检索结果-南通市图书馆

维普期刊数据库

Estimation of gaseous polycyclic aromatic hydrocarbons(PAHs)and characteristics of atmospheric PAHs at a traffic site in Kanazawa,Japan

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第3期149卷 57-67页

作者： Xuan Zhang Hao Zhang YanWang Pengchu Bai Lulu Zhang Akira Toriba Seiya Nagao Nobuo Suzuki Masato Honda Zhijun Wu Chong Han Min Hu Ning Tang graduate School of medical Sciences Kanazawa UniversityKanazawa 920-1192Japan School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China institute of Nature and Environmental Technology Kanazawa UniversityKanazawa 920-1192Japan graduate School of Biomedical Sciences Nagasaki UniversityNagasaki 852-8521Japan College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China School of Metallurgy Northeastern UniversityShenyang 110819China institute of medical Pharmaceutical and Health ScienceKanazawa UniversityKanazawa 920-1192Japan

Size-fractionated particulate matter(PM_(2.5)and PM>_(2.5))was collected at a traffic site in Kanazawa,Japan in a seasonal sampling work in *** polycyclic aromatic hydrocarbons(4-to 6-ring PAHs)were determined in fine and coarse *** gas/particle partitioning coefficients(K_(p))of the PAHs were calculated from the supercooled liquid vapour pressure and octanol-air partitioning coefficient based on the relationships obtained in previous traffic pollution-related *** PAHs were estimated by K_(p) and the concentrations of PM and particulate *** concentrations of total PAHs were 32.5,320.1 and 5646.2 pg/m^(3) in the PM>_(2.5),PM_(2.5) and gas phases,*** seasonal trends in PAHs were observed(particle phase:lowest in summer,gas phase:lowest in spring,particle and gas phase:lowest in spring).Compared to 2019,the total PAH concentrations(in particles)decreased in 2020,especially in spring and summer,which might be due to reduced traffic trips during the COVID-19 *** incremental lifetime cancer risk(ILCR)calculated from the toxic equivalent concentrations relative to benzo[a]pyrene(BaP_(eq))was lower than the acceptable limit issued by the US Environmental Protection Agency,indicating a low cancer risk in long-term exposure to current PAH *** is notable that gaseous PAHs considerably contributed to BaP_(eq) and ILCR(over 50%),which highlighted the significance of gaseous PAH monitoring for public health *** low-cost estimation method for gaseous PAHs can be expected to reliably and conveniently obtain PAH concentrations as a surrogate for traditional sampling in the future work.

关键词： Polycyclic aromatic hydrocarbons Gas-particle partitioning Traffic Exposure-response relationship COVID-19

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Prevalence of malnutrition among adult inpatients in China:a nationwide cross-sectional study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Yan Liu Chunhua Song Xue Wang Xianghua Ma Pianhong Zhang Gaiyun Chen Zhenqian Cheng Juying Liu Ying Yao Wenjun Ma Zengning Li Ping Sun Fan Lin Weilian Hou Ting Han Ying Zhang Min Weng Wanying Shi Dagang Yang Ji Feng Junqiang Chen Li Li Hua Jiang Hongxia Xu Ruifang Guo Ying Liu Xiaopan Chen Qian Zhao Yumei Qi Qiang Chi Rong Liu Rui Xiong Tiantian Wu Shangfeng Tang Shuyan Guo Wei Chen Department of Clinical nutrition The First Hospital of Hebei Medical University Department of Clinical nutrition The First Affiliated Hospital of Shanxi Medical University Department of Clinical nutrition Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial Hospital Department of Clinical nutrition The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Clinical nutrition Shanghai Tenth People’s HospitalTongji University School of Medicine Department of Clinical nutrition Shaanxi Provincial People’s Hospital Department of Clinical nutrition The First Affiliated Hospital of Kunming Medical University Department of Clinical nutrition The First Affiliated Hospital of China Medical University The Affiliated Hospital of Guizhou medical university The Second Affiliated Hospital of Nanchang university Department of Clinical nutrition Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College The First Affiliated Hospital of Guangxi medical university Department of Clinical nutrition The First Affiliated Hospital of Xinjiang Medical University institute for Emergency and Disaster Medicine Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China Department of Clinical nutrition Daping HospitalArmy Medical University (Third Military Medical University) Inner Mongolia People’s Hospital Jilin People’s Hospital (Jilin) The First Affiliated Hospital of Hainan medical university Department of Clinical nutrition Ningxia Hui Autonomous Region People’s Hospital Department of Clinical nutrition Tianjin Third Central Hospital The Second Affiliated Hospital of Harbin medical university Department of Epidemiology and Statistics College of Public HealthZhengzhou University The First Hospital of Lanzhou university Qinghai Provincial People’s Hospital School of Medicine and health Management Tongji Medical CollegeHuazhong Uni

Malnutrition substantially contributes to adverse clinical ***,no national survey has been conducted to characterize its epidemiology in hospital settings in *** conducted the China nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces,autonomous regions and municipalities(except for Hong Kong,Macao,Taiwan Province,and the Xizang Autonomous Region,please see MATERIALS AND METHODS for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk *** collected information on participants' sociodemographic characteristics,physical examinations,and laboratory test *** was defined according to the Global Leadership Initiative on Malnutrition(GLIM) *** standardized prevalence of malnutrition was calculated,and factors associated with malnutrition were examined using logistic regression *** included 54,652 individuals with seven systemic diseases who completed all the survey documents in the final *** overall prevalence of malnutrition was 12.5%,representing 7.6 million adult inpatients in *** prevalence of malnutrition was higher in men,individuals aged≥60 years,residents of central and western regions,people from lower economic areas,and those with lower education levels than in women,individuals agednutrition than those without such ***,age,region,economic level,education level,disease severity score,infectious diseases,and neoplasms were independently associated with *** conclusion,malnutrition is prevalent among Chinese adult inpatients,necessitating national-and hospital-level *** surv

关键词：

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

维普期刊数据库

Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2025年第1期17卷 1-7页

作者： Mahnoor Sukaina Marium Waheed Shafi Rehman Md Al Hasibuzzaman Rabab Meghani Department of Internal Medicine Karachi Medical and Dental CollegeKarachi 75270Pakistan Department of Histopathology Khyber Medical UniversityPeshawar25000Pakistan institute of nutrition and Food Science University of DhakaDhaka 1000Bangladesh Department of Bioethics Columbia UniversityNew YorkNY 10027United States

Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac *** known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or *** study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among *** the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United *** this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older *** 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled *** a 50.2%increase in the number of deaths due to AF/***,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.

关键词： Demographic trends United States Atrial fibrillation Atrial flutter Older population

Separate and Combained Associations of PM_(2.5) Exposure and Smoking with Dementia and Cognitive Impairment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2025年第2期38卷 194-205页

作者： Lu Cui Zhihui Wang Yuhong Liu Linlin Ma Shige Qi Ran An Xi Chen Haoyan Guo Yuxiang Yan Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijing 100069China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100050China National institute for nutrition and health Control and PreventionChinese Center for Disease Control and PreventionBeijing 100050China

Objective The results of limited studies on the relationship between environmental pollution and dementia have been *** analyzed the combined effects of PM_(2.5)and smoking on the prevalence of dementia and cognitive impairment in an elderly community-dwelling Chinese *** We assessed 24,117 individuals along with the annual average PM_(2.5)concentrations from 2012 to *** was confirmed in the baseline survey at a qualified clinical facility,and newly suspected dementia was assessed in 2017,after excluding cases of suspected dementia in *** census data were used to weight the sample data to reflect the entire population in China,with multiple logistic regression performed to analyze the combined effects of PM_(2.5)and smoking frequency on dementia and cognitive *** Individuals exposed to the highest PM_(2.5)concentration and smoked daily were at higher risk of dementia than those in the lowest PM_(2.5)concentration group(OR,1.603;95%CI[1.626−1.635],Phealth.

关键词： PM_(2.5) exposure Smoking Dementia Cognitive impairment Environmental protection Smoking cessation

维普期刊数据库

Hepatitis B virus infection and its treatment in Eastern Ethiopia

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 167-171页

作者： Tatsuo Kanda Reina Sasaki-Tanaka Atsunori Tsuchiya Shuji Terai Division of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinamiuonuma 949-7302NiigataJapan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8520Japan

Hepatitis B virus(HBV)infection causes acute and chronic hepatitis,compensated and decompensated cirrhosis,and hepatocellular carcinoma *** actual status of HBV infection and its treatment in certain regions of Asian and African countries,including Ethiopia,has not been well-documented thus *** therapy for HBV infection can prevent the progression of HBV-related liver diseases and decrease the HBV-related symptoms,such as abdominal symp-toms,fatigue,systemic symptoms and *** Eastern Ethiopia,HBV-infected patients with cirrhosis were found to be positive for the HBV e antigen and to have a higher viral load than those without ***,54.4%of patients practiced khat chewing and 18.1%consumed excessive amounts of ***-fovir disoproxil fumarate effectively suppressed HBV DNA in those infected with *** is important to elucidate the actual status of HBV infection in Eastern Ethiopia to eliminate HBV infection worldwide by *** vaccination and the educational programs for health Science students that provide practical strategies could help to reduce HBV infection in Eastern Ethiopia.

关键词： Antivirals Ethiopia Hepatitis B virus Liver cirrhosis Vaccines

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第4期31卷 42-58页

作者： Qing-Wen Liu Lin Liu Jun-Xi Hu Jia-Qi Hou Wen-Bo He Yu-Sheng Shu Xiao-Lin Wang Department of graduate School Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Thoracic Surgery The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi People's HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214000Jiangsu ProvinceChina Clinical medical College Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of Thoracic Surgery Northern Jiangsu People's HospitalYangzhou 225000Jiangsu ProvinceChina

BACKGROUND The relationship between patient nutritional,immune,and inflammatory status is linked to tumor progression and ***,there are limited studies on the prognosis of esophageal squamous cell carcinoma(ESCC)after surgery based on the comprehensive indicators of these *** To develop and validate a novel nomogram based on a nutritional immuneinflammatory status(NIIS)score for predicting postoperative outcomes in *** This retrospective study examined 829 patients with ESCC who underwent radical surgery between June 2016 and June 2020,with 568 patients in the training cohort and 261 patients in the validation *** incorporated comprehensive indicators related to nutrition,immunity,and inflammation to develop the NIIS score, using LASSO regression. Subsequently, a nomogram combining the NIIS score and other clinicopathologicalparameters was developed and validated using calibration curves, time-dependent area under curves, and decisioncurve *** identified eight indicators that constitute the NIIS score. High-risk scores emerged as an independent riskfactor for overall survival [training set HR 2.497 (1.802, 3.458), P < 0.001]. A NIIS nomogram for personalizedprognostic prediction was developed by integrating the NIIS score with clinicopathological variables, yieldingenhanced predictive value relative to individual indicators and the UICC/TNM staging *** NIIS score provides strong predictive value for postoperative outcomes in ESCC, thus offering a valuable toolfor clinical decision-making.

关键词： Esophageal squamous cell carcinoma nutrition Immunity Inflammation Overall survival