检索结果-南通市图书馆

Single-cell and spatial omics:exploring hypothalamic heterogeneity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Brain age estimation:premise,promise,and problems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Experimental Analysis of Shear Strength of Undisturbed Soil in Leucaena Forest in Jiangjia Ravine,Yunnan,China

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2010年第4期7卷 386-395页

作者： JIAO Zhen Key Laboratory of Mountain Hazards and earth surfaceprocesses ChineseAcademy of Sciences Chengdu 610041 China graduate university of chineseacademy of sciences Beijing I ooo49 China Institute of Mountain Hazards and Environment Chinese Academy of Science Chengdu 61oo41 China

Five leucaena trees of similar age were chosen in Jiangjia Ravine of Dongchuan,Yunnan Province,China,near which the soil samples were collected by digging profiles 2m in depth and 1m in *** each section,soil samples at different depths were taken for direct shear experiments to determine the root amount and mechanical *** is found that the cohesion and internal friction angle of the undisturbed soil are related to the root amount,depth,clay content and breccias *** correlates negatively with root content,a finding that differs from that of other *** addition,internal friction angle correlates positively with all these factors.

关键词： Jiangjia Ravine Leucaena Undisturbedsoil Shear strength Impact factors

Insights from an academic endeavor into central nervous system drug discovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands university MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

Hydrogen Bonding Effects on the Photophysical Properties of 2,3-dihydro-3-keto- 1H-pyrido[3,2,1-kl] phenothiazine

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2012年第3期25卷 254-260,373页

作者： Song-qiu Yang Guo-zhong He State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics ChineseAcademy of Sciences Dalian 115023 China graduate School of the Chinese Academy of sciences Beijing 100039 China

Time-dependent density functional theory （TDDFT） and femtosecond transient absorption spectroscopy were used to investigate the photophysical properties of 2,3-dihydro-3-keto-lH- pyrido[3,2,1-kl]phenothiazine （PTZ4） and 3-keto-lH-pyrido[3,2,1-kl]phenothiazine （PTZ5）. The calculated results obtained from TDDFT suggest that the red-shifts of the absorption spectra of these two fluorophores in methanol are due to the formation of hydrogen-bonded complexes at the ground state. Four conformers of PTZ4 were obtained by TDDFT. The two fluorescence peaks of PTZ4 in tetrahydrofuran （THF） came from the ICT states of the four conformers. The fluorescence of PTZ4 in THF showed a dependence on the excitation wavelength because of butterfly bending. The excited state dynamics of PTZ4 in THF and methanol were obtained by transient absorption spectroscopy. The lifetime of the excited PTZ4 in methanol was 53.8 ps, and its relaxation from the LE state to the ICT state was completed within several picoseconds. The short lifetime of excited PTZ4 in methanol was due to the formation of out-of-plane model hydrogen bonds between PTZ4 and methanol at the excited state.

关键词： 2,3-dihydro-3-keto-lH-pyrido[3,2,1-kl]phenothiazine Time-dependent densityfunctional theory Femtosecond transient absorption spectroscopy Hydrogen bonding effect

Investigation of Work Hardening Behavior of Inconel X-750 Alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2017年第9期30卷 869-877页

作者： Pei-Tao Hua Wei-Hong Zhang Lin-Jie Huan Wen-Ru Sun Superalloys Division Institute of Metal Research ChineseAcademy of Sciences 110016 Shenyang China university of Chinese Academy of sciences 100049 BeijingChina

The constant strain rate uniaxial compression tests were conducted in this paper for studying the work hardening behavior and revealing the underlying microstructure evolution involved in the plastic response of the nickel-based Inconel X-750 alloy. The work hardening rate versus true strain plots of Inconel X-750 alloy resembled that of low-stacking-fault energy （SFE） alloys with distinct four stages. The dislocations were found in the planar arrangements at a strain of 0.1 located at the onset of stage II, and the dislocation density was increased and the planar arrangement configuration was partially destroyed at a strain of 0.36 located in stage III. It was unexpected that deformation twins were observed at a strain of 0.69 located in stage IV although the alloy has been classified into materials with a higher SFE value. The result is different with a similar study, in which the deformation twins were absent in Ni-Cr-based alloy Inconel 625 even when the strain was as high as 0.65. It was deemed that the low level of solution strengthening favored the deformation of matrix and the activation of slip system for twining in Inconel X-750 alloy. Unlike the low-SFE alloys that the twins were always formed at the end of stage Ⅰ, the higher SFE delayed the twin formation to stage IV for Inconel X-750 alloy. The well- developed planar dislocation configuration gave rise to the stage Ⅱ with a slightly decreasing rate, the collapse of planar dislocation arrangements caused the occurrence of stage Ⅲ with an accelerated decreasing rate, and the twin formation led to the stage IV with a nearly constant work hardening rate.

关键词： Inconei X-750 alloy Work hardening behavior Planar dislocation arrangement Deformationtwins

WAVELET METHOD FOR BOUNDARY INTEGRALEQUATIONS

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2000年第1期18卷 25-42页

作者： Pin-wen Zhang Yu Zhang School of Mathematical sciences Peking UniversityBeliing 100871China Institute of Computational Mathematics and Scientific/Engineering Computing ChineseAcademy if SciencesBeijing 100080China

Presents a study which showed how to use wavelet to discretize the boundary integral equations. Application of wavelets to signal and image processing; Kinds of boundary reduction; Sparsity of the matrices in the stan... 详细信息

关键词： wavelet bases boundary integral equation preconditioning