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Analysis of differentially expressed genes in Verruca vulgaris *** normal skin by RNA-sequencing

BIOCELL 2023年第11期47卷 2435-2443页

作者： QINGQING GUO JIAYUE QI XIAOQIANG LIANG ZIGANG ZHAO JIA BAI FANG XIE CHENGXIN LI school of Medicine Nankai UniversityTianjin300071China Department of Dermatology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing100853China

Introduction:Verruca vulgaris is one of the most common low-risk HPV infections and is characterized by excessive proliferation of ***,very little genetic information is available regarding verruca vulgaris in the chinese *** study aimed to obtain comprehensive transcript information of verruca vulgaris by RNA ***:High-throughput sequencing was performed on three fresh verruca vulgaris samples and adjacent normal skin on the Illumina sequencing *** transcriptomes were analyzed using bioinformatics and the differentially expressed genes(DEGs)were verified by *** vulgaris exhibited a unique molecular ***:In total,1,643 DEGs were identified in verruca vulgaris compared to normal *** functions of the DEGs were studies by Gene Ontology(GO)enrichment,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis,DEGs Reactome analysis,disease annotation function,and sTRING protein-protein interaction(PPI)network *** results revealed 595 GO terms associated with the cell cycle,signal transduction,immune system,signaling molecules,and *** Reactome analysis revealed enrichment in reversible hydration of carbon dioxide and BMP signaling,while the disease annotation function revealed that the enriched DEGs are involved in keratosis *** sTRING PPI network showed that the edges with the highest density mainly included the 2′-5′oligoadenylate synthase(OAs)family-related ***,the M-code analysis found IsG15,IRF7,and OAsL were scored as significant modules and their high expression compared to the control was verified by ***:These findings contribute to the genetic information of verruca vulgaris in the chinese population,revealing that interferon-stimulated genes may play essential roles in verruca vulgaris.

关键词： Differentially expressed genes RNA-seq Transcriptome Verruca vulgaris Interferon-stimulated genes

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summarization and comparison of dermoscopic features on different subtypes of rosacea

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chinese medical Journal 2022年第12期135卷 1444-1450页

作者： Wenmin Fei Yang Han Ang Li Keke Li Xiaoli Ning Chengxu Li Wenju Wang Rusong Meng Yong Cui Department of Dermatology China-Japan Friendship HospitalBejing 100029China graduate school Peking Union Medical College and Chinese Academy of Medical SciencesBejng 100730China graduate school of Peking University Health science Center Bejing 100191China Department of Dermatology Chengdu Second People's HospitalChengduSichuan 610017China Department of Dermatology Specialty Medical Center of the Air ForceChinese People's Liberation ArmyBeijing 100142China

Background:The dermoscopic features of rosacea have already been ***,the current findings are incomplete,and little is known about phymatous ***,this study aimed to summarize and compare the dermoscopic features and patterns of three rosacea subtypes(erythematotelangiectatic[ETR],papulopustular[PPR],and phymatous[PHR])in the chinese Han population and to evaluate whether these features differ with patients’genders,ages,and ***:Dermoscopic images of 87 rosacea patients were collected in non-polarized and polarized dermoscopy contact modes at 20-fold *** features,including vessels,scales,follicular findings,and other structures,were summarized and ***::The reticular linear vessels and red diffuse structureless areas of ETR were *** PPR,red diffuse structureless areas,reticular linear vessels,yellow scales,follicular plugs,and follicular pustules were typical dermoscopic *** common dermoscopic features of PHR were:orange diffuse structureless areas,linear vessels with branches,perifollicular white color,orange focal structureless areas,and white *** following features statistically differed among the three rosacea subtypes:reticular linear vessels(Pspecific linear vessels(P=0.005),linear vessels with branches(Pscales(P=0.001),follicular plugs(Pse structureless areas(P=0.022),orange diffuse structureless areas(Pstructureless areas(P=0.002),orange focal structureless areas(P=0.003),white lines(Pstules(Ps hairs(Psions:The dermoscopic patterns of ETR are red diffuse structureless areas and reticular linear *** PPR,the pattern comprehends combinations of red diffuse structureless areas,reticular linear vessels,yellow scales,follicular plugs,and follicular ***,PHR is characterized by remarkable orange d

关键词： Rosacea Dermoscopic features Patterns summarizations Comparisons

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Current progress in cancer treatment by targeting FGFR signaling

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Cancer Biology & Medicine 2023年第7期20卷 490-499页

作者： sicheng Du Ying Zhang Jianming Xu Department of graduate Administration Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China Department of Oncology The Fifth Medical Center of the PLA General HospitalBeijing 100071China

Fibroblast growth factor receptors(FGFRs),a family of transmembrane receptors with intracellular tyrosine kinase domains,and fibroblast growth factors(FGFs)form the FGF/FGFR signaling pathways,which participate in cel... 详细信息

关键词： carcinogenesis treatment cancer

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The theory of critical flicker fusion frequency and its application in cataracts

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Advances in Ophthalmology Practice and Research 2023年第1期3卷 29-32页

作者： Guangcan Xu Junxia Fu Haolan Qi Linyu Li Wenqian Chen Yi Gao Tianju Ma Zi Ye Zhaohui Li school of Medicine Nankai UniversityTianjinChina Department of Ophthalmology The Third Medical CenterThe Chinese People's Liberation Army General HospitalBeijingChina Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina The chinese people.s liberation army medical school BeijingChina

Background:Due to media opacity,it is usually difficult to accurately evaluate the postoperative visual acuity in cataracts *** a small and portable tool,the critical flicker fusion frequency(CFF)device reflects the temporal resolution of visual function and has been widely used in clinical ***,poor understanding of the technique and equipment limitations have restricted its clinical application in *** text:There was a decrease in the CFF value in various ophthalmic diseases,indicating that the CFF is sensitive to detect visual functional changes.A number of studies have shown that the CFF test can accurately distinguish patients with simple cataracts from those with cataracts combined with fundus disease,and,as a visual test,it can more accurately predict postoperative visual acuity without being affected by media *** study comprehensive reviews the basic principles of CFF and its application in ophthalmology,especially in ***:As one of the tools for dynamic visual function detection,the CFF test could help doctors to assess the possible presence of fundus disease in cataracts patients,especially in eyes with dense cataracts,and more precisely provide a reasonable visual prognosis than other available visual tests.

关键词： Critical flicker fusion frequency Cataracts Review

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Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

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Military medical Research 2022年第3期9卷 319-330页

作者： Wei Hu Jia-Wu Liang song Liao Zhi-Dong Zhao Yu-Xing Wang Xiao-Fei Mao si-Wei Hao Yi-Fan Wang Heng Zhu Bin Guo medical school of chinese people.s liberation army(PLA) Beijing100853China Department of stomatology the First Medical CentreChinese PLA General HospitalBeijing100853China Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing100840China

Background:The healing of bone defects can be challenging for clinicians to manage,especially after exposure to ionizing *** this regard,radiation therapy and accidental exposure to gamma(o inhibit bone formation and increase the risk of *** bone-derivγ)-ray radiation have been shown ted stem cells(CBsCs)are reportedly essential for osteogenic lineages,bone maintenance and *** study aimed to investigate the effects of melatonin on postradiation CBsCs and bone defect ***:CBsCs were extracted from C57BL/6 mice and were identified by flow *** CBsCs were subjected to 6 Gyγ-ray radiation followed by treatment with various concentrations of *** effects of exogenous melatonin on the self-renewal and osteogenic capacity of postradiation CBsCs in vitro were *** underlying mechanisms involved in genomic stability,apoptosis and oxidative stress-related signaling were further analyzed by Western blotting,flow cytometry and immunofluorescence ***,postradiation femoral defect models were established and treated with Matrigel and *** effects of melatonin on postradiation bone healing in vivo were evaluated by micro-CT and pathological ***:The decrease in radiation-induced self-renewal and osteogenic capacity were partially reversed in postradiation CBsCs treated with melatonin(Pstability,reduced postradiation CBsC apoptosis and intracellular oxidative stress,and enhanced expression of antioxidant-related enzymes(Pstern blotting validated the anti-inflammatory effects of melatonin by downregulating interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α)levels via the extracellular regulated kinase(ERK)/nuclear factor erythroid 2-related factor 2(NRF2)/heme oxygenase-1(HO-1)signaling *** was also found to exhibit antioxidant effects via NRF2 *** vivo experiments demonstrated that the newly formed bone in th

关键词： Melatonin stem cells Ionizing radiation Bone regeneration

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Revisiting the role of human memory CD8+ T cells in immune surveillance

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Cellular & Molecular Immunology 2022年第11期19卷 1319-1321页

作者： You-Yuan Wang Wei Hu Fu-sheng Wang Chao Zhang medical school of chinese people.s liberation army(PLA) BeijingChina Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina

Virtual memory T(TVM)cells were first described 13 years ago in mice as a specialized subset of CD8+T cells that are semi-differentiated,antigen-naïve,and characterized by a memory phenotype and functionality[1].A putative TVM cell subset has been identified in humans for its presence in cord blood,indicating that it does not necessarily have to be antigen experienced[2].

关键词： specialized necessarily immune

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A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer

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Cancer Innovation 2023年第3期2卷 172-180页

作者： Zheng Zhang Yadi Zhang Chuanling Liu Jiakang shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao medical school of chinese PLA BeijingChina Nankai University school of Medicine TianjinChina Department of medical Oncology Xi'an Jiaotong UniversityXi'anShaanxiChina Department of medical Oncology Fifth Medical CenterGeneral Hospital of the Chinese People's Liberation ArmyBeijingChina Department of medical Oncology First Medical CenterGeneral Hospital of the Chinese People's Liberation ArmyBeijingChina Cancer Biology Program Fox Chase Cancer CenterPhiladelphiaPennsylvaniaUSA Department of Pathology First Medical CenterGeneral Hospital of the Chinese People's Liberation ArmyBeijingChina

Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast *** checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain *** aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible ***:The clinical data of advanced TNBC patients who received ICI treatment in the chinese people.s liberation army(PLA)General Hospital were *** responses,outcomes and adverse events(AEs)were ***:Eighty-one patients were included in the *** confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFs)was 4.2 months,and the median overall survival(Os)was 11.0 *** and Os were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer *** AEs were ***:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment.

关键词： biomarkers efficacy evaluation ICIs prognosis safety TNBC

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Expression characteristics of peripheral lymphocyte programmed death 1 and FoxP3+ Tregs in gastric cancer during surgery and chemotherapy

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World Journal of Gastroenterology 2023年第40期29卷 5582-5592页

作者： Hao Li Guan-Mei Cao Guo-Li Gu song-Yan Li Yang Yan Ze Fu Xiao-Hui Du graduate school Medical School of Chinese People’s Liberation ArmyBeijing 100039China Department of General surgery Air Force Medical CenterAir Force Medical UniversityBeijing 100142China Department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General surgery Chinese PLA General HospitalBeijing 100039China

BACKGROUND Programmed death 1(PD-1)and CD4^(+)CD25^(+)FoxP3^(+)expression in peripheral blood T-cells has been previously reported in various types of ***,the specific variation tendency during surgery and chemotherapy,as well as their relationship in gastric cancer patients,still remain *** this aspect may provide some novel insights for future studies on tumor recurrence and tumor immune escape,and also serve as a reference for determining the optimal timing and dose of clinical anti-PD-1 *** To observe and analyze the expression characteristics of peripheral lymphocyte PD-1 and FoxP3^(+)regulatory T cells(FoxP3^(+)Tregs)before and after surgery or chemotherapy in gastric cancer *** Twenty-nine stomach cancer patients undergoing chemotherapy after a D2 gastrectomy provided 10 mL peripheral blood samples at each phase of the perioperative period and during *** study also included 29 agematched healthy donors as a control ***-1 expression was detected on lymphocytes,including CD4^(+)CD8^(+)CD45RO^(+),CD4^(+)CD45RO^(+),and CD8^(+)CD45RO^(+)lymphocytes as well as regulatory T *** We observed a significant increase of PD-1 expression on immune subsets and a larger number of FoxP3^(+)Tregs in gastric cancer patients(Pstrectomy,peripheral lymphocytes PD-1 expression and the number of FoxP3^(+)Tregs notably decrease(Pstoperative chemotherapy,we only observed a decrease in PD-1 expression on lymphocytes in the CD8^(+)CD45RO^(+)and CD8^(+)CD45RO^(+)***,linear correlation analysis indicated a positive correlation between PD-1 expression and the number of CD4^(+)CD45RO^(+)FoxP3high activated Tregs(aTregs)on the total peripheral lymphocytes(r=0.5622,PsION The observed alterations in PD-1 expression and the activation of regulatory T cells during gastric cancer treatment may offer novel insights for future investigat

关键词： Programmed death 1 Active regulatory T cells stomach cancer Peripheral lymphocyte

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H_2s Protecting against Lung Injury following Limb Ischemia-reperfusion by Alleviating Inflammation and Water Transport Abnormality in Rats

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Biomedical and Environmental sciences 2014年第6期27卷 410-418页

作者： QI Ying Chun CHEN Wen LI Xiao Ling WANG Yu Wei XIE Xiao Hua Department of Comprehensive surgery in south Building Chinese People's Liberation Army General HospitalChinese People's Liberation Army Medical School

Objective To investigate the effect of H2s on lower limb ischemia-reperfusion （LIR） induced lung injury and explore the underlying mechanism. Methods Wistar rats were randomly divided into control group, IR group, IR＋ sodium Hydrosulphide （Naris） group and IR＋ DL-propargylglycine （PPG） group. IR group as lung injury model induced by LIR were given 4 h reperfusion following 4 h ischemia of bilateral hindlimbs with rubber bands. Naris （0.78 mg/kg） as exogenous H2s donor and PPG （60 mg/kg） which can suppress endogenous H2s production were administrated before LIR, respectively. The lungs were removed for histologic analysis, the determination of wet-to-dry weight ratios and the measurement of mRNA and protein levels of aquaporin-1 （AQP1）, aquaporin-5 （AQP5） as indexes of water transport abnormality, and mRNA and protein levels of Toll-like receptor 4 （TLR4）, myeloid differentiation primary-response gene 88 （MyD88） and p-NF-KB as indexes of inflammation. Results LIR induced lung injury was accompanied with upregulation of TLR4-Myd88-NF-κB pathway and downregulation of AQP1/AQP5. Naris pre-treatment reduced lung injury with increasing AQP1/AQP5 expression and inhibition of TLR4-Myd88-NF-KB pathway, but PPG adjusted *** and TLR4 pathway to the opposite side and exacerbated lung injury. Conclusion Endogenous H2s, TLR4-Myd88-NF-κB pathway and AQP1/AQP5 were involved in LIR induced lung injury. Increased H2s would alleviate lung injury and the effect is at least partially depend on the adjustment of TLR4-Myd88-NF-κB pathway and AQP1/AQP5 expression to reduce inflammatory reaction and lessen pulmonary edema.

关键词： Hydrogen sulfide Limb Ischemia-reperfusion Toll-like receptors Nuclear Factor-κB Aquaporin-i Aquaporin-5

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Extracts from Huangqi(Radix Astragali Mongoliciplus) and Ezhu(Rhizoma Curcumae Phaeocaulis) inhibit Lewis lung carcinoma cell growth in a xenograft mouse model by impairing mitogen-activated protein kinase signaling, vascular endothelial growth factor prod

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Journal of Traditional chinese Medicine 2019年第4期39卷 559-565页

作者： Xu Chengyong Wang Yuguo Feng Jian Xu Ran Dou Yongqi medical school of chinese people.s liberation army Chinese People's Liberation Army General HospitalBeijing 100853China Department of Traditional chinese Medicine Hainan Branch of Chinese People's Liberation Army General HospitalSanyaHainan province 572013China medical school of chinese people.s liberation army Chinese People's Liberation Army General HospitalBeijing 100853China Department of Traditional chinese Medicine Chinese People's Liberation Army General HospitalBeijing 100853China

OBJECTIVE: To study the anti-tumor effects of the extracts from Huangqi(Radix Astragali Mongolici)and Ezhu(Rhizoma Curcumae Phaeocaulis) on the growth of Lewis lung carcinoma(LLC) in a xenograft mouse model and to investigate the possible underlying ***: LLC tumor-bearing C57 BL/6 mice were treated with normal saline, cisplatin(2 mg/kg intraperitoneally every other day), or Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis)(1∶1, 2∶1, or 3∶1 ratio;5, 8, or 11 g/kg crude drug intragastrically every day) for 15 *** weights and tumor volumes were measured every other day. Tumors were excised on day 15 and analyzed. Tumor microvessel density(MVD)was assessed by immunohistochemical staining of CD34;and expression of vascular endothelial cell growth factor(VEGF), the mitogen-activated protein kinases p38 mitogen-activated protein kinase(MAPK), extracellular signal-regulated kinases 1 and 2(ERK1/2), and Jun N-terminal kinase(JNK)and their phosphorylated forms were assessed by Western ***: Treatment with cisplatin caused a significant loss of body weight compared with controls,whereas Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) extract combinations had no effect. Extracts from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) significantly decreased tumor weight and tumor MVD compared with controls,and at the 3∶1 treatment group had similar efficacy to cisplatin in reducing MVD. Tumors from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) treatments also showed decreased p38 MAPK, p-p38 MAPK, ERK1/2, p-ERK1/2,JNK, and p-JNK expression compared with the control group(all P ssion was significantly reduced in the 2∶1 and 3∶1 treatment groups compared with the control group(P sION: Extracts from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) hindered LLC growth in the xenograft mous

关键词： Carcinoma,Lewis lung Vascular endothelial cell growth factors Extracellular signal-regulated MAP kinases Angiogenesis Huangqi(Radix Astragali Mongolici) Ezhu(Rhizoma Curcumae Phaeocaulis)

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