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Track-Pattern-Based Characteristics of Extratropical Transitioning Tropical Cyclones in the Western North Pacific

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Advances in Atmospheric sciences 2024年第6期41卷 1251-1263页

作者： Hong HUANG Dan WU Yuan WANG Zhen WANG Yu LIU College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410000China No.31631 Army of PLA Huizhou 516000China school of Atmospheric sciences and Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing 210023China No.93721 Army of PLA Shuozhou 038300China

Based on the Regional Specialized Meteorological Center(RSMC)tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FCM)according to their track *** characteristics of the six hard-clustered ETCs with the highest membership coefficient are *** tropical cyclones(TCs)that were assigned to clusters C2,C5,and C6 made landfall over eastern Asian countries,which severely threatened these *** landfalling TCs,93.2%completed their ET after landfall,whereas 39.8%of ETCs completed their transition within one *** frequency of ETCs over the WNP has decreased in the past four decades,wherein cluster C5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for C2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETCs among the six clusters,a number that has increased insignificantly over the past four *** surface roughness variation and three-dimensional background circulation led to C5 containing the maximum number of landfalling TCs and a minimum number of intensifying *** results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP.

关键词： Western North Pacific tropical cyclone extratropical transition fuzzy c-means clustering method

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High-performance magnesium/sodium hybrid ion battery based on sodium vanadate oxide for reversible storage of Na^(+)and Mg^(2+)

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Journal of Energy Chemistry 2024年第9期96卷 79-88页

作者： Xiaoke Wang Titi Li Xixi Zhang Yaxin Wang Hongfei Li Hai-Feng Li Gang Zhao Cuiping Han Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao 999078China school of Physics and Technology University of JinanJinan 250022ShandongChina Songshan Lake Materials Laboratory Dongguan 523808GuangdongChina Faculty of Materials Science and Energy Engineering Shenzhen University of Advanced TechnologyShenzhen 518055GuangdongChina Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina

Magnesium ion batteries(MIBs)are a potential field for the energy storage of the future but are restricted by insufficient rate capability and rapid capacity ***-sodium hybrid ion batteries(MSHBs)are an effective way to address these ***,we report a new type of MSHBs that use layered sodium vanadate((Na,Mn)V_(8)O_(20)·5H_(2)O,Mn-NVO)cathodes coupled with an organic 3,4,9,10-perylenetetracarboxylic diimide(PTCDI)anode in Mg^(2+)/Na^(+)hybrid *** electrochemical cycling,Mg^(2+)and Na^(+)co-participate in the cathode reactions,and the introduction of Na^(+)promotes the structural stability of the Mn-NVO cathode,as cleared by several ex-situ ***,the Mn-NVO cathode presents great specific capacity(249.9 mA h g^(−1)at 300 mA g^(−1))and cycling(1500 cycles at 1500 mA g^(−1))in the Mg^(2+)/Na^(+)hybrid ***,full battery displays long lifespan with 10,000 cycles at 1000 mA g^(−1).The rate performance and cycling stability of MSHBs have been improved by an economical and scalable method,and the mechanism for these improvements is discussed.

关键词： Aqueous battery Hybrid ion battery Mg^(2+)/Na^(+)co-intercalation High-rate performance Organic-water hybrid electrolyte

Community structure and species diversity dynamics of a subtropical evergreen broad-leaved forest in China:2005 to 2020

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Plant Diversity 2024年第1期46卷 70-77页

作者： Shi-Guang Wei Lin Li Kun-Dong Bai Zhi-Feng Wen Jing-Gang Zhou Qin Lin Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal university) Ministry of EducationGuilin 541004GuangxiChina school of Life&Environmental sciences Guilin University of Electronic TechnologyGuilin 541004GuangxiChina Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guilin 541004GuangxiChina Key Laboratory of Vegetation Restoration and Management of South China Botanical Garden of Degraded Ecosystems Chinese Academy of SciencesGuangzhou 510650GuangdongChina Center of Plant Ecology Core Botanical GardensChinese Academy of SciencesGuangzhou 510650GuangdongChina

Here,we characterize the temporal and spatial dynamics of forest community structure and species diversity in a subtropical evergreen broad-leaved forest in *** found that community structure in this forest changed over a 15-year ***,renewal and death of common species was large,with the renewal of individuals mainly concentrated within a few populations,especially those of Aidia canthioides and Cryptocarya *** numbers of individual deaths for common species were concentrated in the small and mid-diameter *** spatial distribution of community species diversity fluctuated in each monitoring period,showing a more dispersed diversity after the 15-year study period,and the coefficient of variation on quadrats *** 2010,the death and renewal of the community and the spatial variation of species diversity were different compared to other survey *** weather may have affected species regeneration and community stability in our subtropical monsoon evergreen broad-leaved *** findings suggest that strengthening the monitoring and management of the forest community will help better understand the long-and short-term causes of dynamic fluctuations of community structure and species diversity,and reveal the factors that drive changes in community structure.

关键词： Community structure Death and renewal dynamics Species diversity dynamics South subtropical forest

Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model

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Virologica Sinica 2024年第3期39卷 414-421页

作者： Yuming Li Yanhong Tang Xiaoqian Wang Airu Zhu Dongdong Liu Yiyun He Hu Guo Jie Zheng Xinzhuo Liu Fengyu Chi Yanqun Wang Zhen Zhuang Zhaoyong Zhang Donglan Liu Zhao Chen Fang Li Wei Ran Kuai Yu Dong Wang Liyan Wen Jianfen Zhuo Yanjun Zhang Yin Xi Jingxian Zhao Jincun Zhao Jing Sun school of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal UniversityHunan Normal UniversityChangsha410005China Guangzhou National Laboratory GuangzhouGuangdong510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghai Tech UniversityShanghai201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518005China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of COVID-19,encodes several accessory proteins that have been shown to play crucial roles in regulating the innate immune ***,their expressions in infected cells and immunogenicity in infected humans and mice are still not fully *** study utilized various techniques such as luciferase immunoprecipitation system(LIPS),immunofluorescence assay(IFA),and western blot(WB)to detect accessory protein-specific antibodies in sera of COVID-19 *** antibodies to proteins 3a,3b,7b,8 and 9c can be detected by LIPS,but only protein 3a antibody was detected by IFA or *** against proteins 3a and 7b were only detected in ICU patients,which may serve as a marker for predicting disease ***,we investigated the expression of accessory proteins in SARS-CoV-2-infected cells and identified the expressions of proteins 3a,6,7a,8,and *** also analyzed their ability to induce antibodies in immunized mice and found that only proteins 3a,6,7a,8,9b and 9c were able to induce measurable antibody productions,but these antibodies lacked neutralizing activities and did not protect mice from SARS-CoV-2 *** findings validate the expression of SARS-CoV-2 accessory proteins and elucidate their humoral immune response,providing a basis for protein detection assays and their role in pathogenesis.

关键词： SARS-CoV-2 Accessory protein Humoral immune responses COVID-19 Mouse model

Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and school of Health and Behavioural sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China school of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

Investigating the Evolution of Amati Parameters with Redshift

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Research in Astronomy and Astrophysics 2024年第1期24卷 188-200页

作者： Meghendra Singh Darshan Singh Kanhaiya Lal Pandey Dinkar Verma Shashikant Gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka university Gurugram 122103India Department of Physics Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Physics School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray bursts(GRBs) are among the brightest objects in the Universe and, hence, can be observed up to a very high redshift. Properly calibrated empirical correlations between intensity and spectral correlations of GRBs can be used to estimate the cosmological parameters. However, the possibility of the evolution of GRBs with redshift is a long-standing puzzle. In this work, we used 162 long-duration GRBs to determine whether GRBs below and above a certain redshift have different properties. The GRBs are split into two groups, and we fit the Amati relation for each group separately. Our findings demonstrate that estimations of the Amati parameters for the two groups are substantially dissimilar. We perform simulations to investigate whether the selection effects could cause the difference. Our analysis shows that the differences may be either intrinsic or due to systematic errors in the data, and the selection effects are not their true origin. However, in-depth analysis with a new data set comprised of 119 long GRBs shows that intrinsic scatter may partly be responsible for such effects.

关键词： Cosmology gamma rays:general (cosmology:)large-scale structure of universe galaxies:high-redshift

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia school of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach

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Oncology Research 2024年第2期32卷 409-419页

作者： KEGANG JIA YAWEI WANG QI CAO YOUYU WANG Department of Thoracic Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina school of Medicine University of Electronic Science and Technology of ChinaChengduChina Department of Assisted Reproductive Medicine Sichuan Provincial Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina

Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death *** failure in lung cancer(LUAD)is heavily influenced by drug *** challenge stems from the diverse cell populations within the tumor,each having unique genetic,epigenetic,and phenotypic *** variations lead to varied therapeutic responses,thereby contributing to tumor relapse and disease ***:The Genomics of Drug Sensitivity in Cancer(GDSC)database was used in this investigation to obtain the mRNA expression dataset,genomic mutation profile,and drug sensitivity information of *** Learning(ML)methods,including Random Forest(RF),Artificial Neurol Network(ANN),and Support Vector Machine(SVM),were used to predict the response status of each compound based on the mRNA and mutation characteristics determined using statistical *** most suitable method for each drug was proposed by comparing the prediction accuracy of different ML methods,and the selected mRNA and mutation characteristics were identified as molecular features for the drug-responsive cancer ***,the prognostic influence of molecular features on the mutational subtype of LUAD in publicly available ***:Our analyses yielded 1,564 gene features and 45 mutational features for 46 *** the ML approach to predict the drug response for each medication revealed an upstanding performance for SVM in predicting Afuresertib drug response(area under the curve[AUC]0.875)using CIT,GAS2L3,STAG3L3,ATP2B4-mut,and IL15RA-mut as molecular ***,the ANN algorithm using 9 mRNA characteristics demonstrated the highest prediction performance(AUC 0.780)in Gefitinib with ***:This work extensively investigated the mRNA and mutation signatures associated with drug response in LUAD using a machine-learning approach and proposed a priority algorithm to predict drug response for different drugs.

关键词： Lung adenocarcinoma Drug resistance Machine learning Molecular features Personalized treatment

Silicon Mitigates Aluminum Toxicity of Tartary Buckwheat by Regulating Antioxidant Systems

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 1-13页

作者： Anyin Qi Xiaonan Yan Yuqing Liu Qingchen Zeng Hang Yuan Huange Huang Chenggang Liang Dabing Xiang Liang Zou Lianxin Peng Gang Zhao Jingwei Huang Yan Wan Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural AffairsSichuan Engineering&Technology Research Center of Coarse Cereal IndustrializationCollege of Food and Biological EngineeringChengdu UniversityChengdu610106China Research Center of Buckwheat Industry Technology School of Life SciencesGuizhou Normal UniversityGuiyang550001China

Aluminum (Al) toxicity is a considerable factor limiting crop yield and biomass in acidic soil. Tartary buckwheatgrowing in acidic soil may suffer from Al poisoning. Here, we investigated the influence of Al stress on the growthof tartary buckwheat seedling roots, and the alleviation of Al stress by silicon (Si), as has been demonstrated inmany crops. Under Al stress, root growth (total root length, primary root length, root tips, root surface area, androot volume) was significantly inhibited, and Al and malondialdehyde (MDA) accumulated in the root tips. At thesame time, catalase (CAT) and ascorbate peroxidase activities, polyphenols, flavonoids, and 1,1-diphenyl-2-picrylhydrazyl(DPPH) and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) free-radical scavenging abilitywere significantly decreased. After the application of Si, root growth, Al accumulation, and oxidative damage wereimproved. Compared to Al-treated seedlings, the contents of ·O2− and MDA decreased by 29.39% and 25.22%,respectively. This was associated with Si-induced increases in peroxidase and CAT enzyme activity, flavonoidcompounds, and free-radical scavenging (DPPH and ABTS). The application of Si therefore has positive effectson Al toxicity in tartary buckwheat roots by reducing Al accumulation in the roots and maintaining oxidationhomeostasis.

关键词： Tartary buckwheat aluminum stress silicon root growth oxidative stress