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Antibacterial and angiogenic dual-functional fibrous membrane dressing for infected wound healing

Biomedical engineering Communications 2024年第1期3卷 4-14页

作者： Chao Zhou Che Zhao Hao-Yu Dai Tian-Jun Zhu Jia-Pei Yao Li Chen Jing-Jing Wen Jia Ling Celestine Loh Xin-Die Zhou Yong Huang School of Medical and Health engineering Changzhou UniversityChangzhouJiangsu 213164China School of aerospace and mechanical engineering Changzhou Institute of TechnologyChangzhouJiangsu 213032China Department of Orthopedics The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou Medical CenterNanjing Medical UniversityChangzhou 213000China Duke-NUS graduate Medical School National University of SingaporeKent Ridge 169547Singapore

Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental *** full-thickness skin defects becomes especially challenging when infections and vascular injuries are *** wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound *** address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic ***:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic ***:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air *** not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo ***:These findings highlight the immense potential of this wound dressing material for future clinical applications.

关键词： electro spinning antibacterial polymer angiogenesis wound healing membrane dressing

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Break-up Characteristics of Gelled Propellant Simulants with Various Gelling Agent Contents

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Journal of Thermal Science 2010年第6期19卷 545-552页

作者： Inchul Lee Jaye Koo graduate student Korea Aerospace University School of aerospace and mechanical engineering Korea Aerospace University

Gel propulsion systems have many advantages with respect to high performance, the energy management of liquid propulsion systems, storability, high density impulse, and low leakage of liquid propellants. The atomization process provides sufficient contact surface area between the gelled fuel and oxidizer jets. It is important to study how injection characteristics of gelled propellants are related with break-up and spray distribution. The break-up and mixing processes are very important in achieving maximum efficiency and necessitate the careful study of combustion instability. Gelled propellants are non-Newtonian fluids in which the viscosity is a function of the shear rate, and they have a high dynamic shear viscosity which depends on the amount of gelling agent contents. The present study has focused on the break-up process, wave development of ligament and liquid sheets formed by impinging jets with various gelling agent contents. Especially, the break-up processes of the impinging jets at the initial conditions are studied. The break-up process of like-on-like doublet impinging jets are experimentally characterized using non-Newtonian liquids which are mixed by ionized water 98.5 wt%, Carbopol 941 0.5wt% or 1.0wt%, and NaOH(concentration 10%) 1.0wt%. For the like-on-like doublet injector, the generation of a liquid sheet at the impinging point of two jets was observed. The spray shape with elliptical pattern is distributed in a perpendicular direction to the momentum vectors of the jets. Gelled propellant simulants with high viscosity jets are more stable and produce less pronounced surface waves than low viscosity jets. Generally, the break-up length decreased due to the increasing Reynolds number. However, surface waves and atomized droplets increased. Gelled propellant simulants from like-on-like doublet impinging jets have the spray shape of closed rim patterns at low pressure. Also, the rim patterns of spray have no disturbances on the spray sheet. As the

关键词：胶凝推进剂破裂特性胶凝剂模拟液体推进系统凝胶推进剂冲击射流飞机撞击

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Breakup Structure of Two-phase Jets with Various Momentum Flux from a Porous Injector

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Journal of Thermal Science 2014年第1期23卷 60-67页

作者： Inchul Lee Dohun Kim Jaye Koo graduate student Korea Aerospace University School of aerospace and mechanical engineering Korea Aerospace University

Spray structure and atomization characteristics were investigated through a comparison of a porous and a shear coaxial injector. The porous injector shows better atomization performance than the shear coaxial injector. To increase atomization performance and mixing efficiency of two-phase jets, a coaxial porous injector which can be applicable to liquid rocket combustors was designed and tested. The characteristics of atomization and spray from a porous and a shear coaxial injector were characterized by the momentum flux ratio. The breakup mechanism of the porous injector is governed by Taylor-Culick flow and axial shear forces. Momentum of injected gas flow through a porous material which is composed of sintered metal is radically transferred to the center of the liquid column, and then liquid column is effectively broken up. Although the shapes of spray from porous and shear coaxial jets were similar for various momentum ratio, spray structures such as spray angle and droplet sizes were different. As increasing the momentum flux ratio, SMD from the porous injector showed smaller value than the shear coaxial

关键词：多孔材料动量通量两相射流喷油器结构通量分裂同轴射流雾化特性

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Genetic Algorithm to Optimize the Design of Main Combustor and Gas Generator in Liquid Rocket Engines

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Journal of Thermal Science 2014年第3期23卷 259-268页

作者： Min Son Sangho Ko Jaye Koo graduate student Korea Aerospace University School of aerospace and mechanical engineering Korea Aerospace University

A genetic algorithm was used to develop optimal design methods for the regenerative cooled combustor and fuel-rich gas generator of a liquid rocket engine. For the combustor design, a chemical equilibrium analysis was applied, and the profile was calculated using Rao's method. One-dimensional heat transfer was assumed along the profile, and cooling channels were designed. For the gas-generator design, non-equilibrium properties were derived from a counterflow analysis, and a vaporization model for the fuel droplet was adopted to calculate residence time. Finally, a genetic algorithm was adopted to optimize the designs. The combustor and gas generator were optimally designed for 30-tonf, 75-tonf, and 150-tonf engines. The optimized combustors demonstrated superior design characteristics when compared with previous non-optimized results. Wall temperatures at the nozzle throat were optimized to satisfy the requirement of 800 K, and specific impulses were maximized. In addition, the target turbine power and a burned-gas temperature of 1000 K were obtained from the optimized gas-generator design.

关键词：优化设计方法液体火箭发动机主燃烧室遗传算法气体发生器气根再生冷却管壁温度

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Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

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Journal of Magnesium and Alloys 2022年第9期10卷 2516-2533页

作者： Man Soo Joun Mohd Kaswandee Razali Jae Dong Yoo Min Cheol Kim Jeong Muk Choi ReCAFT Gyeongsang National UniversityGraduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea Gyeongsang National University Graduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea MFRC Research CenterJinju 52818South Korea Jinhap Daejeon 34302South Korea

Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated *** traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain *** coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural ***,metallurgy-related values can be calculated directly from the flow stress *** the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range.

关键词： Flow stress Power law model Piecewise bilinear function Numerical analysis Microstructural prediction Peak strain

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Mixing Characteristics of Pulsed Air-assist Liquid Jet into an Internal Subsonic Cross-flow

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Journal of Thermal Science 2010年第2期19卷 136-140页

作者： Inchul Lee Youngsu Kang Jaye Koo graduate student Korea Aerospace University School of aerospace and mechanical engineering Korea Aerospace University

Penetration depth,spray dispersion angle,droplet sizes in breakup processes and atomization processes are very important parameters in combustor of air-breathing *** processes will enhance air/fuel mixing inside the *** results from the pulsed air-assist liquid jet injected into a cross-flow are *** experiments were conducted to a range of cross-flow velocities from 42～136 m/*** is injected with 0～300kPa,with air-assist pulsation frequency of 0～*** frequency was modulated by solenoid *** Doppler Particle Analyzer(PDPA) was utilized to quantitatively measuring droplet ***-speed CCD camera was used to obtain injected spray *** air-assist liquid jet will offer rapid mixing and good liquid jet ***-assist makes a very fine droplet which generated mist-like *** air-assist liquid jet will introduce additional supplementary turbulent mixing and control of penetration depth into a cross-flow *** results show that pulsation frequency has an effect on penetration,transverse velocities and droplet *** experimental data generated in these studies are used for a development of active control strategies to optimize the liquid jet penetration in subsonic cross-flow conditions and predict combustion low frequency instability.

关键词：脉冲频率调制空气进入液体射流混合特性亚音速横流相位多普勒粒子分析仪穿透深度

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Noise Reduction and Surge Margin Improvement Using Tapered Diffuser Vane in a Centrifugal Compressor

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Journal of Thermal Science 2010年第1期19卷 21-25页

作者： Takashi Goto Eri Ohmoto Yutaka Ohta Eisuke Outa Department of Applied Mechanics and aerospace engineering Waseda University graduate student Graduate School of Applied Mechanical EngineeringWaseda University

Improvement of surge margin and reduction of interaction tone noise radiated from a centrifugal compressor with a vaned diffuser is discussed from experiments and CFD *** types of one-side tapered diffuser vanes,which are shroud-and hub-side tapered vanes,were used in the *** height of the leading edge of the tapered vanes varied from 100% to 10%.Both types of tapered vanes are effective for the reduction of the interaction tone noise radiated from the compressor,because of the smaller interaction area between impeller-discharge flow and diffuser vane ***,the hub-side tapered diffuser vane suppresses the evolution of the leading-edge vortex,which causes reverse-flow in the diffuser ***,the hub-side tapered diffuser vane,which has an optimized diffuser leading edge shape,can improve the compressor pressure-rise characteristics at low-flow operation and can enlarge the surge margin.

关键词：叶片扩压器离心压缩机降噪利润率浪涌扩散抑制喘振裕度 CFD分析

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Conceptual Design for a Kerosene Fuel-rich Gas-generator of a Turbopump-fed Liquid Rocket Engine

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Journal of Thermal Science 2012年第5期21卷 428-434页

作者： Min Son Jaye Koo Won Kook Cho Eun Seok Lee graduate student Korea Aerospace UniversityGoyang Republic of Korea School of aerospace and mechanical engineering Korea Aerospace UniversityGoyang Republic of Korea Korea aerospace Research Institute Daejeon Republic of Korea

A design method for a kerosene fuel-rich gas-generator of a liquid rocket engine using turbopumps to supply propellant was performed at a conceptual level. The gas-generator creates hot gases, enabling the turbine to operate the turbopumps. A chemical non-equilibrium analysis and a droplet vaporization model were used for the estimation of the burnt gas properties and characteristic chamber length. A premixed counter-flow flame analysis was performed for the prediction of the burnt gas properties, namely the temperature, the specific heat ratio and heat capacity, and the chemical reaction time. To predict the vaporization time, the Spalding model, using a single droplet in convective condition, was used. The minimum residence time in the chamber and the characteristic length were calculated by adding the reaction time and the vaporization time. Using the characteristic length, the design methods for the fuel-rich gas-generator were established. Finally, a parametric study was achieved for the effects of the O/F ratio, mass flow rate, chamber pressure, initial droplet temperature, initial droplet diameter and initial droplet velocity.

关键词：液体火箭发动机涡轮泵天然气发电机概念设计煤油气体发生器液滴直径化学反应

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Development of Preliminary Design Program for Combustor of Regenerative Cooled Liquid Rocket Engine

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Journal of Thermal Science 2011年第5期20卷 467-473页

作者： Won Kook Cho Woo Seok Seol Min Son Min Kyo Seo Jaye Koo Korea aerospace Research Institute DaejoenRepublic of Korea graduate student Korea Aerospace UniversityGoyangRepublic of Korea School of aerospace and mechanical engineering Korea Aerospace UniversityGoyangRepublic of Korea

An integrated program was established to design a combustor for a liquid rocket engine and to analyze regenerative cooling results on a preliminary design *** of burnt gas from a kerosene-LOx mixture in the combustor and rocket performance were calculated from CEA which is the code for the calculation of chemical *** heat transfer of regenerative cooling was analyzed by using SUPERTRAPP code for coolant properties and by one-dimensional correlations of the heat transfer coefficient from the combustor liner to the *** of the combustors of F-1 and RS-27A engines were designed from similar input data and the present results were compared to actual data for ***,the combustors of 30 tonf class,75 tonf class and 150 tonf class were designed from the required thrust,combustion chamber,exit pressure and mixture ratio of *** wall temperature,heat flux and pressure drop were calculated for heat transfer analysis of regenerative cooling using the profiles.

关键词：液体火箭发动机设计水平蓄热式燃烧器发动机燃烧室过冷再生冷却压降计算燃烧室设计

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Disintegration Process and Performance of a Coaxial Porous Injector

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Journal of Thermal Science 2016年第5期25卷 394-401页

作者： Keonwoong Lee Dohun Kim Jaye Koo graduate School Korea Aerospace University School of aerospace and mechanical engineering Korea Aerospace University

In order to understand the breakup performance of coaxial porous injectors,the sprays of coaxial porous injectors with two different porous material cylinder lengths were compared with those of conventional shear coaxial *** allow comparison,the wall injection lengths were designed to be equivalent to the value of the recess *** flow sprays were visualized using back-lit photography methods and analyzed quantitatively with a laser diffraction apparatus,in order to study the effects of the momentum flux ratio and Weber number on the breakup for each type of *** case of the shear coaxial injector,the large liquid core was observed in low air mass flow rate ***,the destabilization of the liquid jet from the coaxial porous injector is almost complete within the inner region,near the injector face ***,better breakup performance in low gas flow rate condition was obtained when the porous cylinder length decreased,while the shear coaxial injectors showed better breakup efficiency when the recess length *** conclusion,the different breakup process caused by the radial momentum in the inner region of the porous injector disintegrated the liquid core.

关键词：多孔喷嘴同轴性能破碎效率崩解喷油器喷射器多孔材料

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