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Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： Lin-yan Jiang Jun Tian Ya-nan Yang Shao-hui Jia Qing Shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair *** is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related *** comorbidities comprise a significant public health *** anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and *** treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side ***,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural *** this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was *** on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： Qian-Cheng Du Xin-Yu Wang Hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of general Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

Confinement of Fe atoms between MoS_(2) interlayers drives phase transition for improved reactivity in Fenton-like reactions

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Nano Research 2024年第3期17卷 1132-1139页

作者： Yibing Sun Yu Zhou Hongchao Li Chuan Wang Xuan Zhang Qian Ma Yingchun Cheng Jieshu Qian Bingcai Pan Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Flexible Electronics and Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China Department of general Dentistry Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Province Key Laboratory of Oral DiseasesNanjing 210029China Research Center for Environmental Nanotechnology(ReCENT) State Key Laboratory of Pollution Control and Resources ReuseSchool of EnvironmentNanjing UniversityNanjing 210023China

Phase manipulation of MoS_(2) from thermodynamically stable 2H phase to the unstable but more reactive 1T phase represents a crucial strategy for improving the reactivity in many *** widely adopted wet chemistry approach uses intercalating entities especially alkali metal ions to achieve the phase transition;however,these entities are normally inert for the target ***,we describe the first use of iron atoms for the intercalation of 2H-MoS_(2) layers,driving the partial transition from 2H to 1T ***,in the peroxymonosulfate(PMS)-based Fenton-like reactions,the interlayered confinement of Fe atoms not only activates the inert basal plane,but also adds more reactive Fe sites for the formation of metal-PMS complex as primary reactive species for pollutant *** the degradation of a model pollutant carbamazepine(CBZ),the Fe-intercalated MoS_(2) exhibits a first order rate constant 13.3 times higher than 2H-MoS_(2).This strategy is a new direction for manipulating the phase composition and boosting the catalytic reactivity of MoS_(2)-based catalysts in various scenarios,including environmental remediation and energy applications.

关键词： confinement MoS_(2) Fe atoms Fenton-like reactions hydrogen evolution reaction

摩洛哥卡萨布兰卡-穆罕默迪耶沿海地区波浪能资源分析

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Journal of Marine Science and Application 2022年第1期21卷 92-101页

作者： Laila Mouakkir Mohamed El hou Soumia Mordane Mohamed Chagdali Physics Department Polymer PhysicsMechanical Sciences and Materials LaboratoryFaculty of Sciences Ben M’sikUniversity HassanII20023Moroccan Regional direction DRMC General Direction of Meteorology80007Moroccan

In the last two decades,the exploitation of marine renewable energies(70%of the globe is made up of oceans),especially wave energy,has attracted great interest,not only for their high potential,but also for their high energy *** development of wave energy is suitable for countries or regions with extensive coastline and high waves approaching the *** paper focuses on the study of wave potential and wave energy distribution in the Casablanca-Mohammedia nearshore area(Moroccan Atlantic coast)in order to identify prospective wave energy *** achieve this purpose,the offshore wave potential was firstly estimated from a 20 years wave data provided by ECMWF(European Center for Medium range Weather Forecasts).In the second step,a numerical modeling of the wave propagation in the study area was performed using the SWAN model jointly with *** performance of the model to simulate accurately the wave field was evaluated in a real situation characterized by large *** model then was applied to determine the patterns of wave field in the Casablanca-Mohammedia nearshore area for a typical wave conditions(winter,summer and storm).The results of this study show the abundance of wave energy in the region with an average annual wave potential of about 22 kW/m.A seasonal variability of the wave resource was demonstrated,with values five times higher in winter than in *** addition,a major hotspot site was identified that should be considered when studyingWEC *** hotspot is located at the southern edge of the Casablanca-Mohammedia coast,near the coastal area of Sidi Rahal.

关键词： Wave energy Numerical wave modeling SWAN model WAVEWATCHIII model Casablanca-Mohammedia coast(Morocco)

The protective effects of fermented vinegar on acute alcohol-induced hepatic and neuro-toxicity by regulating ethanol metabolism and gut microbiota

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Food Science and Human Wellness 2024年

作者： Yuan Meng Yunfan Liu Ting Xia Beibei Geng Yinglei Tian Hailong Cao Jin Yan Xiaoqi Pang Kai Liang Yufeng Yan Min Wang State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Fermentation Microbiology College of Biotechnology Tianjin University of Science and Technology Department of Gastroenterology and Hepatology general Hospital Tianjin Medical University National Key Clinical Specialty Tianjin Institute of Digestive Diseases Tianjin Key Laboratory of Digestive Diseases Shanxi Provincial Key Laboratory for Vinegar Fermentation Science and Engineering Shanxi Zilin Vinegar Industry Co. Ltd.

Alcohol abuse constitutes a significant health hazard， leading to various organ damage， notably the liver and brain. Shanxi aged vinegar (SAV) is one of the famous fermented and functional foods containing a variety of bioactive ingredients with beneficial effects on the human body. This study aimed to explore the potential protective effect of SAV in alleviating acute alcohol intoxication (AAI) in mice. It was found that SAV at 2.5 mg/kg BW effectively ameliorated the decline in behavioral abilities following alcohol consumption， characterized by a shortened sobering period. SAV reduces alcohol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels. Additionally， SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels (AchE， 5-HT， and DA)， thereby reducing ethanol-induced brain damage. Meanwhile， SAV significantly decreased concentrations of alcohol and acetaldehyde in the blood and increased ADH and ALDH activities in the liver， indicating enhancement of ethanol metabolism. Moreover， we found that some gut microbiota including Verrucomicrobiota， Akkermansia， and Enterococcus were downregulated after SAV treatment in mice with AAI. These bacteria showed a negative correlation with anti-oxidative markers (GSH and CAT) and enzymes related to ethanol metabolism pathways (ADH and ALDH)， and a positive correlation with hepatic function markers (ALT， AST， and MDA)， alcohol metabolites (alcohol and acetaldehyde) and neurotransmitters (AchE， 5-HT， and DA). However， Bacteroidota， norank＿f＿Muribaculaceae， and Alistipes exhibited the opposite direction. These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity， and could be a potential functional food for AAI prevention.

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NIR-II fluorescence imaging in liver tumor surgery: A narrative review

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 29-44页

作者： Zihao Liu Lifeng Yan Qingsong Hu Dalong Yin Department of general Surgery Anhui Provincial Hospital Anhui Medical UniversityHefei 230001P.R.China Department of Hepatobiliary Surgery and Centre for Leading Medicine and Advanced Technologies of IHM The First A±liated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230001P.R.China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry and Department of Chemical Physics University of Science and Technology of China Hefei 230026P.R.China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230001P.R.China

In liver tumor surgery,the recognition of tumor margin and radical resection of microcancer focis have always been the crucial points to reduce postoperative recurrence of ***,naked-eye inspection and palpation have limited effectiveness in identifying tumor boundaries,and traditional imaging techniques cannot consistently locate tumors in real *** an intraoperative real-time navigation imaging method,NIRfluorescence imaging has been extensively studied for its simplicity,reliable safety,and superior sensitivity,and is expected to improve the accuracy of liver tumor *** recent years,the research focus of NIRfluorescence has gradually shifted from the-rst near-infrared window(NIR-I,700–900 nm)to the second near-infrared window(NIR-II,1000–1700 nm).Fluorescence imaging in NIR-II reduces the scattering effect of deep tissue,providing a preferable detection depth and spatial resolution while signi-cantly eliminating liver autofluorescence background to clarify tumor *** combined with tumor antibodies will further improve the precision offluorescence-guided surgical *** the development of a bunch offluorophores with phototherapy ability,NIR-II can integrate tumor detection and treatment to explore a new therapeutic strategy for liver ***,we review the recent progress of NIR-IIfluorescence technology in liver tumor surgery and discuss its challenges and potential development direction.

关键词： Fluorescence guided-surgery liver cancer near infrared-II optical imaging

The effect of Saccharomyces cerevisiae on digestion and mortality in the volcano rabbit(Romerolagus diazi)

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Journal of Integrative Agriculture 2015年第3期14卷 520-525页

作者： Rogelio Campos-Morales Germán D Mendoza Javier Ojeda Fernando X Plata José A Martínez Nutrition Area Surveillance General Direction of Zoos Mexico from City and Wildlife México Master Program in Animal and Agricultural Sciences Metropolitan Autonomous University (Xochimilco Unit)

An experiment was conducted to evaluate whether supplementation with a probiotic could enhance digestion and reduce mortality in the volcano rabbit in captivity. Two enclosures at Chapultepec Zoo, Mexico（114 individuals） were used in a crossover design（two periods of 60 days） with the following treatments： control group and supplementation with Saccharomyces cerevisiae（2×108 CFU/exhibit/day）. Supplementation with the probiotic negatively affected（P〈0.01） the digestibility of dry matter, organic matter, neutral detergent fiber（NDF） and energy. Mortality increased（P〈0.04） following supplementation with the probiotic（4.26% vs. 8.89%）, primarily in the juvenile rabbits. The results indicate that yeast supplementation in the volcano rabbit negatively affects digestion and mortality in captivity.

关键词： Saccharomyces cerevisiae volcano rabbit digestibility mortality

New insights into mechanisms and interventions of locoregional therapies for hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 167-194页

作者： Hanyuan Liu Chunmei Wang Ruiqiang Wang Hengsong Cao Yongfang Cao Tian Huang Zhengqing Lu Hua Xiao Mengcheng Hu Hanjin Wang Jun Zhao Department of general surgery Nanjing First HospitalNanjing Medical UniversityNanjing 210019China Department of Oncology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China School of Public Health China Medical UniversityShenyang 110122China Hepatobiliary/Liver Transplantation Center the First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor TransplantationChinese Academy of Medical SciencesNanjing 210024China Department of Gastroenterology the Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211103China Department of Nuclear Medicine the Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213001China

Hepatocellular carcinoma(HCC) is responsible for a significant number of cancer-related deaths worldwide and its incidence is increasing. Locoregional treatments, which are precision procedures guided by imaging to specifically target liver tumors, play a critical role in the management of a substantial portion of HCC cases. These therapies have become an essential element of the HCC treatment landscape, with transarterial chemoembolization(TACE)being the treatment of choice for patients with intermediate to advanced stages of the disease. Other locoregional therapies, like radiofrequency ablation, are highly effective for small, early-stage HCC. Nevertheless, the advent of targeted immunotherapy has challenged these established treatments. Tyrosine kinase inhibitors(TKIs) and immune checkpoint inhibitors(ICIs) have shown remarkable efficacy in clinical settings. However, their specific uses and the development of resistance in subsequent treatments have led clinicians to reevaluate the future direction of HCC therapy. This review concentrates on the distinct features of both systemic and novel locoregional therapies. We investigate their effects on the tumor microenvironment at the molecular level and discuss how targeted immunotherapy can be effectively integrated with locoregional therapies. We also examine research findings from retrospective studies and randomized controlled trials on various combined treatment regimens, assessing their validity to determine the future evolution of locoregional therapies within the framework of personalized, comprehensive treatment.

关键词： Locoregional therapies transarterial chemoembolization hepatocellular carcinoma immunotherapy tumor microenvironment

Misuse of the metabolic modulator meldonium in sports

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Journal of Sport and Health Science 2017年第1期6卷 49-51页

作者： Giuseppe Lippi Camilla Mattiuzzi Section of Clinical Biochemistry University Hospital of VeronaVerona 37134Italy Medical direction General Hospital of TrentoTrento 38121Italy

*** structure and molecular activity of meldonium Meldonium(commercial name Mildronate)was originally synthesized in the mid-1970s at the Institute of Organic Synthesis of the Latvian Soviet Socialist Republic Academy... 详细信息

关键词： Misuse of the metabolic modulator meldonium in sports