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Numerical simulation of the dynamic migration mechanism and prediction of saturation of tight sandstone oil

Science China Earth sciences 2024年第1期67卷 179-195页

作者： Gaohui CAO Mian LIN Likuan ZHANG Lili JI Wenbin JIANG Institute of Mechanics Chinese Academy of SciencesBeijing 100190China school of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

Quantitative characterization of tight sandstone oil migration and accumulation is an emerging research frontier in the field of oil and gas *** this study,a conceptual model containing multiple basic geological elements is developed,and a nonlinear seepage numerical model for tight sandstone oil migration and accumulation is *** effects of the slip effect,overpressure driving force,buoyancy,and capillary force on the migration and accumulation of tight oil are *** results showed that(1)the differences in oil migration and accumulation between tight and conventional reservoirs are reflected in the growth mode of oil saturation,distribution characteristics of oil and water,and extent of the effect of the formation dip angle;(2)the slip effect has a significant impact when the average pore throat radius is less than 150 nm and the overpressure driving force and capillary force are the main mechanical mechanisms controlling oil migration and accumulation in tight sandstone,while the coupling effect of buoyancy,capillary force,and overpressure driving force controls the upper and lower limits of oil ***,a dimensional and dimensionless identification chart for rapidly predicting the oil saturation of tight sandstone is proposed and verified using the measured *** study provides a basis for analyzing the migration and accumulation mechanisms of tight sandstone oil and a new approach for predicting oil ***,we developed digital and visual analysis methods for the migration results,enriching the expression of the dynamics of hydrocarbon accumulation.

关键词： Tight sandstone Migration and accumulation Dynamics Oil saturation Numerical simulation

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Genesis of the Jianbeigou Gold Deposit on the Southern Margin of the North China Craton: Insights from Fluid Inclusions, H-O-S Isotopes, and Pyrite in situ Trace Element Analyses

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 969-991页

作者： LI Fengchun ZENG Qingdong ZHU Rixiang CHU Shaoxiong XIE Wei YU Bing WU Jinjian LI Xinghui Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China school of Earth Science and Engineering Hebei University of EngineeringHandanHebei 056038China

The Jianbeigou gold deposit is a typical lode gold deposit in the Qinling metallogenic belt, located on the southern margin of the North China Craton. Three stages of the hydrothermal process can be distinguished, including the quartz ± pyrite, quartz-polymetallic sulfide, and quartz-carbonate ± pyrite stages. From the early to late stages, the homogenization temperatures of primary fluid inclusions are 281–362°C, 227–331°C, and 149–261°C, respectively. The corresponding salinities estimated for these fluids are 3.9–9.9 wt%, 0.4–9.4 wt%, and 0.7–7.2 wt% Na Cl equiv. Combined with laser Raman spectroscopy data, the ore-forming fluid belongs to a H_(2)O-CO_(2)-Na Cl ± CH_4 system with medium–low temperature and salinity. The δ~(18)Ofluid and δD values for the quartz veins are-1.0‰ to 6.0‰ and-105‰ to-84‰, respectively, which indicates that the ore-forming fluid is of mixed source, mainly derived from magma, with a contribution from meteoric water. Pyrite has been identified into three generations based on mineral paragenetic sequencing, including Py1, Py2, and Py3. The pyrites have δ~(34)S sulfur isotopic compositions from three stages between 3.7‰ and 8.4‰, indicating that sulfur mainly originated from magma. Te, Bi, Sb, and Cu contents in pyrite were all high and showed a strong correlation with Au concentrations. Native gold and the Au-Ag-Bi telluride minerals were formed concurrently, and the As concentration was low and decoupled from the Au content. Therefore, Te, Bi, Sb and other low-melting point chalcophile elements play an important role for gold mineralization in arsenic-deficient ore-forming fluid. Combined with the geological setting, evolution of pyrite, and ore-fluids geochemistry, we propose that the Jianbeigou deposit can be classified as a magmatic–hydrothermal lode gold deposit. Gold mineralization on the southern margin of the North China Craton is related to Early Cretaceous magmatism and formed in an extensional setting.

关键词： ore genesis H-O-S isotopes fluid inclusions in-situ trace element Jianbeigou gold deposit

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A peak enhancement of frequency response of waveguide integrated silicon-based germanium avalanche photodetector

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Journal of Semiconductors 2024年第7期45卷 61-68页

作者： Linkai Yi Daoqun Liu Wenzheng Cheng Daimo Li Guoqi Zhou Peng Zhang Bo Tang Bin Li Wenwu Wang Yan Yang Zhihua Li Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China school of Electronic Electrical and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China

Avalanche photodetectors(APDs) featuring an avalanche multiplication region are vital for reaching high sensitivity and responsivity in optical transceivers. Waveguide-coupled Ge-on-Si separate absorption, charge, and multiplication(SACM)APDs are popular due to their straightforward fabrication process, low optical propagation loss, and high detection sensitivity in optical communications. This paper introduces a lateral SACM Ge-on-Si APD on a silicon-on-insulator(SOI) wafer, featuring a 10 μm-long, 0.5 μm-wide Ge layer at 1310 nm on a standard 8-inch silicon photonics platform. The dark current measures approximately 38.6 μA at-21 V, indicating a breakdown voltage greater than-21 V for the device. The APDs exhibit a unitgain responsivity of 0.5 A/W at-10 V. At-15 V, their responsivity reaches 2.98 and 2.91 A/W with input powers of-10 and-25 dBm, respectively. The device's 3-dB bandwidth is 15 GHz with an input power of-15 dBm and a gain is 11.68. Experimental results show a peak in impedance at high bias voltages, attributed to inductor and capacitor(LC) circuit resonance, enhancing frequency response. Furthermore, 20 Gbps eye diagrams at-21 V and-9 dBm input power reveal signal to noise ratio(SNRs) of 5.30. This lateral SACM APD, compatible with the stand complementary metal oxide semiconductor(CMOS) process,shows that utilizing the peaking effect at low optical power increases bandwidth.

关键词： photodetectors optical communications responsivity 3-dB bandwidth

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chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients:A Systematic Review and Network Meta-Analysis

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chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong YAN Shao-hua YAN Yun-zi DING Ya-cong WANG Yan-song YANG Yu-fei Department of Oncology China Academy of Chinese Medical SciencesXiyuan HospitalBeijing100091China Department of Oncology Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China graduate school Beijing University of Chinese MedicineBeijing100029China

Objective To assess the effectiveness of chinese herbal medicine(CHM)combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC)patients using network meta-analysis(NMA).Methods Literature searches in both international(PubMed,Embase,Web of Science,and Cochrane Library)and chinese(China Science and Technology Journal Database,Wanfang Data,China National Knowledge Infrastructure)databases for relevant randomized controlled trials(RCTs)were conducted from inception until October 10,*** included RCTs of patients who received CHM combined with chemotherapy,including FOLFOX,XELOX,FOLFIRI,and other relevant regimens in the CHM treatment *** outcomes included the incidence of myelosuppression,leukopenia,hemoglobin reduction,and *** reviewers independently screened the databases,extracted the data,and assessed the risk of bias and credibility of *** 5.4.1 software and STATA 14.0 were used to perform the *** A total of 31 RCTs were included,published from 2008 to 2021 in *** these,2,314 participants comparing the following 9 CHMs were identified:Shengbai Recipe(SBR),Bazhen Decoction(BZD),Jianpi Jiedu Recipe(JJR),Jianpi Recipe(JR),Compound Cantharis Capsule(CCC),Zaofan Pill(ZFP),Guilu Erxian Gel(GL),Buzhong Tiaogan Decoction(BZ),and Qiamagu Capsule(QM).The results of NMA found an indirect *** on the surface under the cumulative ranking curve(SUCRA),the ZFP+chemotherapy group had the lowest incidence of myelosuppression,with an odds ratio(OR)of 0.08[95%confidence interval(CI):0.01,0.76],whereas the GL+chemotherapy group had the lowest incidence of leukopenia,hemoglobin reduction,and thrombocytopenia,with an OR of 5.25(95%CI:2.41,11.43),4.66(95%CI:2.23,9.72),and 0.27(95%CI:0.13,0.54),***,BZD+chemotherapy could alleviate leukopenia,hemoglobin reduction,and thrombocytopenia(P<0.01).Pairwise comparison showed that there was no difference in the efficacy among the 8 CHMs+c

关键词： chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy

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New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth sciences 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling ZHANG Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi ZhANG Bing XU Chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the chinese academy of sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China school of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

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Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

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World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： Le-Yang Li Song-Mei Li Bo-Xian Pang Jun-Ping Wei Qiu-Hong Wang Department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China graduate school Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The PubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,P=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,P<0.00001),homeostatic model assessment for insulin resistance(HOMA-IR)(SMD:-1.58;95%CI:-2.20 to-0.97,P<0.00001),interleukin-6(IL-6)(SMD:-1.31;95%CI:-2.07 to-0.55,P=0.0007),C-reactive protein(CRP)(SMD:-0.64;95%CI:-1.21 to-0.08,P=0.03),and leptin(SMD:-3.43;95%CI:-5.82 to-1.05,P=0.005)in overweight and obese *** training increased adiponectin levels(SMD:1.24;95%CI:0.30 to 2.18,P=0.01)but did not improve tumor necrosis factor-alpha(TNF-α)levels(SMD:-0.80;95%CI:-1.77 to 0.18,P=0.11).CONCLUSION In summary,exercise therapy improves glucose metabolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRP,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

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Surface pollen and modern vegetation in Southern Xinjiang,China

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Science China Earth sciences 2024年第2期67卷 510-530页

作者： Yun ZHANG Lixin CHEN Yaoyao XI Zhaochen KONG Xianguo QIAO State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Institute of Botany Chinese Academy of SciencesBeijing100093China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China University of chinese academy of sciences Beijing100049China school of Geosciences and Resources China University of Geosciences(Beijing)Beijing100083China

The study of modern pollen,and vegetation can improve the accuracy of paleoenvironmental reconstruction based on fossil pollen data.A total of 188 pollen surface samples were collected from Southern Xinjiang(34°00’–43°00’N,74°00’–94°00’E)in China,with an elevation range of 888–4530 *** pollen and vegetation were studied in the northern region of the Kunlun Mountains and the southern region of the Tianshan *** results showed that the surface pollen assemblages on the southern slope of the Tianshan Mountains(3530–1124 m)were divided into three pollen zones,namely,montane steppe,montane desert steppe,and montane *** zones were dominated by Artemisia,Chenopodiaceae,and Ephedra *** surface pollen assemblages in the eastern Pamir Plateau(4530–1287 m)could be divided into alpine meadow,montane desert steppe,and montane desert zones,which were predominantly characterized by Artemisia,Chenopodiaceae,and Asteraceae ***,the Southern Tarim Basin(3548–888 m)comprised montane desert steppe and montane desert zones,which was dominated by Artemisia and Chenopodiaceae *** geographic distribution of the surface pollen sites obtained using ArcGIS,the R-value,and Pearson correlation analyses indicated that the over-represented Picea and Pinus pollen were of external origin and were transported by wind,water(rivers),and ice(glacier movement).Over-representation of Ephedra and Nitraria pollen was mainly distributed in the montane desert and desert steppe zones,*** from Chenopodiaceae and Artemisia were over-represented and broadly distributed across Southern *** pollen was concentrated in areas with walnut trees,strongly indicating the presence of local parent *** to the Hybrid Singleparticle Lagrangian Integrated Trajectory model,more Pinus pollen was transported to the Pamir region by external airflows during spring and summer,resulting in its higher surface pollen *** elucidating t

关键词： Surface pollen Vegetation Distribution Picea Southern Xinjiang

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Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

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chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong WANG Zhixing MA Zhi JIA Kexin LI Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang school of Life sciences Beijing University of Chinese MedicineBeijing 100029China school of chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H19 remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H19 in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang Qian-Hui Sun Lu-Chang Cao Xin-Yi Ma Jia-Xi Wang Ke-Xin Liu Jie Li graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical SAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety

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Fangchinoline induces antiviral response by suppressing STING degradation

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Journal of Pharmaceutical Analysis 2024年第6期14卷 902-913页

作者： Jinyong Wang Fang Xie Xin Jia Xuejiao Wang Lingdong Kong Yiying Li b Xue Liang Meiqi Zhang Yuting He Wandi Feng Tong Luo Yao Wang Anlong Xu school of chinese Materia Medica Beijing University of Chinese MedicineBeijing100029China school of Life Science Beijing University of Chinese MedicineBeijing100029China beijing Key Laboratory of Drug Target Identification and New Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

The stimulator of interferon genes(STING),an integral adaptor protein in the DNA-sensing pathway,plays a pivotal role in the innate immune response against ***,it presents a valuable therapeutic target for infectious diseases and *** observed that fangchinoline(Fan),a bis-benzylisoquinoline alkaloid(BBA),effectively impedes the replication of vesicular stomatitis virus(VSV),encephalomyocarditis virus(EMCV),influenza A virus(H1N1),and herpes simplex virus-1(HSV-1)in *** treatment significantly reduced the viral load,attenuated tissue inflammation,and improved survival in a viral sepsis mouse ***,Fan activates the antiviral response in a STING-dependent manner,leading to increased expression of interferon(IFN)and interferon-stimulated genes(ISGs)for potent antiviral effects in vivo and in ***,Fan interacts with STING,preventing its degradation and thereby extending the activation of IFN-based antiviral ***,our findings highlight the potential of Fan,which elicits antiviral immunity by suppressing STING degradation,as a promising candidate for antiviral therapy.

关键词： Fangchinoline Virus Type I interferons Stimulator of interferon genes Protein degradation

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