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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 19-20页

作者： Crowell M.D. Lacy B.E. Schettler V.A. 樊菁 gastrointest. physiol. and motility Div. of Gastroenterol. and Hepatol. Mayo Clinic Scottsdale 13400 E. Shea Blvd. Scottsdale AZ 85259 United StatesDr.

BACKGROUND: We hypothesized that functional anal incontinence with no structur al explanation comprises distinct pathophysiol.gic subgroups that could be ident ified on the basis of the predominant presenting bowel pattern. METHODS: Consecu tive patients (n = 80) were prospectively grouped by bowel symptoms as 1) incont inence only, 2) incontinence +constipation, 3) incontinence +diarrhea, and 4) incontinence +alternating bowel symptoms. The Hopkins Bowel Symptom Questionnai re, the Symptom Checklist 90-R, and anorectal manometry were completed. RESULTS : Significant group differences were found between subcategories of incontinent patients on the basis of symptoms. Abdominal pain was more frequent in patients with altered bowel patterns. Patients with alternating symptoms reported the hig hest prevalence of abdominal pain, rectal pain, and bloating. Basal anal pressur es were significantly higher in alternating patients (P = 0.03). Contractile pre ssures in the distal anal canal were diminished in the incontinent only and dia rrhea groups (P = 0.004). Constipated patients with incontinence exhibited eleva ted thresholds for the urge to defecate (P = 0.027). Dyssynergia was significant ly more frequent in patients with incontinence and constipation or alternating b owel patterns. CONCLUSIONS: Distinct patterns of pelvic floor dysfunction were i dentified in patient subgroups with anal incontinence, based on the presence or absence of altered bowel patterns. physiol.gic assessments suggested different p athophysiol.gic mechanisms among the subgroups. The evaluation of patients with fecal incontinence should consider altered bowel function.

关键词：肛门失禁功能失调肠道症状社会心理肛门直肠测压交替性便时盆底功能直肠痛腹胀症状

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TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve

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World Journal of Gastroenterology 1998年第2期4卷 70-72页

作者： Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ Shandong Univ Dept Physiol Jinan 250012 Shandong Peoples R China

AIM To investigate the effects of TRH in DVC on motility of the gallbladder in rabbits. METHODS After fasted for 15h - 18h , rabbits were anesthetized with urethane (1 0g/kg) . Gallbladder pressure (GP) was measured by a frog bladder perfused with normal saline. RESULTS After microinjection of TRH (8 8nmol, 1μl ) into DVC, GP was raised and the frequency of phasic contraction of gallbladder (FPCGB) increased. All the doses of TRH (0 13, 0 25, 0 50, 0 80, 1 30nmol , 1μl ) injected into DVC could excite the motility of gallblader. As the dose of TRH was enlarged, the amplitude and duration of the reaction increased. Effects of TRH in DVC on motility of the gallbladder could be completely abolished by atropine ( 0 2mg/g , i.v.) or vagotomy, but could not be inhibited by phentolamine iv (1 5mg/g) or propranolol iv (1.5mg/g) or by transecting the spinal cord. CONCLUSION Thyrotropin releasing hormone in DVC can excite motility of gallbladder. This effect was mediated by vagus nerves and peripheral M receptor. Its physiol.gical significance may be related to maintaining the phasic contraction of gallbladder in interdigestive period.

关键词： gallbladder vagus nerve dorsal vagal complex thyrotropin releasing hormone cholinergic M receptors rabbits

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Actions of genistein on contractile response of smooth muscle isolated from guinea pig gallbladder

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 614-619页

作者： Luo, Ya-Li Wang, Ya-Li Li, Neng-Lian Zheng, Tian-Zhen Zhang, Li She, Ya-Li Hu, Shu-Ming Gansu Coll Tradit Chinese Med Dept Pathol Dept Basic Med Lanzhou 730000 Peoples R China Lanzhou Univ Dept Physiol Coll Basic Med Lanzhou 730000 Peoples R China

BACKGROUND: Defective contractile motility of the gallbladder is an important factor for gallstone formation. Estrogen might increase the risk of gallstones and cholecystitis, and estradiol inhibits the contractile activity of isolated strips of guinea pig gallbladder. The potential risks associated with hormone replacement therapy (HRT) include symptomatic gallstones. Phytoestrogen have been used to treat menopause syndromes by replacing traditional estrogen. This experiment aimed to determine the effects of the phytoestrogen genistein on the contractile response of smooth muscle strips isolated from guinea pig gallbladder and its possible mechanism of action. METHODS: Guinea pigs were sacrificed to remove the whole gallbladder. Two or three smooth muscle strips were cut longitudinally. Each strip was suspended in a tissue chamber containing Krebs solution. After 2 hours of equilibration, contractile response indexes were recorded. Different concentrations of genistein were added to the chamber and the contractile responses were measured. Each antagonist was added 2 minutes before genistein to study possible mechanisms. The effect of genistein on calcium-dependent contraction curves and biphasic contraction in calcium-free Krebs solution were measured. RESULTS: Genistein decreased the resting tension dose-dependently, and reduced the mean contractile amplitude and frequency in gallbladder strips. Ranitidine partly inhibited the effect of genistein, but methylene blue, N(omega)-nitro-L-arginine, and propranolol hydrochloride did not influence this action. Genistein had no significant effects on calcium-dependent contraction. Genistein reduced the first contraction induced by acetylcholine chloride, but did not affect the second contraction caused by CaCl(2). CONCLUSIONS: Genistein relaxed smooth muscle isolated from the gallbladder of guinea pigs and this might contribute to the formation of gallstones. The inhibitory action might be related to H(2) receptors and th

关键词： genistein isolated gallbladder smooth muscle calcium channel H(2) receptor guinea pigs

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Separate locations of urocortin and its receptors in mouse testis： Function in male reproduction and the relevant mechanisms

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南京医科大学学报（自然科学版） 2007年第10期27卷 510-510页

作者： Tao, J. Lin, M. Sha, J. H. Tan, G. Soong, T. W. Li, S. N. Nanjing Med Univ Dept Pharmacol Key Lab Reprod Med Nanjing 210029 Peoples R China Natl Univ Singapore Dept Physiol Ion Channel ＆ Transporter Lab Singapore 0511 Singapore

Urocortin (UCN), a newly identified co rticotrophin-releasing-factor (CRF) related peptide, has been demonstrated to play important roles in female reproductive system。However, few studies were reported about its effects on male reproduction。This study aimed to investigate the expression profile of UCN and CRF receptors (CRFR) in mouse testis and functions of UCN in male reproduction。

关键词：睾丸促肾上腺皮质激素相关因子精子活力顶体反应精原细胞钙离子通道受体

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肝癌门静脉高压症诊断与监测的新技术(下)

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中华实验和临床感染病杂志（电子版） 2021年第2期15卷 144-144页

作者：祁小龙兰州大学第一医院兰州大学第一医院门静脉高压研究所(中心) 中国门静脉高压诊断与检测研究组中国人体健康科技促进会门静脉高压专业委员会美国肝病学会(AASLD)门静脉高压全球外联委员会 EBio Medicine(The LANCET family、IF:6.68) Hepatol Int(IF:5.490) Am J physiol.gastrointest.Liver physiol.IF:3.729)

【内容简介】本视频(下)部分重点介绍中国门静脉高压诊断与监测研究组(Chinese Portal Hypertension Diagnosis and Monitoring Study Group,CHESS)的核心工作以及研究成果。CHESS于2016年成立,核心工作为开展肝硬化门静脉高压领域的应... 详细信息

【内容简介】本视频(下)部分重点介绍中国门静脉高压诊断与监测研究组(Chinese Portal Hypertension Diagnosis and Monitoring Study Group,CHESS)的核心工作以及研究成果。CHESS于2016年成立,核心工作为开展肝硬化门静脉高压领域的应用基础研究、转化研究和前瞻性临床试验。目前,CHESS牵头的多中心研究已先后发表于“The Lancet Gastroenterology&Hepatology”、“Radiology”、“Journal of Hepatology”等国际一流期刊。2018年,CHESS牵头制定了《中国肝静脉压力梯度临床应用专家共识(2018版)》,这一“中国标准”先后获得全球多国权威医学杂志的翻译刊发。此外,CHESS参与制定了亚太肝病学会(Asian Pacific Association for the Study of the Liver,APASL)慢加急性肝功能衰竭指南并执笔门静脉高压章节。CHESS系列转化和临床研究不仅获得我国200余家高水平肝病诊疗中心的积极支持和广泛参与,还有效推动了与美国、西班牙、法国、英国、意大利、德国、瑞士、日本、印度、巴西、土耳其、泰国、缅甸、印度尼西亚、尼泊尔等国家的学术合作。

关键词：门静脉高压慢加急性肝功能衰竭诊疗中心肝静脉压力梯度学术合作前瞻性临床试验

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