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Implementation of a polling protocol for predicting celiac disease in videocapsule analysis

World Journal of Gastrointestinal Endoscopy 2013年第7期5卷 313-322页

作者： Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green Department of Medicine Columbia University Medical CenterNew York NY 10032 United States Department of Pathology and Cell Biology Columbia University Medical CenterNew York NY 10032 United States

AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image ***: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensit

关键词： Automata Celiac disease Small intestine Videocapsule Villous atrophy

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Shallow geophysical investigations at the Akhmim archaeological site,Suhag,Egypt

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Applied Geophysics 2008年第2期5卷 136-143页

作者： Mahfooz A.Hafez Magdy A.Atya Azza M.Hassan Motoyuki Sato Thomas Wonik Abeer A.El-Kenawy National Research Institute of Astronomy and Geophysics 11722 HelwanCairoEgypt Leibniz Institute for Applied Geosciences(GGA)30655 HannoverGermany National Research Institute of Astronomy and Geophysics 11722 HelwanCairoEgypt Tohoku university Center for Northeast Asian Studies980-8576 SendaiJapan Leibniz Institute for Applied Geosciences(GGA) 30655 HannoverGermany Geology Department Faculty of Science Zagazig University.44519 ZagazigEgypt

Ground penetrating radar, electromagnetic terrain conductivity, and electric tomography have proven to be effective tools if they are combined together to investigate archeological sites. We have conducted a geophysical survey at the Akhmim archaeological site, the main objective of our survey is to locate additional buried structures for further excavation. geophysical data were acquired in the area using the GEM-300 multi-frequency terrain conductivity profiler, the SIR 2000 ground penetrating radar, and the Syscal R2 resistivity meter systems. The results of the integrated interpretation show a number of buried features and a strong linear zone about 1 m wide that coincides with the suspected trend of a buried wall. There appears to be two parallel ridges of strong reflections on either side, indicating two parallel walls extended East-West and a room is identified at the bottom left comer of the site. Moreover, the interpretation results of some selected GPR and dipoledipole resistivity profiles adjacent to the open-air museum suggest the existence of a second statue of Ramses Ⅱ to the right of the previously discovered statue which could still be buried in the sand.

关键词： Archaeological prospecting Akhmim GPR GEM resistivity

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Time Transfer Analysis of GPS-and BDS-Precise Point Positioning based on iGMAS Products

Time Transfer Analysis of GPS-and BDS-Precise Point Position...

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第九届中国卫星导航学术年会

作者： Yulong Ge Xuhai Yang Weijin Qin Hang Su Meifang Wu Yuanxi Wang Shengli Wang National Time Service center Chinese Academy of Sciences Key Laboratory of Precise Positioning and Timing Technology Chinese Academy of Sciences University of Chinese Academy of Sciences School of Astronomy and Space Science University of Chinese Academy of Sciences Institute of Ocean Engineering Shandong University of Science and Technology

International time transfer experiment based on GPS-and BDS-precise point positioning(PPP) technique is carried out using final(ISC) and rapid(ISR) precise satellite clock products provided by iG MAS(international GNSS continuous Monitoring and Assessment System). As a comparison, the same processing is conducted by using COD products provided by the center for Orbit Determination in Europe(CODE). Experimental data come from observation of seven stations from Multi-GNSS-Experiment(MGEX) and two stations including PT11(PTB) and BRUX(ROB) from time keeping laboratory in 70 days from 5 August to 15 October 2017. With PTB as the center node, the solutions of 8 time-links are formed. In order to verify the type A uncertainty(uA) of time transfer based on GPS-and BDS-PPP by using iG MAS products, this paper compares the differences between GPS-and BDS-PPP results and GPS PPP results using IGR products. The experimental results demonstrate that uA of time transfer based on GPS-and BDS-PPP using iG MAS1 products are roughly equal to CODE products. For the results of time-links based on GPS-and BDS-PPP, the STD of one-day arc solutions can reach better than 0.1 and 0.8 ns for all of processing, while 0.1 and 1 ns were achieved for ten-day arc solutions, respectively. Since uA of GPS-and BDS-PPP time transfer using iG MAS products was up to sub nanosecond, therefore, the experiments can provide a reference for BIPM to use BDS PPP based on iG MAS products for International UTC/TAI comparison. Moreover, this also illustrates iG MAS products is reliable.

关键词： Precise point positioning Time transfer iGMAS GPS BDS

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Preliminary Study on HPLC Fingerprint of Thlaspi arvense L.

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Medicinal Plant 2017年第4期8卷 15-19页

作者： Jiamin MENG Hanmei JIANG Jinqing LU Kun ZHOU Yushuo XIAO Research and Development center of Medicinal Plant in Hubei Province/Hubei University of Chinese Medicine

[Objectives] To establish Thlaspi arvense L. HPLC fingerprints,to provide reference for quality evaluation Thlaspi arvense L.[Methods]HPLC chromatography was used,HPLC column Acclaim~ 120C_(18)( 250 mm × 3. 0 mm,5 μm),mobile phase of acetonitrile-0. 2% phosphoric acid aqueous solution gradient elution,flow rate of 0. 7 m L/min,column temperature of 30 ℃,detection wavelength of 320nm; the chromatographic fingerprint similarity evaluation software( Version 2004 A) was used for similarity evaluation and data processing on 10 origin Thlaspi arvense L. spectra,and the median method was used to generate control Thlaspi arvense L. fingerprint. [Results] The similarity of 10 origin Thlaspi arvense L. spectra was greater than 0. 90,19 common peaks were separated from different origin Thlaspi arvense L. and isovitexin,apigenin,luteolin and acacetin were identified. [Conclusions] The established HPLC fingerprint contained a lot of information and showed good specificity for Thlaspi arvense L.,which can provide a scientific basis for Thlaspi arvense L. quality evaluation system.

关键词： Thlaspi arvense L. HPLC Chromatographic fingerprint Isovitexin

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Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo

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Translational Neurodegeneration 2018年第1期7卷 175-186页

作者： Ming-Shu Mo Gui-Hua Li Cong-Cong Sun Shu-Xuan Huang Lei Wei Li-Min Zhang Miao-Miao Zhou Zhuo-Hua Wu Wen-Yuan Guo Xin-Ling Yang Chao-Jun Chen Shao-Gang Qu Jian-Xing He Ping-Yi Xu Department of Neurology First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120GuangdongChina Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012ShandongChina Department of Neurology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of Neurology Second Affiliated Hospital of Xinjiang Medical UniversityUrumchi 830011XinjiangChina Clinic Brain center Guangzhou Hospital of Integrated Traditional and Western MedicineGuangzhou 510800GuangdongChina Department of Blood Transfusion Fifth Affiliated Hospital Southern Medical UniversityGuangzhou 510900GuangdongChina Department of Thoracic Surgery First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong China

Background:Abnormal expression of major histocompatibility complex class I(MHC-I)is increased in dopaminergic(DA)neurons in the substantia nigra(SN)in Parkinson’s disease(PD).Low-molecular-mass protein 7(β5i)is a proteolytic subunit of the immunoproteasome that regulates protein degradation and the MHC pathway in immune ***:In this study,we investigated the role of β5i in DA neurons using a 6-hydroxydopamine(6-OHDA)model in vitro and ***:We showed that 6-OHDA upregulatedβ5i expression in DA neurons in a concentration-and time-dependent *** and downregulation ofβ5i induced the expression of glucose-regulated protein(Bip)and exacerbated 6-OHDA neurotoxicity in DA *** inhibition of β5i further promoted the activation of Caspase 3-related pathways induced by 6-OHDA.β5i also activated transporter associated with antigen processing 1(TAP1)and promoted MHC-I expression on DA ***:Taken together,our data suggest that β5i is activated in DA neurons under 6-OHDA treatment and may play a neuroprotective role in PD.

关键词： Parkinson’s disease 6-hydroxydopamine Immunoproteasome TAP1

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Analysis of New Developments and Key Technologies of Autonomous Underwater Vehicle in Marine Survey

Analysis of New Developments and Key Technologies of Autonom...

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2011 3rd International Conference on Environmental Science and Information Application Technology(ESIAT 2011)

作者： Minqiang Tang Zhiqiang Zhang Yuqing Xing Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sicences key Laboratory of Technology and Application for Safeguarding of Marine Rights and Interests SOA South China Sea Marine Engineering surveying center SOA Graduate University Chinese Academy of Sciences

The paper illustrates some marine survey AUVs plus their features and typical configurations, and analyzes their key technologies through classification and analysis, which are currently existed or under development. Their composition can be divided into basic modules and functional modules. Basic modules include central processing system, propeller system, power supply system and navigation system etc. Meanwhile, functional modules refer to auxiliary sensor and survey equipment. As for AUV applied in marine survey, designer should pay more consideration to the running state in high velocity flow and strengthen the control of side thrust. The configurations of marine survey AUVs from companies like Kongsberg in Norway, Hydroid in U.S., Bluefin Robotics in U.S. and Hafmynd in Iceland are analyzed and classified. The research and development process of domestic AUV are also be reviewed. As AUV can collect data with highly efficiency and better quality, it will replace traditional means of surface vessels with towed systems for its portability. Easy use of AUV can significantly reduce fuel consumption of ships, which will be widely used in marine survey in the future as a cost-effective method.

关键词： Marine survey AUV new development key technologies analysis

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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

LARP7-Mediated U6 snRNA Modification Ensures Splicing Fideli...

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中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： Xin Wang Zhi-Tong Li Yue Yan Mo-Fang Liu State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences-University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University

U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally with 2’-O-methylation being most common. The role of these modifications in pre-mRNA splicing, as well as their physiological function in mammals, has remained largely unclear. Here, we report that the La-related protein LARP7 functions as a critical cofactor for the 2’-O-methylation of U6 in mouse male germ cells. Mechanistically, LARP7 promotes U6 loading onto box C/D snoRNP, thereby facilitating U6 2’-O-methylation by box C/D snoRNP. Importantly, ablation of LARP7 in the male germline causes defective U6 2’-O-methylation, massive alterations in pre-mRNA splicing, and spermatogenic failure in mice, which can be rescued by ectopic expression of wildtype LARP7 but not an U6-loading deficient mutant LARP7. Our data uncover a novel role for LARP7 in regulating U6 2’-O-methylation and demonstrate the functional requirement of such modification for splicing fidelity and spermatogenesis in mice.

关键词： U6 snRNA 2’-O-methylation LARP7 box C/D snoRNP pre-mRNA splicing spermatogenesis

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超越原子可视化—利用扫描透射电子显微镜表征双原子单团簇催化剂

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Science China Materials 2023年第7期66卷 2733-2740页

作者：李铖陈俊池汪兴坤黄明华 Wolfgang Theis 李隽谷猛 Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Physics and Astronomy University of BirminghamBirminghamB152TTUK Department of Chemistry and Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and TechnologyShenzhen 518055China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Department of Chemistry and Engineering Research center of Advanced Rare-Earth Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

本研究利用扫描透射电子显微镜(STEM)表征了碳掺杂氮负载的FeFe和CoFe双原子单团簇催化剂.同时本工作开发了一个STEM图像处理程序,以精准识别原子的位置并得到可能的原子对中原子之间的投影距离.大数据分析结果显示CoFe和FeFe原子对的... 详细信息

本研究利用扫描透射电子显微镜(STEM)表征了碳掺杂氮负载的FeFe和CoFe双原子单团簇催化剂.同时本工作开发了一个STEM图像处理程序,以精准识别原子的位置并得到可能的原子对中原子之间的投影距离.大数据分析结果显示CoFe和FeFe原子对的距离均呈现三峰分布,对应于模拟得到的多种稳定的原子结构.我们的工作为通过STEM图像的大数据统计和相关理论模拟直接揭示双原子单团簇催化剂中双原子位点的可能原子构型提供了一条途径.

关键词： single-cluster catalysts aberration-corrected HAADF-STEM image processing big data statistics DFT simulation

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Sustainability and Market Orientation in the Brazilian Beef Chain

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Journal of Agricultural Science and Technology(B) 2014年第4期4卷 249-260页

作者： Miguelangelo Gianezini Julio Otavio Jardim Barcellos Clandio Favarini Ruviaro Tamara Esteves de Oliveira Homero Dewes center for Study and Research in Agribusiness (CEPAN) Universidade Federal do Rio Grande do Sul Porto Alegre 33086-586Brazil Department of Socioeconomic Development (PPGDS) Universidade do Extremo Sul Catarinense (UNESC) Cricifima 88806-000Brazil Department of Agribusiness (FACE) Universidade Federal da grande Dourados (UFGD) Dourados 79804-970 Brazil

The demand for natural resources, energy and food facing the contemporary perception of sustainability is imposing challenges to the productive sectors in accordance with market guidelines. In this context, the Brazilian agribusiness seeks to maintain external competitiveness and to satisfy growing domestic demands. In beef production, this competitiveness pervades traceability, food safety and sustainability. This article aims to identify the sustainability state of the art in agribusiness and characterize it within the Brazilian beef chain. Descriptive methodology, combining a literature review and a documentary data survey were adopted. An outline of the dimensions of agribusiness sustainability, drawn from benchmark practices, indicates that environmental, social and technological demands have become part of the industry＇s agenda. The data for beef cattle point to a growth in production but demonstrate that expansion has occurred in areas of environmental tension, which creates a demand for sustainability in the beef chain. A table of guidelines for sustainability demonstrates that although perceptions are not yet harmonized among the links in the whole beef chain, many of the technological guidelines for sustainable production may increase the producer＇s economic efficiency. In the Brazilian case, the increment of initiatives and dissemination of sustainable practices among the beef chain is desirable to provide a coordinated response of production, processing and distribution organizations facing market opportunities for sustainable livestock.

关键词： Agribusiness livestock process sustainable production demand chains.

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Mobile Internet Mobile Agent System dynamic trust model for cloud computing

Mobile Internet Mobile Agent System dynamic trust model for ...

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2018中国信息通信大会(CICC2018)

作者： JIANG Wei-Jin WANG Yang XU Yu-Hui CHEN Jia-Hui School of Computer National University of Defense Technology School of computer science and technology Wuhan university School of Computer and information engineering Hunan University of Commerce Hunan Collaborative Innovation center of Buildiung Energy Conservation ＆ Environmental Control North navigation control technology Co. Ltd.

As a product of the combination of mobile Internet and cloud computing,mobile cloud computing has developed rapidly in recent years,and has spawned many new information services and application *** has received extensive attention from academia and *** cloud computing inherits cloud *** advantages of application dynamic deployment,resource scalability,multi-user sharing,and multi-service integration provide an effective way to solve the problem of limited resources of mobile terminals,but dynamic mobile users,limited terminal power,illegal access,and privacy *** the case of increasing security threats,there are still many research *** management is a prominent security issue in mobile cloud *** goal of trust building is to ensure that the data is trustworthy,authentic,reliable and *** mobile cloud computing,trust is a very important parameter in mobile cloud computing security because data storage and data processing are performed remotely in the *** computing environment of the mobile Agent system security and trust management issues,first SPKI trust mechanism is proposed based on an objective Mobile Agent System,such as trust management model（MAOTM）,unified solution Mobile Agent System authentication,authorization to operate and access control issues;on this basis,drawing on human trust mechanism（Human Trust Mechanism,HTM）,focusing on the formation of subjective trust,confidence and trust propagation laws of evolution,dynamic management algorithm proposed subjective trust（MASTM）,based on Mobile Agent and execution host of interactive experiences and recommendation information to third parties collect data based on trust,credibility given host selection algorithm,isolated malicious hosts trust calculation algorithms and integrated algorithm,choose to trust the fleet,malicious hosts a stand alone features to enhance the mobile Agent host interaction effects and *** algorithm simulation a

关键词： Cloud computing Mobile Agent System Subjective trust Objective trust Dynamic trust management Mobile Internet

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