

作者： Shengyan Xi Kunhan Chuang Kwangming Fang Yimin Lee Jinggung Chung Yaochen Chuang department of Traditional Chinese Medicine Medical College of Xiamen University Cancer Research Center of Xiamen University department of Applied Cosmetology Hwa Hsia Institute of Technology department of Dental technology and Materials science Central Taiwan University of Science and Technology department of Medical Laboratory science and Biotechnology Central Taiwan University of Science and Technology graduate Institute of biological science and technology China Medical University Center of General Education Central Taiwan University of Science and Technology Chinaand Kiang Wu Nursing College of Macao

OBJECTIVE： To study the effects of berberine on ac- tivity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549. METHODS： N-acetyltransferase antibodies wereprepared. The human lung cancer A549 cells were cultivated randomly in the wells of culture plate, and divided into the control group, and berberine 0.0008, 0.008, 0.08, 0.8 and 1.6 mM treatment groups, with 3 wells for each group. 24 h later, A549 cells in each group were collected respectively, the content of N-acetyltransferase was detected by Flow cytometry, and the mRNA expression of N-acetyltransferase was observed by reverse tran- scription polymerase chain reaction. RESULTS The N-acetyltransferase content in hu- man lung cancer A549 cells decreased with the in- creasing of berberine concentration, significantly lower than that in the control group （P〈O.05 or P〈 0.001）; and the mRNA expression of N-acetyltrans- ferase also decreased with the increasing of berber- ine concentration, significantly lower in Huanglian- su treatment groups （P〈0.O01）. CONCLUSION： Berberine can inhibit the activity of N-acetyltransferase in human lung cancer cell line A549, and shows negative correlations of dose and time in a certain extent. The inhibited gene expres- sion of N-acetyltransferase in human lung cancer A549 cell may probably represent one of the mech- anisms for its antineoplastic effect.

关键词： Berberine Acetyltransferases Cell line,tumor Neoplasms

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Molecular analyses of Xenopus laevis Mesp-related genes

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Integrative Zoology 2009年第4期4卷 387-394页

作者： Keisuke HITACHI Akiko KONDOW Hiroki DANNO Yusuke NISHIMURA Koji OKABAYASHI Makoto ASASHIMA department of Life sciences(Biology) Graduate School of Arts and SciencesThe University of TokyoTokyoJapan department of biological sciences Graduate School of ScienceThe University of TokyoTokyoJapan ICORP Organ Regeneration Project Japan Science and Technology AgencyTokyoJapan Organ Development Research Laboratory National Institute of Advanced Industrial Science and TechnologyIbarakiJapan

During vertebrate somitogenesis,somites bud off from the anterior end of the presomitic mesoderm(PSM).Meso-dermal posterior(Mesp)-related genes play essential roles in somitogenesis,particularly in the definition of the somite boundary *** vertebrates,two types of Mesp-related genes have been identified:Mesp1 and Mesp2 in the mouse;Meso-1 and Meso-2 in the chicken;Xl-mespa and Xl-mespb(also known as Thylacine1)in the African clawed frog(Xenopus laevis);and mesp-a and mesp-b in the ***,the functional differences between two Mesp-related genes remain *** the present study,we carried out comparative analyses of the Xl-mespa and Xl-mespb *** amino acid sequences of the Xl-mespa and Xl-mespb proteins showed a high level of *** expression of Xl-mespa started broadly in the ventrolateral mesoderm and gradually shifted to a striped pattern of *** contrast,Xl-mespb showed a striped pattern of expression from the *** expression profiles completely overlapped at the PSM during *** investigate the functional differ-ences between Xl-mespa and Xl-mespb in terms of target gene regulation,we carried out a luciferase assay using the murine Lunatic fringe(L-fng)*** of the L-fng promoter was activated more strongly by Xl-mespb than by *** same pattern was observed for the murine Mesp-related *** results suggest that the functional differences between the two types of Mesp-related genes are evolutionally conserved in vertebrates.

关键词： homology presomitic mesoderm somite segmentation somitogenesis Xenopus laevis.

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Computational Cavitation Flows at Inception and Light Stages on an Axial-Flow Pump Blade and in a Cage-Guided Control Valve

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Journal of Thermal science 2007年第4期16卷 337-345页

作者： Sumio SAITO MasahiroSHIBATA HideoFUKAE Eisuke OUTA Tokyo National College of technology 1220-2 Kunugida-machiHachioji-shiTokyo 193-0997 graduate student Graduate School of Science and EngineeringWaseda University department of Mechanical Engineering Waseda UniversityOkubo 3-4-1Shinjyuku-ku Tokyo 1600072Japan

Cavitation flows induced around an axial-flow pump blade and inside a high pressure cage-type valve are simulated by a two-dimensional unsteady Navier-Stokes analysis with the simplest treatment of bubble dynamics. The fluid is assumed as a continuum of homogeneous dispersed mixture of water and vapor nuclei. The analysis is aimed to capture transient stages with high amplitude pressure change during the birth and collapse of the bubble especially at the stage of cavitation inception. By the pump blade analysis, in which the field pressure is moderate, cavitation number of the inception and locations of developed cavitation are found to agree with experimental results in a wide flow range between high incidence and negative incidence. In the valve flow analysis, in which the water pressure of 5MPa is reduced to 2MPa, pressure change responding to the bubble collapse between the vapor pressure lower than 1 KPa and the extreme pressure of higher than 104 KPa is captured through a stable computation. Location of the inception bubble and pressure force to the valve plug is found agree well with the respective experimental features.

关键词： Cavitation unsteady CFD hydrofoil control valve homogeneous mixture inception and collapse transient pressure

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Animal models in the study of Alzheimer's disease and Parkinson's disease:A historical perspective

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Animal Models and Experimental Medicine 2022年第1期5卷 27-37页

作者： Rajashree Banerjee Arushi Rai Shreyas M.Iyer Sonia Narwal Meghana Tare department of biological sciences Birla Institute of Technology and SciencePilaniIndia

Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases *** are proteinopathic conditions and while occasionally inherited,are largely sporadic in *** the advances in our understanding of the two have been significant,they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately *** models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological *** review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease,and highlights the shifting paradigms in studying two humanspecific conditions in non-human organisms.

关键词： Alzheimer's disease animal models neurodegeneration Parkinson's disease

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Microstructural Characteristics of Underwater Shock Consolidated Aluminum Composites

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Journal of Materials science & technology 2003年第4期19卷 341-345页

作者： K.Raghukandan K.Hokamoto J.S.Lee A.Chiba B.C.Pai department of Mechanical Engineering and Materials science Kumamoto UniversityKumamotoJapanShock Wave and Condensed Matter Research Center2-39-1 KurokamiKumamoto UniversityKumamotoJapanGraduate studentGraduate School of Science and TechnologyKumamoto UniversityKumamotoJapanDepartment of Mechanical Engineering and Materials ScienceKumamoto UniversityKumamotoJapanRegional Research LaboratoryThiruvananthapuramKeralaIndia

Metal matrix composites (MMCs) offer extra strength and high temperature capabilities in comparison with unrein-forced metals. Aluminum composites possess higher stiffness, strength, fatigue properties and low weight advantages. Carbon fiber reinforced Al composites (Al-Cf) and silicon carbide particulate reinforced Al composites (AI-SiCp) were shock densified using axisymmetric assemblies for underwater explosions. Unidirectional planar shock waves were applied to obtain uniform consolidation of the composites. The energy generator was a high explosive of 6.9 km/s detonation velocity. Irregular morphological powders of Al were the base material. The reinforcement ratio was 15 Vol. pet for Al-Cf composites and 30 Vol. pet for AI-SiCp composites. The microstructural and the strength characteristics of the shock consolidated Al composites are reported.

关键词： Shock consolidation Aluminum composites Microstructure Strength characteristics

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