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Open Journal of gastroenterology 2021年第10期11卷 194-202页

作者： Laté Mawuli Lawson-Ananissoh Lidawu Roland-Moïse Kogoe Venceslas Debehoma Redah Oumboma Bouglouga Rafiou El-Hadji Yakoubou Laconi Kaaga Aklesso Bagny Hepatogastroenterology unit University Hospital Campus Lomé Togo Hepatogastroenterology unit University Hospital of Kara Kara Togo

Background: Anemia is multifactorial and very frequently observed in the evolution of cirrhosis. Only biological investigations can clarify its mechanisms. Objective: To determine the frequency of anemia in cirrhosis patients and to identify the different types of anemia encountered. Patients and Methods: Descriptive and analytical study based on the retrospective collection of data was carried out over 12 months in the hepato-gastroenterology unit of the University Hospital Campus of Lome (Togo). This study included hospitalized cirrhotic patients with a complete medical file including a blood count and presenting anemia. Results: During the study period, we collected 253 cases of cirrhosis, of which 153 patients had anemia (60.5%);there was a male predominance of 73.2%. The mean age was 51 ± 13 years. The B viral origin of cirrhosis was the most common (60.1%). Oedemato-ascitic decompensation (82.4%) and hepatocellular carcinoma (34%) were the main complications

关键词： Anemia Blood Count Cirrhosis Hepatitis B Virus Togo

Trans-jugular intrahepatic portosystemic stent shunting benefits and limits

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 307-309页

作者： Salvatore Stefano Sciarrone Lucia Fini Luca De Luca Department of Surgery Gastroenterology and Digestive Endoscopy UnitASST Santi Paolo e CarloUniversity of MilanMilan 20142LombardyItaly

Trans-jugular intrahepatic portosystemic stent shunting(TIPSS)has been in use for many years with great results and many *** procedure essentially involves the insertion of a metal covert stent to create an Hepato-Hepatic portosystemic *** time,TIPSS has become the subject of many studies aimed at examining its clinical utility and evaluating the results of using TIPSS to manage complications related to portal *** the outset,this procedure has been met with hope and enthusiasm and give the chance to consider another possibility to treat the complications of portal hypertension without the use of *** that TIPSS is an attractive alternative to shunt surgery because it does not require the use of general anesthesia or laparotomy,in fact this method is applicable to many patients with severe liver disease not suitable for *** has been studied for the management of variceal bleeding,ascites,hepatic hydrothorax,hepatorenal syndrome,and other types of ***,some drawbacks of the TIPSS,such as shunt stenosis and hepatic encephalopathy,have also been reported in the *** the basis of the available evidence and the new epidemiological findings regarding liver disease,the following question may be posed:What is the place of TIPSS in current clinical practice?

关键词： Hepatic compensation Decompensation Trans-jugular intrahepatic portosystemic stent-shunt Bleeding Ascites

Can Emax and platelet count truly differentiate between benign and malignant liver lesions?

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World Journal of gastroenterology 2025年第3期31卷 120-122页

作者： Manjeet Kumar Goyal Omesh Goyal Department of gastroenterology and Human Nutrition unit All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of gastroenterology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet *** notable findings,significant methodological and interpretative limitations are *** study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold *** nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with ***,the study's limitations,such as selection bias and confounding factors,are not adequately *** research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.

关键词： Emax Platelet count Benign liver lesions Malignant liver lesions Hepatocellular carcinoma Cirrhosis Diagnostic biomarkers Shear wave elastography Methodological limitations Clinical utility

Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis

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World Journal of gastroenterology 2025年第7期31卷 26-38页

作者： Yi-Kang Song Lin Zheng Ai-Xin Liu Jun-Ji Ma Department of gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000Hebei ProvinceChina

BACKGROUND Fungal esophagitis(FE)is caused by fungal invasion of the esophageal *** endoscopy,the esophageal mucosa shows edema,congestion,erosion,and ulceration,and bleeds easily when touched,and the surface of the mucosa is covered with small white spots like"bean curd residue".Clinical cases showing typical FE under endoscopic imaging but negative esophageal mucosal brush(referred to as suspected FE)have increased the difficulty and challenge of clinical diagnosis and *** present,the esophageal fungal flora of suspected case has not been thoroughly *** To characterize the fungal flora in FE,suspected FE,and the esophageal normal controls(NCs),and to identify marker species to improve detection of *** This was a case-control study.A total of 19 patients with FE,16 with suspected FE,and 10 NCs were selected by *** esophageal cell brush samples of each group were sequenced by internal transcribed spacer(ITS)1 and analyzed by *** In FE and suspected FE patients,species richness,species diversity and species evenness,as measured by the Chao1 index,Shannon index and Pielou index,were lower than in the NCs,and the comparison between the FE and NCs was the most significant(Punity was similar in the F

关键词： Fungal microbiota Esophagitis Candida Yarrowia Biomarker

New perspectives and prospects for the next generation of combination therapy in inflammatory bowel disease

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World Journal of gastroenterology 2025年第5期31卷 124-128页

作者： Wen-Ting Xie Hui Yang Lan Bai Feng-Fei Wu Guangdong Provincial Key Laboratory of gastroenterology Institute of Gastroenterology of Guangdong ProvinceDepartment of GastroenterologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

This article comments on the letter by Lowell et al,which addresses the next generation of combination therapy for inflammatory bowel disease(IBD).As the understanding of the pathogenesis of IBD continues to improve,treatment strategies are evolving *** letter examines the current status and future directions of combination therapy for IBD,focusing on approaches that combine biologics with immunomodulators and the emerging dual-biologic therapy(DBT).The traditional combination of biologics and immunomodulators has demonstra-ted preliminary efficacy by enhancing the effects of biologics through ***,concerns regarding long-term safety warrant careful *** trials,including DUET-Crohn's disease and DUET-ulcerative colitis,have shown promising potential for the broader adoption of ***,comprehensive data on efficacy and safety,as well as the effective integration of supportive treatments,remain essential to establish new paradigms for the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Dual-biologic therapy Supportive treatment The next generation of combination therapy

Patient and physician factors contributing to delays in inflammatory bowel diseases:Enhancing timely diagnosis

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World Journal of gastroenterology 2025年第6期31卷 115-120页

作者： Horia Minea Ana-Maria Singeap Laura Huiban Cristina Maria Muzica Carol Stanciu Anca Trifan Department of gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this article,we comment on the article by Blüthner et *** article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German *** highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing *** study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial ***,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other *** detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early *** importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.

关键词： Inflammatory bowel disease Diagnostic delay Disease awareness Healthcare system Screening tools

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies

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Neural Regeneration Research 2025年第12期20卷 3461-3475页

作者： Wouter Claeys Anja Geerts Lien Van Hoecke Christophe Van Steenkiste Roosmarijn E.Vandenbroucke Department of Internal Medicine and Paediatrics Hepatology Research UnitGhent UniversityGhentBelgium Liver Research Center Ghent Ghent UniversityGhent University HospitalGhentBelgium Barriers in Inflammation VIB-UGent Center for Inflammation ResearchVIBGhentBelgium Department of Biomedical Molecular Biology Ghent UniversityGhentBelgium Department of gastroenterology and Hepatology Ghent University HospitalGhentBelgium Department of gastroenterology and Hepatology Antwerp UniversityAntwerpBelgium Department of gastroenterology and Hepatology Maria Middelares HospitalGhentBelgium

Hepatic encephalopathy,defined as neuropsychiatric dysfunction secondary to liver disease,is a frequent decompensating event in *** clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of ***,liver disease,liver function failure,portosystemic shunting,and associated multi-organ dysfunction result in the increase of disease-causing neurotoxins in the circulation,which impairs cerebral *** circulating neurotoxins are ammonia and inflammatory *** the brain,pathophysiology is less well understood,but is thought to be driven by glial cell *** are the only brain resident cells that have ammonia-metabolizing machinery and are therefore putatively most susceptible to ammonia *** on a large body of mostly in vitro evidence,ammonia-induced cellular and molecular disturbances include astrocyte swelling and oxidative ***,the brain resident macrophages,have been linked to the translation of systemic inflammation to the brain *** evidence from animal studies has provided novel insights into old and new downstream effects of astrocyte and microglial dysfunction such as toxin clearance disruption and myeloid cell attraction to the central nervous system ***,state of the art research increasingly implicates neuronal dysfunction and possibly even irreversible neuronal cell ***-type specific investigation in animal models highlights the need for critical revision of the contribution of astrocytes and microglia to well-established and novel cellular and molecular alterations in hepatic *** this review,we therefore give a current and comprehensive overview of causes,features,and consequences of astrocyte and microglial dysfunction in hepatic encephalopathy,including areas of interest for future investigation.

关键词： ammonia astrocytes cirrhosis hepatic encephalopathy microglia neuroinflammation osmotic stress oxidative stress systemic inflammation

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-Ji Ma Department of gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta Gabriele Capurso Ivo Boskoski Cristiano Spada Jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly gastroenterology unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

Mitochondrial dysfunction in the pathogenesis of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 76-83页

作者： Xia Chen Rui Zhong Bing Hu Department of gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041China Department of gastroenterology Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500China

The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as a key event in the pathophysiology of AP. Mitochondrial dysfunction is closely related to calcium (Ca^(2+)) overload, intracellular adenosine triphosphate depletion, mitochondrial permeability transition pore openings, loss of mitochondrial membrane potential, mitophagy damage and inflammatory responses. Mitochondrial dysfunction is an early triggering event in the initiation and development of AP,and this organelle damage may precede the release of inflammatory cytokines, intracellular trypsin activation and vacuole formation of pancreatic acinar cells. This review provides further insight into the role of mitochondria in both physiological and pathophysiological aspects of AP, aiming to improve our understanding of the underlying mechanism which may lead to the development of therapeutic and preventive strategies for AP.

关键词： Acute pancreatitis Autophagy Calcium Cell death Inflammation Mitochondria Mitophagy