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High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS

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Science China(Life Sciences) 2009年第7期52卷 651-656页

作者： GALLIGAN Derek C. LAMERS Susanna L. YU Stephanie SHAGRUN Lamia SALEMI Marco MCGRATH Michael S. Department of Laboratory Medicine Positive Health Program University of CaliforniaSan Francisco California 94110 USA gene johnson inc. St.Augustine Florida32080USA Pathologica inc. Burlingame California 94010 USA Department of Pathology Immunology and Laboratory Medicine University of FloridaGainesville Florida 32610 USA

Highly active antiretroviral treatment(HAART) has had a significant impact on survival of individuals with acquired immunodeficiency syndrome(AIDS);however,with the longer life-span of patients with AIDS,there is inc.easing prevalence of AIDS dementia complex(ADC) and other non-AIDS-defining illness,and cardiovascular diseases(CVD) are also *** influence of these varied disease processes on HIV-1 DNA concentration in brain tissues has not been thoroughly assessed in the post-HAART *** purpose of the current study is to clarify the impacts of ADC and other complications of HIV disease on the viral load in the brains in AIDS patients with *** examined autopsy specimens from the brains of thirteen patients who died from complications of AIDS with quantitative polymerase chain reaction(QPCR).All but one patient had received HAART prior to death sinc. *** patients died with severe CVD,multiple cerebrovascular atherosclerosis(CVA) throughout the brain and five patients died with *** patients had no ADC/CVA.A QPCR was used to measure the presence of HIV-1 DNA in six brain tissues(meninges,frontal grey matter,frontal white matter,temporal subcortex,cerebellum and basal ganglia).In the post-HARRT era,for non-ADC/CVA patients,HIV-1 DNA concentration in brain tissues was statistically higher than that in patients with *** a new finding,two patients who suffered from severe CVD,especially CVA,also had high concentrations of HIV-1 in brain compartments not showing ADC related *** our knowledge,this is the first report of a relationship between the CVA and HIV-1 viral burden in *** current observations suggest that HAART-resistant HIV reservoirs may survive within ADC lesions of the brain as well as the macrophage rich atherosclerosis,which needs to be confirmed by more AIDS cases with CVA.

关键词： HIV-1 AIDS dementia complex quantitative PCR DNA cardiovascular disease cerebrovascular atherosclerosis

Consistent constitutive modeling of metallic target penetration using empirical, analytical, and numerical penetration models

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Defence Technology（防务技术） 2016年第2期12卷 201-213页

作者： John(Jack) P.RIEGEL III David DAVISON R3 Technology Inc. 7324 Fountain Spring Ct. Shock Transients Inc.

Historically, there has been little correlation between the material properties used in(1) empirical formulae,(2) analytical formulations, and(3) numerical models. The various regressions and models may each provide excellent agreement for the depth of penetration into semi-infinite targets. But the input parameters for the empirically based procedures may have little in common with either the analytical model or the numerical model. This paper builds on previous work by Riegel and Anderson(2014) to show how the Effective Flow Stress(EFS) strength model, based on empirical data, can be used as the average flow stress in the analytical Walker–Anderson Penetration model(WAPEN)(Anderson and Walker,1991) and how the same value may be utilized as an effective von Mises yield strength in numerical hydrocode simulations to predict the depth of penetration for eroding projectiles at impact velocities in the mechanical response regime of the materials. The method has the benefit of allowing the three techniques(empirical, analytical, and numerical) to work in tandem. The empirical method can be used for many shot line calculations, but more advanced analytical or numerical models can be employed when necessary to address specific geometries such as edge effects or layering that are not treated by the simpler methods. Developing complete constitutive relationships for a material can be costly. If the only concern is depth of penetration, such a level of detail may not be required. The effective flow stress can be determined from a small set of depth of penetration experiments in many cases, especially for long penetrators such as the L/D = 10 ones considered here, making it a very practical approach. In the process of performing this effort, the authors considered numerical simulations by other researchers based on the same set of experimental data that the authors used for their empirical and analytical assessment. The goals were to establish a baseline with a full constitut

关键词：本构模型渗透模型数值模型金属靶材料性质流动应力程序模拟数值计算

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第2期2卷 51-59页

作者： Thierry Oddos Romain Roure James Leyden Valérie Bruère Christiane Bertin johnson & johnson Santé Beauté France Issy-les-Moulineaux France johnson & johnson Santé Beauté France Val-de-Reuil France KGL inc. Broomall USA

Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

关键词： Retinol DihydroxyMethylChromone Hyaluronic Acid Anti-Age Long-Lasting Effect

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加拿大多伦多红牛办公室

现代装饰 2015年第3期 52-57页

作者： johnson Chou Silke Stadtmueller Tom Arban Photography 姜敏华 johnson Chou inc.

项目地址加拿大项目面积465m^2设计单位johnson Chou inc.本案是设计师对原有红牛办公空间一次大规模的扩建项目：设计主要体现在三个方面：创造与原有设计理念相一致的空间,并在此基础上赋予其新的诠释;打造能够激发员工活力与创造思... 详细信息

项目地址加拿大项目面积465m^2设计单位johnson Chou inc.本案是设计师对原有红牛办公空间一次大规模的扩建项目：设计主要体现在三个方面：创造与原有设计理念相一致的空间,并在此基础上赋予其新的诠释;打造能够激发员工活力与创造思维的空间：使用材料主要来源于可再生资源。扩建项目一直延伸至红牛现有建筑空间的南侧,设置有酒吧/休息区、开放式办公区、会议区和私人办公室。设计着重子四个主要部分：酒吧/休息区,线性开放式工作站,以羊毛毡包覆的会议室,以及一个包覆有黑板的会议室。

关键词：办公室加拿大红牛多伦多设计单位办公空间扩建项目可再生资源

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Fused-core particle technology in high-performance liquid chromatography: An overview

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Journal of Pharmaceutical Analysis 2013年第5期3卷 303-312页

作者： Joseph J.Kirkland Stephanie A.Schuster William L.johnson Barry E.Boyes Advanced Materials Technology Inc. Complex Carbohydrate Research Center

The advent of superficially porous particles （SPPs） for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology, and widespread applications in many sciences. This report contains an overview of the SPP technology first developed in 2006 by Advanced Materials Technology, inc., for sub-3-11m particles, then expanded into a family of SPP products with different particle sizes, pore sizes and other physical parameters. This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds, usually based on solute size.

关键词： Superfcially porous particles Fused-core particles Core–shell particles Peptides Proteins Drug separations

Minimally manipulated autologous adherent bone marrow cells (ABMCs):a promising cell therapy of spinal cord injury

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Neural Regeneration Research 2015年第7期10卷 1058-1060页

作者： Kamana Misra Hatem E.Sabaawy Celvive inc. Departments of Neuroscience and Cell Biology RBHS-Robert Wood Johnson Medical School Rutgers University Cellular and Molecular Pharmacology and MedicineRBHS-Robert Wood Johnson Medical School Rutgers University Rutgers Cancer Institute of New Jersey Rutgers University

Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorr... 详细信息

关键词： bone cell Minimally manipulated autologous adherent bone marrow cells a promising cell therapy of spinal cord injury ABMCs MSCs

Effect of the Laser Heating of Nanotube Nuclei on the Nanotube Type Population

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Nano Research 2009年第10期2卷 818-827页

作者： Pavel Nikolaev William Holmes Edward Sosa Peter Boul Sivaram Arepalli Department of Energy Science Sungkyunkwan University300 Cheoncheon-dongJangan-guSuwon 440-746Korea Alan G.MacDiarmid NanoT ech Institute The University of Texas at Dallas800 West Campbell RoadRichardsonTX 75080USA ERC inc./NASA johnson Space Center Mail Stop ES-4P.O.Box 58561HoustonTX 77258USA

Many potential applications of carbon nanotubes are expected to benet from the availability of single-walled carbon nanotube materials enriched in metallic species,and specifically armchair *** present work focuses on the modification of the pulsed laser vaporization(PLV)technique to selectively produce certain carbon nanotube *** nuclei were“warmed-up”with an additional laser pulse,timed to coinc.de approximately with the nucleation *** effect of the second laser on the carbon vapor temperature was studied by emission *** type populations with and without warm-up were compared by means of absorption,photoluminescence,and Raman *** was found that the warm-up of nanotube nuclei with a laser pulse has a noticeable,albeit small,effect on the nanotube *** intensity of spectral features associated with(9,7)nanotube and its large chiral angle neighbors inc.eased,while small chiral angle nanotubes decreased,with exception of the(15,0)*** experiment demonstrates that nanotube population during PLV synthesis can be manipulated in a controlled fashion.

关键词： Nanotube synthesis pulsed laser vaporization nanotube population

Applying Gregory johnson’s Concepts of Scalar Stress to Scale and Information Thresholds in Holocene Social Evolution

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Journal of Social Computing 2022年第1期3卷 38-56页

作者： Laura J.Ellyson the Department of Anthropology Washington State UniversityPullmanWA 99163USA Terrestrial Archaeology Division SEARCH Inc.PensacolaFL 32503USA.

Although Gregory johnson’s models have influenced social theory in archaeology,few have applied or built upon these models to predict aspects of social organization,group size,or *** have been limited to small case ***,the relationship between a society’s scale and its information-processing capacities has been explored using the Seshat ***,I apply multiple-linear regression analysis to the Seshat data using Turchin and colleagues’9“complexity characteristics”(CCs)to further examine the relationship between the hierarchy CC and the remaining 8 CCs which inc.ude both aspects of a polity’s scale and aspects of what Kohler et ***“collective computation”.The results support johnson’s ideas that stratification will generally inc.ease with inc.eases in a polity’s scale(population,territory);however,stratification is also higher when polities inc.ease their developments in information-processing variables such as texts.

关键词： hierarchy scalar stress Seshat Databank multiple imputation multiple regression

Static generation and Control in Fiber Processing

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合成纤维 2004年第B10期33卷 38-38页

作者： Thomas W. Theyson Goulston Technologies inc. 700N johnson Street Monroe NC 28111USA

静电是纤维生产及后加工过程中常见的问题。介绍了美国高尔斯顿公司在抗静电方面的研究与开发。

关键词：静电纤维生产后加工抗静电