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Episodes 2006年第1期29卷 46-46页

作者： Colin Simpson gem Information Coordinator

The Coordinating Committee for Geoscience Programmes in East and Southeast Asia （CCOP） is an intergovernmental organization whose mission is to facilitate and coordinate the implementation of applied geoscience programmes in East and Southeast Asia in order to contribute to economic development and the improvement of the quality of life in the region. To this end, CCOP promotes capacity building, technology transfer, exchange of information and institutional linkages for sustainable resource development, management of geo-information, geo-hazard mitigation and protection of the environment （http：//***/***）.

关键词：北京地质环境地质资源可持续发展学术讨论

Nanoskin®-ACT—The Impact of Natural Membrane & Soft with Chronic and Untreated Wounds

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Journal of Biomaterials and Nanobiotechnology 2024年第3期15卷 39-50页

作者： Saqer Al Mualla Noura Salim Salman Salma Saeed Ns. Nasreen Abdelatif Mohamed Kanjou Gabriel Molina de Olyveira Pierre Basmaji Antônio Carlos Guastaldi Qassimi Hospital GEM International Sharjah United Arab Emirates Innovatecs-Biotechnology Research and Development So Carlos Brazil UNESP-IQ-Physical Chemistry Department Araraquara Brazil

Bacterial cellulose (BC) is a versatile biomaterial with unique properties that make it promising for various biomedical applications, including wound healing. The extracellular matrix (ECM) plays a crucial role in wound healing, providing a structural scaffold and signaling cues for cell migration and proliferation. This study investigates the potential of BC as a scaffold for ECM production and its effect on in vivo wound healing. In this work, the bacterial cellulose fermentation process is modified by the addition of Green Propolis and Usnic acid to the culture medium and natural materials before the bacteria are inoculated. In vivo behaviour using natural membranes for regenerative medicine is presented and it is in edit. Overall, our findings demonstrate the potential of BC as a scaffold for ECM production and its beneficial effects on in vivo wound healing. BC-based dressings may offer a novel approach to promoting wound healing and tissue regeneration in clinical settings. Further studies are warranted to optimize BC-based therapies and explore their full potential in regenerative medicine.

关键词： Bacterial Cellulose Biomaterials Nanomedicine Wound Healing Green Propolis and Usnic Acid

Biological factors driving colorectal cancer metastasis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An Zhao-Jin Yu Chen Fu Min-Jie Wei Long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

Provenance of Coloured gemstones-Availability,Testing Methods,Future Trends

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宝石和宝石学杂志 2018年第S1期20卷 145-146页

作者： Lore Kiefert Klemens Link Gübelin gem Lab Maihofstrasse 102

gemstones have fascinated mankind forever,and people traveled far to find *** Silk Road is one of the most traditional trade routes in the middle ages that was used to bring the precious stones to the European ***,eme... 详细信息

关键词： Provenance of Coloured gemstones-Availability,Testing Methods,Future Trends

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou Xinhui Huang Chunmei Zhang Yongjie Ma Jinqiu Hu Xiaoyan Bi Junyu Ma Mengyao Li Dong Lu Liang Hu Jiahua Fan Fuli Ya Department of Nutrition， School of Public Health， Dali University Department of Laboratory Teaching Center， School of Public Health， Dali University Department of Health Management， gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine School of Integrative Medicine， Shanghai University of Traditional Chinese Medicine School of Public Health， Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases， Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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Diversity of Gram negative bacteria antagonistic against major pathogens of rice from rice seed in the tropic environment

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Journal of Zhejiang University Science 2003年第4期4卷 463-468页

作者：谢关林 SOADAlgam SWINGSJ. MEWT.W. IstituteofBiotechnology ZhefiangUniversityHangzhou310029China LabofMicrobiology UniversityofGentGemBelgium EntomologyandPlantPathologyDivision InternationalRiceResearchInstituteManilaPhilippines

With the use of a seed washing technique, more than 4000 Gram negative bacteria were isolated by two improved isolation methods from 446 batches of 1 kg rice seed samples obtained from 22 provinces in the Philippines. They were initially characterized on the basis of colony morphology and results of biochemical and pathogenicity tests. Six hundred and fifty two strains were further identified by Biolog, from which 133 were selected for fatty acid methyl ester (FAME) analysis together with 80 standard reference!strains. Sixteen species or types of Pseudomonas and 17 genera of non pseudomonads were identified, more than one third of which have not been recorded in rice. The most predominant species observed were P. putida and P. fulva. About 17% of the strains of Pseudomonas and 2% of the non pseudomonads were antagonistic to one or more fungal or bacterial pathogens of rice. Rice seed is an important source of biological control agents.

关键词： Rice seed Non pathogenic bacteria Antagonistic bacteria Pseudomonas

Influence of natural deposition plane orientation on oedometric consolidation behavior of three typical clays from southeast coast of China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第11期14卷 767-777页

作者： Qi-yin ZHU Yin-fu JIN Zhen-yu YIN Pierre-Yves HICHER Department of Civil Engineering Shanghai Jiao Tong University LUNAM University Ecole Centrale de NantesGeM UMR CNRS 6183 Nantes France

The parameters obtained from oedometric consolidation tests are commonly used in the development of constitutive modeling and for engineering practice. This paper focuses on the influence of the natural deposition plane orientation on oedometric consolidation behavior of three natural clays from the southeast coast of China. Oedometer tests were conducted on intact specimens prepared by sampling at a series of angles relative to the natural deposition plane. For each specimen, yield stress,compressibility indexes, secondary compression, and permeability coefficients were determined. The influence of the sampling angle on these properties was investigated, revealing that yield stress, compression index, swelling index, creep index, ratio of secondary compression coefficient to compression index(Cae/Cc) and permeability coefficient were all dependent to some extent on the sampling angle. These findings indicate the role of the anisotropy due to the natural deposition on the oedometric consolidation behavior.

关键词： Clay Compressibility Consolidation Creep Permeability Natural deposition

Laparoscopic iliopubic tract repair for pediatric inguinal hernia has very low recurrence: an Indian experience

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World Journal of Pediatric Surgery 2020年第3期3卷 5-10页

作者： Sunil Kumar Nayak Ramakrishnan Parthasarathi Raghavendra Gupta G H V Subbaiah Rajapandian Nalankilli Vaiyapurigoundar Palanisamy Chinnusamy Palanivelu Minimal Access Surgery GEM Hospital and Research CentreCoimbatoreTamil NaduIndia

Background The aim of this study is to document results of laparoscopic iliopubic tract(IPT)repair for inguinal hernia in the pediatric age *** Hospital records of 190 children who underwent IPT repair between January 2015 and January 2020 were analyzed retrospectively for demographic details,variations between clinical,radiological and laparoscopic diagnosis,associated pathologies,operative time,hospital stay,postoperative complications and *** internal ring was narrowed by approximating IPT to conjoint tendon using 3-0 polypropylene continuous or interrupted *** In total,238 IPT repairs were done under general anesthesia in 190 children aged between 1 and 17 years.7.9%of children had phimosis,and three children had *** patients had undescended testis and another three IPT repairs were done in cases who presented with *** patent processus vaginalis(CPPV)was detected at the time of laparoscopy in 18.3%of *** far,166 children had been followed,and no recurrence was observed in any of these 96 of whom have completed more than 3 years after their ***,two patients developed hernia on the contralateral *** Laparoscopy is beneficial to pick up *** IPT repair for pediatric inguinal hernia is reproducible and safe with the least recurrence reported thus ***,further follow-up is ***,development of contralateral hernia needs to be investigated.

关键词： hernia Laparoscopic anesthesia

Effective antibacterial and phase change PEG/Cu2O@A-HNTs composites for melt-spun difunctional PA6 fiber

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Progress in Natural Science:Materials International 2022年第6期32卷 776-785页

作者： Mian Zhai Jialiang Zhou Zexu Hu Mugaanire Tendo Innocent Ruixue Wang Chao Jia Hengxue Xiang Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Jiangsu gem Advanced Fiber Materials Research Institute Co. Ltd

Serving as the only defensive line between pathogens and human body,personal protective equipment(PPE) is increasingly attractive among researchers because of their strong antibacterial and temperature control ***,efficient antibacterial properties and regenerative thermal control simultaneously remain unexplored in ***,one-dimensional halloysite nano tubes(HNTs) modified by acid etch method,are used to synthesis a multifunctional material of PEG/Cu2O@A-HNTs via in-situ reduction and physical adsorption which serves the above two ***/Cu2O@A-HNTs showed rapid bacterial inactivation and achieved 96.3% bacteriostatic rate against *** in only 20 *** a broad and complete inactivation spectrum included both *** and *** following a series of antibacterial ***,adsorption of 70 wt% PEG by acid etch HNTs is attributed to the nearly 3 times increased specific surface area compared with native *** enabled PEG/Cu2O@A-HNTs to attain a phase change enthalpy of 108.4 J/*** addition,using PEG/Cu2O@A-HNTs as additives,antibacterial and phase change fiber(APCF) were *** efficiency factor against *** and *** was above 99.99%,and retained a temperature control ability for 180s and 272s compared with PA6 fiber in hot and frigid environments respectively.

关键词： Antibacterial activity Halloysite nanotube Personal protective equipment Phase change material

MICROMECHANICAL MODELLING OF PHASE TRANSFORMATION BEHAVIOUR OF A TRANSITIONAL SOIL

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Acta Mechanica Solida Sinica 2014年第3期27卷 259-275页

作者： Chuang Yu Zhenyu Yin Dongmei Zhang College of Architecture and Civil Engineering Wenzhou University LUNAM University Ecole Centrale de Nantes UMR CNRS GeM Nantes France Department of Geotechnical Engineering College of Civil Engineering Tongji University

Experiments show that silts and silty soils exhibit contraction followed by dilation during shearing and the slope of failure line decreases at large strains, termed as phase transformation behaviour. This paper is to develop a new micromechanical stress-strain model that accounts for the phase transformation behaviour by explicitly employing the phase transformation line and its related friction angles. The overall strain includes plastic sliding and plastic compression among grains. The internal-friction angle at the phase transformation state and the void state variable are employed to describe the phase transformation behaviour. The model is examined by simulating undrained and drained triaxial compression tests performed on Pitea silts. The local stress-strain behaviour for contact planes is also investigated.

关键词： micromechanics silts constitutive models elastoplasticity anisotropy simulation