检索结果-南通市图书馆

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

引用

Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen aerospace Clinical Medical center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation Analysis of Deformation Control for Magnetic Soft Medical Robots

引用

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： Jingxi Wang Baoyu Liu Edmond Q.Wu Jin Ma Ping Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of aerospace medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis

引用

Virologica Sinica 2023年第5期38卷 741-754页

作者： Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma Department of Microbiology School of Basic MedicineAir Force Medical UniversityXi'an710032China Department of Neurology Xijing HospitalAir Force Medical UniversityXi'an710032China center of Clinical aerospace medicine School of Aerospace MedicineKey Laboratory of Aerospace Medicine of Ministry of EducationAir Force Medical UniversityXi'an710032China Department of Anesthesiology&Critical Care medicine Xijing HospitalAir Force Medical UniversityXi'an710032China The College of Life Sciences and medicine Northwest UniversityXi'an710069China

Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)***,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains ***,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 ***-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral ***3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I ***,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV ***3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune ***,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase ***,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV.

关键词： Hantaan virus(HTNV) RIPK3 Interferons IFN-stimulated genes STAT1 Innate immune response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma

引用

Neural Regeneration Research 2023年第4期18卷 922-928页

作者： Yu Huan Xiu-Quan Wu Tao Chen Ya-Nan Dou Bo Jia Xin He Dong-Yu Wei Zhou Fei Fei Fei Department of Neurosurgery Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina center of Clinical aerospace medicine Air Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina

Retinal injury after blunt ocular trauma may directly affect prognosis and lead to vision *** investigate the pathological changes and molecular mechanisms involved in retinal injury after blunt ocular trauma,we established a weight drop injury model of blunt ocular trauma in male Beagle ***-eosin staining,immunofluorescence staining,western blotting,and TUNEL assays were performed to investigate retinal injury within 14 days after blunt ocular *** with the control group,the thicknesses of the inner and outer nuclear layers,as well as the number of retinal ganglion cells,gradually decreased within 14 days after *** number of bipolar cells in the inner nuclear layer began to decrease 1 day after injury,while the numbers of cholinergic and amacrine cells in the inner nuclear layer did not decrease until 7 days after ***,retinal cell necroptosis increased with time after injury;it progressed from the ganglion cell layer to the outer nuclear *** electrophysiological findings indicated that visual impairment began on the first day after injury and worsened over ***,blunt ocular trauma induced nerve regeneration and Müller glial hyperplasia;it also resulted in the recruitment of microglia to the retina and polarization of those microglia to the M1 *** findings suggest that necroptosis plays an important role in exacerbating retinal injury after blunt ocular trauma via gliosis and *** a role has important implications for the development of therapeutic strategies.

关键词： Beagle dogs blunt ocular trauma gliosis M1 microglia Müller cells necroptosis neuroinflammation retinal ganglion cells retinal injury weight drop injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs

引用

International Journal of Ophthalmology(English edition) 2022年第2期15卷 213-220页

作者： Yu-Fei Zhang Xiao-Hong Zhou Rui-Dan Cao Jun-Bo Song Dong-Yu Wei Fu-Jun Duan Wei Wang Zuo-Ming Zhang Tao Chen center of Clinical aerospace medicine Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina The air force Hospital from Northern Theater PLA Shenyang 110092Liaoning ProvinceChina Ophthalmology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Basic Medical College Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Aviation medicine Air Force Hospital of Southern Theater CommandGuangzhou 510062Guangdong ProvinceChina Naval Medical center of PLA Shanghai 200433China Department of Aviation medicine Xijing HospitalAir Force Medical UniversityXi5an 710032Shaanxi ProvinceChina

AIM:To explore the effects of laser-activated remote phosphors(LARP)on visual function in guinea ***:Electroretinogram(ERG)of guinea pigs were observed after LARP irradiation at different frequencies and irradiation *** evaluated the expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP ***:After LARP irradiation,the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation(P<0.05).The expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pig ***:There is frequency cumulative damage effect on the retina that relates to LARP illumination *** has significance for staff visual protection policies under LARP lighting conditions.

关键词： irradiation visual function visual protection retina

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-Model Ensemble Deep Learning Method to Diagnose COVID-19 Using Chest Computed Tomography Images

引用

Journal of Shanghai Jiaotong university(Science) 2022年第1期27卷 70-80页

作者：王志明董静静张军鹏 College of Electrical Engineering Sichuan UniversityChengdu 610056China Key Laboratory of aerospace medicine of Ministry of Education Air Force Medical UniversityXi’an 710032China Lintong Rehabilitation and Recuperation center PLA Joint Logistic Support ForceXi’an 710600China

Deep learning based analyses of computed tomography(CT)images contribute to automated diagnosis of COVID-19,and ensemble learning may commonly provide a better ***,we proposed an ensemble learning method that integrates several component neural networks to jointly diagnose *** ensemble strategies are considered:the output scores of all component models that are combined with the weights adjusted adaptively by cost function back propagation;voting strategy.A database containing 8347 CT slices of COVID-19,common pneumonia and normal subjects was used as training and testing *** show that the novel method can reach a high accuracy of 99.37%(recall:0.9981;precision:0.9893),with an increase of about 7% in comparison to single-component *** the average test accuracy is 95.62%(recall:0.9587;precision:0.9559),with a corresponding increase of 5.2%.Compared with several latest deep learning models on the identical test set,our method made an accuracy improvement up to 10.88%.The proposed method may be a promising solution for the diagnosis of COVID-19.

关键词： COVID-19 deep learning computed tomography(CT)images ensemble model convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts

引用

International Journal of Oral Science 2023年第1期15卷 63-75页

作者： Qingyuan Ye Xinyu Qiu Jinjin Wang Boya Xu Yuting Su Chenxi Zheng Linyuan Gui Lu Yu Huijuan Kuang Huan Liu Xiaoning He Zhiwei Ma Qintao Wang Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi International Joint Research center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyAir Force Medical UniversityXi’anChina State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi Key Laboratory of Stomatology Digital Dentistry CenterSchool of StomatologyAir Force Medical UniversityXi’anChina State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi Clinical Research center for Oral Diseases Department of Preventive DentistrySchool of StomatologyAir Force Medical UniversityXi’anChina State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi Engineering Research center for Dental Materials and Advanced Manufacture Department of PeriodontologySchool of StomatologyAir Force Medical UniversityXi’anChina State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases Department of ProsthodonticsSchool of StomatologyAir Force Medical UniversityXi’anChina aerospace Clinical Medical center School of Aerospace MedicineAir Force Medical UniversityXi’anChina Department of Otolaryngology Head and Neck Surgery Peking University Third HospitalBeijingChina

Severe muscle injury is hard to heal and always results in a poor *** studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine,however,whether extracellular vesicles have therapeutic effects on severe muscle injury is still ***,we extracted apoptotic extracellular vesicles derived from mesenchymal stem cells(MSCs-Apo EVs)to treat cardiotoxin induced tibialis anterior(TA)injury and found that MSCs-Apo EVs promoted muscles regeneration and increased the proportion of multinucleated *** that,we also found that apoptosis was synchronized during myoblasts fusion and MSCs-Apo EVs promoted the apoptosis ratio as well as the fusion index of ***,we revealed that MSCs-Apo EVs increased the relative level of creatine during myoblasts fusion,which was released via activated Pannexin 1 ***,we also found that activated Pannexin 1 channel was highly expressed on the membrane of myoblasts-derived Apo EVs(Myo-Apo EVs)instead of apoptotic myoblasts,and creatine was the pivotal metabolite involved in myoblasts ***,our findings firstly revealed that MSCs-Apo EVs can promote muscle regeneration and elucidated that the new function of Apo EVs as passing inter-cell messages through releasing metabolites from activated Pannexin 1 channel,which will provide new evidence for extracellular vesicles-based therapy as well as improving the understanding of new functions of extracellular vesicles.

关键词： apo extracellular release

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

引用

Military Medical Research 2022年第4期9卷 444-483页

作者： Stefan Sammito Vedran Hadzic Thomas Karakolis Karen R.Kelly Susan P.Proctor Ainars Stepens Graham White Wes O.Zimmermann Section Experimental aerospace medicine Research German Air Force Centre of Aerospace MedicineFlughafenstraBe 151147 CologneGermany Occupational medicine Faculty of MedicineOtto-Von-Guericke-University of Magdeburg39120 MagdeburgGermany Faculty of Sport University of Ljubljana1000 LjubljanaSlovenia Defence Research and Development Canada TorontoON M3K 2C9Canada Warfighter Performance Naval Health Research CenterSan DiegoCA 921063599USA Military Performance Division US Army Research Institute of Environmental MedicineNatickMA 01760USA Research Service VA Boston Healthcare SystemBostonMA 02130USA Centre for Military medicine Research Riga Stradins UniversityRiga 1007Latvia Human and Social Sciences Group Defense Science and Technology LaboratoryPortsdown Hill RoadFareham PO176ADUK Department of Military Sports medicine Royal Netherlands Army3584 AB UtrechtThe Netherlands Department of Military/Emergency medicine Uniformed Services University of the Health SciencesBethesdaMD 20814USA.

Background: Musculoskeletal injuries(MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during initial training,operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk factors for MSkIs in the military is not ***: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed(using the “snowball method”). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk factor, and a classification of modifiable/non-modifiable was ***: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk factors was formed. For 21 risk factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk factors identified, introducing the idea of the “order of importance” and including concepts that are modifiable/nonmodifiable, as well as extrinsic/intrinsic risk ***: This is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups.

关键词： Military Musculoskeletal injuries Risk factors Prevention Intervention Injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

引用

中华医学杂志(英文版) 2024年第15期137卷 2024 Jul 3页

作者： Xing Changyang Xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi Mu Yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu Xie Mingxing Jiang Tianan Yuan Lijun Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China Department of Ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of Ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China Department of Ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound First Affiliated Hospital of Anhui Medical University Hefei Anhui China Department of Ultrasound medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China Department of Abdominal Ultrasound The Affiliated Hospital of Qingdao University Qingdao Shandong China Department of Ultrasound Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China Department of Ultrasound The First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology Baotou Inner Mongolia China Department of Medical Ultrasonics First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China Department of Ultrasound The Fourth People’s Hospital Xi’an Shaanxi China Department of Ultrasound Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Cardiovascular Ultrasound The First Hospital of China Medical University Shenyang Liaoning China Department of Ultrasound center Affiliated Hospital of G

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Drug discovery of sclerostin inhibitors

引用

Acta Pharmaceutica Sinica B 2022年第5期12卷 2150-2170页

作者： Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang Law Sau Fai Institute for Advancing Translational medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Precision medicine and Innovative Drug Discovery HKBU Institute for Research and Continuing EducationShenzhen 518000China School of Chinese medicine Faculty of Medicinethe Chinese University of Hong KongHong Kong 999077China The Key Laboratory of aerospace medicine Ministry of EducationAir Force Medical UniversityXi’an 710000China Shanghai Clinical Research center of Bone Disease Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Afﬁliated Sixth People’s HospitalShanghai 200000China

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy.

关键词： Sclerostin WNT signalling pathway Sclerostin inhibitors Antibody Bone diseases Aptamer Small molecule inhibitors Artificial intelligence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：