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Toxicity of a seafood toxin， domoic acid， in the retina via modulation of the NRF2 and NF-κB pathways

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Food Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Sebasti?o Tumitangua James Reilly Patricia E.Martin Xinhua Shu Department of Biological and Biomedical Sciences， glasgow caledonian University Department of Marine Biology， Faculty of Natural Science， University of Namibe Puai Medical School， Shaoyang University Department of Vision Science， glasgow caledonian University

Domoic acid (DA)， a biotoxin， is produced by several species of marine dinoflagellate and diatom during harmful algal bloom events. DA is a neurotoxin， in humans and non-human primates， oral exposure to DA results in gastrointestinal effects， while DA at higher doses leads to neurological symptoms， seizures and memory deficiency. Exposure of humans to DA occurs mainly through consumption of contaminated seafoods containing an accumulation of the toxin. Previously， it was unclear if DA can have toxic effects on the retina. We assessed the toxicity of DA in human retinal cells (ARPE-19) and in zebrafish embryos. DA significantly lowered ARPE-19 cell viability dose-dependently， and decreased anti-oxidative capacity， increased inflammation， and promoted cell death， possibly through modulating the NRF2 and NF-κB signalling pathways. Zebrafish embryos exposed to DA for four days from one day post fertilization (dpf) had an increase in mortality and a decrease in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment also significantly downregulated expression of antioxidant genes and upregulated expression of inflammation mediators， as well as causing photoreceptor death in zebrafish embryos. The results demonstrate that consuming seafood containing DA will have potential toxic effects in human retinas.

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Nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

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International Journal of Oral Science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston Miguel Carda-Diéguez Annabel Simpson Elena Cabello-Yeves Krystyna Piela Robert Reilly Alejandro Artacho Chris Easton Mia Burleigh Shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical Sciences Glasgow Caledonian UniversityGlasgowUK Oral Sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Sport and Physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(P < 0.05 in all five datasets with n = 20–82 samples per dataset). Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/L nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. Salivary NRC was found to be diminished in periodontal patients before treatment(P < 0.05) but recovered to healthy levels 90 days post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(P < 0.01). No significant effect of periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

自我肯定干预促进低收入家庭学生的挑战性任务偏好:内隐自尊的中介作用

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心理技术与应用 2024年第6期12卷 364-373页

作者：张红川刘益潼王路宽孙铃于泳红中央财经大学社会与心理学院北京100098 School of Education University of GlasgowGlasgow G128QQ

一个人从事挑战性任务意愿的高低,往往影响其个人能力的提升和未来的发展,而这可能与个体的内隐自尊有关。本研究旨在探索家庭收入的高低是否通过影响个体内隐自尊从而削弱其挑战性任务的偏好,同时探究自我肯定干预对个体内隐自尊和挑... 详细信息

一个人从事挑战性任务意愿的高低,往往影响其个人能力的提升和未来的发展,而这可能与个体的内隐自尊有关。本研究旨在探索家庭收入的高低是否通过影响个体内隐自尊从而削弱其挑战性任务的偏好,同时探究自我肯定干预对个体内隐自尊和挑战性任务偏好的影响。以甘肃省某县一所职业中等专科学校建档立卡的低收入家庭学生为被试,通过两项研究发现:(1)低收入家庭会降低学生的内隐自尊,进而削弱他们对挑战性任务的偏好;(2)短时的自我肯定干预能显著提升低收入家庭学生的内隐自尊,并促进其挑战性任务偏好。

关键词：低收入家庭挑战性任务偏好自我肯定干预内隐自尊

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一种电力电缆的随机电热退化模型（英文）

高电压技术 2015年第4期41卷 1178-1187页

作者： Swati Sachan Rui Wen Yong Xiang Leiming Yao Chengke Zhou School of Engineering & Built Environment Glasgow Caledonian University Suzhou Power Supply Company State Grid Corporation of China

In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in *** cable life and the reliability are predicted by estimating the accumulated electro-thermal degradation during seasonal load *** degradation is considered,in a novel approach,as stochastic in nature due to variations in the manufacturing process of insulation raw material and in operational and environmental *** methodology is based on estimation of life by using combined electro-thermal life model,simulation of degradation accumulation process under electro-thermal stress in each season of the year based on Miner’s cumulative damage theory and reliability prediction from a probabilistic point of view.A case study is demonstrated on 10 k V XLPE cables which are directly buried in the UK and *** show that,the electro-thermal life of the cable is 56 and 69 years in China and the UK,respectively at 50%failure probability,or the life of the cable in the UK would be 13 years longer than in China,when other stresses such as mechanical and environmental are also considered and assumed to be the same.

关键词：电力电缆退化模型随机可靠性预测电热使用寿命积累过程季节性负荷

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面向电力市场的配电管理信息系统设计

电力系统自动化 2000年第21期24卷 56-58页

作者：张华美 C.Zhou 烟台东方电子信息产业股份有限公司烟台264001 glasgow caledonian大学

介绍了一种面向电力市场的、集成的配电管理信息系统 ,分析了该配电管理信息系统所需要的商业信息 ,包括提供给监督机构所必须的信息 ,以及使配电系统高效管理、运行所需要的信息 ,同时 ,描述了该系统的业务模型。

关键词：配电系统管理信息系统电力市场系统设计

使用体积生长重构理论量化肺动脉高压下小鼠心脏的生长重构

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医用生物力学 2024年第S1期 56-56页

作者：关德宝 Hao Gao 山东大学控制科学与工程学院 School of Mathematics and Statistics University of Glasgow

目的肺动脉高压(PAH)为一种进展迅速且致命性高的疾病,其中右心室衰竭是导致PAH患者死亡的主要原因。本研究旨在通过开发一套基于实验数据的心脏生长与重塑(G&R)模型,为理解PAH条件下右心室(RV)衰竭提供生物力学判据。方法通过个体化...

目的肺动脉高压(PAH)为一种进展迅速且致命性高的疾病,其中右心室衰竭是导致PAH患者死亡的主要原因。本研究旨在通过开发一套基于实验数据的心脏生长与重塑(G&R)模型,为理解PAH条件下右心室(RV)衰竭提供生物力学判据。方法通过个体化多尺度生物力学数值模拟,对大鼠心脏在PAH环境下的不良生长与重塑过程进行了深入分析。首先,基于超声成像数据,重建了包含左心室(LV)和RV解剖结构的大鼠心脏模型。随后,通过改进的大变形微分同胚度量映射(LDDMM)框架对RV和LV在不同阶段的结构变化进行了定量评估。最终,通过体积生长模型对LDDMM预测的G&R张量进行了验证,并对其与生物力学因素间的相关性进行了分析。结果本研究成功量化了PAH条件下患病心脏相对于对照心脏的生长张量。结果显示G&R主要发生在心肌纤维方向、透壁方向及第三正交方向,且剪切组分相对很小。生长量与相应的心肌应变高度相关。利用运动学心脏生长模型,估计的生长张量能够解释患病心脏观测到的84.3%几何变化。结论本研究开发的方法不仅能够利用稀疏的体内图像精准量化心脏的G&R,而且从生物力学角度为揭示触发右心室衰竭的潜在机制提供了重要见解,为心脏疾病的精准诊断和治疗策略的优化贡献了新的科学依据。

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CFD investigation of dense phase pneumatic conveying at a pipeline enlargement

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Particuology 2012年第2期10卷 176-183页

作者： Don McGlinchey Andrew Cowell Ryan Crowe School of Engineering and Computing Glasgow Caledonian University Glasgow Scotland UK

The practice of stepping a conveying line is not new and there are many examples in industry; however, the details of the flow behaviour at the step have not been extensively studied. Three step geometries were modelled： an ＇abrupt＇ step and two ＇gradual＇ step-up geometries from a pipe bore of 75-100 ram. The flow behaviour of a single plug of material passing through these geometries was investigated using the ＇Eulerian＇ CFD model from Fluent. Solids volume fractions were recorded at 0.01 s time steps at several point locations, and visualised throughout the pipe.

关键词： Pneumatic conveyingStepped pipelinePlug flowCFD

不同装载条件下小型渔船参数横摇的非定常RANS CFD仿真

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 327-351页

作者： Muhammad Iqbal Momchil Terziev Tahsin Tezdogan Atilla Incecik Department of Naval Architecture Oceanand Marine EngineeringUniversity of StrathclydeGlasgow-G40LZUK Department of Naval Architecture Diponegoro UniversitySemarang-50275Indonesia Department of Civil Maritime and Environmental EngineeringUniversity of SouthamptonSouthampton-SO167QFUK

Fishing boats have unique features that make them prone to changing loading *** the boat leaves the port,the empty fish tank gradually fills up during fishing operations which may result in parametric roll(PR).This dangerous phenomenon that can lead to *** present study aims to understand better the behaviour of parametric roll in fishing boats and its relation to changing loading *** study considers the effects of displacement and the GM/KM ratio on parametric roll,as well as the longitudinal flare distribution at the *** assessments to detect the parametric roll occurrence in early stage were carried out by using the level 1 assessment of parametric roll based on the Second Generation of Intact Stability criteria(SGIS)from International maritime Organisation(IMO)and the Susceptibility criteria of Parametric roll from the American Bureau of Shipping(ABS).Then,the CFD method is used to predict the amplitude of the parametric roll *** results provide important insights to fishing vessel operators on how to manage loading conditions to maintain stability and avoid hazardous *** following the guidelines outlined in this study,fishing boats can operate more safely and efficiently,reducing the risk of accidents and improving the overall sustainability of the fishing industry.

关键词： Small fishing boat Parametric roll URANS-CFD KRISO Container Ship(KCS) Stability in waves

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从国际税收竞争走向国际税收合作

涉外税务 2003年第3期 27-30页

作者：余峻梅魏佳 glasgow caledonian University 中国人民大学商学院北京100872

经济全球化向深层发展,给我们带来了全新的经济环境。日益增长的电子商务和新通信技术将处于世界贸易的支配地位;跨国企业将不再把自己看成是某国的跨国企业,全球管理的理念将日益盛行;不只是资本更具流动性,高技术专业人员也将具有很... 详细信息

经济全球化向深层发展,给我们带来了全新的经济环境。日益增长的电子商务和新通信技术将处于世界贸易的支配地位;跨国企业将不再把自己看成是某国的跨国企业,全球管理的理念将日益盛行;不只是资本更具流动性,高技术专业人员也将具有很大的流动性;地区经济集团的地位将越发重要。在这种新的环境下,政治压力将会促使各国在税收政策方面有更大程度的协调,各国税务当局之间需要有新的合作形式。但纵观世界税收,当今处于主导地位的仍然是以本国利益为出发点的国际税收竞争,并且税收竞争有愈演愈烈的趋势。本文从国际税收竞争开始分析,逐步得出在经济全球化的推动下税收竞争必将走向税收协调的结论。

关键词：国际税收竞争国际税收合作环境分析经济全球化跨国公司税收政策电子商务