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identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KiRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN Li dANdAN Li BARBOd HAFEZ MOUNiR M.SALEM BEKHiT YOUSEF A.BiN JARdAN FARS KAEd ALANAZi EHAB i.TAHA SAYEd H.AUdA FAiQAH RAMZAN MUHAMMAd JAMiL The Second Affiliated Hospital of Harbin Medical university Harbin Medical UniversityHarbinChina department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina department of Biological Engineering University of SalfordSalfordUK department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KiRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KiRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPiA,OncodB,HPA,cBioPortal,GSEA,TiMER,ENCORi,drugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRiNG and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KiRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KiRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KiRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).in addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KiRC.

关键词： KiRC MMP gene family Chemotherapy Overall survival

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Color-flavor dependence of the Nambu-Jona-Lasinio model and QCd phase diagram

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Chinese Physics C 2022年第8期46卷 128-140页

作者： Aftab Ahmad Ali Murad institute of Physics Gomal University29220D.I.KhanKhyber PakhtunkhawPakistan

We study the dynamical chiral symmetry breaking/restoration for various numbers of light quarks flavors N_(f) and colors N_(c) using the Nambu-Jona-Lasinio(NJL) model of quarks in the Schwinger-dyson equation framework,dressed with a color-flavor dependence of effective *** fixed N_(f)=2 and varying N_(c),we observe that the dynamical chiral symmetry is broken when N_(c) exceeds its critical value N_(c)^(c)≈*** a fixed N_(c)=3 and varying N_(f),we observe that the dynamical chiral symmetry is restored when Nf reaches its critical value N_r^(c)≈*** interplay is observed between N_(c) and N_(f),i.e.,larger values of N_(c) tend to strengthen the dynamical generated quark mass and quark-antiquark condensate,while higher values of N_(f) suppress both *** further sketch the quantum chromodynamics(QCd) phase diagram at a finite temperature T and quark chemical potential μ for various N_(c) and N_(f).At finite T and μ,we observe that the critical number of colors N_(c)^(c) is enhanced,whereas the critical number of flavors N_(f)^(c) is suppressed as T and μ ***,the critical temperature T_(c),μ_(c),and co-ordinates of the critical endpoint(T_(c)^(E),μ_(c)^(E)) in the QCd phase diagram are enhanced as N_(c) increases and suppressed when N_(f) *** findings agree with the lattice QCd and Schwinger-dyson equations predictions.

关键词： chiral symmetry breaking Schwinger-dyson equation finite temperature and density QCd phase diagram

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Circulating tumor dNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali khan Saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar Khawar Zhiguang Ren Xinying Ji Malik ihsan Ullah khan institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan department of internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. it has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor dNA(ctdNA). Varied methods are used to investigate ctdNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctdNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctdNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCNd1;2) copy number variations which include markers such as CdK6, EFGR, MYC and BRAF;3) dNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctdNA markers as CdKN2A, AXiN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctdNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctdNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor dNA biomarkers single nucleotide variations diagnosis prognosis

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A novel 2d-GO@WS2 electrochemical platform for the determination of thiram fungicide

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Journal of Environmental Sciences 2024年第2期136卷 226-236页

作者： Khouloud Abid daniela iannazzo Consuelo Celesti Amani Khaskhoussi Antonino Foti Ramzi Maalej Pietro Giuseppe Gucciardi Giovanni Neri department of Engineering University of MessinaC.da Di DioI-98166 MessinaItaly iNSTM Research Unity of MessinaItaly Laboratory of dielectric and Photonic Materials Faculty of Sciences of SfaxSfaxUniversitySfax 3018Tunisia CNR iPCF istituto per i Processi Chimico-Fisici viale F.Stagno D’Alcontres 37I-98156 MessinaItaly

in this paper,the determination of Thiram fungicide by a novel modified screen-printed carbon electrode(SPCE)fabricated modifying the working electrode(WE)with 2d-GO/WS2nanohybrid composites,is *** electron microscopy(SEM),Raman spectroscopy,and fluorescence analysis(PL)were used to reveal the morphological and microstructural characteristics of the 2d-GO/WS2 nanohybrids with different graphene oxide:tungsten disulphide(GO:WS_(2))*** characterization demonstrated that the 2d-WS2/GO nanohybrids having a GO:WS_(2)ratio=2:1 shows the highest electrocatalytic activity towards oxidation of *** developed sensor permits the quantification of Thiram in the linear range 0.083-0.33μM with a limit of detection(LOd)of 0.02μM,which is below the legal limits for this fungicide in drinking water or foods.

关键词： WS_(2)nanosheets Graphene Oxide(GO) Electrochemical sensor Fungicides Thiram

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Recalibrating impact of Regional Actors on Security of China–Pakistan Economic Corridor (CPEC)

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Fudan Journal of the Humanities and Social Sciences 2022年第3期15卷 437-462页

作者： Muhammad ismail Syed Mehdi Husnain department of Politics and iR Qurtuba UniversityD.I.KhanPakistan department of Political Science&iR Qurtuba UniversityD.I.KhanPakistan

China and Pakistan's collaboration in attaining regional integration can alter the regional geopolitical and geostrategic *** is the steps toward benefiting Pakistan,China,and the whole *** article explored the regional actors’role in undermining and threatening the *** of the secondary data revealed that india,iran,Afghanistan,and the USA could create security problems for *** Framework,based on Behavioralist theory,was developed to investigate these security threats through the primary data collected through the structured questionnaire with the help of *** primary data also revealed that iran and india have vital *** study also discussed suggestions and implications for future research.

关键词： CPEC india iran USA Afghanistan Terrorism Baluch Conundrum Political Turmoil Peace in Afghanistan

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Facile synthesis of graphene anchored rare earth doped mixed metal ferrite nanorods:A potential candidate for azo dye mineralization

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Journal of Rare Earths 2024年第5期42卷 907-916,I0004页

作者： Tehmina Kousar Muhammad Aadil Sonia Zulfiqar Sobhy Mibrahim Sidra Mubeen Warda Hassan Kashuf Shafiq Farzana Mahmood institute of Chemical Sciences Bahauddin Zakariya UniversityMultan60800Pakistan department of Chemistry Rahim Yar Khan CampusThe Islarnia University of BahawalpurRahim Yar Khan64200Pakistan department of Chemistry Faculty of ScienceUniversity of Ostrava30.Dubna 22Ostrava70103Czech Republic department of Chemical and Biological Engineering Iowa State UniversitySweeney Hall618 Bissell RoadAmeslowa50011United States department of Biochemistry College of ScienceKing Saud UniversityPO.Box 2455Riyadh11451Saudi Arabi department of Chemistry The Women University Multan66000Pakistan

Bandgap tuning using rare earth metals as dopants in ferrite-based photocatalytic materials has received a lot of interest because the Fermi 4f energy of these metals generates a sub-energy state in the bandgap generated by the overlapping of Fe-3d and O-2p ***,dysprosium-doped cobalt-nickel mixed ferrite(d-CNFO)and its graphene-reinforced composite(d-CNFO@G)were prepared and an ideal photocatalyst material for azo dye mineralization was proposed.A cost-effective combination of wetchemical and ultrasonication methods was used to prepare the doped and composite *** characterization methodologies were used to scrutinize the optical,compositional,structural,morphological,and photocatalytic characteristics of as-prepared *** X-ray diffraction analysis identified the spinel phase's(cubic)structure,while the electronic spectroscopy examination confirmed the prepared samples'rod-like *** UV/visible absorbance spectrum shows the higher light harvesting behavior of the d-CNFO@G in the visible *** mineralization performance of the dCNFO and d-CNFO@G composites was analyzed using Congo-red(an anionic dye),a well-known azo *** d-CNFO@G sample removes Congo-red dye at a rate almost 2.4%faster than the d-CNFO *** experiment involving trapping free radicals indicates that hydroxyl radical play s a crucial role in dye *** the d-CNFO@G catalyst is magnetic and can be isolated easily from the photocatalytic system,it shows an awkward cycle activity of more than 96%after five mineralization *** asprepared d-CNFO@G composite is proved as an excellent option for azo dye mineralization because of the combined impacts of rare earth doping,graphene reinforcement and nanotechnology.

关键词： azo-dye Composite Graphene dy-doped Nanotechnology Rare earths

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inhibitive efficacy of Nymphoides indica rhizome extract onα-glucosidase, and cross-link formation of advanced glycation end products

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Journal of Traditional Chinese Medicine 2021年第3期41卷 376-380页

作者： Muhammad Hanif Muzammil Ahmad khan Muhammad Ramzan Abdul Rafey Ali Zaman imran Aziz Ama'null'ah Adnan Amin gomal Centre of Biochemistry and Biotechnology(GCBB) Gomal University D.I.Khan29050Pakistan NPRL Department of PharmacognosyFaculty of PharmacyGomal University D.I.Khan29050Pakistan FVAS Gomal University D.I.Khan29050Pakistan

OBJECTiVE: To investigate the inhibitive efficacy of Nymphoides indica(L.) Kuntze rhizome extract onα-glucosidase and on cross-link formation of advanced glycation end products(AGEs).METHOdS: The plant extracts were prepared by cold maceration and fractionated in solvents of diverse polarity. The in vitro α-glucosidase inhibition assay, fluorescence spectrometry and SdS-PAGE analysis was performed for antiglycation ***: during α-glucosidase inhibition assay significant inhibition by chloroform(0.43 mg/mL)and methanol fractions(0.66 mg/mL) was *** the AGEs inhibition assay, both oxidative(BSA-MGO) and non-oxidative(BSA-glucose)modes were employed. The inhibition of AGEs by total extract was considered moderate(iC_(50)0.10 mg/mL) as a result of non-oxidative mode, whereas in case of oxidative mode(BASA-MGO) no activity was recorded. Among fractions the methanolic fraction presented significant results both in oxidative(iC_(50)0.01 mg/mL) and non-oxidative modes(iC_(50) 0.3 mg/mL). Likewise the ethyl acetate fraction was more active in non-oxidative mode(iC_(50)0.04 mg/mL) compared to oxidative mode(iC_(50)0.32 mg/mL).during assay for inhibition of cross-link formation,the chloroform fraction significantly inhibited cross-link formation in a dose dependent ***: it was finally concluded that N. indica rhizome extract possesses significant properties that inhibit α-glucosidase, and AGEs cross-link formation.

关键词： Nymphoides indica alpha-glucosidases glycation end products advanced protein cross links antiglycation

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Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley Osman Paul Ashwood department of Medical Microbiology and immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

during pregnancy,maternal immune activation(MiA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASd)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASd by the age of 8 years,with ASd rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASd is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MiA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

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Chiral symmetry restoration and deconfinement in the contact interaction model of quarks with parallel electric and magnetic fields

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Chinese Physics C 2021年第7期45卷 111-121页

作者： Aftab Ahmad institute of Physics Gomal University29220D.I.KhanKhyber PakhtunkhawPakistan

We study the impact of steady,homogeneous,and external parallel electric and magnetic field strengths(eE||eB)on the chiral symmetry breaking-restoration and confinement-deconfinement phase *** also sketch the phase diagram of quantum chromodynamics(QCd)at a finite temperature T and in the presence of background *** unified formalism for this study is based on the Schwinger-dyson equations,symmetry preserving vector-vector contact interaction model of quarks,and an optimal time regularization *** T=0,in the purely magnetic case(i.e.,eE→0),we observe the well-known magnetic catalysis ***,in a pure electric field background(eB→0),the electric field tends to restore the chiral symmetry and deconfinement above the pseudo-critical electric field eE^(x,C)_(c).in the presence of both eE and eB,we determine the magnetic catalysis effect in the particular region where eB dominates over eE,whereas we observe the chiral inhibition(or electric chiral rotation)effect when eE overshadows *** finite T,in the pure electric field case,the phenomenon of inverse electric catalysis appears to exist in the proposed ***,for a pure magnetic field background,we observe the magnetic catalysis effect in the mean-field approximation and inverse magnetic catalysis with eB-dependent *** combined effects of eE and eB on the pseudo-critical T^(x,C)_(c)yields an inverse electromagnetic catalysis,with and without an eB-dependent effective coupling of the *** findings of this study agree well with the already predicted results obtained via lattice simulations and other reliable effective models of QCd.

关键词： chiral symmetry breaking confinement electric and magnetic fields schwinger-dyson equations QCd phase diagram

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Recess-free enhancement-mode AlGaN/GaN RF HEMTs on Si substrate

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Journal of Semiconductors 2024年第6期45卷 81-86页

作者： Tiantian Luan Sen Huang Guanjun Jing Jie Fan Haibo Yin Xinguo Gao Sheng Zhang Ke Wei Yankui Li Qimeng Jiang Xinhua Wang Bin Hou Ling Yang Xiaohua Ma Xinyu Liu High-Frequency High-Voltage device and integrated Circuits R&d Center Institute of Microelectronics of Chinese Academy of SciencesBe i-jing 100029China School of integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Faculty of integrated Circuits Xidian UniversityXi’an 710071China

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(<6 nm)/GaN heterostructure featuring a naturally depleted 2-d electron g... 详细信息

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(ing a naturally depleted 2-d electron gas(2dEG)*** fabricated E-mode HEMTs exhibit a relatively high threshold voltage(VTH)of+1.1 V with good uniformity.A maxi-mum current/power gain cut-off frequency(fT/fMAX)of 31.3/99.6 GHz with a power added efficiency(PAE)of 52.47%and an out-put power density(Pout)of 1.0 W/mm at 3.5 GHz were achieved on the fabricated E-mode HEMTs with 1-μm gate and Au-free ohmic contact.

关键词： AlGaN/GaN heterostructure ultrathin-barrier enhancement-mode radio-frequency power added efficiency silicon substrate

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