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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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MAVEN observation of magnetosonic waves in the Martian magnetotail region

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Earth and Planetary Physics 2024年第2期8卷 317-325页

作者： ShangChun Teng JiCheng Sun JiaWei Gao Y.Harada Markus Fraenz DeSheng Han State Key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophysics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar System Research GoettingenGermany

Magnetosonic waves are an important medium for energy transfer in collisionless space *** waves have been widely investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly propagating magnetosonic emissions near the proton gyrofrequency in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxygen *** excited magnetosonic waves could possibly heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dynamics and offer insights into possible energy redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

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Review on Dating Methods:Numerical Dating in the Quaternary Geology of High Asia

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Journal of Mountain Science 2010年第2期7卷 105-122页

作者： Matthias Kuhle Sabine Kuhle georg-august-university of goettingen Department of Geography and High Mountain Geomorphology

Over the past few years,OSL and TCN datings of glacial material from High Asia have come into *** this day,however,these techniques do not permit safe *** intensity of the cosmic ray flux is being modulated by the solar and terrestrial magnetic fields and their secular fluctuations in the *** far,these variations cannot be converted into the respective local TCN production rates for High *** have reason to believe that the ages that are being calculated despite these uncertainties are generally *** assessment is supported by conventional radiocarbon dates and above all by the glacial chronology developed independently on the basis of the Quaternary geological *** strongly emerging evidence for a much more extensive LGM glaciation of High Asia is,however,either being ignored or rejected by many authors,solely on the basis of the above-mentioned uncalibrated *** self-conceit based on the "dating fallacy",as we call it,should be avoided since it goes decidedly against the standards of the scientific method established in Quaternary geology and makes a fundamental scientific discussion impossible.

关键词：第四纪地质定年方法天花粉蛋白数值综述冰川作用末次盛冰期高亚洲

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Malware homology identification based on a gene perspective

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Frontiers of Information Technology & Electronic Engineering 2019年第6期20卷 801-815页

作者： Bing-lin ZHAO Zheng SHAN Fu-dong LIU Bo ZHAO Yi-hang CHEN Wen-jie SUN State Key Laboratory of Mathematical Engineering and Advanced Computing Zhengzhou 450001 China georg-august-university of goettingen Goettingen 37077 Germany

Malware homology identification is important in attacking event tracing, emergency response scheme generation, and event trend prediction. Current malware homology identification methods still rely on manual analysis, which is inefficient and cannot respond quickly to the outbreak of attack events. In response to these problems, we propose a new malware homology identification method from a gene perspective. A malware gene is represented by the subgraph, which can describe the homology of malware families. We extract the key subgraph from the function dependency graph as the malware gene by selecting the key application programming interface(API) and using the community partition algorithm. Then, we encode the gene and design a frequent subgraph mining algorithm to find the common genes between malware families. Finally, we use the family genes to guide the identification of malware based on homology. We evaluate our method with a public dataset, and the experiment results show that the accuracy of malware classification reaches 97% with high efficiency.

关键词： Malware classification Gene perspective Dependency graph Homology analysis

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灰盖鬼伞中过表达的碱性真菌漆酶在高盐染料废水中的应用潜力

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微生物学报 2024年第8期64卷 3014-3029页

作者：王先华朱雪玲林嘉钇谷贤富彭齐霞肖亚中 Ursula Kües 方泽民安徽大学生命科学学院安徽合肥230601 安徽省现代生物制造重点实验室安徽合肥230601 安徽省微生物与生物催化工程技术研究中心安徽合肥230601 university of goettingen Goettingen 237077Germany

【目的】本研究利用双孢菇(Agaricus bisporus)gpdII启动子,实现了碱性真菌漆酶PIE5(CcPIE5)在灰盖鬼伞(Coprinopsis cinerea)FA2222中的同源过表达。【方法】在mKjalke液体培养基中37℃培养7 d,漆酶活力达到(24.2±1.1)U/mL。纯化的CcPIE5在pH 8.0和60℃下表现出最佳催化活性。【结果】与已经研究报道的真菌漆酶不同,CcPIE5能耐受高浓度NaCl,当NaCl浓度从0升至1.5 mol/L时,CcPIE5的k_(cat)和K_(m)均呈下降趋势,表示CcPIE5在纺织印染废水脱色中有潜在应用价值。进一步在染料废水脱色应用中,以丁香酸作为介体,CcPIE5在pH 8.5和60℃条件下可高效降解(92.9±2.3)%的靛蓝胭脂红。通过LC-MS分析确认,Isatin 5-sulfonic acid(ISA)是靛蓝胭脂红降解的主要副产物。【结论】CcPIE5在高温、碱性和含盐条件下高效脱色染料,是处理环境和工业特定应用的理想选择。

关键词：真菌漆酶过表达灰盖鬼伞高盐靛蓝胭脂红

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Climate Change, Risk and Grain Yields in China

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Journal of Integrative Agriculture 2013年第7期12卷 1279-1291页

作者： Rainer Holst Xiaohua Yu Carola Grün Courant Research Center 'Poverty Equity and Growth' Georg-August-University of Goettingen World Bank

Adopting Just and Pope （1978, 1979） style yield functions, this paper proposes a method to analyze the impacts of regional climate change on grain production in China. We find that changes in climate will affect grain production in North and South China differently. Specifically, it emerges that a 1℃ increase in annual average temperature could reduce national grain output by 1.45% （1.74% reduction in North China and 1.19% reduction in South China）, while an increase in total annual precipitation of around 100 mm could increase national grain output by 1.31% （3.0% increase in North China and 0.59% reduction in South China）.

关键词： grain yield climate change yield risk China

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Effects of solvents and temperature on spherulites of self-assembled phloroglucinol tristearate

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 389-396页

作者： Yawen Yao Sabine Rosenfeldt Kai Zhang Wood Technology and Wood Chemistry Georg-August-University of Goettingen37077 GottingenGermany Department of Chemistry and Bavarian Polymer Institute University of Bayreuth95447 BayreuthGermany

Herein,phloroglucinol tristearate(PhgTS)was used to study the crystallization process due to its unique symmetric structure containing a benzene ring and three aliphatic *** of crystallized PhgTS from four solvents under diverse conditions were analyzed in detail and their formation process was *** cross is shown by PhgTS spherulites obtained from aprotic solvents via polarized optical *** comparison,no Maltese cross can be observed from branch-like crystals formed from protic *** on the micro-scaled morphology,lamellae were found to be the basic blocks constructing both PhgTS spherulites and branch-like crystals,which were formed predominantly by stacked PhgTS *** differential characters of the solvents did not affect the formation of lamellas,the solvents played a crucial role in the formation of self-assembled microscaled *** particular,the morphologies of spherulites were strongly affected by the concentration of PhgTS solutions,surrounding tempera-ture and evaporation rate of ***,a higher concentration of PhgTS led to more homogeneous spherulites,a lower evaporation rate resulted in more compact spherulites,and a higher surounding temperature generated preferentially more ring-banded spherulites of PhgTS.

关键词： phloroglucinol tristearate aprotic and protic solvent self-assembly spherulites

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Distribution of persistent organic pollutants in aggregate fractions of a temperate forest and semi-rural soil

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Journal of Forestry Research 2017年第5期28卷 953-962页

作者： Shafique Maqsood Rajasekaran Murugan Department of Environmental Chemistry University of Kassel Department of Physical Geography Georg August-University Goettingen Department of Soil Biology and Plant Nutrition University of Kassel

The fate of persistent organic pollutants (POPs) and their interactions with aggregates of forest soils are not completely understood. Our objectives here were to quantify the distribution of different POPs in water-stable aggregate fractions and to study their influence on soil organic carbon (Corg) content. Soil samples were taken from a forest-site, Gogerddan (G) and a semi-rural site, Hazelrigg (H) in Great Britain, from 0-2 and 2-5 cm and 0-4 and 8-12 cm soil depth, respectively. POPs analyzed were PAHs, PCBs, total DDT, PBDEs and HCB. The bulk soil analysis showed that the concentration of POPs was significantly higher (p ≤ 0.05) in forest site G than in semi-rural site H, particularly at the surface soil levels compared to the subsurface soil depths in both sites. Total concentrations of PCBs and PAHs of both sites were positively correlated with Corg contents. POPs concentrations and Corg, Nt contents of forest site G were significantly higher (p ≤ 0.05) in water-stable macro aggregates (>0.25, >1, >2 mm) than the micro aggregates (>0.053 mm). The POP concentrations of all aggregate fractions after normalizing to their respective Corg content were increased due higher contamination and strong sorption by Corg. These results showed a strong effect of Corg on the partitioning of organic pollutants to soil aggregate size fractions. The present study affirms the ecological significance of forest soils act as a potential sink of POPs. In summary, our results suggest that aggregate fractions may promote soil C storage and act as a potential POP sink in surface soil without increasing their concentration in the aggregate fraction of subsoil.

关键词： Aggregate fractions Forest soil Organic carbon Persistent organic pollutants

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Importance of genetic data from type specimens:The questionable type locality of southern white-cheeked gibbon,Nomascus siki(Delacour,1951)

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Zoological Research 2022年第4期43卷 666-670页

作者： Christian Roos Roberto Portela Miguez Dietmar Zinner Tilo Nadler Van Ngoc Thinh Gene Bank of Primates German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Natural History Museum London SW7 BDUK Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany Department of Primate Cognition Georg-August-UniversityGoettingen 37083Germany Three Monkeys Wildlife Conservancy Cuc Phuong CommuneNho Quan DistrictNinh Binh ProvinceVietnam World Wide Fund for Nature(WWF)Vietnam Nam Tu Liem DistrictHanoiVietnam

DEAR EDITOR,Many historical descriptions of new species have included vague or inaccurate information about the type *** can lead to confusion in the study of the species and their geographic distributions,thereby hindering conservation *** such example is the southern white-cheeked gibbon(Nomascus siki(Delacour,1951)).The type locality is given as Thua Luu in central Vietnam,which is located within the range of another crested gibbon species(***)and more than 200 km south of the known range of *** investigate the problematic type locality of ***,we sequenced the mitochondrial genome of the holotype and compared its cytochrome b gene sequence to those of other georeferenced crested gibbon samples.

关键词： thereby hinder locality

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Physiological and Molecular Features of the Pathosystem Arabidopsis thaliana L.-Sclerotinia sclerotiorum Libert

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Journal of Integrative Plant Biology 2006年第1期48卷 44-52页

作者： Fu-Ming Dai Tong Xu Gerhard A. Wolf Zu-Hua He College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences Shanghai 200032 China Institute of Plant Pathology Georg-August University Goettingen Goettingen 37077 Germany

The fungal pathogen Sclerotinia sclerotiorum Libert causes rot diseases on many crops worldwide and large economic losses occur frequently because of a lack of resistant varieties. The pathogenesis of S. sclerotiorum and the molecular basis of plant responses to the pathogen are poorly understood. In the present investigation, the process of S. sclerotiorum infection in Arabidopsis thaliana L., a plant that is highly susceptible to this fungus, was analysed. In addition, the defense activation in the host was investigated. A convenient inoculation method using millet grain was developed for S. sclerotiorum in Arabidopsis. The fungus rapidly infected the plants, probably through ball- or cushion-like infection structures. Visible symptoms developed within 24 h and plants were killed 72 h after inoculation. Cellulase, the main enzyme that caused host tissues to rot, was secreted by S. sclerotiorum in a pH-dependent manner. Oxalic acid, another pathogenic factor secreted by the fungus, induced necrotic lesions on the leaves, infection with S. sclerotiorum strongly induced the production of the pathogenesis-related （PR） proteins β-1,3-glucanase and chitinase in Arabidopsis. Furthermore, the PR gene PDF. 1 was induced, but not PR1, indicating that the pathogen activated basal defense of jasmonic acid/ethylene dependence, which is consistent with its necrotrophic characteristics. This pathosystem for Arabidopsis-S. sclerotiorum could provide an approach for the analysis of the interactions between S. sclerotiorum and other crops, thereby facilitating genetic manipulation techniques for controlling this pathogen.

关键词： Arabidopsis defense pathogenesis pathosystem Sclerotinia sclerotiorum.

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