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Preterm neonate with a large congenital hemangioma on maxillofacial site causing thrombocytopenia and heart failure:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5756-5763页

作者： Neng Ren Chun-Shun Jin Xiao-Qi Zhao Wen-Hui Gao Yu-Xian Gao Yuan Wang Yun-Feng Zhang Department of Neonatology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Pediatrics The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND We report a rare case of a large congenital hemangioma(CH)in the maxillofacial region in a female neonate that caused thrombocytopenia and heart *** close multidisciplinary collaboration,the congenital hemangioma was successfully resected with good *** SUMMARY The patient was delivered at gestational age of 36 wk by cesarean section due to cephalopelvic disproportion and lack of onset of labor(birth weight:2630 g).A right-sided facial tumor was detected in the fetus during routine antenatal ultrasound examination of the mother at 32 wk of *** examination revealed a 7 cm×7 cm×3 cm hard,dull purple-colored mass on the right maxillofacial *** mass was tense and had prominent surface *** investigations revealed reduced hemoglobin and platelet count,and increased activated partial thromboplastin time,prothrombin time,and thrombin *** normalized ratio,fibrin degradation products,and D-Dimer levels were significantly *** showed increased alpha angle,mean amplitude,and the clot formation ***-stimulating hormone level was significantly *** patient was administered prednisone,propranolol,euthyrox,vitamin K1,milrinone,and *** operation,cefepime was administered for anti-infection and propranolol was prescribed at *** We report a rare case of CH in the right maxillofacial region causing thrombocytopenia and heart failure.

关键词： Congenital hemangioma Maxillofacial site Thrombocytopenia Heart failure Case report

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Expression of miR-1304 in patients with esophageal carcinoma and risk factors for recurrence

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World Journal of Gastroenterology 2020年第6期26卷 670-685页

作者： Yun-Gang Luo Li-Wei Duan Xuan Ji Wen-Yuan Jia Yun Liu Mao-Lei Sun Guo-Min Liu jilin Provincial Medicine Anti-Tumor Engineering center the Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Stomatology the Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Gastroenterology the Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Orthopedics the Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Esophageal carcinoma is a malignant gastrointestinal tumor with a very poor ***(miR)-1304 is a newly discovered non-coding RNA,which shows differential expression in other cancers,and its clinical value in esophageal carcinoma remains *** To explore the expression of miR-1304 in patients with esophageal carcinoma and its clinical *** The expression of miR-1304 in patients with esophageal carcinoma was analyzed based on the data on miR in esophageal carcinoma downloaded from The Cancer Genome Atlas *** real-time polymerase chain reaction was adopted to determine the expression of miR-1304 in the tissues and serum of *** clinical diagnostic value of miR-1304 and independent factors for recurrence and prognosis of esophageal carcinoma were then *** potential target genes of miR-1304 were predicted,and then analyzed based on gene ontology,Kyoto Encyclopedia of Genes,and Genomes,and protein-protein *** The expression of miR-1304 in the tissues and serum of patients with esophageal carcinoma increased,and was also increased according to the *** with high expression of miR-1304 suffered increased rates of tumor≥3 cm,low differentiation and stage II+***-1304 had a diagnostic value in identifying esophageal carcinoma,tumor size,differentiation and TNM *** size,differentiation,TNM stage,and miR-1304 were independent risk factors for recurrence of esophageal carcinoma,and they had certain predictive and diagnostic value for the recurrence of esophageal ***-eight patients showed a 3-year survival rate of 38.46%,and patients with high expression of miR-1304 had a relatively lower survival *** analysis revealed that tumor size,differentiation,recurrence and miR-1304 were independent factors for the prognosis of ***,miRDB,and Targetscan predicted 20 target genes in *** ontology enrichment analysis found 18 func

关键词： miR-1304 Recurrence Prognosis Diagnosis Bioinformatics analysis The Cancer Genome Atlas Esophageal carcinoma

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Bioinformatics analysis of microarray data to explore the key genes involved in HSF4 mutation-induced cataract

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 910-917页

作者： Rui Tian Yang Xu Wen-Wen Dou Hui Zhang Department of Ophthalmology the Second Hospital of Jilin University Department of Oral and Maxillofacial surgery School of Stomatology of Jilin University

AIM： To reveal the mechanisms of heat-shock transcription factor 4 （HSF4） mutation-induced ***： GSE22362, including 3 HSF4-null lens and 3 wild-type lens, was obtained from Gene Expression Omnibus database. After data preprocessing, the differentially expressed genes （DEGs） were identified using the limma package. Based on Database for Annotation, Visualization and Integrated Discovery （DAVID） tool, functional and pathway enrichment analyses were performed for the DEGs. Followed by protein-protein interaction （PPI） network was constructed using STRING database and Cytoscape software. Furthermore, the validated microRNA （miRNA）-DEG pairs were obtained from miRWalk2.0 database, and then miRNA-DEG regulatory network was visualized by Cytoscape software. RESULTS： A total of 176 DEGs were identified in HSF4-null lens compared with wild-type lens. In the PPI network, FBJ osteosarcoma oncogene （FOS）, early growth response 1 （EGR1） and heme oxygenase （decycling） 1 （HMOX1） had higher degrees and could interact with each other. Besides, mmu-miR-15a-5p and mmu-miR-26a-5p were among the top 10 miRNAs in the miRNA-DEG regulatory network. Additionally, mmu-miR-26a-5p could target EGR1 in the regulatory network. CONCLUSION： FOS, EGR1, HMOX1, mmu-miR-26a-5p and mmu-miR-15a-5p might function in the pathogenesis of HSF4 mutation-induced cataract.

关键词： cataract heat-shock transcription factor 4 differentially expressed genes protein-protein interaction network regulatory network

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World Journal of Gastroenterology 2024年第44期30卷 4689-4696页

作者： Dong-Ming Li Xue-Yuan Cao Jing Jiang Department of Gastric and Colorectal surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Clinical Epidemiology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Pancreatic cancer(PC),a highly lethal tumor with nearly identical incidence and mortality rates,has become the sixth leading cause of cancer-related *** is an important malignant factor in PC,as it regulates angiogenesis,metabolic reprogramming,tumor progression,and *** the hypoxic microenvironment can enhance the efficacy of antitumor therapy and improve the prognosis of patients with *** the advent of bioinformatics,hypoxia-related PC models have emerged in recent *** provide a reference for estimating the prognosis and immune microenvironment of patients with PC and identify potential biomarkers for targeting hypoxic ***,these findings based on bioinformatic analysis may not be completely reliable without further experimental evidence and clinical cohort *** application of these models and biomarkers in clinical practice to predict survival time and develop anti hypoxic therapeutic strategies for patients with PC remains in its *** this editorial,we review the current status of hypoxia-related prognostic models in PC,analyze their similarities and differences,discuss several existing challenges,and provide potential solutions and directions for further *** editorial will facilitate the optimization,validation,and determination of the molecular mechanisms of related models.

关键词： Pancreatic cancer Hypoxia Bioinformatics analysis Prognosis Tumor microenvironment

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Effect of glial cells on remyelination after spinal cord injury

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Neural Regeneration Research 2017年第10期12卷 1724-1732页

作者： Hai-feng Wang Xing-kai Liu Rui Li Ping Zhang Ze Chu Chun-li Wang Hua-rui Liu Jun Qi Guo-yue Lv Guang-yi Wang Bin Liu Yan Li Yuan-yi Wang Department of Neurosurgery First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Hepatobiliary and Pancreas surgery First Hospital of Jilin UniversityChangchunJilin ProvinceChina Hand& Foot surgery and Reparative& Reconstruction surgery center Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Emergency First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Cardiology First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of surgery School of MedicineUniversity of LouisvilleLouisvilleKYUSA Department of Orthopedics First Hospital of Jilin UniversityChangchunJilin ProvinceChina

Remyelination plays a key role in functional recovery of axons after spinal cord *** cells are the most abundant cells in the central nervous *** spinal cord injury occurs,many glial cells at the lesion site are immediately activated,and different cells differentially affect inflammatory reactions after *** this review,we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination *** astrocytes influence proliferation,differentiation,and maturation of oligodendrocyte precursor cells,while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord *** the interaction between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury.

关键词： nerve regeneration spinal cord injury remyelination oligodendrocyte precursor cells astrocytes oligodendrocytes microglia glial scar demyelination myelin central nervous system neural regeneration

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New strategy during complicated open appendectomy: Convert open operation to laparoscopy

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World Journal of Gastroenterology 2014年第31期20卷 10938-10943页

作者： Jin-Hui Zhu Wei Li Kai Yu Jia Wu Yun Ji Jian-Wei Wang Department of general surgery and Laparoscopic center The Second Affiliated Hospital Zhejiang University School of Medicine Department of general surgery Zhejiang Provincial People’s Hospital Department of Oncology the Second Affiliated Hospital Zhejiang University School of Medicine

AIM: To introduce a new strategy during complicated open appendectomy - converting open operation to laparoscopy.

关键词： Complicated appendectomy Open Laparoscopy Conversion Complication

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Effects of alcohol consumption on viral hepatitis B and C

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World Journal of Clinical Cases 2021年第33期9卷 10052-10063页

作者： Hong-Qin Xu Chun-Guang Wang Qiang Zhou Yan-Hang Gao Department of Hepatology The First Hospital of Jilin UniversityJilin UniversityChangchun 130021Jilin ProvinceChina Department of surgery The Second Hospital of Jilin UniversityJilin UniversityChangchun 130041Jilin ProvinceChina

The liver is the main target organ for hepatitis viruses and the vital organ for alcohol *** two factors of viral hepatitis and alcohol abuse in combination can exert dual harmful actions,leading to enhanced damage to the *** studies have revealed a higher prevalence of hepatitis C virus(HCV)infection among alcoholics than the general *** interaction of alcohol with viral hepatitis[e.g.,hepatitis B virus(HBV),HCV]and the underlying mechanisms are not fully *** effects of alcohol on viral hepatitis include promoted viral replication,weakened immune response,and increased oxidative ***,alcohol abuse is correlated with an increased risk of developing end-stage liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B and C,suggesting that the combination of alcohol and HBV/HCV lead to more severe liver *** influence of mild to moderate alcohol drinking on the HBV-induced liver fibrosis,cirrhosis,and hepatocellular carcinoma among patients infected with HBV remains *** HBV infected patients,no safe level of alcohol intake has been established for patients with *** light to moderate alcohol use can exert a synergistic effect with viral hepatitis,leading to the rapid progression of liver ***,interferon-based therapy is less effective in alcohol drinkers than in control patients,even after abstinence from alcohol for a period of ***,abstaining from alcohol is highly recommended to protect the liver,especially in individuals with HBV/HCV infection,to improve the clinical efficacy of antiviral treatment and prevent the rapid progression of chronic viral hepatitis.

关键词： Alcohol Hepatitis B virus Hepatitis C virus Viral hepatitis

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Arthroscopic surgery for synovial chondroma of the subacromial bursa with non-traumatic shoulder subluxation complications:Two case reports

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World Journal of Clinical Cases 2022年第5期10卷 1645-1653页

作者： Xiong-Feng Tang Yan-Guo Qin Xian-Yue Shen Bo Chen Ying-Zhi Li Orthpoeadic Medical center Jilin University Second HospitalChangchun 130041Jilin ProvinceChina

BACKGROUND Synovial chondromatosis is a disease originating from the synovium and characterized by the presence of metaplastic cartilaginous nodules in synovial *** exact prevalence of synovial chondromatosis remains unknown,and the involvement of the shoulder joint is very *** chondromatosis accompanied by subluxation of the humeral head without a history of trauma is rarely encountered,and to our knowledge,no published reports describe this *** SUMMARY We present two cases of synovial chondromatosis in the shoulder joint,accompanied by subluxation of the humeral head,in two arthroscopically managed adult *** performed arthroscopic labrum fixation and removal of the loose body from the shoulder *** identify primary and secondary categories,pathological analysis was *** and radiographic evaluations at the 1-mo follow-up were *** The biomechanical function of the shoulder joint requires attention,especially following the detection of loose bodies,as observed with synovial chondroma occurring in rare *** management is successful in patients with synovial chondromatosis combined with shoulder subluxation.

关键词： Synovial chondromatosis Shoulder Subluxation Arthroscopic surgery Case report

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Congenital dysfibrinogenemia misdiagnosed and inappropriately treated as acute fatty liver in pregnancy:A case report and review of literature

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World Journal of Clinical Cases 2022年第35期10卷 12996-13005页

作者： Yan Jia Xi-Wen Zhang Yi-Shi Wu Qing-Yu Wang Shu-Li Yang Department of Obstetrics and Gynecology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Orthopedic Medical center The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND The purpose of this study was to report the rare case of a pregnant woman with congenital dysfibrinogenemia(CD)misdiagnosed as acute fatty *** was treated according to the principles of acute fatty liver but achieved good clinical *** SUMMARY A 30-year-old woman presented with 39(6/7)wk of menopause and 6 h of irregular abdominal pain and attended our *** surgery was performed due to fetal *** management followed the treatment principle of acute fatty *** sequencing was carried out on the pregnant woman and her *** values of the patient on admission were prothrombin time 33.7 s,activated partial thromboplastin time 60.4 s,thrombin time 45.2 s,and fibrinogen 0.60 g/*** sequencing results showed that the woman carried a pathogenic heterozygous variation of the fibrinogen alpha chain gene(FGA),which is closely related to hereditary fibrinogen abnormality,and the mutation site was located in *** a follow-up period of 12 mo,the mother and her newborn had a good prognosis without bleeding or *** Pregnant women with CD may have atypical symptoms,which can easily lead to *** addition,treatment can be attempted according to the principles of acute fatty liver *** rare pregnant patient with CD was caused by a novel FGA(p.R350H)gene mutation.

关键词： Gene mutation Fibrinogen Congenital dysfibrinogenemia Pregnancy Case report

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Hepatoid adenocarcinoma of the rectal

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Hepatobiliary surgery and Nutrition 2023年第6期12卷 987-990页

作者： Sitong Zhou Ziqi Wang Hao Sun Shuo Han Pengda Sun Department of Gastrointestinal Nutrition and Hernia surgery The Second Hospital of Jilin UniversityChangchunChina Department of Breast surgery The Second Hospital of Jilin UniversityChangchunChina

We would here like to present a treatment experience of an interesting case of hepatoid adenocarcinoma(HAC),which is a very rare clinical malignancy of the gastrointestinal tract.A 58-year-old male was admitted to our hospital with intermittent hematochezia for 1 month.A computed tomography(CT)of the abdomen revealed the thickened anterior wall and nodules of the middle rectum,the lumen of which was narrowed.

关键词： admitted adenocarcinoma clinical

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