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Scraping therapy for knee osteoarthritis: a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 633-641页

作者： CHEN Dandan JIN Qianhong SHEN Yuanjuan WANG Qing DAI Zhengxiang School of Nursing Guangxi University of Chinese MedicineNanning 530200China School of Nursing Nanjing University of Chinese MedicineNanjing 210023China general Surgery Department Jiangsu Province Hospital of Chinese MedicineNanjing 210004China Hospital Infection Control office Jiangsu Province Hospital of Chinese MedicineNanjing 210004China

OBJECTIVE:To systematically evaluate the efficacy of scraping therapy on knee osteoarthritis(KOA).METHODS:A computerized search was conducted in several databases,including PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,and Chinese BioMedical Literature Database,from the establishment date of these databases to April 9,*** controlled trials(RCTs)on scraping therapy for KOA were collected in accordance with the“Participants-Intervention-Control-Outcome-Study design”*** methodological evaluation of the included studies was carried out using RoB 2.0,and Meta-analysis was conducted using *** Grades of Recommendations Assessment,Development and Evaluation(GRADE System)was applied to grade the quality of ***:A total of 12 RCTs with 997 subjects were included in the *** indicated that compared with the control group,the scraping therapy treatment group exhibited increased Lysholm scores[mean difference(MD)=4.96,95%confidence intervals(CI)(3.18,6.74),P<0.00001]and Hospital for Special Surgery scores[MD=8.35,95%CI(3.92,12.78),P=0.0002]and decreased visual analog scale scores[MD=-2.11,95%CI(-3.79,-0.44),P=0.01]and Western Ontario and McM aster University Osteoarthritis Index scores[MD=-6.77,95%CI(-8.99,-4.56),P<0.00001)].The quality of evidence obtained in this Meta-analysis was low according to the GRADE ***:The available evidence suggests that scraping therapy may have certain clinical efficacy in the treatment of ***,further high-quality RCTs are needed to confirm the findings.

关键词： osteoarthritis,knee scraping Meta-analysis systematicreview

Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： Chenlu Zhu Xiao Ren Chen Liu Yawei Liu Yonggang Wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the general office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal *** in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s *** evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy *** study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s ***,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this *** Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD *** sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein *** conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-Chien Chen Lin-Ju Chou Shih-Chen Huang Ta-Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive officer's office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

Navigating the hydrogen prospect:A comprehensive review of sustainable source-based production technologies,transport solutions,advanced storage mechanisms,and CCUS integration

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Journal of Energy Chemistry 2024年第10期97卷 166-215,I0005页

作者： Sehar Tasleem Chandra Sekhar Bongu Mohan Raj Krishnan Edreese Housni Alsharaeh College of Science and general Studies Alfaisal UniversityPO Box 50927Riyadh 11533Saudi Arabia

The review is a comprehensive discussion of current research advances,commercial scale developments,challenges,and techno-eco nomics for the entire H_(2) value chain,including production,mainly focusing on sustainable sources,storage,and *** challenges,advantages,and uses of H_(2) energy are included at ***,apart from the sustainable production approaches,the approaches and current developments for combating the carbon dioxide(CO_(2))emissions from existing H_(2) production facilities are highlighted in terms of ca rbon capture,utilization,and storage(CCUS).Concisely,the review discusses current material and recent technological adva ncements in developing pilot projects and large-scale establishments for viable and rapidly emerging sou rce-ba sed H_(2) productio ***,the review also aims to provide an in-depthdiscussion and explore current developments based on the advantages of H_(2) energy in terms of its utilization,based on its high energy density,and its ability to be used as a feedstock and *** the other hand,the challenges of H_(2) are also elabo ***,the role of CCUS in a carbon-neutral economy and value chain for minimization of emissions from existing facilities is thoroughly deliberated,and the recent commercial-scale implementation of CCUS technologies is *** the utilization and recycling of captured CO_(2) emissions along with H_(2) to produce e-fuels in terms of current advances is detailed in this *** rthermore,the most applicable,efficient,a nd develo ping approaches are discussed for physical and chemical H_(2) storage,considering recent la rge-scale implementations of liquid carriers and liquid organic hydrogen carriers as storage ***,the review elaborates on recent insights into advances in H_(2) transport infrastructure,including compressed and liquid H_(2) delivery via roads,ships,pipelines,and flight *** review gives precise insights into the recent scenario through

关键词： Source-based hydrogen Hydrogen utilization Carbon capture E-fuels Hydrogen storage Transport infrastructure

general practice trainee,supervisor and educator perspectives on the transitions in postgraduate training:a scoping review

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Family Medicine and Community Health 2024年第4期12卷 17-28页

作者： Michael Tran Joel Rhee Wendy Hu Parker Magin Boaz Shulruf Discipline of general Practice School of Clinical MedicineUniversity of New South WalesSydneyNew South WalesAustralia School of Medicine Western Sydney UniversitySydneyNew South WalesAustralia Discipline of general Practice School of Medicine and Public HealthThe University of NewcastleNewcastleNew South WalesAustralia office of Medical Education University of New South WalesSydneyNew South WalesAustralia

Transitions are a period and a process,through which there is a longitudinal adaptation in response to changing circumstances in clinical practice and *** the experience of the transition in medical student learning and in hospital-based specialty training programmes are well described and researched,the experience of the transition in community-based postgraduate general practitioner(GP)training has not been described *** We aimed to identify,and categorise,the formative experiences of transitions in GP training and their impacts on personal and professional *** We adopted Levac et al’s scoping review *** 1543 retrieved records,76 were selected for data *** on a combined model of the socioecological and multiple and multi-dimensional theories of transitions,data relating to the experiences of transitions were organised into contextual themes:being physical,psychosocial,organisational culture and *** criteria Empirical studies focused on general practice trainees or training,that discussed the transitions experienced in general practice training and that were published in English were *** sources PubMed,MEDLINE and Web of Science databases were searched in January 2024 with no date limits for empirical studies on the transition experiences of GP into,and through,*** Our findings describe context-dependent formative experiences which advance,or impede,learning and *** is a significant modulator of the factors contributing to more negative experiences,with some initially adverse experiences becoming more *** of the inflection point that represents a shift from initially adverse to more positive experiences of transitions may help moderate expectations for learning and performance at different stages of *** Challenges in training can either advance development and contribute positively to pr

关键词： finding initially programme

Public Organization Participation in the Prevention of Sexual Crimes against Minors and Adolescents:International Practices

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Journal of Forensic Science and Medicine 2024年第2期10卷 99-105页

作者： Saltanat Azhibekova Bibigul Kulmukhanbetova Department of Postgraduate Education Karaganda Academy of the Ministry of Internal Affairs of the Republic of Kazakhstan Named After Barimbek BeisenovKaragandaKazakhstan1Center for Research of Criminal Policy and Criminology IssuesLaw Enforcement Academy Under the Prosecutor General’s Office of the Republic of KazakhstanKosshyKazakhstan

Background:The study of how to prevent crimes against kids’and adolescents’sexual freedom and inviolability is an ongoing topic of interest for scientific-legal *** Kazakhstan,the trend of the dynamics of committing such crimes is relatively high,as in other countries,which indicates the need to change approaches and means to prevent such sexual *** and Objective:The goal of this study is to analyze statistical data on the number of crimes against minors and adolescents’sexual integrity in Kazakhstan,as well as the effectiveness of domestic and international best practices in combating this issue,as well as the level of public sector involvement in this *** and Methods:The issue under study is quite broad in its content;therefore,several scientific and methodological tools were used for its in-depth *** functional and dialectical approaches are specifically mentioned,along with the methods of analysis and synthesis,comparison,formal-legal procedure,and ***:Both theoretical and practical facets of the issue under investigation were examined as a result of the research that was ***,at the beginning of the study,all the necessary theoretical foundations for a qualitative understanding of the research object are ***:The practical part of the study determines the effectiveness of the available methods for preventing sexual crimes against minors and adolescents,considers the regulations governing this type of criminal offense,and analyses the approaches and tools used by foreign countries in this area.

关键词： Criminal offense physical violence rape sexual harassment sexual integrity

Latest Scientific Results of China's Lunar and Deep Space Exploration(2022–2024)

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空间科学学报 2024年第4期44卷 622-632页

作者： XU Lin LI Lei LIU Jianzhong LIN Honglei LI Yang LIU Yang XIE Lianghai ZHANG Jinhai QIAO Fuhao HAN Juanjuan ZOU Yongliao general office of the Lunar and Deep Space Exploration Chinese Academy of SciencesBeijng 100190 State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029

China has successfully launched six lunar probes so *** Chang'E-1 to Chang'E-4,they completed the circling,landing and roving exploration,of which Chang'E-4 was the first landing on the far side of the Moon in human ***'E-5 was launched in December 2020,bringing back 1731 g of lunar soil *** the detailed analysis of the samples,the scientists understand the history of late lunar volcanism,specifically extending lunar volcanism by about 800 million to 1 billion years,and proposed possible *** addition,there are many new understandings of space weathering such as meteorite impacts and solar wind radiation on the ***'s first Mars exploration mission Tianwen-1 was successfully launched in July *** the study of scientific data,a number of important scientific achievements have been made in the topography,water environment and shallow surface structure of *** paper introduces the main scientific achievements of Chang'E-4,Chang'E-5 and Tianwen-1 in the past two years,excluding technical and engineering *** to the large number of articles involved,this paper only introduces part of the results.

关键词： Lunar and deep space exploration of China Chang’E-4 mission Chang’E-5 mission Tianwen-1 mission

Comprehensive Strategic Planning and Enhancement of China CDC Contributes to High-Quality Development of the National Disease Control and Prevention System

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China CDC weekly 2024年第4期6卷 61-63页

作者： Hongbing Shen Director-general of China CDC Academician of the Chinese Academy of EngineeringBeijingChina

The Chinese government has always attached great importance to disease control and prevention ***,the general office of China’s State Council issued the“Guidelines for High-Quality Development of Disease Prevention and Control”(hereinafter referred to as the“Guidelines”)(1).The Guidelines focus on promoting high-quality development of disease control and prevention and the strategic goal of“Healthy China,”providing specific implementation pathways for the development of national disease control and prevention in the new era,including overall planning,restructuring of governance,enhancing core capabilities,strengthening talent development,and improving organizational support.

关键词： prevention attached Quality

China’s Initiatives and Achievements in Enhancing the Professional Capabilities of CDCs

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China CDC weekly 2024年第38期6卷 979-981页

作者： Hao Chen Ying Cui Kaixuan Liu Chengyu Lai Yuan Wang Qingfeng Chen Zhi Zeng Yang Mei office of Policy and Planning Research Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina.

Capacity building is essential for developing a robust disease control and prevention system(1).Recognizing this,on December 25,2023,the general office of China’s State Council issued the“Guidelines for Promoting the High-Quality Development of Disease Control and Prevention”(hereinafter referred to as the“Guidelines”)(2),emphasizing the need to enhance six key professional capabilities within the disease control and prevention *** Guidelines provide a foundational framework for the future growth and enhancement of centers for disease control and prevention(CDCs).

关键词： Professional prevention system.