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Population-based epidemiology,risk factors and screening of intraductal papillary mucinous neoplasm patients

World Journal of Gastrointestinal Surgery 2010年第10期2卷 314-318页

作者： Saboor Khan Guido Sclabas Kaye M Reid-Lombardo Division of gastroenterologic and General Surgery Mayo Clinic

Intraductal papillary mucinous neoplasm(IPMN) was first recognized in the 1980s with increasing publications over the last decade as the incidence increased sharply,especially at tertiary-care referral *** studies have estimated the age and sex-adjusted cumulative incidence of IPMN to be 2.04 per 100 000 person-years(95% conf idence interval:1.28-2.80).It is now understood that IPMN can be classified anywhere along the spectrum of the adenoma to carcinoma sequence and often harbors mutations in genes such as KRAS early in the disease *** patients are diagnosed incidentally after imaging of the abdomen for other diagnostic *** that present with a history of symptoms such as pancreatitis and abdominal pain are at high risk of harboring a ***-copathologic features such as involvement of the main pancreatic duct,presence of mural nodules,and side branch disease > 3.0 cm in size may indicate that there is an underlying invasive component to the *** addition,the incidence of extra-pancreatic neoplasms is higher in patients with IPMN,with reported rates of 25% to 50%.There are no current screening recommendations to detect and diagnose IPMN but once the diagnosis is made,screening for extrapancreatic neoplasms such as colon polyps and colorectal cancer should be *** resection is the recommend treatment for patients with high-risk features while close observation can be offered to patients without worrisome signs and symptoms of carcinoma.

关键词： Intraductal papillary mucinous neoplasm Incidence Prevalence Risk factors Screening

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When the skin meets the bowel: About a case

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Open Journal of Gastroenterology 2013年第6期3卷 303-306页

作者： Ganzetti Giulia Campanati Anna Di Sario Antonio Rubini Corrado Zizzi Antonio Tarantino Giuseppe Benedetti Antonio Offidani Annamaria Anatomic Pathology Institute Department of Neurosciences Polytechnic University of Marche Ancona Italy Dermatological clinic Department of Clinical and Molecular Medicine Polytechnic Marche University Ancona Italy gastroenterologic clinic Department of Clinical and Molecular Medicine Polytechnic Marche University Ancona Italy

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal region which may be complicated by extraintestinal manifestations, as cutaneous involvement. Immune dysregulation resulting in a lymphocyte mediated destructive process has been suggested as a possible pathogenetic link between gut and skin-related manifestations. The authors describe an atypical clinical aspect of lichen ruber planus in a patient affected by vitiligo, alopecia areata and ulcerative colitis.

关键词： Ulcerative Colitis Vitiligo Lichen Ruber Planus Alopecia Areata Autoimmunity

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