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Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer:A multicenter retrospective study

World Journal of Gastroenterology 2021年第11期27卷 1043-1054页

作者： Takuya Satomi Seiji Kawano Tomoki Inaba Masahiro Nakagawa Hirokazu Mouri Masao Yoshioka Shoichi Tanaka Tatsuya Toyokawa Sayo Kobayashi Takehiro Tanaka Hiromitsu Kanzaki Masaya Iwamuro Yoshiro Kawahara Hiroyuki OkadaDepartment of Gastroenterology and Hepatology Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558OkayamaJapan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557KagawaJapan Department of Endoscopy Hiroshima City Hiroshima Citizens HospitalHiroshima 730-8518HiroshimaJapan Department of Gastroenterology and Hepatology Kurashiki Central HospitalKurashiki 710-8602OkayamaJapan Department of Gastroenterology and Hepatology Okayama Saiseikai General HospitalOkayama 700-8511OkayamaJapan Department of Gastroenterology National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan Department of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 720-8521HiroshimaJapan Department of Internal Medicine Fukuyama City HospitalFukuyama 721-8511HiroshimaJapan Department of Pathology Okayama University HospitalOkayama 700-8558OkayamaJapan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558OkayamaJapan

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer(GTC)in the reconstructed gastric ***,there are few reports on the treatment results of endoscopic submucosal dissection(ESD)for *** To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter *** We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study *** clinical indications of ESD for early gastric cancer were similarly applied for GTC after *** specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment *** characteristics,treatment results,clinical course,and treatment outcomes were *** The median age of patients was 71.5 years(range,57-84years),and there were 34 men and 4 *** median observation period after ESD was 884 d(range,8-4040 d).The median procedure time was 81 min(range,29-334 min),the en bloc resection rate was 91.7%(44/48),and the curative resection rate was 79%(38/48).Complications during ESD were seen in 4%(2/48)of case,and those after ESD were seen in 10%(5/48)of *** survival rate at 5 years was 59.5%.During the observation period after ESD,10 patients died of other *** there were differences in the procedure time between institutions,a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure *** ESD for GTC after esophagectomy was shown to be safe and effective.

关键词： Endoscopic submucosal dissection Gastric tube Gastric cancer Esophagectomy Multicenter study Retrospective study

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Phenotypes and Chronic Organ Damage May Be Different among Siblings with Wilson's Disease

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Journal of Clinical and Translational Hepatology 2017年第1期5卷 27-30页

作者： Shinsuke Yahata Seitetsu Yung Mari Mandai Takakazu Nagahara Daisaku Kuzume Hiroshi Sakaeda Shinya Wakusawa Ayako Kato Yasuaki Tatsumi Koichi Kato Hisao Hayashi Ryohei Isaji Yoji Sasaki Motoyoshi Yano Kazuhiko Hayashi Masatoshi Ishigami Hidemi Goto Division of Community Medicine and Career Development Kobe University Graduate School of Medicine2-1-5Arata-choHyogo-kuKobe 652-0032Japan Department of Gastroenterology Hyogo Prefectural Kakogawa Medical CenterKakogawaHyogoJapan Department of Gastroenterology and Hepatology Tottori Prefectural Kousei HospitalKurayoshiTottoriJapan Departments of Neurology and Gastroenterology Chikamori HospitalKochiJapan Medical Laboratory sciences Nagoya University Graduate School of MedicineHigashi-kuNagoyaJapan Department of Medicine Aichi Gakuin University School of PharmacyChikusa-kuNagoyaJapan Department of Gastroenterology Konan Kosei HospitalTakaya-choKonanAichiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiMieJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineShowa-kuNagoyaJapan

Background and Aims:Cloning of ATP7B provided evidence that Wilson's disease is a hepatic copper toxicosis with a variety of extrahepatic *** siblings with the same genetic background and exposure to similar environmental factors may be a good model for the study of genotype-phenotype ***:Twenty-three affected siblings in 11 families were selected from a *** first phenotypes were determined according to the international *** final types of chronic organ damage were re-evaluated for life-long ***:Phenotypes were identical in 5 of the families and different in 6 of the *** acute hepatic phenotype H1 was found in 3 younger siblings and 1 older *** survived an acute episode of hemolysis with underlying chronic liver *** also presented complication with neurological *** neurological phenotype N1 with neuropsychiatric symptoms and hepatic disease was found in 2 aged siblings of 1 family,in an older sibling in 3 families and in the oldest sibling in 1 *** in siblings were mainly split by either H1 occurring in random order or age-dependent *** of chronic organ damage were identical in 8 of the families and different in 3 of the *** same combination of chronic liver disease was found in 6 families and chronic liver disease complicated with neurological disease in 2 *** organ damage in siblings was found when an older sibling was complicated by neurological *** was no reverse combination of a younger sibling being complicated by neurological disease in any of the ***:Phenotype combinations of siblings were mainly modified by externally-induced hemolytic episodes,while chronic organ damage in siblings was split by age-dependent neurological complications.

关键词： Hemolysis Liver disease Neurological disease Wilson's disease

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Development of Japanese Version of Smartphone Dependence Scale

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Open Journal of Preventive Medicine 2016年第7期6卷 179-185页

作者： Satoko Ezoe Tadayuki Iida Ken Inoue Masahiro Toda Health Service center Izumo Shimane University Shimane Japan Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Hiroshima Japan Department of Public Health Gunma University Graduate School of Medicine Gunma Japan 4Graduate School of Human Life sciences Notre Dame Seishin University Okayama Japan

We designed a Japanese version of the Smartphone Dependence Scale (J-SDS) for university students, and assessed its validity and reliability. For development of this scale, we initially selected 43 preliminary items based on previous studies of Internet and mobile phone dependence. Each response was scored using a Likert scale (0, 1, 2, 3), with higher scores indicating greater dependence. After administering the preliminary scale to 149 university students, the final 29 items were selected according to exploratory factor analysis. The final scale consisted of 5 factors: 1) craving and withdrawal, 2) overuse and tolerance, 3) virtual life orientation, 4) disturbance of concentration in class, and 5) physical symptoms. Reliability coefficient (Cronbach’s alpha) values for the 5 factors and total J-SDS were 0.87, 0.87, 0.76, 0.77, 0.69, and 0.92, respectively. We then summed the Likert scores for each item to provide a quantitative overall smartphone dependence score, with higher scores indicating greater dependence. The J-SDS score became significantly higher with longer hours of smartphone use (p < 0.001). Our results suggest that the J-SDS is a reliable and valid scale for screening university students who may be at risk of developing smartphone dependence.

关键词： Smartphone Dependence Japanese Version of Smartphone Dependence Scale Internet Addiction Reliability Validity Factor Analysis University Students

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Assessment of Quality of Life, Family Function and Family Empowerment for Families Who Provide Home Care for a Child with Severe Motor and Intellectual Disabilities in Japan

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Health 2016年第4期8卷 304-317页

作者： Rie Wakimizu Keiko Yamaguchi Hiroshi Fujioka Chieko Numaguchi Kaori Nishigaki Naho Sato Miyuki Kishino Hiroshi Ozawa Nobuhiro Iwasaki Department of Child Health Care Nursing Division of Health Innovation and Nursing Faculty of Medicine University of Tsukuba Tsukuba City Japan Department of Nursing Science Graduate school of Comprehensive Human Sciences University of Tsukuba Tsukuba City Japan Department of Nursing Faculty of Health Sciences Tsukuba International University Tsuchiura City Japan Department of Nursing Faculty of Health Sciences Ibaraki Prefectural University of Health Sciences Ami Town Japan Division of Nursing Faculty of Healthcare Tokyo Healthcare University Shinagawa-ku Japan Department of Child and Family Nursing Graduate School of Nursing Chiba University Chuo-ku Japan AI-Clinic Nakazawa Departments by Medical Foundation Tenoukai Hachioji City Japan Department of Child Neurology Shimada Ryoiku Center Hachioji Hachioji City Japan Department of Pediatrics Ibaraki Prefectural University of Health Sciences Ami Town Japan

Background: About 70% of Japanese children with severe motor and intellectual disabilities (SMID) live at home, and the number is increasing. Family members have an enormous burden of daily physical care for these children. A top priority is to understand quality of life (QoL), family function, and family empowerment to effectively support these families. We aimed to assess current living situations of families with a SMID child, and to reveal the relationships between QoL, family function, and family empowerment. Methods: Sixty-five family members from 34 families with a SMID child participated in this study. We assessed 5 parameters using the Japanese versions of the following instruments: World Health Organization Quality of Life 26 (WHOQOL26), Kinder Lebensqualitats Fragebogen (KINDL), Family Assessment Device (FAD), Family Adaptability and Cohesion Evaluation Scale KG-4 (FACESKG-4), and Family Empowerment Scale (FES). Correlation and multiple regression analyses were conducted;QoL score was the objective variable. Results: Participants included 54 parents (34 mothers, 20 fathers) and 11 siblings. The mean age of SMID children was 10.4 ± 5.03 years. Twenty-two children needed multiple types of medical care. The mean age of parents and siblings was 41.5 ± 6.16 years and 15.5 ± 2.35 years, respectively. The mean QoL score (3.28 ± 0.5) was similar to the Japanese average. The mean KINDL score (77.2 ± 12.1) was higher than those of previous studies. The mean FAD score was 1.97 ± 0.32. For FACEKG-4, the score of adaptability was correlated with WHOQOL score (r = 0.459, p < 0.05). The mean score of FES was 113.6 ± 14. As the result of multiple regression analysis, lower family FAD scores ([sb] = ?0.61, p < 0.01) indicated higher family function and greater age of participants (sb = 0.495, p < 0.01) was correlated with higher WHOQOL scores (F = 15.208, p < 0.01). Conclusions: Our results indicated that the individual QoL depended on the age of participants (equals the

关键词： Home Care Caregivers Family Japan Quality of Life Children with Disabilities Severe Motor and Intellectual Disabilities

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Emergency Response for a Laboratory Biosafety Incident

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Biomedical and Environmental sciences 2019年第3期32卷 231-233页

作者： ZHANG En Min WANG Jia Qi GAO Li Dong ZHAN Zhi Fei ZHANG Heng HU Yan Hong WEI Jian Chun LIANG Xu Dong WAN Kang Lin WEI Qiang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control Chinese center for Disease Control and Prevention Hunan Provincial center for Disease Control and Prevention Changsha center for Disease Control and Prevention Yuelu District center for Disease Control and Prevention

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.

关键词： Emergency Response Laboratory Biosafety Incident

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Line identification of extreme ultraviolet (EUV) spectra from low-Z impurity ions in EAST tokamak plasmas

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Plasma Science and Technology 2021年第7期23卷 15-30页

作者： Lei LI Ling ZHANG Zong XU Shigeru MORITA Yunxin CHENG Fengling ZHANG Wenmin ZHANG Yanmin DUAN Qing ZANG Shouxin WANG Shuyu DAI Guizhong ZUO Zhen SUN Liang WANG Xiaobin DING Jinping QIAN Haiqing LIU Liqun HU Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China Advanced Energy Research center Shenzhen UniversityShenzhen 518060People’s Republic of China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China National Institute for Fusion Science Toki 509-5292GifuJapan Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024People’s Republic of China Key Laboratory of Atomic and Molecular Physics and Functional Materials of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070People’s Republic of China

Extreme ultraviolet(EUV) spectra emitted from low-Z impurity ions in the wavelength range of10–500Å were observed in Experimental Advanced Superconducting Tokamak(EAST)discharges. Several spectral lines from K-and L-shell partially ionized ions were successfully observed with sufficient spectral intensities and resolutions for helium, lithium, boron, carbon,oxygen, neon, silicon and argon using two fast-time-response EUV spectrometers of which the spectral intensities are absolutely calibrated based on the intensity comparison method between visible and EUV bremsstrahlung continua. The wavelength is carefully calibrated using wellknown spectra. The lithium, boron and silicon are individually introduced for the wall coating of the EAST vacuum vessel to suppress mainly the hydrogen and oxygen influxes from the vacuum wall, while the carbon and oxygen intrinsically exist in the plasma. The helium is frequently used as the working gas as well as the deuterium. The neon and argon are also often used for the radiation cooling of edge plasma to reduce the heat flux onto the divertor plate. The measured spectra were analyzed mainly based on the database of National Institute of Standards and Technology. As a result, spectral lines of He Ⅱ, Li Ⅱ–Ⅲ, B Ⅳ–Ⅴ, C Ⅲ–Ⅵ, O Ⅲ–Ⅷ, Ne Ⅱ–Ⅹ,Si Ⅴ–Ⅻ, and Ar Ⅹ–XVI are identified in EAST plasmas of which the central electron temperature and chord-averaged electron density range in Te0=0.6–2.8 keV and ne=(0.5–6.0)×1019 m-3, respectively. The wavelengths and transitions of EUV lines identified here are summarized and listed in a table for each impurity species as the database for EUV spectroscopy using fusion plasmas.

关键词： line identification EUV spectroscopy EUV spectra impurity line emissions tokamak plasmas

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Utilization of fruit waste for H_(2)-rich syngas production via steam co-gasification with brown coal

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Carbon Resources Conversion 2023年第4期6卷 315-325页

作者： Aisikaer Anniwaer Nichaboon Chaihad Aghietyas Choirun Az Zahra Irwan Kurnia Yutaka Kasai Suwadee Kongparakul Chanatip Samart Katsuki Kusakabe Abuliti Abudula Guoqing Guan Graduate School of Science and Technology Hirosaki University1-BunkyochoHirosaki 036-8560Japan Energy Conversion Engineering Laboratory Institute of Regional InnovationHirosaki University3-BunkyochoHirosaki 036-8561Japan Industrial Research Institute Aomori Prefectural Industrial Technology Research Center4-11-6Daini-TonyamachiAomori 030-0113Japan Department of Chemistry Faculty of Science and TechnologyThammasat UniversityPathumtani 12120 Thailand Department of Nanoscience Sojo University4-22-1Nishi-kuKumamoto-shiKumamoto 860-0082Japan Department of Chemistry Faculty of Mathematics and Natural SciencesUniversitas PadjadjaranJl.Raya Bandung–Sumedang KM.21 JatinangorSumedang 45363Indonesia

In this work,to efficiently utilize waste fruit and low-rank coal for the hydrogen(H_(2))-rich syngas production,steam co-gasification of banana peel(BP)and brown coal(BC)was studied in a fixed-bed *** results showed that the gasification rate of BC was highly enhanced after mixing it with BP and the obvious synergistic effect was observed in all investigated three mixing weight ratios(i.e.,1:1,1:4,4:1),resulting in a higher carbon conversion as well as a H_(2)-rich gas production yield for the ***,the extent of promotion by synergistic effect was affected by the reaction temperature,mixing ratio,and steam *** was found that the high potassium(K)species content in the BP provided the catalytic effect not only on water-gas shift reaction but also on tar reforming/cracking,thereby enhancing the gasification of *** addition,it is confirmed that steam should be an important factor to promote the synergistic effect and H_(2)-rich gas production.

关键词： Steam co-gasification Waste banana peel Brown coal H2-rich syngas Synergistic effect

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The New Molecular Entity Evolocumab, One Kind of PCSK9 Inhibitor, Reduce Plasma Small Size LDL-Cholesterol Levels by Using a New Standardized Method of Measuring LDL Size

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Open Journal of Molecular and Integrative Physiology 2017年第1期7卷 1-23页

作者： Ikuo Inoue Ryo Kubota Shohan Yanagi Masumi Akita Takanari Nakano Shigehiro Katayama Akira Shimada Mistuhiko Noda Department of Endocrinology and Diabetology Saitama Medical University Saitama Japan Department of Health sciences Saitama Prefectural University Saitama Japan Research and Development Department Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute Tokyo Japan Division of Morphological Science Biomedical Research Center Saitama Medical University Saitama Japan Department of Biochemistry Saitama Medical University Saitama Japan

Aims: There has been no evidence on the effects of evolocumab, protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, on small size LDL. We observationally investigated the efficacy and side effects of evolocumab on the LDL subfraction particle diameter using PAGE system for lipoprotein analysis. Methods: We defined 30 patients with high-risk hyperlipidemia. As for analysis of LDL subfraction profile, we used polyacrylamide gel electrophoresis three methods: 1) 3% nondenatured poly-acrylamide gel electrophoresis method (3%PAGE), 2) 2% - 16% nondenatured poly-acrylamide gradient gel electro-phoresis method (2% - 16% GGE) and 3) 2.7% - 5% GGE. Evolocumab 140 mg/day administered together with statin significantly improved serum total cholesterol (TC), triglyceride (TG), high-dense lipoprotein-cholesterol (HDL-C), and LDL-C after four-week treatment. Results: TC, TG, HDL-C and LDL-C levels were improved by, respectively, 33%, 20%, 10%, and 54%. The mean LDL size significantly increased from 25.6 ± 0.4 nm to 26.4 ± 0.8 nm. The small dense LDL-cholesterol (sdLDL-C), large buoyant LDL-cholesterol (lbLDL-C), and mid-band lipoprotein-cholesterol were reduced, respectively. Therefore, the preliminary study on this paper can be the first step into a new insight on the world of lipid metabolism. Conclusion: Short-term administration of evolocumab addedons to statin therapy, significantly reduced small size LDL levels.

关键词： PCSK9 Inhibitor Evolocumab LDL Heterogeneicity Small Size LDL 3% PAGE 2% - 16% GGE

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Mitigating Root Knot Nematode Propagation on Transgenic Tobacco via <i>in Planta</i>Hairpin RNA Expression of <i>Meloidogyne incognita</i>—Specific PolA1 Sequence

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American Journal of Plant sciences 2019年第5期10卷 866-884页

作者： Peter Nkachukwu Chukwurah Samuel Aduse Poku Akira Yokoyama Ai Takeda Masahiro Shishido Ikuo Nakamura Laboratory of Plant Cell Technology Chiba University Matsudo Japan Department of Genetics and Biotechnology University of Calabar Calabar Nigeria Laboratory of Plant Pathology Chiba University Matsudo Japan Chiba prefectural Agriculture and Forestry Research center Daizennocho Chiba Japan

Root knot nematodes are top priority nematode pests that significantly constrain agricultural productivity globally especially in developing countries. However, expressing double stranded RNA (dsRNA) of essential nematode genes in susceptible plants is known to confer protection against these pests via RNA silencing. This molecular-based strategy is called host induced gene silencing (HIGS) and the selection of appropriate target nematode gene is critical to its success. In this study, therefore, we focused on root knot nematode PolA1, an essential single copy nuclear gene encoding the largest subunit of RNA polymerase I enzyme and evaluated its effectiveness as a target in conferring nematode resistance on Agrobacterium-mediated transformed tobacco plants. Transgenic tobacco expressing Meloidogyne incognita-specific (MiS) dsRNA of PolA1 gene showed significant reduction in nematode fecundity and multiplication compared to wild type plants in both T0 and T1 generations. T0 plants showed varying degrees of agronomic vigorover WT plants possibly due to varying levels of processed siRNA. However, production of MiS siRNAs in the transgenic plants coupled with significant reduction of PolA1 transcript expression in nematodes feeding on roots of transgenic plants provided evidence of HIGS. Taken together, our results show that PolA1 is a potentially effective target for HIGS-mediated reduction of root knot nematode damage on transgenic tobacco. Given the homology of our target sequence among Meloidogyne species, this protection could be broad range against other root knot nematodes aside M. incognita.

关键词： M. incognita Nematode Resistance N. tabacum RNA Silencing PolA1 Gene

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Analysis on Composition and Antioxidative Properties of Phlorotannins Isolated from Japanese Eisenia and Ecklonia Species

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American Journal of Plant sciences 2015年第15期6卷 2510-2521页

作者： Toshiyuki Shibata Kohki Nagayama Shingo Sugiura Saki Makino Mitsuyoshi Ueda Yutaka Tamaru Graduate School of Bioresources Mie University Mie Japan Japan Science and Technology Agency Core Research for Evolutional Science and Technology Tokyo Japan Kumamoto prefectural Fisheries Research center Kumamoto Japan Graduate School of Agriculture Kyoto University Kyoto Japan

The composition and antioxidative properties of crude phlorotannins isolated from Japanese Eisenia and Ecklonia species including cultured E. kurome were analyzed. As a result of liquid chromatography mass spectrometry analysis, it was suggested that the phlorotannins were composed of compounds containing 3 - 7 phloroglucinol units for Eisenia species and 3 - 8 phloroglucinol units for Ecklonia species. The antioxidant properties of phlorotannins were evaluated using the hydrophilic oxygen radical absorbance capacity (H-ORAC) assay, the measurements of superoxide anion radical scavenging activity (SOSA) with electron spin resonance method, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay. It was clarified that the phlorotannins contained H-ORAC values of 8.9 × 103 - 1.0 × 104 μmol-Trolox equivalents (TE)/g, SOSA of 1.5 × 104 - 2.9 × 104 superoxide dismutase units/g, DPPH radical scavenging activity of 4.7 × 103 - 5.5 × 103 μmol-TE/g, and reducing power of 6.5 × 102 - 7.0 × 102 mg-ascorbic acid equivalents/g, and had excellent antioxidative properties.

关键词： Eisenia Species Ecklonia Species Cultured E. kurome H-ORAC Phlorotannins Radical Scavenging Activities

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