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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil graduate program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil graduate program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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DETERMINANT SOLUTIONS OF THE NONAUTONOMOUS DISCRETE TODA EQUATION ASSOCIATED WITH THE DEAUTONOMIZED DISCRETE KP HIERARCHY

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Journal of Systems Science & Complexity 2010年第1期23卷 153-176页

作者： Satoshi TSUJIMOTO Department of applied Mathematics and Physics Graduate School of InformaticsKyoto University

It is shown that the nonautonomous discrete Toda equation and its Backlund transformation can be derived from the reduction of the hierarchy of the discrete KP equation and the discrete two-dimensional Toda equation. Some explicit examples of the determinant solutions of the nonautonomous discrete Toda equation including the Askey-Wilson polynomial are presented. Finally we discuss the relationship between the nonautonomous discrete Toda system and the nonautonomous discrete Lotka- Volterra equation.

关键词： Askey-Wilson polynomial Darboux transformation discrete KP hierarchy nonautonomous discrete Lotka-Volterra equation nonautonomous discrete Toda equation.

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A COMBINATORIAL ASPECT OF A DISCRETE-TIME SEMI-INFINITE LOTKA-VOLTERRA EQUATION

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Journal of Systems Science & Complexity 2010年第1期23卷 71-80页

作者： Shuhei KAMIOKA Satoru MIZUTANI Department of applied Mathematics and Physics Graduate School of InformaticsKyoto University KDDI Corporation Garden Air Tower

A graph is introduced,which allows of a combinatorial interpretation of a discrete-timesemi-infinite Lotka-Volterra (dLV) *** particular,Hankel determinants used in a determinantsolution to the dLV equation are evaluated,via the Gessel-Viennot method,in terms of ***,the recurrence of the dLV equation describing its time-evolution is equivalentlyexpressed as a time-evolution of weight of specific subgraphs.

关键词： Combinatorial proofs discrete integrable systems dynamics on graphs Gessel-Viennot method Hankel determinants non-intersecting paths weighted paths on labeled graphs.

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A Generalization of Haussler's Convolution Kernel——Mapping Kernel and Its Application to Tree Kernels

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Journal of Computer Science & Technology 2010年第5期25卷 1040-1054页

作者： Kilho Shin Tetsuji Kuboyama graduate School of applied informatics University of HyogoKobeJapan Carnegie Mellon CyLab PittsburghU.S.A Computer Center Gakushuin UniversityTokyoJapan

Haussler＇s convolution kernel provides an effective framework for engineering positive semidefinite kernels, and has a wide range of *** the other hand,the mapping kernel that we introduce in this paper is its natural generalization,and will enlarge the range of application *** main theorem with respect to positive semidefiniteness of the mapping kernel（1） implies Haussler＇s theorem as a corollary,（2） exhibits an easy-to-check necessary and sufficient condition for mapping kernels to be positive semidefinite,and（3） formalizes the mapping kernel so that significant flexibility is provided in engineering new *** an evidence of the effectiveness of our results,we present a framework to engineer tree *** tree is a data structure widely used in many applications,and tree kernels provide an effective method to analyze tree-type ***,not only is the framework important as an example but also as a practical research *** description of the framework accompanies a survey of the tree kernels in the literature,where we see that 18 out of the 19 surveyed tree kernels of different types are instances of the mapping kernel,and examples of novel interesting tree kernels.

关键词： kernel convolution kernel tree edit distance

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Developing Reliable Digital Healthcare Service Using Semi-Quantitative Functional Resonance Analysis

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Computer Systems Science & Engineering 2023年第4期45卷 35-50页

作者： Zhengshu Zhou Yutaka Matsubara Hiroaki Takada graduate School of informatics Nagoya UniversityNagoya464-8601Japan

Since entering the era of Industry 4.0,the concept of Healthcare 4.0 has also been put forward and explored by *** to use Information Technology(IT)to better serve people’s healthcare is one of the most featured emerging directions in the academic *** important field of Healthcare 4.0 research is the reliability engineering of healthcare *** healthcare systems often affect the health and even life of their users,developers must be very cautious in the design,development,and operation of these healthcare systems and *** problems to be solved include the reliability of business process,system functions,and personal healthcare *** Functional Resonance Analysis Method(FRAM)has been applied in reliability engineering for safety-critical systems in available studies,using both qualitative and quantitative ***,the method has not been applied in the field of digital healthcare services ***,to narrow the gap,we present in this paper a semi-quantitative functional resonance analysis method to develop reliable healthcare services for ***,this paper has tried to improve the reliability design of the service-oriented architecture(SOA)of traditional insulin pump therapy by system thinking.

关键词： Reliability safety-critical system functional resonance analysis method systemigram

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Controllability of descriptor multi-agent systems with signed networks

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Science China(Information Sciences) 2024年第12期67卷 208-226页

作者： Yu SHEN Yongqiang GUAN Ye TIAN School of Mechano-Electronic Engineering Xidian University graduate School of informatics Kyoto University

This paper studies the controllability of descriptor multi-agent systems(DMASs) with signed networks, where the networks are signed, and agents have descriptor linear dynamics. First, the basis for the eigenspace of the system matrix is derived completely and qualitatively by leveraging the maximum generalized left Jordan chain defined in this paper. Taking advantage of the explicit form of the basis, necessary and sufficient conditions for the controllability of DMASs are established. Furthermore, a necessary and sufficient condition is provided to ensure the controllability of DMASs with heterogeneous dynamics. Particularly, for some special cases, controllability conditions are expressed more precisely in terms of eigenvectors. Then,the relationship between the controllability of DMASs with signed and unsigned networks is *** is shown that the controllability of DMASs under structurally balanced signed networks is equivalent to that under the associated underlying unsigned networks whether the individual dynamics is homogeneous or heterogeneous. Finally, theoretical results are applied to the multi-agent supporting systems.

关键词： controllability signed networks descriptor multi-agent systems heterogeneous dynamics

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Numerical simulation of effect of convection-diffusion on oxygen transport in microcirculation

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applied Mathematics and Mechanics(English Edition) 2015年第2期36卷 179-200页

作者： N.ZHAO K.IRAMINA graduate School of Systems Life Sciences Kyushu University Department of informatics Graduate School of Information Science and Electrical Engineering Kyushu University

The entire process of oxygen transport in microcirculation by developing a3 D porous media model is calculated numerically with coupled solid deformation-fluid seepage-convection and diffusion. The principal novelty of the model is that it takes into account volumetric deformation of both capillary and tissues resulting from capillary fluctuation. How solid deformation, fluid seepage, and convection-diffusion combine to affect oxygen transport is examined quantitatively：（1） Solid deformation is more significant in the middle of capillary, where the maximum value of volumetric deformation reaches about 0.5%.（2） Solid deformation has positive influence on the tissue fluid so that it flows more uniformly and causes oxygen to be transported more uniformly, and eventually impacts oxygen concentration by 0.1%–0.5%.（3） Convection-diffusion coupled deformation and seepage has a maximum（16%） and average（3%） increase in oxygen concentration,compared with pure molecular diffusion. Its more significant role is to allow oxygen to be transported more evenly.

关键词： porous medium microcirculation oxygen transport convection-diffusion solid deformation fluid seepage

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Text Encryption Using Pell Sequence and Elliptic Curves with Provable Security

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Computers, Materials & Continua 2022年第6期71卷 4971-4988页

作者： Sumaira Azhar Naveed Ahmed Azam Umar Hayat Department of Mathematics Quaid-i-Azam UniversityIslamabad45320Pakistan Department of applied Mathematics and Physics Graduate School of InformaticsKyoto UniversityKyoto606-8501Japan

The demand for data security schemes has increased with the significant advancement in the field of computation and communication *** propose a novel three-step text encryption scheme that has provable security against computation attacks such as key attack and statistical *** proposed scheme is based on the Pell sequence and elliptic curves,where at the first step the plain text is diffused to get a meaningless plain text by applying a cyclic shift on the symbol *** the second step,we hide the elements of the diffused plain text from the *** this purpose,we use the Pell sequence,a weight function,and a binary sequence to encode each element of the diffused plain text into real *** encoded diffused plain text is then confused by generating permutations over elliptic curves in the third *** show that the proposed scheme has provable security against key sensitivity attack and statistical ***,the proposed scheme is secure against key spacing attack,ciphertext only attack,and known-plaintext *** to some of the existing text encryption schemes,the proposed scheme is highly secure against modern cryptanalysis.

关键词： Text encryption pell numbers elliptic curves key sensitivity statistical cryptanalysis

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Theoretical and numerical analysis of coherent Smith-Purcell radiation

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Chinese Physics C 2008年第11期32卷 916-923页

作者：卑华戴志敏 Shanghai Institute of applied Physics CAS graduate University of Chinese Academy of Sciences

Coherent enhancement of Smith-Purcell radiation has attracted people＇s attention not only in adopting a better source but also in beam diagnostics aspect. In this paper, we study the intrinsic mechanism of coherent Smith-Purcell radiation on the basis of the van den Berg model. The emitted power of Smith-Purcell radiation is determined by the bunch profile in transverse and longitudinal directions. For short bunch whose longitudinal pulse length is comparable with the radiation wavelength, it can be concluded approximately that the power is proportional to the square number of electrons per bunch.

关键词： Smith-Purcell radiation van den Berg model induced surface current model coherence

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A possible experimental observable for the determination of neutron skin thickness

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Chinese Physics B 2008年第4期17卷 1216-1222页

作者：马春旺傅瑶方德清马余刚蔡翔舟郭威田文栋王宏伟 Shanghai Institute of applied Physics Chinese Academy of Sciences graduate School of Chinese Academy of Sciences

The dependence between neutron skin thickness and neutron abrasion cross section （σnabr） for neutron-rich nuclei is investigated within the framework of the statistical abrasion ablation model. Assuming that the density distributions for proton and neutron are of Fermi-type, and adjusting the diffuseness parameter of neutron density distribution in the droplet model, we find out the good linear correlation between the neutron skin thickness and the abrasion cross section σnabr for neutron-rich nuclei. The uncertainty of neutron skin thickness determined from σnabr is very small. It is suggested that σnabr can be used as a new experimental observable to extract the neutron skin thickness for neutronrich nucleus. The scaling behaviours between neutron skin thickness and σnabr, separately, for isotopes of ^26-35Na, ^44-56Ar, ^48-60Ca, ^67-78Ni are also investigated.

关键词： neutron skin thickness neutron abrasion cross section statistical abrasion ablation model

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