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Changes of the peripapillary vascular parameters inpremature infants without retinopathy of prematurityusing U-net segmentation

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1453-1461页

作者： Shuai Liu Lei Liu Cui-Xia Ma Liu-Hui Huang Bin Li School of Information Science and Technology University of Science and Technology of ChinaHefei 230022Anhui ProvinceChina Zhejiang Lab Hangzhou 311121Zhejiang ProvinceChina Eye institute Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226006Jiangsu ProvinceChina anhui province Maternity and Child Health Hospital Maternity and Child Health Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Ophthalmology Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China

AIM:To quantitatively assess the changes in mean vascular tortuosity(mVT)and mean vascular width(mVW)around the optic disc and their correlation with gestational age(GA)and birth weight(BW)in premature infants without retinopathy of prematurity(ROP).METHODS:A single-center retrospective study included a total of 133(133 eyes)premature infants[mean corrected gestational age(CGA)43.6wk]without ROP as the premature group and 130(130 eyes)CGA-matched fullterm infants as the control *** peripapillary mVT and mVW were quantitatively measured using computerassisted ***:Premature infants had significantly higher mVT(P=0.0032)and lower mVW(P=0.0086)by 2.68(10^(4) cm^(-3))and 1.85μm,*** analysis with GA showed significant differences(P=0.0244)in mVT between the early preterm and middle to late preterm groups,but the differences between mVW were not significant(P=0.6652).The results of the multiple linear regression model showed a significant negative correlation between GA and BW with mVT after adjusting sex and CGA(P=0.0211 and P=0.0006,respectively).For each day increase in GA at birth,mVT decreased by 0.1281(10^(4) cm^(-3))and for each 1 g increase in BW,mVT decreased by 0.006(10^(4) cm^(-3)).However,GA(P=0.9402)and BW(P=0.7275)were not significantly correlated with ***:Preterm birth significantly affects the peripapillary vascular parameters that indicate higher mVT and narrower mVW in premature infants without *** in these parameters may provide new insights into the pathogenesis of ocular vascular disease.

关键词： premature infants retinopathy of prematurity retinal vessels parameter computer-assisted techniques

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Uncovering the action mechanism of Shenqi Tiaoshen formula(参芪调肾方) in the treatment of chronic obstructive pulmonary disease through network pharmacology,molecular docking,and experimental verification

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Journal of Traditional Chinese Medicine 2024年第4期44卷 770-783页

作者： YANG Qinjun YIN Dandan WANG Hui GAO Yating WANG Xinheng WU Di TONG Jiabing WANG Chuanbo LI Zegeng School of Chinese Medicine Anhui University of Chinese Medicine anhui province Key Laboratory of the Application and Transformation of Traditional Chinese Medicine in the Prevention and Treatment of Major Pulmonary Diseases Department of Pharmacy the First Affiliated Hospital of Anhui Medical University institute of Traditional Chinese Medicine Respiratory Disease Prevention and Control Anhui Academy of Traditional Chinese Medicine Department of Respiratory the First Affiliated Hospital of Anhui University of Chinese Medicine Department of Chinese Medicine the Second Affiliated Hospital of Anhui Medical University

OBJECTIVE: To reveal the potential underlying mechanism of the Shenqi Tiaoshen formula(参芪调肾方, SQTS) in the treatment of chronic obstructive pulmonary disease(COPD) by utilizing network pharmacology, molecular docking, and experimental verification. METHODS: Multiple open-source databases and research related to Traditional Chinese Medicine or compounds were employed to screen active ingredients and corresponding potential targets of the SQTS. The protein-protein interaction network screened hub genes, the relevant molecular mechanism and gene regulation were initially identified through the Kyoto Encyclopedia of Genes and Genomes(KEGG) and Gene Ontology(GO) analysis, and molecular docking was used to confirm further the interaction of the main components bound to the core targets. In vivo experiments on the COPD combined Qi-deficiency syndrome rat model were performed to verify the intervention effects and predicted potential molecular mechanisms of the SQTS. RESULTS: This study selected 156 active compounds and 326 candidate targets for treating COPD. Quercetin, Nobiletin, Kaempferol, Luteolin, Ginsenoside Rh2 and Formononetin were probably the main active compounds of SQTS in COPD treatment as they affected the most COPD-related targets, and interleukin-1(IL-6), signal transducing activator of transcription 3(STAT3), matrix metalloproteinase-9(MMP9), vascular endothelial growth factor A(VEGFA), protein kinase B(AKT1), hypoxiainducible factor-1α(HIF-1α), and forkhead box O3(FoxO3) were identified as the hub genes associated with its therapeutic effect. KEGG analysis was mainly enriched in the signaling pathways closely related to inflammation, immunity and oxidative stress, such as HIF-1, tumor necrosis factor(TNF), phosphatidylinositol 3 kinase(PI3K)-AKT, FoxO, apoptosis, IL-17, and toll-like receptor. Molecular docking confirmed that the main active components shared a good affinity with the hub genes. In vivo experiments, the SQTS was found to improve the body w

关键词： Shenqi Tiaoshen formula experimental validation inflammation molecular docking simulation network pharmacology pulmonary disease, chronic obstructive

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A compact route for efficient production of high-purity β-Ga2O3 powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou Gao-Jie Chen Liang Xu Zhi-Jun Shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of Technology Low-Carbon Research institute Anhui University of Technology

The present study has proposed a compact process for the production of high-purity β-Ga2O3powder by simply using gallium metal and water as the raw materials. The process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product of β-Ga2O3. Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization. X-ray diffractometer（XRD）, scanning electron microscopy（SEM）, thermogravimetryDdifferential scanning calorimetry（TG-DSC） and X-ray photoelectron spectroscopy（XPS） were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH to β-Ga2O3by calcination. Chemical analysis of the final product of β-Ga2O3obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry（ICP-MS）, and the results showed that the contents of the representative impurities such as Ni, Cu, In, Mn, Co, Zn and Cr are obviously lower than the requirement of 5N β-Ga2O3standard, exhibiting excellent application prospect of the proposed process to produce high-purity β-Ga2O3.

关键词： Calcination Hydrothermal synthesis Purity Reaction mechanism β-Ga2O3

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CFD simulation of pumping ventilation in a three-story isolated building with internal partitioning:Effects of partition widths,heights and locations

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Building Simulation 2024年第2期17卷 267-284页

作者： Huai-Yu Zhong Jie Sun Chao Lin Song-Heng Wu Jin Shang Hideki Kikumoto Fu-Ping Qian Carlos Jimenez-Bescos Fu-Yun Zhao School of Energy and Environment Anhui University of TechnologyMa-An-ShanAnhui Province243002China State Key Laboratory of Green Building in Western China Xi’an University of Architecture&TechnologyXi’anShaanxi ProvinceChina School of Power and Mechanical Engineering Wuhan UniversityWuhanHubei Province430072China institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo153-8505Japan School of Built and Natural Environment University of DerbyDerbyUK

Pumping ventilation(PV),a special single-sided ventilation(SSV),has been certified as an effective strategy to improve the air exchange rate of ***,most studies targeted on the single space,and few studies have been focused on the effect of internal partitioning on *** paper aims to evaluate the ventilation performance of PV influenced by different configurations of internal *** fluid dynamics(CFD)simulation was used to predict the flow fields and ventilation *** width(w/H),height(h/H)and location(d/H)are the three main internal partition parameters considered in this *** simulation results showed that the total,mean and fluctuating ventilation rates all decrease with wider internal *** normalized total ventilation rate decreases by 7.6%when w/H is increased from 50%to 75%.However,the reduction rate is only 0.23%between w/H=0 and 25%,and only 0.61%between w/H=25%and 50%.The ventilation rate is hardly reduced by increasing the partition width when w/H50%.Increasing the partition height will reduce the mean ventilation rate but promote the fluctuating and total ventilation rate in some *** increase of total ventilation rate by 1.4%is observed from h/H=50%to 75%.The ventilation rate is larger when the internal partition is attached to the leeward or windward *** total,mean and fluctuating ventilation rates for d/H=50%are relatively higher than d/H=0 by 1.5%,3.1%and 0.8%,*** the internal partition should be mounted attached to the windward wall so as to obtain the greatest pumping ventilation *** periodicity of pumping flow oscillation and pumping frequency are independent of the partition *** peak power of pumping flow is the lowest for the widest internal partition and is negatively affected by the partition height,but it generally has a positive correlation with the distance between the partition and leeward wa

关键词： pumping ventilation single-sided ventilation internal partitioning periodic oscillation ventilation rate

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New material of Coniopteris simplex from the Middle Jurassic of the Ordos Basin,Inner Mongolia,China and implications on its spatio-temporal distribution and paleogeography

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Journal of Palaeogeography 2024年第2期13卷 199-211页

作者： Yun-Feng Li Chang-Lu Zhang Fei Liang Xiao Tan Fan-Hao Gong Chun-Lin Sun Tao Li Yu-Ling Na Research Center of Paleontology and Stratigraphy Jilin UniversityChangchun 130026Jilin ProvinceChina College of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina College of Paleontology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key Lab of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shenyang Center of geological Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Coniopteris simplex is a common component in many Jurassic ***,due to morphological variations in sterile fronds and incomplete preservation of reproductive organs,its classification has been controversial for a long ***,we present new material collected from the Middle Jurassic Yan’an Formation in the Ordos Basin,Inner *** new material reveals important morphological characters,including hemi-dimorphic fronds,two forms of sterile pinnae,short-stalked sori and sporangia on fertile fronds,annulus of sporangium composed of about 30 cells,in situ rounded triangular spores with protruded suture,and the lips of trilete laesura encircled by one or two rows of small *** on these observations,we emended the diagnosis of this common *** spatio-temporal distribution of Coniopteris simplex shows that the iconic species was restricted to the paleolatitudes ranging from 19.5°N to 48.9°N in the Northern Hemisphere during the Early—Late Jurassic,mainly distributed in the tropical to paratropical zones,and the paleolongitude ranging from 9.6°E to 129.3°E,which may be limited by the opening of the Viking Corridor and the splitting of the Central Atlantic Ocean.

关键词： Coniopteris simplex Yan'an Formation Middle Jurassic Inner Mongolia Paleogeography

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Removal of rubidium from brine by an integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide

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Chinese Journal of Chemical Engineering 2024年第5期69卷 112-121页

作者： Huanxi Xu Peihua Lin Pei-Jun Liu Hai-Gang Liu Hui-Bin Guo Chao-Xiang Wu Ming Fang Xu Zhang Guan-Ping Jin anhui province Engineering Research Center of Flexible and Intelligent Materials School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Chemical Design and Research institute Co. LTD of Qinghai ProvinceQinghai Engineering and Technology Research Center of Fine ChemicalXining 810008China

A novel integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide(KCuFC/SPSG)was used for selectively extracting rubidium ion(Rb^(+))from *** form KCuFC/SPSG,the precursor film of sulfonated polysulfone/graphene(SPSG)was synthesized by phase conversion process,which was alternately immersed in 0.1 mol·L^(-1)CuSO_(4)/K_(4)[Fe(CN)_(6)]by in-situ adsorption coupled co-precipitation *** data such as nuclear magnetic resonance spectrometer,Fourier transform infrared spectroscope,X-ray photoelectron spectroscope,X-ray diffraction,scanning electron microscope,and energy dispersive spectroscopy all verified that abundant KCuFC were uniformly located on the *** resulting KCuFC/SPSG was used in film separation *** the solution was fed into the system,the Rb^(+)could be selectively adsorption by KCuFC/*** the saturation adsorption,0.5 mol·L^(-1)NH_(4)Cl/HCl was fed into the film cell,Rb^(+)could be quickly desorbed by ion-exchange between Rb^(+)and NH_(4)^(+)in the lattice of *** purpose of separating and recovering Rb^(+)from the brine can be achieved after the repeated *** effects of pH,adsorption time,and interferential ions on the adsorption capacity of Rb^(+)were investigated by batch *** adsorption behavior fits the pseudo-second order kinetic process,while KCuFC has a higher adsorption capacity(Langmuir maximum sorption 165.4 mg·g^(-1)).In addition,KCuFC/SPSG shows excellent selectivity for Rb^(+)even in complex brine ***/SPSG could maintain 93.5%extraction efficiency after five adsorption/desorption cycles.

关键词： Rubidium extraction Potassium copper ferricyanide Sulfonated polysulfone Graphene oxide Adsorption

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Exploring Long-Memory Process in the Prediction of Interval-Valued Financial Time Series and Its Application

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Journal of Systems Science & Complexity 2024年第2期37卷 759-775页

作者： SHEN Tingting TAO Zhifu CHEN Huayou School of Economics Anhui UniversityHefei 230601China Center for Financial and Statistical Research Anhui UniversityHefei 230061China Stony Brook institute at anhui University Anhui UniversityHefei 230601China Center for Applied Mathematics Anhui UniversityHefei 230601China

Long-memory process has been widely studied in classical financial time series analysis,which has merely been reported in the field of interval-valued financial time *** aim of this paper is to explore long-memory process in the prediction of interval-valued time series(IvTS).To model the long-memory process,two novel interval-valued time series prediction models named as interval-valued vector autoregressive fractionally integrated moving average(IV-VARFIMA)and ARFIMAX-FIGARCH were *** the developed long-memory pattern,both of the short term and long-term influences contained in IvTS can be *** an application of the proposed models,interval-valued form of WTI crude oil futures price series is *** to current IvTS prediction models,IV-VARFIMA and ARFIMAX-FIGARCH can provide better in-sample and out-of-sample forecasts.

关键词： ARFIMAX-FIGARCH interval-valued time series IV-VARFIMA long-memory process WTI crude oil futures price

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Analysis of Intraspecies Diversity of Rice Reveals Variation Patterns of Oryza sativa Basic Leucine Zippers

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 859-873页

作者： Jing Wang Wenqing Xiao Qingnan Wang Xu Wang Bin Jiang Yangchun Han Yang Sun anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases Key Laboratory for Conservation and Use of Important Biological Resources of Anhui ProvinceCollege of Life SciencesAnhui Normal UniversityWuhu241000China institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing210000China

The basic leucine zipper(bZIP)is an important class of transcription factors in plants,playing a critical role in plant growth and development and responses to biotic and abiotic *** to gene presence/absence variations,it is limited to identify bZIP genes based on the reference ***,we performed the bZIP gene family analysis in the rice *** employing a rice pan-genome,ninety-four OsbZIPs(72 core genes and 22 variable genes)were identified and divided into 11 groups in a phylogenetic *** upon Ka/Ks values in 33 accessions,OsbZIPs were subjected to different selection pressures during *** analysis of the effects of structural variations(SVs)on gene expression,gene structure,and conserved domains showed that SVs could significantly alter the expression levels of certain OsbZIPs,leading to gene truncation and the emergence of numerous atypical ***-four differentially expressed OsbZIPs were identified by analyzing RNA-seq data of the Xanthomonas oryzae ***(Xoo)infection susceptible(IR24)and resistant(IRBB67)lines under high temperature,and by counting the number of differentially expressed OsbZIPs in different *** Osb-ZIPs were found to respond to Xoo infection at an early stage and may not be involved in the mechanism of Xa4 and Xa7 resistance to *** multiple variation patterns of OsbZIP genes provide new insights into the OsbZIP genes in *** results provide new resources and offer new directions for functional studies of OsbZIPs.

关键词： Rice OsbZIP pan-genome structure variation atypical gene bacterial blight

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Multiple isotopes reveal the driving mechanism of high NO_(3)^(-) level and key processes of nitrogen cycling in the lower reaches of Yellow River

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Journal of Environmental Sciences 2024年第4期138卷 597-606页

作者： Qianqian Zhang Huiwei Wang Lu Liu Tianlun Zhai Xueqing Zhang Hebei and China geological Survey Key Laboratory of Groundwater Remediation Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesHebei 050061China Geo-Environmental Monitoring institute of Hebei province Hebei 050011China Hebei Provincial Laboratory of Water Environmental Science Hebei 050037China Hebei Provincial Academy of Ecological Environmental Science Hebei 050037China

The continuous increase of nitrate(NO_(3)^(-))level in rivers is a hot issue in the ***,the driving mechanism of high NO_(3)^(-)level in large rivers is still lacking,which has limited the use of river water and increased the cost of water *** this study,multiple isotopes and source resolution models are applied to identify the driving mechanism of high NO_(3)^(-)level and key processes of nitrogen cycling in the lower reaches of the Yellow River(LRYR).The major sources of NO_(3)^(-)were sewage and manure(SAM)in the low-flow season and soil nitrogen(SN)and chemical fertilizer(CF)in the high-flow *** was the most key process of nitrogen cycling in the ***,in the biological removal processes,denitrification may not occur *** temporal variation of contributions of NO_(3)^(-)sources were estimated by a source resolution model in the *** proportional contributions of SAM and CF to NO_(3)^(-)in the low-flow and high-flow season were 32.5%-52.3%,44.2%-46.2%and 36.0%-40.8%,54.9%-56.9%,*** driving mechanisms of high NO_(3)^(-)level were unreasonable sewage discharge,intensity rainfall runoff,nitrification and lack of nitrate removal *** control the NO_(3)^(-)concentration,targeted measures should be implemented to improve the capacity of sewage and wastewater treatment,increase the utilization efficiency of nitrogen fertilizer and construct ecological *** study deepens the understanding of the driving mechanism of high nitrate level and provides a vital reference for nitrogen pollution control in rivers to other area of the world.

关键词： Nitrate Driving mechanism Nitrogen cycle Source apportionment Transformation Yellow River

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A CNN-SVR model for NO_(2)profile prediction based on MAX-DOAS observations:The influence of Chinese New Year overlapping the 2020 COVID-19 lockdown on vertical distributions of tropospheric NO_(2)in Nanjing,China

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Journal of Environmental Sciences 2024年第7期141卷 151-165页

作者： Xin Tian Zijie Wang Pinhua Xie Jin Xu Ang Li Yifeng Pan Feng Hu Zhaokun Hu Mingsheng Chen Jiangyi Zheng Information Materials and Intelligent Sensing Laboratory of anhui province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Key laboratory of Environmental Optical and Technology Anhui Institute of optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China

In this study,a hybrid model,the convolutional neural network-support vector regression model,was adopted to achieve prediction of the NO_(2)profile in Nanjing from January 2019to March *** the sudden decline in NO_(2)in February 2020,the contribution of the Coronavirus Disease-19(COVID-19)lockdown,Chinese New Year(CNY),and meteorologi cal conditions to the reduction of NO_(2)was ***_(2)vertical column densities(VCDs) from January to March 2020 decreased by 59.05%and 32.81%,relative to the same period in 2019 and 2021,*** the period of 2020 COVID-19,the average NO_(2)VCDs were 50.50%and 29.96%lower than those during the pre-lockdown and post-lockdown pe riods,*** NO_(2)volume mixing ratios(VMRs)during the 2020 COVID-19 lock down significantly decreased below 400 *** NO_(2)VMRs under the different wind fields were significantly lower during the lockdown period than during the pre-lockdown period This phenomenon could be attributed to the 2020 COVID-19 *** NO_(2)VMRs be fore and after the CNY were significantly lower in 2020 than in 2019 and 2021 in the same period,which further proves that the decrease in NO_(2)in February 2020 was attributed to the COVID-19 *** source analysis of an NO_(2)pollution episode during the lockdown period showed that the polluted air mass in the Beijing-Tianjin-Hebei was trans ported southwards under the action of the north wind,and the subsequent unfavorable meteorological conditions(local wind speed of<2.0 m/sec)resulted in the accumulation o pollutants.

关键词： MAX-DOAS CNN-SVR Nitrogen dioxide COVID-19 Chinese New Year Regional transport

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