检索结果-南通市图书馆

Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells

引用

Acta Pharmacologica Sinica 2007年第4期28卷 459-472页

作者： Sujit NAIR Ah-Ng Tony KONG graduate program in Pharmaceutical sciences Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe StateUniversity of New JerseyPiscatawayNew Jersey 08854USA

Many dietary phytochemicals exhibit health-beneficial effects including preven-tion of diseases such as cancer,as well as neurological,cardiovascular,inflam-matory,and metabolic ***,herbivorous and omnivorousanimals have been ingesting *** interaction between"animal-plant"ecosystems has resulted in an elaborate system of detoxification and defensemechanisms evolved by animals including *** cells,includinghuman cells,respond to these dietary phytochemicals by"non-classical receptorsensing"mechanisms of electrophilic chemical-stress typified by"thiol-modu-lated"cellular signaling events primarily leading to the gene expression of phar-macologically beneficial effects,but sometimes unwanted cytotoxicity *** has been studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols),which areeffective in chemical-induced,as well as genetically-induced,animal carcinogen-esis *** compounds typically generate"cellular stress"and modulategene expression of phase Ⅱ detoxifying/antioxidant ***,reac-tive oxygen species,and reactive nitrogen species are known to act as secondmessengers in the modulation of many cellular signaling pathways leading togene expression changes and pharmacological ***-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2),AP-1,NF-κB,tocite a few examples,sense and transduce changes in the cellular redox status andmodulate gene expression responses to oxidative and electrophilic stresses,pre-sumably via sulfhydryl modification of critical cysteine residues found on theseproteins and/or other upstream redox-sensitive molecular *** the currentreview,we will explore dietary cancer chemopreventive phytochemicals,discussthe link between oxidative/electrophilic stresses and the redox circuitry,and con-sider different redox-sensitive transcription *** will also discuss thekelch-l

关键词： redox Nrf2 Keapl NES NLS gene expression profiles

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effectiveness and safety of Suxiao Jiuxin pill in treating acute coronary syndrome:a systematic review and Meta-analysis

引用

Journal of Traditional Chinese Medicine 2020年第4期40卷 518-529页

作者： Liu Chao Duan Lian Huang Mingyan Li Jun Xiong Xingjiang Chen Guang He Haoqiang Zhang Zhenpeng Wang Jie Department of cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China graduate School Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the effectiveness and safety of Suxiao Jiuxin pill(SX)in acute coronary syndrome(ACS)***:An extensive search of four English databases(Medline/PubMed,Cochrane Library,Embase,and World Health Organization International Clinical Trials Registration Platform)and four Chinese databases(Chinese National Knowledge Infrastructure,Wanfang,China Science and Technology Journal,and Chinese Biomedical Literature Service System)was ***,controlled trials(RCTs)involving SX combined with conventional therapy versus conventional therapy were *** extracted data included populations,interventions,outcomes,and risk of *** cardiovascular events served as the primary *** Manager 5.3 software was used for data *** risks(RRs)with 95%confidence intervals(CIs)were the effect ***:A total of eight RCTs with 979 patients were *** were 559 patients with unstable angina(UA)in six RCTs and 420 patients with acute myocardial infarction(AMI)in two *** review showed that SX plus conventional therapy might reduce the incidence of the total endpoint(RR:0.34,95%CI:0.17,0.68,P=0.002),with no obvious adverse events(RR:1.29,95%CI:0.60,2.77,P=0.52)compared with conventional therapy for patients with ***,SX plus conventional therapy also reduced the incidence of the total endpoint(RR:0.35,95%CI:0.18,0.68,P=0.002)compared with conventional therapy in patients with *** plus conventional therapy also reduced the incidence of ventricular fibrillation(RR:0.23,95%CI:0.10,0.57,P=0.001)compared with conventional therapy in patients with ***:Our results suggest that SX is beneficial for treating patients with UA or ***,our findings should be treated with caution because of the poor methodological quality of the included ***,more multicenter,large-sample,high-quality RCTs are required to provide high-quality evidence.

关键词： Acute coronary syndrome Angina,unstable Myocardial infarction Endpoint Determination Meta-analysis Suxiao Jiuxin pill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction

引用

Chinese Medical Journal 2014年第4期127卷 627-632页

作者： Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of cardiology First Hospital of Hohhot Hohhot Inner Mongolia 010030 China

Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with Gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.

关键词： N-terminal pro-brain natriuretic peptide coronary artery disease risk factors modified Gensini score

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型完全生物可吸收封堵器经导管封堵膜周部室间隔缺损:一项多中心前瞻性随机对照研究

引用

Science Bulletin 2023年第10期68卷 1051-1059,M0004页

作者：王首正李泽夫王云兵赵天力莫绪明范太兵李建华尤涛邓润迪欧阳文斌王伟伟张闯年 Gianfranco Butera Ziyad MHijazi 逄坤静朱达蒋世良张戈军胡晓鹏谢涌泉张凤文房芳孙静平李萍陈娟骆志玲潘湘斌 Department of Structural Heart Disease Fuwai Hospital&National Center for Cardiovascular DiseaseKey Laboratory of Innovative Cardiovascular DevicesChinese Academy of Medical Sciences&Peking Union Medical CollegeNational Health Commission Key Laboratory of Cardiovascular Regeneration MedicineNational Clinical Research Center for Cardiovascular DiseasesBeijing 100037China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of cardiovascular Surgery Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of cardiovascular Surgery Fuwai Central China Cardiovascular HospitalZhengzhou 451464China Department of cardiovascular Surgery The Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of cardiovascular Surgery Gansu Province HospitalLanzhou 730000China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Science&Peking Union Medical CollegeTianjin 300192China Department of Pediatric and Adult Congenital Heart Disease Evelina London Children’s HospitalGuy’s and St Thomas’NHS Foundation TrustLondon SE19RTUK Department of Pediatrics Sidra Heart CenterSidra Medical&Research CenterDoha 999043Qatar Department of Echocardiography Fuwai Hospital&National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeNational Health Commission Key Laboratory of Cardiovascular Regeneration MedicineNational Clinical Research Center for Cardiovascular DiseasesBeijing 100037China Department of Structural Heart Disease Fuwai Yunnan Cardiovascular HospitalKunming 650102China cardiology Department The Clinic Cleveland FoundationCleveland 44195USA cardiology Department Fuwai Hospital&National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences&Peking Union Medical College

生物可吸收封堵器的应用有望降低传统金属封堵器并发症的风险.之前研制的生物可吸收封堵器存在不完全降解的局限性并导致新的并发症,因此目前尚未有相关产品获批上市.本研究使用了一种新型完全可吸收封堵器,旨在探索完全可吸收封堵器治... 详细信息

生物可吸收封堵器的应用有望降低传统金属封堵器并发症的风险.之前研制的生物可吸收封堵器存在不完全降解的局限性并导致新的并发症,因此目前尚未有相关产品获批上市.本研究使用了一种新型完全可吸收封堵器,旨在探索完全可吸收封堵器治疗室间隔缺损的疗效和安全性.从2019年4月到2020年1月,本研究在七个医学中心入组125名膜周部室间隔缺损患者,经筛查后108名患者被纳入研究并随机分为植入生物可吸收封堵器实验组和金属封堵器组.所有受试者均成功植入封堵器并完成24个月的随访.生物可吸收封堵器组患者经胸超声心动图显示高亮回声在24个月内逐渐消失,说明可吸收封堵器在体内实现完全降解.对比金属封堵器,实验组器械相关心律失常发生率(5.56%vs.14.81%,P=0.112)和持续传导阻滞发生率(0/54 vs.6/54,P=0.036)显著降低.本研究提示新型完全可吸收封堵器可以在单纯超声引导下实现成功植入,同时降低术后永久性心律失常的发生率.

关键词： Ventricular septal defect Transcatheter closure Bioabsorbable Degradation Echocardiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heart failure and left ventricular dysfunction in older patients with chronic kidney disease: the China Hypertension Survey (2012‒2015)

引用

Journal of Geriatric cardiology 2020年第10期17卷 597-603页

作者： Xin WANG Guang HAO Lu CHEN Lin-Feng ZHANG Zuo CHEN Yu-Ting KANG Ying YANG Cong-Yi ZHENG Hao-Qi ZHOU Zeng-Wu WANG Run-Lin GAO Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Epidemiology School of MedicineJinan UniversityGuangzhouChina Department of cardiology Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Heart failure(HF)is a leading cause of hospitalization and mortality for older chronic kidney disease(CKD)***,the epidemiological data is *** aimed to determine the prevalence of left ventricular(LV)dysfunction and HF,and to explore the risk factors for HF among those *** This is a cross-sectional analysis of the China Hypertension Survey conducted between October 2012 and December 2015.A total of 5,808 participants aged≥65 years were included in the ***-reported history of HF and any other cardiovascular diseases was acquired.2-D and Doppler echocardiography were used to assess LV *** was defined as either estimated glomerular filtration rate(eGFR)<60 mL/min per 1.73 m2 or urinary albumin to creatinine ratio(ACR)≥30 mg/*** Among CKD patients aged≥65 years,the weighted prevalence of HF,heart failure with preserved ejection fraction(HFpEF),heart failure with mid-range ejection fraction(HFmrEF),and heart failure with reduced ejection fraction(HFrEF)was 4.8%,2.5%,0.8%,and 1.7%,*** weighted prevalence of HF was 5.0%in patients with eGFR<60 mL/min per 1.73 m2,and was 5.9%in patients with ACR≥30 mg/*** prevalence of LV systolic dysfunction was 3.1%,and while it was 8.9%for moderate/severe diastolic *** analysis showed that smoking was significantly associated with the risk of ***,age,smoking,and residents in rural areas were significantly associated with a risk of LV diastolic *** The prevalence of HF and LV dysfunction was high in older patients with CKD,suggesting that particular strategies will be required.

关键词： Chronic kidney disease Heart failure Left ventricular dysfunction Older population

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fruit and vegetable intake and the risk of arterial hypertension in China:A prospective cohort study

引用

Chronic Diseases and Translational Medicine 2023年第4期9卷 309-319页

作者： Zhi He Yanhui Jia Jianxin Li IJie Cao Fangchao Liu Hongfan Li Jichun Chen Dongsheng Hu Chong Shen Yingxin Zhao Xiaoqing Liu Ling Yu Jianfeng Huang Xiangfeng Lu Dongfeng Gu Shufeng Chen Key Laboratory of cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBeijingChina Department of Epidemiology and Health Statistics Cllege of Public HealthZhengzhou UniversityZhengzhouHenanChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen UniversityShenzhenGuangdongChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical University(Shandong Academy of Medicine Sciences)JinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouGuangdongChina Department of cardiology Fujian Provincial HospitalFuzhouFujianChina

Background:Population-based epidemiological evidence regarding the association between fruit and vegetable intake and the incidence of hypertension is *** prospective cohort study aimed to investigate the association between fruit and vegetable intake and the risk of new-onset ***:Based on the project of Prediction for Atherosclerotic cardiovascular Disease Risk in China(China-PAR),58,981 Chinese adults without hypertension at baseline were *** on fruit and vegetable intake was collected using a food-frequency *** proportional hazards models were performed to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)of incident ***:During 640,795 person-years of follow-up,21,008 new cases of hypertension were *** with participants in the lowest quintile(Q1)of total fruit and vegetable(TFV)intake,the HRs(95%CIs)of incident hypertension were 0.90(0.86-0.95),0.85(0.81-0.90),0.82(0.78-0.86),and 0.83(0.78-0.88)for the Q2 to Q5 group(ptrend<0.001),*** further analyses categorizing participants according to the recommended intake level(500 g/day),we found that increasing the intake of TFV,even though it was still insufficient for the recommendation,also had a protective effect against the incident *** considering the intake of fruit or vegetable separately,we found similar trends as the TFV ***:These results suggest that a higher intake of fruit and vegetable is beneficial for preventing hypertension in Chinese adults.

关键词： fruit and vegetable hypertension prospective study

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential benefits of Chinese Herbal Medicine for elderly patients with cardiovascular diseases

引用

Journal of Geriatric cardiology 2013年第4期10卷 305-309页

作者： Jing Luo Hao Xu Ke-Ji Chen graduate school Beijing University of Chinese Medicine Beijing 100029 China cardiovascular Diseases Centre Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Chinese Herbal Medicine (CHM), as the most common form of traditional Chinese medicine (TCM), has been playing an important role in the treatment of elderly cardiovascular diseases (CVDs) in China。 In this paper, we briefly discuss on the potential benefits of CHM for elderly patients with CVDs。 Initially, we summarize the characteristics of CVDs in the elderly, the present treatment of CVDs in the elderly, and the clinical applications of CHM for CVDs。 Secondly, in addition to introducing the features of CHM, we discuss the differences between CHM and Western medicine。 Lastly, the potential benefits of CHM are presented。 We came to a conclusion that as mutual complementary, Western medicine and TCM together shall benefit the elderly patients with CVDs。

关键词： cardiovascular diseases Chinese medicine Elderly patients Herb

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The gut microbiome and microbial metabolites in acute myocardial infarction

引用

Journal of Genetics and Genomics 2022年第6期49卷 569-578页

作者： Chenglin Liu Zhonghan Sun Shalaimaiti Shali Zhendong Mei Shufu Chang Hanjun Mo Lili Xu Yanni Pu Huihui Guan Guo-Chong Chen Qibin Qi Zhexue Quan Ji Qi Kang Yao Yuxiang Dai Yan Zheng Junbo Ge State Key Laboratory of Genetic Engineering School of Life Sciences and Human Phenome InstituteFudan UniversityShanghai 200433China Ministry of Education Key Laboratory of Contemporary Anthropology Fudan UniversityShanghai 200433China Department of cardiology Shanghai Institute of Cardiovascular DiseaseZhongshan HospitalFudan University1609 Xietu RoadShanghai 200032China Department of Epidemiology and Population Health Albert Einstein College of MedicineBronxNY 10461USA Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity ScienceSchool of Life SciencesFudan UniversityShanghai 200433China

Emerging evidence has highlighted the role of gut microbiome in human ***,the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction(AMI)remains *** current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 *** microbial alternations are observed in AMI patients compared with controls(P=0.001).The abundances of nine species(e.g.,Streptococcus salivarius and Klebsiella pneumoniae)are positively associated,and one species(Roseburia hominis)is inversely associated with AMI status and severity.A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years(hazard ratio[95%CI]:2.01[1.04-4.24])in AMI *** molar proportions of fecal acetate and butyrate are higher,and the circulating levels of choline and carnitine are lower in AMI patients than in *** addition,disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or *** findings suggest that microbial composition and functional potentials are associated with AMI status and severity.

关键词： Acute myocardial infarction Atherosclerosis Microbiome Short-chain fatty acids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension

引用

Frontiers of Medicine 2022年第1期16卷 102-110页

作者： Huai-yu Wang Suyuan Peng Zhanghui Ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong National Institute of Health Data Science at Peking University Beijing 100191China Peking University Advanced Institute of Information Technology Hangzhou 311215China Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Taikang Tongji(Wuhan)Hospital Wuhan 430050China First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Peking-Tsinghua Center for Life sciences Beijing 100871China Department of cardiology and Institute of Vascular Medicine Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthKey Laboratory of Molecular Cardiovascular SciencesMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China

Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this *** between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients ***-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with *** patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),***-I exhibited protective effects on the survival outcome of *** use was associated with a reduced risk of all-cause mortality among patients with COVID-19.

关键词： COVID-19 RAS inhibitor hypertension all-cause mortality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Abnormal expression of miR-331 leads to impaired heart function

引用

Science Bulletin 2019年第14期64卷 1011-1017页

作者： Jin-Jing Zhang Li-Peng Wang Rong-Chang Li Meng Wang Zeng-Hui Huang Min Zhu Jia-Xing Wang Xiu-Jie Wang Shi-Qiang Wang Ming Xu Department of cardiology Institute of Vascular Medicine Peking University Third Hospital NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of sciences Beijing 100049 China

MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether miR-331 regulates cardiac function under physiological and pathological conditions still remains unknown. In the present study, we investigated the function and underlying mechanisms of miR-331 in a pressure overload-induced heart failure model and miR-331 transgenic rat model. First, we found that the expression of miR-331-3p exhibited a 1.7-fold increase in hypertrophy compared with that in the sham group (P<0.01), yet the expression of miR-331-5p remained unchanged. Furthermore, overexpression of miR-331 in cardiomyocytes and defective excitation-contraction (E-C) coupling efficiency were observed. Luciferase assays showed that miR-331-3p suppressed JPH2 expression by binding to the coding region of JPH2 mRNA. Finally, in the miR-331 transgenic rat model, JPH2 expression was suppressed at both the mRNA and protein levels in vivo, which resulted in impairment of both the E-C coupling efficiency of cardiomyocytes and systolic function of the heart. This finding mechanistically linked miR-331 to JPH2 downregulation and suggested an important role for the abnormal expression of miR-331 leading to the dysfunction of E-C coupling in heart failure.

关键词： MiR-331 Excitation-contraction coupling Junctophilin 2 Heart function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：