检索结果-南通市图书馆

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Neural Regeneration Research 2024年第6期19卷 1249-1255页

作者： Shuho Gotoh Masahito Kawabori Miki Fujimura Department of Neurosurgery Hokkaido University Graduate School of Medicine

Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular communication. These nanosized vesicles transport internalized proteins, mRNA, miRNA, and other bioactive molecules. Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders. These exosomes exhibit multifaceted properties including antiapoptotic, anti-inflammatory, neurogenic, and vasculogenic effects. Furthermore, exosomes offer several advantages over stem cell therapy, such as high preservation capacity, low immunogenicity, the ability to traverse the blood-brain barrier, and the potential for drug encapsulation. Consequently, researchers have turned their attention to exosomes as a novel therapeutic avenue. Nonetheless, akin to the limitations of stem cell treatment, the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application. To overcome this hurdle, intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system. By exploiting the olfactory and trigeminal nerve axons, this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier. Notably, exosomes, owing to their small size, can readily access the nerve pathways using this method. As a result, intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments. In this comprehensive review, we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases. Furthermore, we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

关键词： central nervous system disease exosome extracellular vesicle intranasal administration stem cell

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Characterization of size-resolved effective density of atmospheric particles in an urban atmosphere in Southern China

引用

Journal of Environmental Sciences 2024年第7期141卷 194-204页

作者： Tingting Xie Liming Cao Jinyi Zheng Peng Xuan Xiaofeng Huang Laboratory of Atmospheric Observation Supersite School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Effective density(ρ_(eff))is one of the most important physical properties of atmospheric particles,providing important references in exploring the emissions and aging processes of fresh particles.In this study,a combined system of differential mobility analyzer,centrifugal particle mass analyzer,and condensation particle counter was used to periodically measure theρ_(eff)of atmospheric particles in Shenzhen from Oct.2021 to Jan.2022.Results showed that theρ_(eff)of particles with various size presented a bimodal distribution,which could be divided into main density(ρ_(m),main peak,corresponding to relatively dense particles after aging)and sub density(ρ_(s),sub peak,corresponding to fresh particles).The occurrence frequencies ofρ_(s)of particles with diameters of 50 and 80 nm were less than 20%,but were as high as about 40%of that with diameters from 120 to 350 nm.Theρ_(m)showed increasing trend with the size of particles,whileρ_(s)decreased as the increasing of the size of particles.Theρ_(eff)on pollution day varied significantly with chemical compositions.The increasing of the proportion of sulfate could promote the increasing ofρ_(eff),while black carbon and organic matter caused opposite effects,which may be related to various factors,including the difference of the material density and morphology of various chemical components.Theρ_(eff)of 50,80 and 120 nm particles decreased considerably during the new particle formation event,indicating that organic condensation was an important contributor to new particle growth.

关键词： DMA-CPMA-CPC Effective density Main/sub density Size distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hyperspectral image super resolution using deep internal and self-supervised learning

引用

CAAI Transactions on Intelligence Technology 2024年第1期9卷 128-141页

作者： Zhe Liu Xian-Hua Han graduate school of Science and Technology for Innovation Yamaguchi UniversityYamaguchiJapan graduate school of Artificial Intelligence and Science Rikkyo UniversityTokyoJapan

By automatically learning the priors embedded in images with powerful modelling ca-pabilities,deep learning-based algorithms have recently made considerable progress in reconstructing the high-resolution hyperspectral(HR-HS)image.With previously collected large-amount of external data,these methods are intuitively realised under the full supervision of the ground-truth data.Thus,the database construction in merging the low-resolution(LR)HS(LR-HS)and HR multispectral(MS)or RGB image research paradigm,commonly named as HSI SR,requires collecting corresponding training triplets:HR-MS(RGB),LR-HS and HR-HS image simultaneously,and often faces dif-ficulties in reality.The learned models with the training datasets collected simultaneously under controlled conditions may significantly degrade the HSI super-resolved perfor-mance to the real images captured under diverse environments.To handle the above-mentioned limitations,the authors propose to leverage the deep internal and self-supervised learning to solve the HSI SR problem.The authors advocate that it is possible to train a specific CNN model at test time,called as deep internal learning(DIL),by on-line preparing the training triplet samples from the observed LR-HS/HR-MS(or RGB)images and the down-sampled LR-HS version.However,the number of the training triplets extracted solely from the transformed data of the observation itself is extremely few particularly for the HSI SR tasks with large spatial upscale factors,which would result in limited reconstruction performance.To solve this problem,the authors further exploit deep self-supervised learning(DSL)by considering the observations as the unlabelled training samples.Specifically,the degradation modules inside the network were elaborated to realise the spatial and spectral down-sampling procedures for transforming the generated HR-HS estimation to the high-resolution RGB/LR-HS approximation,and then the reconstruction errors of the observations were formulated for measuring the network modelling performance.By cons

关键词： computer vision deep learning deep neural networks hyperspectral image enhancement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent progress about transmission electron microscopy characterizations on lithium-ion batteries

引用

Journal of Energy Chemistry 2024年第8期95卷 39-56页

作者： Yihang Liu Qiuyun Li Ziqiang Wang Institute of Materials Research Shenzhen International Graduate School Tsinghua University

With the rapid development of portable electronics, new energy vehicles, and smart grids, ion batteries are becoming one of the most widely used energy storage devices, while the safety concern of ion batteries has always been an urgent problem to be solved. To develop a safety-guaranteed battery, the characterization of the internal structure is indispensable, where electron microscopy plays a crucial role. Based on this, this paper summarizes the application of transmission electron microscopy(TEM) in battery safety, further concludes and analyzes the aspects of dendrite growth and solid electrolyte interface(SEI) formation that affect the safety of ion batteries, and emphasizes the importance of electron microscopy in battery safety research and the potential of these techniques to promote the future development of this field. These advanced electron microscopy techniques and their prospects are also discussed.

关键词： Dendrites Electron microscopy characterizations Lithium-ion batteries SEI

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Non-Kramers doublet ground state in a quaternary cubic compound PrRu_(2)In_(2)Zn_(18) investigated by ultrasonic measurements

引用

Chinese Physics B 2024年第6期33卷 405-411页

作者：张化远 Kazuhei Wakiya Mitsuteru Nakamura Masahito Yoshizawa Yoshiki Nakanish graduate school of Science and Engineering Iwate UniversityMorioka 020-8551Japan

We performed ultrasonic measurements on a quaternary cubic compound PrRu_(2)In_(2)Zn_(18) to explore the ground state properties derived from non-Kramers Γ_(3) doublet of Pr^(3+).PrRu_(2)In_(2)Zn_(18) is a quaternary derivative of the ternary compound PrRu_(2)Zn_(20) that exhibits a structural phase transition at T_S=138 K.In PrRu_(2)In_(2)Zn_(18),the Zn atoms at the 16c site in PrRu_(2)Zn_(20) are selectively replaced by In atoms.A monotonic increase was observed in the temperature dependence of elastic constants C_L=(C_(11)+2C_(12)+4C_(44))/3 and C_(T)=(C_(11)-C_(12)+C_(44))/3 in the temperature range around T_(S) to which an elastic softening was observed in(C_(11)-C_(12))/2 for PrRu_(2)Zn_(20).The disappearance of the softening indicates that the structural transition in PrRu_(2)Zn_(20) is suppressed by the substitution of Zn ions by In ones with a larger ionic radius.Alternatively,the C_(T) of PrRu_(2)In_(2)Zn_(18) exhibits a precursor Curie-type elastic softening toward low temperatures being responsible for the non-Kramers Γ_(3) ground state.We discuss the ground state and the evolution of the elastic properties of the different single-crystal samples of PrRu_(2)In_(2)Zn_(18) grown under different conditions.

关键词： ultrasonic measurements non-Kramers doublet structural phase transition crystalline electric field effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sequential Inverse Optimal Control of Discrete-Time Systems

引用

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 608-621页

作者： Sheng Cao Zhiwei Luo Changqin Quan the graduate school of System Informatics Kobe University Kobe 657-8501Japan

This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time system.The proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian assumption.It calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to one.The remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC solution.The paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution space.The effectiveness of the proposed method is demonstrated through simulation results.

关键词： Inverse optimal control promised calculation step sequential calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rebuilding insight into the pathophysiology of Alzheimer’s disease through new blood-brain barrier models

引用

Neural Regeneration Research 2024年第9期19卷 1954-1960页

作者： Kinya Matsuo Hideaki Nshihara Yamaguchi University graduate school of Medicine YamaguchiJapan Department of Neurotherapeutics Yamaguchi UniversityUbeJapan

The blood-brain barrier is a unique function of the microvasculature in the brain parenchyma that maintains homeostasis in the central nervous system.Blood-brain barrier breakdown is a common pathology in various neurological diseases,such as Alzheimer’s disease,stroke,multiple sclerosis,and Parkinson’s disease.Traditionally,it has been considered a consequence of neuroinflammation or neurodegeneration,but recent advanced imaging techniques and detailed studies in animal models show that blood-brain barrier breakdown occurs early in the disease process and may precede neuronal loss.Thus,the blood-brain barrier is attractive as a potential therapeutic target for neurological diseases that lack effective therapeutics.To elucidate the molecular mechanism underlying blood-brain barrier breakdown and translate them into therapeutic strategies for neurological diseases,there is a growing demand for experimental models of human origin that allow for functional assessments.Recently,several human induced pluripotent stem cell-derived blood-brain barrier models have been established and various in vitro blood-brain barrier models using microdevices have been proposed.Especially in the Alzheimer’s disease field,the human evidence for blood-brain barrier dysfunction has been demonstrated and human induced pluripotent stem cell-derived blood-brain barrier models have suggested the putative molecular mechanisms of pathological blood-brain barrier.In this review,we summarize recent evidence of blood-brain barrier dysfunction in Alzheimer’s disease from pathological analyses,imaging studies,animal models,and stem cell sources.Additionally,we discuss the potential future directions for blood-brain barrier research.

关键词： Alzheimer’s disease blood-brain barrier human induced pluripotent stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamics of 2×2 matrix non-Hermitian quantum systems on Bloch sphere

引用

Communications in Theoretical Physics 2024年第4期76卷 66-71页

作者： Libin Fu graduate school of China Academy of Engineering Physics Beijing 100193China

By casting evolution to the Bloch sphere, the dynamics of 2 × 2 matrix non-Hermitian systems are investigated in detail. This investigation reveals that there are four kinds of dynamical modes for such systems. The different modes are classified by different kinds of fixed points, namely,the elliptic point, spiral point, critical node, and degenerate point. The Hermitian systems and the unbroken PT non-Hermitian cases belong to the category with elliptic points. The degenerate point just corresponds to the systems with exceptional point(EP). The topological properties of the fixed point are also discussed. It is interesting that the topological charge for the degenerate point is two, while the others are one.

关键词： non-Hermitian quantum system two-level system dynamics on the Bloch sphere PT-symmetry fixed points

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural plasticity in Parkinson's disease: a neuroimaging perspective

引用

Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： Christina Andica Koji Kamagata Department of Radiology Juntendo University Graduate School of Medicine Faculty of Health Data Science Juntendo University

Parkinson’s disease(PD) is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Environmental arsenic(As)and its potential relationship with endemic disease in southwestern China

引用

Journal of Environmental Sciences 2024年第5期139卷 46-59页

作者： Donglin Li Hucai Zhang Fengqin Chang Lizeng Duan Yang Zhang Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650500China Southwest United graduate school Kunming 650500China

Many cases of an unknown disease exhibiting the clinical features of limb gangrene,blisters,ulceration,and exfoliation have been reported in Daping village(DV)in southwestern China.However,the pathogenesis is unknown and has puzzled doctors for many years.A preliminary study on heavy metals and symptoms indicated that arsenic might pose the greatest threat to the health of local residents.Here,to explore the sources of and factors influencing arsenic enrichment in DV,whose residents exhibit signs of arsenic poisoning,the As contents in soil,water,and plants were systematically measured.The results indicated high As contents in plant and soil samples obtained from the area,and the source of As may be linked to the weathering of black shale rock.Ingestion of soil and consumption of plants were the two main As exposure pathways among children and adults,respectively,and children exhibited a higher health risk than adults.We presume and emphasize that when extreme drought events occur,humans might face unusual risks resulting from exposure to toxic elements and the direct consumption of highly polluted water.Our study provides a new perspective and sheds light on the environmental geochemistry and health links of this disease.

关键词： Endemic disease Arsenic(As) Risk assessment Black shale Climate change

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：