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Physical habitat condition as a key tool to maintain freshwater biodiversity in neotropical artificial ponds

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Water Biology and Security 2023年第3期2卷 30-35页

作者： Marden S.Linares Livia B.dos Santos Marcos Callisto Jean C.Santos Universidade Federal de Minas Gerais Instituto de Ciencias BiologicasDepartamento de GeneticaEcologia e EvoluçaoLaboratorio de Ecologia de BentosAv.Antonio Carlos 6627CEP 31270-901PampulhaBelo HorizonteMGBrazil Laboratorio de Macroecologia e Conservaçao da Biodiversidade Departamento de Botanica e EcologiaUniversidade Federal do Mato GrossoAv.Fernando Correa da Costa2367Boa EsperançaCuiabaMato GrossoCEP 78060-900Brazil Programa de Pos-Graduaçao em Ciencias Ambientais Instituto de Ciencias NaturaisHumanas e SociaisUniversidade Federal do Mato GrossoAvenida Alexandre Ferronato1200SinopMTCEP 78550-728Brazil Universidade Federal de Sergipe Departamento de EcologiaCampus Sao Cristovao-Cidade Universitaria Prof.Jose Aloísio de CamposCEP 49100-000Sao CristovaoSergipeBrazil

In areas highly affected by anthropogenic disturbances,artificial(human-made)freshwater ecosystems can provide habitat for maintaining and conserving regional freshwater *** assessed how the physical habitat of artificial ponds affected the structure of benthic macroinvertebrate *** do so,we tested two hypotheses.(1)Physical habitat disturbances are not detrimental to the diversity of nearby artificial ponds,and(2)Physical habitat disturbances do not cause significant shifts in taxonomic *** results rejected both null hypotheses,i.e.,macroinvertebrate diversity metrics correlated significantly and positively with Physical Habitat Integrity index scores,and only sites with high habitat condition scores were significantly associated with sensitive indicator *** results highlight the importance of maintaining physical habitat conditions for sustaining the ecological health of artificial ponds.

关键词： Bioindicators Ecosystem management Lentic ecosystems

An Online mtDNA Tool for Identification of Neotropical Psittacid Species and Taxonomic Issues:A Study Case of the Amazona ochrocephala Complex

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Natural Resources 2014年第11期5卷 634-652页

作者： Anderson Vieira Chaves Rodrigo Octavio de Paiva Queiroz-Filho Fabiano Augusto Assuncao Silva Cristina Yumi Miyaki Fabricio Rodrigues dos Santos Departamento de Biologia Geral Instituto de Ciencias Biologicas(ICB)Universidade Federal de Minas GeraisBelo HorizonteBrazil Policia Federal Belo HorizonteBrazil Departamento de genetica e Biologia Evolutiva Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil

Parrots are among the most popular pets in the world and they are also some of the most illegally traded, particularly in Brazil. Some computational tools were recently developed by researchers based on molecular databases for taxonomy support, forensic identification and conservation purposes. In this study, the DNA Surveillance platform was used to build an online database tool for molecular identification of Brazilian Psittacids using DNA sequences of six mitochondrial genes. To illustrate possible taxonomic issues of the online tool due to interspecific hybridization or unresolved taxonomy, we focused on Amazona aestiva that is considered as one of the most common parrots in Brazil, commonly bred as pets, and considered to be part of a species complex with Amazona ochrocephala from South America. We provide three curated sequence databases, which allow the species identification of individuals or tissue samples of birds of the Psittacidae family using mitochondrial DNA markers, and a comprehensive description of a taxonomic issue involving the A. ochrocephala complex. The results obtained corroborate previous studies suggesting that these species are not reciprocally monophyletic, due to either an ancient hybridization in central Brazil, or, they maybe just are morpho-varieties of the same species. Alternatively, if A. aestiva and A. ochrocephala were considered as sister species, the data could be interpreted either as a result of secondary contact or incipient speciation. Beyond the use of mtDNA for species identification, the high mtDNA haplotype diversity observed in A. aestiva indicates its potential use in discrimination of lineages that could be an important auxiliary tool to certify the captive origin of legally commercialized parrots.

关键词： Amazona aestiva Illegal Trade of Birds Psittaciformes Phylogeography DNA-Surveillance

Regulation of the m RNA half-life in breast cancer

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World Journal of Clinical Oncology 2014年第3期5卷 323-334页

作者： Paola Griseri Gilles Pagès United Orthopedic Corporation Genetica MedicaInstitute Giannina Gaslini University of Nice Sophia Antipolis Institute for Research on Cancer and Aging of Nice (IRCAN) UMR CNRS/7284 U INSERM 108106189 NiceFrance

The control of the half-life of m RNA plays a central role in normal development and in disease progression. Several pathological conditions, such as breast cancer, correlate with deregulation of the half-life of m RNA encoding growth factors, oncogenes, cell cycle regulators and inflammatory cytokines that participate in cancer. Substantial stability means that a m RNA will be available for translation for a longer time, resulting in high levels of protein gene products, which may lead to prolonged responses that subsequently result in over-production of cellular mediators that participate in cancer. The stability of these m RNA is regulated at the 3'UTR level by different mechanisms involving m RNA binding proteins, micro-RNA, long non-coding RNA and alternative polyadenylation. All these events are tightly interconnected to each other and lead to steady state levels of target m RNAs. Compelling evidence also suggests that both m RNA binding proteins and regulatory RNAswhich participate to m RNA half-life regulation may be useful prognostic markers in breast cancers, pointing to a potential therapeutic approach to treatment of patients with these tumors. In this review, we summarize the main mechanisms involved in the regulation of m RNA decay and discuss the possibility of its implication in breast cancer aggressiveness and the efficacy of targeted therapy.

关键词： mRNA stability Breast cancer RNA binding proteins MicroRNA Alternative polyadenylation

What physical habitat factors determine the distribution of gastropods in neotropical headwater streams?

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Water Biology and Security 2022年第4期1卷 61-67页

作者： Marden S.Linares Diego R.Macedo Rodrigo L.Massara Marcos Callisto Universidade Federal de Minas Gerais Instituto de Ciencias BiologicasDepartamento de GeneticaEcologia e EvoluçaoLaboratorio de Ecologia de BentosAv.Antonio Carlos 6627PampulhaCP 486Belo HorizonteMGCEP 30270-901Brazil Universidade Federal de Minas Gerais Instituto de GeocienciasDepartamento de GeografiaAv.Antonio Carlos 6627PampulhaBelo HorizonteMGCEP 30270-901Brazil Universidade Federal de Minas Gerais Instituto de Ciencias BiologicasDepartamento de GeneticaEcologia e EvoluçaoLaboratorio de Ecologia e ConservaçaoPrograma de Pos-graduaçao em EcologiaConservaçao e Manejo da Vida SilvestreAv.Antonio Carlos 6627PampulhaCP 486Belo HorizonteMGCEP 30270-901Brazil Instituto SerraDiCal de Pesquisa e Conservaçao Rua Jose Hemeterio de AndradeNo.570BuritisBelo HorizonteMGCEP 30493-180Brazil

Freshwater gastropods play a pivotal role in the structure and functioning of freshwater ecosystems,but despite their importance,there are still gaps in their *** goal was to understand what physical habitat factors are the most important for the distribution of freshwater gastropods in headwater stream ecosystems in the Neotropical Savanna and provide a baseline for conservation and management efforts for freshwater gastropods in this *** identified five taxa,each with different environmental *** presence related negatively with stream slope,Biomphalaria presence related positively with total dissolved solids and the proportions of cobble,fine sediment and organic *** presence correlated positively with elevation and the proportion of pools in the *** presence related negatively with total dissolved solids and positively with *** tuberculata presence correlated positively with the proportion of coarse *** results highlight the challenge for protecting native freshwater gastropod assemblages(and managing non-native invasive species),because environmental preferences vary widely amongst taxa and most are vulnerable to common anthropogenic disturbances.

关键词： Lotic ecosystems Alien species Water quality Freshwater gastropod conservation

Nitrate Transport, Sensing, and Responses in Plants

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Molecular Plant 2016年第6期9卷 837-856页

作者： Jose A. O'Brien Andrea Vega Eleonore Bouguyon Gabriel Krouk Alain Gojon Gloria Coruzzi Rodrigo A. Gutierrez Departamento de genetica Molecular y Microbiologia FONDAP Center for Genome Regulation Millennium Nucleus Center for Plant Systems and Synthetic Biology Pontificia Universidad Cat61ica de Chile 8331150 Chile Departamento de Fruticultura y Enologia Pontificia Universidad Catolica de Chile Santiago 7820436 Chile Departamento de Ciencias Vegetales Pontificia Universidad Catolica de Chile Santiago 7820436 Chile Department of Biology Center for Genomics and Systems Biology New York University New York NY 10003 USA SLaboratoire de Biochimie et Physiologie Moleculaire des Plantes Institut de Biologie Integrative des Plantes 'Claude Grignon' UMR CNRS INRA SupAgro UM 2 Place Viala 34060 Montpellier Cedex France

Nitrogen （N） is an essential macronutrient that affects plant growth and development. N is an important component of chlorophyll, amino acids, nucleic acids, and secondary metabolites. Nitrate is one of the most abundant N sources in the soil. Because nitrate and other N nutrients are often limiting, plants have developed sophisticated mechanisms to ensure adequate supply of nutrients in a variable environment. Nitrate is absorbed in the root and mobilized to other organs by nitrate transporters. Nitrate sensing activates signaling pathways that impinge upon molecular, metabolic, physiological, and developmental responses locally and at the whole plant level. With the advent of genomics technologies and genetic tools, important advances in our understanding of nitrate and other N nutrient responses have been achieved in the past decade. Furthermore, techniques that take advantage of natural polymor- phisms present in divergent individuals from a single species have been essential in uncovering new components. However, there are still gaps in our understanding of how nitrate signaling affects biolog- ical processes in plants. Moreover, we still lack an integrated view of how all the regulatory factors iden- tified interact or crosstalk to orchestrate the myriad N responses plants typically exhibit. In this review, we provide an updated overview of mechanisms by which nitrate is sensed and transported throughout the plant. We discuss signaling components and how nitrate sensing crosstalks with hormonal pathways for developmental responses locally and globally in the plant. Understanding how nitrate impacts on plant metabolism, physiology, and growth and development in plants is key to improving crops for sustainable agriculture.

关键词： nitrate nitrate transporters hormones N-foraging

Meningococcal disease, a clinical and epidemiological review

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1019-1029页

作者： Rodrigo Siqueira Batista Andreia Patricia Gomes Jorge Luiz Dutra Gazineo Paulo Sergio Balbino Miguel Luiz Alberto Santana Lisa Oliveira Mauro Geller Laboratorio de Agentes Patogenicos Departamento de Medicina e Enfermagem Universidade Federal de VicosaVicosaMGBrazil Curso de Medicina Faculdade Dinamica do Vale do PirangaPonte NovaMGBrazil Hospital Universitario Clementino Fraga Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Curso de Medicina Centro Universitario Serra dos Orgaos (UNIFESO)TeresopolisRJBrazil School of Medicine New York University–NYUNew YorkUSA Departamento de genetica Medica Universidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroRJBrazil

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals.

关键词： Neisseria meningitidis Bacterial infection Meningococcal disease

Screening chloroplast regions in Calophyllum brasiliense (Calophyllaceae) for suitability for population genetic analyses

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Journal of Forestry Research 2018年第4期29卷 978-985页

作者： Cecilia B. Percuoco Lucas G. Gimenez Liliana N. Talavera Stefani Jorge V. Crisci Carina F. Argüelles Laboratorio GIGA Instituto de Biologia Subtropical Nodo Posadas Universidad Nacional de Misiones (UNaM) Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Jujuy 1745 N3300NFK Posadas Misiones Argentina Catedra de genetica Molecular Facultad de Ciencias Exactas Quimicas y Naturales (FCEQyN) Universidad Nacional de Misiones (UNaM) Felix de Azara 1552 N3300LQH Posadas Misiones Argentina Laboratorio de Sistematica y Biologia Evolutiva (LASBE) Facultad de Ciencias Naturales y Museo (FCNyM) Universidad Nacional de La Plata-(UNLP) Avenida 122 y 60 1900 La Plata Buenos Aires Argentina

The uniparental inheritance and conserved structure of the chloroplast genome among many angiosperms makes it suitable for constructing gene lineages and inferring population histories based on these relationships. However, the analysis of a single chloroplast region to solve population issues has not yielded the desired amount of variability due to the low mutation rate. Therefore, it is necessary to screen and carefully analyze chloroplast intergenic or intronic regions to select the most appropriate for studying the genetic variability in the chloroplast genome of a particular taxon. In this context, the aim of this work was to characterize 8 regions in Calophyllum brasiliense using 11 selected primer pairs and to evaluate their usefulness for phylogeographic analysis. Intergenic spacers petA-psbJ, petG-trnP and rp132-trnL and the trnL intron demonstrated potentially informative sites. The combination of these 4 regions will allow the analysis of genetic population structure and the integration of historical aspects to inform strategies for conserving C. brasiliense, especially for highly impacted populations and those at risk of local extinction.

关键词： cpDNA cpSSRs Noncoding regions

An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

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Regenerative Biomaterials 2019年第6期6卷 335-347页

作者： Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello Technical Proteins Nanobiotechnology S.L. Paseo Belen 9AValladolid 47011Spain Departamento de traumatologıa Hospital Clınico de ValladolidAv.Ramon y Cajal 3Valladolid 47003Spain Bioforge University of Valladolid CIBER-BBNPaseo de Belen 19Valladolid 47011Spain SIBA-UVA:servicio investigacion y bienestar animal University of ValladolidC/Plaza de Santa Cruz 8Valladolid 47002Spain Instituto de Biologıa y genetica Molecular(IBGM) Universidad de Valladolid y CSICCalle Sanz y Fores 3Valladolid 47003Spain Facultad de veterinaria Campus UniversitarioAvda.Carballo Calero s/nLugo 27002Spain

The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral *** the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand ***,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the *** both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline *** conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis.

关键词： biopolymer animal test cartilage bone

Molecular Docking of 4-Tert-buthyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) on Fas Receptor (CD95)

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Journal of Cancer Therapy 2013年第1期4卷 176-181页

作者： Oscar Zuniga Victor HVazquez Ana Maria Velazquez Victor HAbrego Sandra Diaz-Barriga Arceo Patricia Ramirez Roberto Diaz Enrique Angeles Laboratorio de Toxicologia y genetica Departamento de C.BiologicasFacultad de Estudios Superiores CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Laboratorio de Quimica Medicinal Departamento de Ciencias Quimicas Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma de MexicoCuautitlan IzcalliMrxico.

The balance between cell proliferation and cell growth characterizes tissue homeostasis on one side and cell death on the other side. Fas receptor-mediated apoptosis is a control mechanism for tissue homeostasis, and avoiding this death pathway predisposes to many human diseases, including cancer. Current therapies for this disease are invasive and do not have the desired effect in the control of the disease. In this context, the search for new drugs that contribute to a better treatment is gaining more relevance. 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) [1,2] is a drug currently in preclinical stage, and we have shown that it has a hypertensive effect, similar to captopril, in a hypertensive rat model. Different studies have shown that some chemicals that are used as antihypertensive agents have an antineoplastic effect against certain types of cancer, as is the case of hydralazine [3], and captopril [4], among others [5]. On the other hand, it has been reported that morpholine derivatives may activate Fas (CD95)-mediated apoptosis. The aim of the present study was to show the interaction between CD95 (receptor) and thiomorpholine derivatives (ligand) using molecular modeling and docking studies, and to elucidate the possible action mechanism of 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol.

关键词： Fas Receptor (CD95) Fas Ligand (FasL) Docking