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无症状性患者成功进行冠状动脉血管成形术后连续6年定量血管造影术随访研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 39-40页

作者： Takeda Y. Kobayashi T. Awata N. 张明娟 Department of Cardiology Osaka Med. Ctr. Cancer C. 1-3-3 Na kamichi Higashinariku Osaka City Osaka 537-8511 Japan Dr.

Objective: To evaluate long term(six years) lumen changes after balloon angiop lasty by using quantitative coronary angiography. Methods: Complete serial quant itative coronary angiography(before and after angioplasty and at six months, thr ee years, and six years) was performed in 100 patients with successful angioplas ty and without subsequent repeated revascularisation. In all, 198 dilated segmen ts were compared with 395 non dilated segments thatwere obtained from non targ et arteries of study patients. Results: From six months to three years after ang ioplasty, minimum lumen diameter (MLD) increased significantly by 0.13(0.28)(mea n(SD))mm in dilated segments and decreased significantly by 0.04 (0.27) mm in no n dilated segments. From three years to six years, MLD remained stable in dilat ed segments but decreased further (by 0.04 (0.28)mm) in non dilated segments. C onsequently, the MLD between six months and six years was larger in dilated segm ents than in non dilated segments (0.12 (0.32) v -0.08(0.34); p < 0.001). Furt her, MLD from six months to six years correlated positively with the percentage diameter stenosis (DS) at six months in each group (dilated segments r=0.47, p< 0.0001; nondilated segments r=0.49, p< 0.0001). Multivariate analysis showed tha t the only independent predictor of MLD over six years for each group was the DS at six months. Conclusions: Lesion regression occurs within the first three yea rs after angioplasty and reaches a plateau thereafter. Moreover, the stenosis se verity at six months predicts the magnitude of late regression after angioplasty .

关键词：管成形术血管造影术冠状动脉血无症状性随访研究管腔直径狭窄程度损伤性扩张段血管重建术

外阴阴道糜烂型扁平苔癣局部使用氯倍他索及他克莫司治疗后患者满意度的调查研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 19-20页

作者： Jensen J.T. Bird M. LeClair C.M. 张剑萍 Dept.of Obstetrics and Gyne cology Oregon Health and Science University Portland Ore Dept. Obstet. G. L as VegasNV United States Dr.

Objective The purpose of this study was to compare patient satisfacti on with t he topical immune system modulator tacrolimus to topical clobetasol during treat ment for vulvovaginal erosive lichen planus. Study design Subjects who had been diagnosed with vulvovaginal erosive lichen planus between June 2000 a nd May 2001 received a mail survey regarding clinical satisfaction and response to treatment with clobetasol and tacrolimus. Satisfaction was assessed with a 10 0-mm visual analogue scale (very unsatisfied, 0; very satisfied, 100). Satisfac tion was compared with the use of a paired t-test. Results Nineteen subjects me t the inclusion criteria; 17 subjects (89%) returned completed surveys. Sixteen of the 17 women reported clobetasol therapy, and 11 of the 17 subjects acknowle dged the use of tacrolimus therapy. All but 1 of the women who received tacrolim us had been treated previously with clobetasol therapy. All subjects reported ex periencing sexual pain before their initial examination. After treatment with cl obetasol, 2 of 16 women reported pain-free intercourse. Two additional women re ported pain-free intercourse after switching to tacrolimus therapy. Ten subject s who had used both treatments rated tacrolimus therapy as significantly more sa tisfactory than clobetasol therapy (63 vs 38 mm; P=.03). Conclusion The use of t opical tacrolimus improves satisfaction and may result in better clinical outcom es than therapy with clobetasol for the treatment of vulvovaginal erosive lichen planus.

关键词：外阴阴道糜烂型扁平苔癣氯倍他索性交痛意度视觉模拟免疫抑制剂统计学方法满意度评估

胰岛素和优降糖的治疗剂量、妊娠期糖尿病严重程度与妊娠结局的关系

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 15-16页

作者： Langer O. Yogev Y. Xenakis E.M.J. Rosenn B. 高雪莲 Dept. of Obstetrics and Gynecology St. Luke’ s- Roosevelt Hospital Center Univ. Hosp. of Columbia University New York NY United States Dr.

We sought to investigate the association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulinand glyburide- treated patients. In a secondary analysis of our previous randomized study, 404 women were analyzed. The association among glyburide dose, severity of GDM, and selected maternal and neonatal factors was evaluated. Severity levels of GDM were stratified by fasting plasma glucose (FPG) from the oral glucose tolerance test (OGTT). Infants with birth weight at or above the 90th percentile were considered large- for- ges- tational age (LGA). Macrosomia was defined as birth weight ≥ 4000 g. Well- controlled was defined as mean blood glucose ≤ 95 mg/dL. The association between glyburide- and insulintreated patients by severity of GDM and neonatal outcome was evaluated. The dose received for the glyburide- treated patients was 2.5 mg- 32% ; 5 mg- 23% ; 10 mg- 17% ; 15 mg- 8% ; and 20 mg- 20% . Patients were grouped into low (≤ 10 mg) and high (<10 mg) daily dose of glyburide. A comparison between severity of the disease (fasting plasma glucose categories) and highest dose of glyburide revealed a significant difference between the low- 95 FPG and the other severity categories (P =. 02). Of patients in the well- controlled glycemic group, only 6% required the high dose of glyburide (<10 mg). In patients with poor glycemic control (mean blood glucose <95 mg/dL), 38% received the high dose of glyburide (P =. 0001). Comparison between the high glyburide (<10 mg) and the low glyburide dosages (≤ 10 mg) revealed that the rate of macrosomia was 16% vs 5% and LGA 22% vs 8% , (P =. 01), respectively. No significant difference was found in composite outcome, metabolic complications, and Ponderal Index between the 2 dose groups. Stratification by disease severity revealed a significantly lower rate of LGA for both the glyburide- and insulin- treated subjects. No significant difference was fo

关键词：妊娠结局妊娠期糖尿病优降糖血糖控制水平平均血糖水平新生儿结局大于胎龄儿空腹血糖巨大儿百分位数

One way to pathogenesis, many ways to homeostasis

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Cellular & Molecular Immunology 2013年第1期10卷 2-3页

作者： Linrong Lu Jianli Wang Institute of Immunology Zhejiang University School ofMedicine Hangzheu China and 2program in Molecularand Cellular Biology Zhejiang University School ofMedicine Hangzhou China Correspondence: dr.LR Lu Institute of ImmunologyZhejiang University School of Medicine HangzhouChina.

CD4 T cells play central roles in both immune response and *** can either serve as the mediators of adaptive immune response against infections, or act as gate keepers to maintain immune homeostasis. Upon activation by antigens, naive T cells proliferate and differentiate into different T helper （Th） cells with distinct effector functions. Thl cells, induced by tran- scription factor T-bet and produce interferon- y, are crucial for clearing intracellular patho- gens. In contrast, IL-4 expressing Th2 cells dr.ven by GATA-3 are responsible for the clearing of extraceUular pathogens. Thl7 cells, an additional subset ofT cells expressing tran- scription factor RORyt and cytokine ILl 7, are considered as the main dr.vers of autoimmune tissue injury.

关键词： pathogenesis homeostasis

急性症状性或慢性进展性StanfordB型主动脉夹层血管内修复后的并发症

维普期刊数据库评论

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 60-页

作者： Bckler D. Schumacher H. Ganten M. 张步升 Department of Vascular and EndovascularSurgery Ruprecht-Karls University Heidelberg Germany Dr.

Objective: To outline the complications after endovascular repair in patients with acute symptomatic and chronic expanding Stanford type B aortic dissections. Methods: Between 1997 and 2004, of 125 patients with acute and chronic aortic type B dissections, 88 were treated conservatively. Thirty-seven patients(29 male, mean age 58 years, range 30-82 years) underwent endovascular repair(30%) using 44 stent grafts of 3 different designs: Excluder(W. L. Gore &Associates, Inc, Flagstaff, Ariz), Talent(Medtronic Vascular, Santa Rosa, Calif), and Endofit(Endomed, Inc, Phoenix, Ariz). Indications for treatment were acute symptomatic type B dissection in 15 patients, chronic expanding aortic dissection greater than 55 mm in 14, rupture in 3, and simultaneous type A repair in 5 patients. Twenty-two operations were performed on an emergency basis. Patient characteristics, procedural variables, outcome, and complications were prospectively recorded. All patients underwent follow-up by computed tomography before discharge, at 6 and 12 months, and annually thereafter(mean follow-up: 24 months). Results: Correct deployment was achieved in 97%of cases. There were no instances of primary conversion, paraplegia, or stroke. Complete false lumen thrombosis was observed in 11 patients(44%). Perioperative complication rate was 22%. Thirty-day mortality rate in acute and chronic dissections was 19%and 0%, respectively. Freedom from aortic reintervention was 81%, 73%, and 68%, freedom from late rupture was 97%, 90%, and 80%, and overall success rate was 76%, 65%, and 57%at 1, 2, and 5 years, respectively. Results for patients with chronic dissections are significantly(P=.038) better than results in those with acute dissections. Conclusions: Despite the minimally invasive approach, the complication and mortality rates for endovascular therapy of aortic dissections are still high. Frank reporting of these sequelae is if great importance to clarify the recent limitations of the method.

关键词：主动脉夹层 StanfordB 进展性并发症并发病疾病血管内症状性

阴式子宫切除术结合子宫分碎术后的间质肌瘤型子宫内膜异位症患者因子宫不完全切除而出现周期反复性剧烈疼痛

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 41-41页

作者： Kü hne L. Maurer S. Dettmar P. M. Kolben 王雅楠 Frauenarztpraxis Ruffiniallee 17 82166 Gr felf- ing Germany Dr.

Endometriosis is a possible and likely cause of periodically recurrent pelvic pain in premenopausal women. We report on a patient with a history of a vaginal hysterectomy with morcellation of the uterus who presented with monthly recurrent heavy lower abdominal pain. A solid tumour adherent to the lower anterior abdominal wall was diagnosed. Surgery revealed a significant portion of the uterus that showed intramural endometriosis. After “ completion hysterectomy" the patient was completely free of pain.

关键词：子宫内膜异位症子宫切除术结合子宫分下腹壁实体瘤

渗出性老年性黄斑变性的视网膜下新生血管膜未检出肺炎衣原体

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 51-51页

作者： Kessler W. Jantos C.A. dr.ier J. Pavlovic S. 潘家鸿 Department of Ophthalmology Friedrichstr.1835385 GiessenGermany Dr.

Purpose:Age-related macular degeneration(AMD)is the most frequent cause of severe visual impairment in western countries,but its aetiology remains unclear.A growing body of evidence suggests that inflammation contributes to the pathogenesis of AMD,similarly to that shown for *** view of a number of shared risk factors between the two entities and the hypothesized link between Chlamydia pneumoniae infection and atherosclerosis,we investigated whether *** might be involved in exudative ***:To examine whether *** contributes to the development of subretinal neovascular(SRNV)membranes in AMD,13 consecutive SRNV membranes surgically excised from patients with exudative AMD were collected and assayed for the presence of *** or other bacterial pathogens by means of polymerase chain reaction(PCR).Results:The age of patients ranged from 68 to 85 years(median 73.5 years).In all 13 SRNV membranes,no DNA of either *** or other pathogens was found by ***:These findings indicate that *** is not associated with the development of SRNV membranes in exudative AMD.

关键词：渗出性老年性黄斑变性肺炎衣原体感染视网膜下新生血管膜动脉粥样硬化细菌性病原体 PCR检测 SRNV 多聚酶链反应

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单一大剂量抗生素在传染性沙眼流行中的作用

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 5-6页

作者： Chidambaram J.D. Alemayehu W. Melese M. T.M. Lietman 潘佳鸿 F. I. Proctor Foundation Box 0412 University of California San Francisco 513 Parnassus Ave San Francisco CA 94143- 0412 United States Dr.

Context: The World Health Organization recommends mass antibiotic distributions in its strategy to eliminate blinding trachoma as a public health concern. Some hypothesize that a single distribution is sufficient to control the ocular strains of chlamydia that cause trachoma. Others believe infection will inevitably return and periodic treatments or other measures are essential. Objective: To determine whether ocular chlamydial infection returns to the community up to 24 months after a single mass antibiotic distribution in a hyperendemic region of Ethiopia. Design, Setting, and Participants: Longitudinal cohort study conducted March 2003 to March 2005 in the Gurage Zone of Ethiopia. Eight randomly selected villages were assessed for ocular chlamydial infection. Fifteen untreated villages were randomly chosen at 12 months to allow assessment of a secular trend. Intervention A single dose of oral azithromycin was offered to all residents of the 8 selected villages who were aged 1 year or older. Main Outcome Measure: Prevalence of ocular chlamydial infection in all childr.n aged 1 to 5 years from each intervention village prior to treatment and 2, 6, 12, 18, and 24 months after mass antibiotic treatment, and also in untreated villages enrolled at 12 months. Results: Five hundr.d fifteen childr.n were examined for ocular chlamydial infection at baseline. For the followup examinations, the mean participation rate was 83% . The mean prevalence of infection in childr.n aged 1 to 5 years decreased from 43.5% (95% confidence interval [CI]35.0% - 52.0% ) to 5.1% (95% CI, 1.1% - 9.2% ) after treatment. On average, infection returned gradually over 24 months to 11.3% (95% CI, 4.5% - 18.1% ; P=.001). In 7 of 8 villages, infection was higher at 24 months than at 2 months. In the remaining village, no infection could be identified at any point after treatment. Villages enrolled at 12 months had significantly fewer infections than those enrolled 12 months earlier, suggesting a sec

关键词：大剂量抗生素衣原体感染公共卫生事业阿齐霉素队列研究基线水平趋势评估随访检查

Calorie restriction potentiates epigallocatechin-3-gallate-mediated Nrf2 activation in hepatocytes of aged rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第10期13卷 421-430页

作者： Rajeswari Ravindr.n Malathi Manuel Thangarajeswari Mohan Ravindr.n Jaganathan Kalaiselvi Periandavan Preclinical Department Faculty of MedicineUniversiti Kuala LumpurRoyal College of Medicine Perak30450IpohMalaysia Department of Medical Biochemistry Dr A.L Mudaliar Institute of Basic Medical SciencesUniversity of MadrasTaramaniChennai 600113India

Objective:To explore the combinatorial effect of epigallocatechin-3-gallate(EGCG)and calorie restriction on activation of nuclear factor erythroid 2-related factor 2(Nrf2),a transcription factor involved in the antioxidant defense system of aged ***:Aged male Wistar rats were calorie-restricted and treated with EGCG orally for 45 *** initial body weight of aged rats was recorded,and the final body weight was measured at the end of the experimental *** lipid and lipoprotein status,oxidative stress markers such as free radicals and malondialdehyde levels,and reduced glutathione were *** addition,RT-PCR and Western blotting analyses were ***:Calorie restriction potentiated the effect of EGCG on enhancing antioxidant status,improving the levels of serum lipid and lipoproteins,upregulating Nrf2 and Bcl2,and downregulating Keap1,cullin3,Bax and cytochrome c in aged ***:Calorie restriction can promote EGCG-mediated Nrf2 activation in aged *** preliminary finding paves the way for a combinatory approach to replenishing the antioxidant status during aging,thereby reducing the risk for age-associated degenerative diseases.

关键词： Aging Reactive oxygen species Calorie restriction EGCG Nrf2 Antioxidant