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Scraping therapy for knee osteoarthritis: a systematic review and Meta-analysis

Journal of Traditional Chinese Medicine 2024年第4期44卷 633-641页

作者： CHEN Dandan JIN Qianhong SHEN Yuanjuan WANG Qing DAI Zhengxiang School of Nursing Guangxi University of Chinese Medicine School of Nursing Nanjing University of Chinese Medicine general Surgery Department Jiangsu Province Hospital of Chinese Medicine Hospital Infection Control office Jiangsu Province Hospital of Chinese Medicine

OBJECTIVE: To systematically evaluate the efficacy of scraping therapy on knee osteoarthritis(KOA). METHODS: A computerized search was conducted in several databases, including PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure Database, China Science and Technology Journal Database,Wanfang, and Chinese BioMedical Literature Database,from the establishment date of these databases to April 9,2023. Randomized controlled trials(RCTs) on scraping therapy for KOA were collected in accordance with the “Participants-Intervention-Control-Outcome-Study design”criteria. The methodological evaluation of the included studies was carried out using RoB 2.0, and Meta-analysis was conducted using RevMan. The Grades of Recommendations Assessment, Development and Evaluation(GRADE System) was applied to grade the quality of evidence. RESULTS: A total of 12 RCTs with 997 subjects were included in the Meta-analysis. Results indicated that compared with the control group, the scraping therapy treatment group exhibited increased Lysholm scores [mean difference(MD) = 4.96, 95% confidence intervals(CI)(3.18, 6.74), P < 0.000 01] and Hospital for Special Surgery scores [MD = 8.35, 95% CI(3.92, 12.78), P = 0.0002] and decreased visual analog scale scores [MD =-2.11, 95% CI(-3.79,-0.44), P = 0.01] and Western Ontario and McM aster University Osteoarthritis Index scores [MD =-6.77, 95% CI(-8.99,-4.56), P < 0.000 01)]. The quality of evidence obtained in this Meta-analysis was low according to the GRADE system. CONCLUSION: The available evidence suggests that scraping therapy may have certain clinical efficacy in the treatment of KOA. However, further high-quality RCTs are needed to confirm the findings.

关键词： Meta-analysis osteoarthritis, knee scraping systematic review

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China Today 2024年第2期73卷 36-38页

作者： FOUKIS DIMITRIOS the Public Diplomacy office at the general Consulate of Greece in Shanghai

China’s Lunar New Year and Greece’s New Year’s Eve feature similar themes.G REECE and China have always diachronically pursued knowledge and cultural exchanges in a comprehensive *** it would be remiss of me not to underscore that our cooperation also embraces a wide range of other sectors,and in a similar spirit of mutual understanding and growth as in the cultural *** the bilateral relations context,mutual understanding and a win-win conceptual framework is the ultimate aim of this systematic forging of such synergies.

关键词： mutual exchanges spirit

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Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： Chenlu Zhu Xiao Ren Chen Liu Yawei Liu Yonggang Wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the general office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal *** in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s *** evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy *** study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s ***,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this *** Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD *** sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein *** conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-Chien Chen Lin-Ju Chou Shih-Chen Huang Ta-Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive officer's office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

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Latest Scientific Results of China's Lunar and Deep Space Exploration(2022–2024)

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空间科学学报 2024年第4期44卷 622-632页

作者： XU Lin LI Lei LIU Jianzhong LIN Honglei LI Yang LIU Yang XIE Lianghai ZHANG Jinhai QIAO Fuhao HAN Juanjuan ZOU Yongliao general office of the Lunar and Deep Space Exploration Chinese Academy of SciencesBeijng 100190 State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029

China has successfully launched six lunar probes so *** Chang'E-1 to Chang'E-4,they completed the circling,landing and roving exploration,of which Chang'E-4 was the first landing on the far side of the Moon in human ***'E-5 was launched in December 2020,bringing back 1731 g of lunar soil *** the detailed analysis of the samples,the scientists understand the history of late lunar volcanism,specifically extending lunar volcanism by about 800 million to 1 billion years,and proposed possible *** addition,there are many new understandings of space weathering such as meteorite impacts and solar wind radiation on the ***'s first Mars exploration mission Tianwen-1 was successfully launched in July *** the study of scientific data,a number of important scientific achievements have been made in the topography,water environment and shallow surface structure of *** paper introduces the main scientific achievements of Chang'E-4,Chang'E-5 and Tianwen-1 in the past two years,excluding technical and engineering *** to the large number of articles involved,this paper only introduces part of the results.

关键词： Lunar and deep space exploration of China Chang’E-4 mission Chang’E-5 mission Tianwen-1 mission

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Comprehensive Strategic Planning and Enhancement of China CDC Contributes to High-Quality Development of the National Disease Control and Prevention System

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China CDC weekly 2024年第4期6卷 61-63页

作者： Hongbing Shen Director-general of China CDC Academician of the Chinese Academy of EngineeringBeijingChina

The Chinese government has always attached great importance to disease control and prevention ***,the general office of China’s State Council issued the“Guidelines for High-Quality Development of Disease Prevention and Control”(hereinafter referred to as the“Guidelines”)(1).The Guidelines focus on promoting high-quality development of disease control and prevention and the strategic goal of“Healthy China,”providing specific implementation pathways for the development of national disease control and prevention in the new era,including overall planning,restructuring of governance,enhancing core capabilities,strengthening talent development,and improving organizational support.

关键词： prevention attached Quality

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Does ash dieback affect the reproductive ecology of Fraxinus excelsior L.?

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Journal of Forestry Research 2024年第2期35卷 54-69页

作者： Anna‑Katharina Eisen Lisa Buchner Barbara Fussi Susanne Jochner‑Oette Physical Geography/Landscape Ecology and Sustainable Ecosystem Development Catholic University of Eichstätt-Ingolstadt85072 EichstättGermany Bavarian office for Forest Genetics(AWG) 83317 TeisendorfGermany

Forest tree species reproduction is a key factor in maintaining the genetic diversity of future generations and the stability of forest *** ongoing ash dieback disease could affect the reproductive ecology of Fraxinus excelsior *** have a major impact on the quantity and quality of pollen and *** this study,we investigated pollen production and viability of pollen and seeds of ash trees with different health status from 2018 to *** were collected from 105 trees(pollen production),pollen from 125 trees(pollen viability),and seeds from 53 trees(seed quality)in two seed orchards and in one floodplain forest in southern *** all parameters were examined at every site every *** average pollen production per tree was estimated at 471.2±647.9 billion pollen *** addition,we found that a high number of inflorescences did not equate to high pollen production per *** production of healthy and diseased trees did not differ significantly,although only 47%of severely diseased male trees(vs.72%for healthy trees)produced *** regards to pollen viability,the TTC test showed an average viability of 73%±17%.Overall,there was a slight tendency for diseased trees to have less viable ***,a significant difference could only be calculated for trees in the floodplain *** percentage of germinable seeds in 2018 was 38%in the floodplain forest and 57%in one of the seed *** percentage of viable seeds(TTC test)ranged from 17 to 22%in the orchards in ***-viable seeds were usually heavily infested by *** general,seed quality was not significantly different between healthy and diseased *** results indicate that ash dieback affects flower formation and pollen viability but not pollen production or seed ***,the fact that hardly any flowering was observed,especially for trees that were seriously affected,suggests a negative effect of ash dieback on reproductive per

关键词： Common ash Seed orchard Floodplain forest Pollen production Viability TTC test Seed stratification Phenology

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QBIoT:A Quantum Blockchain Framework for IoT with an Improved Proof-of-Authority Consensus Algorithm and a Public-Key Quantum Signature

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Computers, Materials & Continua 2024年第7期80卷 1727-1751页

作者： Ang Liu Qing Zhang Shengwei Xu Huamin Feng Xiu-bo Chen Wen Liu Network and Information Management Division Beijing Electronic Science and Technology InstituteBeijing100070China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Institute Beijing Electronic Science and Technology InstituteBeijing100070China general office Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China

The Internet of Things(IoT)is a network system that connects physical devices through the Internet,allowing them to ***,IoT has become an integral part of our lives,offering convenience and smart ***,the growing number of IoT devices has brought about a corresponding increase in cybersecurity threats,such as device vulnerabilities,data privacy concerns,and network *** blockchain technology with IoT has proven to be a promising approach to enhance IoT ***,the emergence of quantum computing poses a significant challenge to the security of traditional classical cryptography used in blockchain,potentially exposing it to quantum *** support the growth of the IoT industry,mitigate quantum threats,and safeguard IoT data,this study proposes a robust blockchain solution for IoT that incorporates both classical and post-quantum security ***,we present the Quantum-Enhanced Blockchain Architecture for IoT(QBIoT)to ensure secure data sharing and integrity ***,we propose an improved Proof of Authority consensus algorithm called“Proof of Authority with Random Election”(PoARE),implemented within QBIoT for leader selection and new block ***,we develop a publickey quantum signature protocol for transaction verification in the ***,a comprehensive security analysis of QBIoT demonstrates its resilience against cyber threats from both classical and quantum *** summary,this research introduces an innovative quantum-enhanced blockchain solution to address quantum security concernswithin the realmof *** proposedQBIoT framework contributes to the ongoing development of quantum blockchain technology and offers valuable insights for future research on IoT security.

关键词： IoT quantum blockchain public-key quantum signature quantum hash function

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Seizing Opportunities for Further Advancements——Address at the 35th Anniversary Symposium of BES

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Biomedical and Environmental Sciences 2024年第1期37卷 1-2页

作者： SHEN Hong Bing Chinese Academy of Engineering Director general Chinese Center for Disease Control and Prevention

The year 2023 marks the 35^(th) anniversary of the establishment of Biomedical and Environmental Sciences(BES) by the Chinese Center for Disease Control and Prevention (China CDC).This milestone provides an opportunity to review past achievements and envisage future ***-Five-Year Progress and Achievements In 1988,Professor Chunming Chen,the founding Director general of the Chinese Academy of Preventive Medicine (CAPM,renamed the China CDC in 2002),established the international journal BES to publish research results from Chinese scientists in ***,Professor Chen,along with the renowned toxicologist Professor Frederick Coulston of Albany Medical College in the United States,jointly served as the editors-in-chief,propelling the growth and development of this pioneering journal,while the editorial team is composed exclusively of professionals from the China CDC,and the editorial office was located at the China CDC.

关键词： journal founding jointly

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Dual-directional regulation of spinal cord injury and the gut microbiota

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Neural Regeneration Research 2024年第3期19卷 548-556页

作者： Yinjie Cui Jingyi Liu Xiao Lei Shuwen Liu Haixia Chen Zhijian Wei Hongru Li Yuan Yang Chenguang Zheng Zhongzheng Li Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjinChina International Cooperation and Exchange office Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina International Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina

There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut *** spinal cord is a vital important part of the central nervous system;however,the underlying association between spinal cord injury and gut interactions remains *** studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut *** in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may impede recovery after spinal cord *** review summarizes existing clinical and basic research on the relationship between the gut microbiota and spinal cord *** research identified three key ***,the gut microbiota in patients with spinal cord injury presents a key characteristic and gut dysbiosis may profoundly influence multiple organs and systems in patients with spinal cord ***,following spinal cord injury,weakened intestinal peristalsis,prolonged intestinal transport time,and immune dysfunction of the intestine caused by abnormal autonomic nerve function,as well as frequent antibiotic treatment,may induce gut ***,the gut microbiota and associated metabolites may act on central neurons and affect recovery after spinal cord injury;cytokines and the Toll-like receptor ligand pathways have been identified as crucial mechanisms in the communication between the gut microbiota and central nervous *** microbiota transplantation,probiotics,dietary interventions,and other therapies have been shown to serve a neuroprotective role in spinal cord injury by modulating the gut *** targeting the gut microbiota or associated metabolites are a promising approach to promote functional recovery and improve the complications of spinal cord injury.

关键词： chemokines cytokines gut microbiota NLRP3 spinal cord injury Toll-like receptor ligand tryptophan

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