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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1381-1389页

作者： Ping-Ting Zhao Ling-Jun Zhang Hui Shao Ling-Ling Bai Bo Yu Chang Su Li-Jie Dong Xun Liu Xiao-Rong Li Xiao-Min Zhang eye institute & School of Optometry and Ophthalmology Tianjin Medical University Eye Hospital Department of Ophthalmology and Visual Sciences Kentucky Lions Eye CenterUniversity of Louisville

AIM：To test the therapeutic effects of delayed treatment of mesenchymal stem cells（MSCs） in recurrent experimental autoimmune uveitis（r EAU）.METHODS： The efficacy of different regimens of MSC administration in r EAU were tested by evaluation of clinical and pathological intraocular inflammation,as well as retinal structural and functional integrity using optical coherence tomography（OCT） and electroretinogram（ERG）.The retinal sections were also immunostained with antibodies to glial fibrillary acidic protein（GFAP）and rhodopsin（RHO）. RESULTS： Delayed treatment of MSCs effectively alleviated the severity of intraocular inflammation with relative intact of outer retinal structure and ***,double therapies with longer interval led to an even better clinical evaluation,as well as a trend of decrease in relapse and amelioration of retinal *** therapies also effectively reduced GFAP expression and increased RHO expression in the ***： MSC administration can effectively treat developed diseases of rEAU,and multiple therapies can provide additional therapeutic benefits.

关键词： mesenchymal stem cells recurrent experimental autoimmune uveitis electroretinogram optical coherence tomography

The unfolded protein response signaling and retinal Müller cell metabolism

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Neural Regeneration Research 2018年第11期13卷 1861-1870页

作者： Kristen Kelly Joshua J.Wang Sarah X.Zhang Department of Ophthalmology and Neuroscience Program Ross Eye InstituteUniversity at BuffaloState University of New York SUNY eye institute State University of New YorkBuffaloNYUSA

The retina is one of the most energy demanding tissues in the body. Like most neurons in the central nervous system, retinal neurons consume high amounts of adenosine-5′-triphosphate（ATP） to generate visual signal and transmit the information to the brain. Disruptions in retinal metabolism can cause neuronal dysfunction and degeneration resulting in severe visual impairment and even blindness. The homeostasis of retinal metabolism is tightly controlled by multiple signaling pathways, such as the unfolded protein response（UPR）, and the close interactions between retinal neurons and other retinal cell types including vascular cells and Müller glia. The UPR is a highly conserved adaptive cellular response and can be triggered by many physiological stressors and pathophysiological conditions. Activation of the UPR leads to changes in glycolytic rate, ATP production, de novo serine synthesis, and the hexosamine biosynthetic pathway, which are considered critical components of Müller glia metabolism and provide metabolic support to surrounding neurons. When these pathways are disrupted, neurodegeneration occurs rapidly. In this review, we summarize recent advance in studies of the UPR in Müller glia and highlight the potential role of the UPR in retinal degeneration through regulation of Müller glia metabolism.

关键词： unfolded protein response retina Müller glia metabolism neurodegeneration X-box binding protein 1 glycolysis glucose transporter

In situ cornea harvesting through the Red Cross Organization:a new approach to relieving severe cornea donor shortage in Chinese eye banks

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1611-1613页

作者： Su-Xia Li Fu-Hua Wang Ting Wang Sha-Sha Han Wei-Yun Shi Shandong eye Hospital Shandong Eye InstituteShandong Academy of Medical Sciences The People Hospital of Dongying

Corneal diseases are currently the second main cause of blindness in *** most of the corneal blindness could be treated by corneal transplantation,only about 10 000 operations were carried out each year owing to the severe shortage of corneal donors and limited eye bank programs.A feasible cornea donation program was established through the organization of the Red Cross,and in situ corneal removal techniques were developed to avoid conflicts with Chinese traditions of keeping the deceased *** number of donated corneas,which had a safe and secure quality,increased significantly year by year.

关键词： cornea donor transplantation eye bank

Uncovering the profile of mutations of transforming growth factor beta-induced gene in Chinese corneal dystrophy patients

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 198-203页

作者： Xiao-Dan Hao Yang-Yang Zhang Peng Chen Su-Xia Li Ye Wang State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Shandong Eye InstituteShandong Academy of Medical Sciences Shandong eye Hospital Shandong Eye Institute Shandong Academy of Medical Sciences

AIM： To uncover the mutations profile of transforming growth factor beta-induced （TGFBI） gene in Chinese corneal dystrophy patients and further investigate the characteristics of genotype-phenotype correlations. METHODS： Forty-two subjects （6 unrelated families including 15 patients and 8 unaffected members, and 19 sporadic patients） of Chinese origin were subjected to phenotypic and genotypic characterization. The corneal phenotypes of patients were documented by slit lamp photography. Mutation screening of the coding regions of TGFBI was performed by direct sequencing. RESULTS： We detected four corneal dystrophy types. The most frequent phenotypes were granular corneal dystrophy （GCD）（including 3 families and 8 sporadic patients） and lattice corneal dystrophy （LCD）（including 2 families and 9 sporadic patients）. The next phenotypes were corneal dystrophy of Bowman layer （CDB）（1 family and 1 sporadic patient） and epithelial basement membrane dystrophy （EBMD）（1 sporadic patient）. Six distinct mutations responsible for TGFBI corneal dystrophies were identified in 30 individuals with corneal dystrophies. Those were, p.R124H mutation in 1 family and 2 sporadic patients with GCD, p.R555W mutation in 2 families and 3 sporadic patients with GCD, p.R124C mutation in 2 families and 7 sporadic patients with LCD, p.A620D mutation in 1 sporadic patient with LCD, p.H626R mutation in 1 sporadic patient with LCD, and p.R555Q in 1 family and 1 sporadic patient with CDB. No mutation was detected in the remaining 3 atypical GCD patients and 1 EBMD patient, CONCLUSION： GCD and LCD are the most frequent phenotypes in Chinese population. R555W was the most common mutation for GCD; R124C was the most common mutation for LCD, Our findings extend the mutational spectrum of TFGBI , and this is the extensively delineated TGFBI mutation profile associated with the various corneal dystrophies in the Chinese population.

关键词： transforming growth factor beta-induce corneal dystrophy mutations Chinese

Adaptation of Ocular Opponency Neurons Mediates Attention-Induced Ocular Dominance Plasticity

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Neuroscience Bulletin 2024年第3期40卷 339-349页

作者： Fangxing Song Lili Lyu Min Bao CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing100101China Department of Psychology University of Chinese Academy of SciencesBeijing100049China institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China

Previous research has shown that ocular dominance can be biased by prolonged attention to one *** ocular-opponency-neuron model of binocular rivalry has been proposed as a candidate account for this *** direct neural evidence is still *** manipulating the contrast of dichoptic testing gratings,here we measured the steady-state visually evoked potentials(SSVEPs)at the intermodulation frequencies to selectively track the activities of ocular-opponency-neurons before and after the“dichoptic-backward-movie”*** hour of adaptation caused a shift of perceptual and neural ocular dominance towards the unattended *** importantly,we found a decrease in the intermodulation SSVEP response after adaptation,which was significantly greater when high-contrast gratings were presented to the attended eye than when they were presented to the unattended *** results strongly support the view that the adaptation of ocular-opponency-neurons contributes to the ocular dominance plasticity induced by prolonged eye-based attention.

关键词： Attention Ocular dominance Opponency neuron Adaptation Steady-state visually evoked potential

Ciliary body detachment after secondary intraocular lens implantation in childhood

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 895-896页

作者： Li-Na Meng Xiao-Guang Dong Qingdao eye Hospital Shandong Eye InstituteShandong Academy of Medical Sciences

Dear Sir,Iam ***-Na Meng,from the Qingdao eye Hospital,Shandong eye institute,Shandong Academy of Medical Sciences,Qingdao,China.I want to present a rare case of secondary intraocular lens(IOL)implantation in an11-year-old boy who developed the complication of ciliary body *** he was 2 years old,the boy underwent bilateral cataract extraction for congenital cataract in the other

关键词： body IOL Ciliary body detachment after secondary intraocular lens implantation in childhood

Changes of tear film lipid layer thickness by 3% diquafosol ophthalmic solutions in patients with dry eye syndrome

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1555-1560页

作者： Dong-Hyun Kang Yong-Woo Lee Kyu-Yeon Hwang Kyung-Min Koh Young-A Kwon Byung-Yeop Kim Sang-Wroul Song Kook-Young Kim Myung-Gok eye Research institute Department of Ophthalmology Kim’s Eye Hospital Konyang University College of Medicine

AIM: To evaluate the quantitatively changes in lipid layer thickness(LLT) when 3% diquafosol eye drop is used for dry eye patients using the tear film interferometer. METHODS: A total 124 participants(32 males, 92 females;mean age, 28.9 y) diagnosed with dry eye disease(DED) received topical instillation of 4 ophthalmic solutions in one eye: diquafosol, normal saline, 0.1% sodium hyaluronate and 0.3% gatifloxacin, in a masked manner. LLT was measured using an interferometer at baseline and 20 min after the instillation of each ophthalmic ***: Changes of LLT after instillation(nm, mean± standard error) were as follows: 12.6±2.0 for diquafosol(Peye drop might be effective treatment option of evaporative DED with meibomian gland dysfunction.

关键词： diquafosol ophthalmic solutions dry eye syndrome tear film lipid layer thickness

Factors affecting visual outcome of myopic choroidal neovascularization treated with verteporfin photodynamic therapy

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 327-330页

作者： Colin S. Tan Milton C. Chew Kai-Hung Lim Tock-Han Lim National Healthcare Group eye institute Tan Tock Seng Hospital Fundus Image Reading Center National Healthcare Group Eye Institute

AIM: To evaluate the visual outcomes of choroidal neovascularization (CNV) secondary to pathological myopia and the impact of novel risk factors affecting the final visual outcome. ·METHODS: Interventional case series of 18 consecutive patients with pathological myopia treated with photodynamic therapy (PDT). Inclusion criteria were spherical equivalent -6D or worse or features of pathological myopia on retinal examination. The main outcome measure was final best -corrected visual acuity (BCVA). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR BCVA) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients with LogMAR BCVA ≤0.3 (Snellen equivalent 20/40) at one year were younger than those with BCVA >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes with greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients who were treated within 2 weeks of visual symptoms, 88.9% avoided the loss of 3 or more lines compared to 55.6% for those who presented later. The mean improvement in LogMAR BCVA of those with GLD ≤1 000μm was +0.12 compared to a loss of 0.55 LogMAR units for those with GLD >1 000μm (P =0.02). Visual outcomes were not associated with gender or refractive error.·CONCLUSION: Good visual outcome in myopic CNV is associated with younger age, smaller lesion size and earlier initiation of treatment. These factors are relevant for ophthalmologists considering treatment options for myopic CNV.

关键词： myopic choroidal neovascularization pathologic myopia photodynamic therapy

Task sharing: situation analysis about capacity and resources for management of diabetic retinopathy in Pakistan

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 809-814页

作者： Mufarriq Shah Ayesha Noor C Alex Harper Jill Elizabeth Keeffe Pakistan institute of Community Ophthalmology Hayatabad Medical Complex Vision and Dental Care Clinic Centre for eye Research Australia Department of OphthalmologyUniversity of Melbourneand Royal Victorian Eye and Ear Hospital LV Prasad eye institute

AIM: To assess the capacity and resources of eye care facilities, using the WHO Health Systems Framework, to manage diabetic retinopathy(DR) through task ***: Using purposive sampling, four participants(administrators) from four selected hospitals in two provinces in Pakistan were recruited for this cross-sectional study. A survey, to assess the capacity and resources of the selected eye care facilities for the feasibility to adopt task sharing in management of DR to prevent vision loss, was emailed to participants who were asked to complete. Responses to open-ended questions were entered into a Microsoft Excel spread sheet and inductive approach was applied for ***: All the surveyed eye care facilities offer eye care services for people with diabetes and DR. All surveyed eye care facilities have a shortage in the number of human resources across all cadres. Optometrists and mid-level eye care workers did not have active roles in DR screening and management in all four hospitals. All the hospitals surveyed did not have a computerized record management system for patients who visit ophthalmologists for eye examinations. Equipment for detection and management of DR were short in number and main users were ophthalmologists. There was no policy for population-based screening program for detection of DR in any of the surveyed ***: A system-based approach to manage DR is needed. The capacity of eye care facilities and the potential to improve access of people with diabetes to eyecare services can be enhanced through implementation of task sharing.

关键词： task sharing capacity diabetes diabetic retinopathy Pakistan

Adaptable retinal ganglion cell function: assessing autoregulation of inner retina pathways

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Neural Regeneration Research 2020年第12期15卷 2237-2238页

作者： Tsung-Han Chou Vittorio Porciatti Bascom Palmer eye institute University of Miami Miller School of Medicine

Retinal ganglion cell(RGC)function in health and disease:RGCs are extremely high-maintenance neurons connecting the eye to the brain trough the optic *** order to produce and propagate action potentials along the unmyelinated RGC axons and support axonal transport of materials back and forth from the eye to the brain,RGC require large amounts of ***,RGCs are under considerable metabolic stress when healthy and become particularly vulnerable in disease,resulting in blindness(Morgan,2004).

关键词： assessing function connecting