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Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil

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World Journal of Gastroenterology 2019年第38期25卷 5862-5882页

作者： Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari Department of Surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSP 14049-900Brazil Hospital Universitario da Universidade Federal do Piaui TeresinaPI 64049-550Brazil Carolina D Gonclves Isabella M GuimaraesUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Universidade do Estado da Bahia -SalvadorBA 41150-000Brazil Department of Internal Medicine Botucatu Medical School at Sao Paulo State University(UNESP)BotucatuSP 18618-687Brazil Instituto Goiano de gastroenterologia e Endoscopia Digestiva Ltda GoianiaGO 74535-170Brazil Kaiser Clinica Sao Jose do Rio PretoSP 15015-110Brazil Escola Paulista de Medicina Sao PauloSP 04023-900Brazil UNIFESP Disciplina de GastroenterologiaSao PauloSP 04040-002Brazil Faculdade de Medicina do ABC Santo AndreSP 09060-870Brazil Faculdade de Medicina UFMG Belo HorizonteMG30130-100Brazil Inflammatory Bowel Disease Center Federal University of Juiz de ForaJuiz de ForaMG 36036-247Brazil Takeda Pharmaceuticals Brazil Sao PauloSP 04709-011Brazil 不详 Hospital de Clinicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil Hospital de Clinicas de Porto Alegre Porto Alegre-RS 90035-007Brazil Universidade Federal do Piaui TeresinaPI 64073-500Brazil Hospital de Clínicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil CTI Clinical Trial&Consulting Services Lisbon 1070-274Portugal CMIP Centro Mineiro de Pesquisa Juiz de ForaMG 36010-570Brazil Hospital Nossa Senhora das Gracas CuritibaPR 80810-040Brazil

BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the l

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Quality of life Healthcare resources

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查加斯病患者的胃电描记法

世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 13-14页

作者： Rezende Filho J. De Rezende J.M. Da CunhaMeloJ.R. 陈云茹 Instituto de gastroenterologia de Goi.ania Avenida Prof. Alfredo de Castro 435 Goiania Goias 74110-030 Brazil.Dr

Electrogastrograghy (EGG) was performed in 33 patients with Chagas’disease and in 15 healthy volunteers-control group. The EGG was performed in two different periods: in fasting and postprandial. The EGG was submitted to a continuous spectral analysis. The following parameters were evaluated: %dominant frequency in spectral bands: normogastria (2-4 cpm), bradygastria (1-2 cpm), tachygastria (4-10 cpm) and duod/resp (10-15 cpm). EGG was considered normal if normogastria >65%in both EGG periods. The chagasic group showed %normogastria significantly lower (basal, P 2) gastric dysrhythmias may be considered one of the abnormalities presented in the chagasic gastropathy.

关键词：胃电描记法查加斯病基底部胃节律障碍优势频率胃电图蠕动波光谱带频谱分析食期

Intravenous vs intraperitoneal mesenchymal stem cells administration:What is the best route for treating experimental colitis?

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World Journal of Gastroenterology 2014年第48期20卷 18228-18239页

作者： Fabiany da Costa Goncalves Natália Schneider Fernanda Otesbelgue Pinto Fabíola Schons Meyer Fernanda Visioli Bianca Pfaffenseller Patrícia Luciana da Costa Lopez Eduardo Pandolfi Passos Elizabeth Obino Cirne-Lima Luíse Meurer Ana Helena Paz Centro de Pesquisa Experimental do Hospital de Clínicas de Porto Alegre Porto Alegre 90035-903Rio Grande do SulBrazil Programa de Pós-Gradua??o:Ciências em gastroenterologia e Hepatologia Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Faculdade de Odontologia Universidade Federado Rio Grande do SulPorto Alegre 90035-003Rio Grande doSulBrazil

AIM:To investigate the therapeutic effects of mesenchymal stem cells(MSCs)transplanted intraperitoneally andintravenously in a murine model of colitis.METHODS:MSCs were isolated from C57BL/6 mouse adipose tissue.MSC cultures were analyzed according to morphology,cellular differentiation potential,and surface molecular markers.Experimental acute colitis was induced in C57BL/6 mice by oral administration of2%dextran sulfate sodium(DSS)in drinking water ad libitum from days 0 to 7.Colitis mice were treated with1×106 MSCs via intraperitoneal or intravenous injection on days 2 and 5.The disease activity index was determined daily based on the following parameters:weight loss,stool consistency and presence of blood in the feces and anus.To compare morphological and functional differences in tissue regeneration between different MSC injection modalities,mice were euthanized on day 8,and their colons were examined for length,weight,and histopathological changes.Inflammatory responses were determined by measuring the levels of different serum cytokines using a CBA Th1/Th2/Th17 kit.Apoptotic rates were evaluated by terminal deoxynucleotidyl transferase-mediated d UDPbiotin nick end labeling assay.RESULTS:Intravenous infusion of MSCs was more effective than intraperitoneal treatment(P<0.001)in reducing the clinical and histopathologic severity of colitis,which includes weight loss,diarrhea and inflammation.An histological evaluation demonstrated decreased colonic inflammation based on reduced crypt loss and reduced infiltration of inflammatory cells.This therapeutic effect was most likely mediated by the down-regulation of pro-inflammatory cytokines[interleukin(IL)-6 and tumor necrosis factor(TNF)];and by the up-regulation of anti-inflammatory cytokines(IL-10 and IL-4).Intravenous transplantation alsoinduced high levels of IFN that lead to activation of the immunosuppressive activity of the MSCs,which did not occur with intraperitoneal transplantation(P=0.006).An increase in apoptotic T cells was observed after intravenous,

关键词： Ulcerative colitis Dextran sulfate sodium Inflammatory bowel disease Mesenchymal stem cell Cell transplantation Intravenous injection Immunomodulation

No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil

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World Journal of Gastroenterology 2013年第39期19卷 6598-6603页

作者： Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes Programa de Pós-Graduao: Ciências em gastroenterologia e Hepatologia - Universidade Federal do Rio Grande do Sul Porto AlegreRio Grande do Sul 90035-003Brasil Hospital Universitário de Santa Maria - Universidade Federal de Santa Maria Santa MariaRio Grande do Sul 97119-900Brasil Departamento de Clínica Médica - Universidade Federal de Santa Maria Santa MariaRio Grande do Sul 97119-900Brasil

AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Braz

关键词： Esophageal cancer Esophageal squamous cell carcinoma Human papillomavirus Head and neck cancer Polymerase chain reactions Nested-polymerase chain reaction

The transcontinental variability of nonalcoholic fatty liver disease

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Hepatoma Research 2020年第10期6卷 75-87页

作者： Claudia P.Oliveira Angelo Paredes Mohammed Siddiqui Lawrence Serfaty Abhijit Chowdhury Jose Tadeu Stefano Denise Siqueira Vanni Sherry Boyett Arun J.Sanyal Department of Gastroenterology Faculdade de Medicina da Universidade de São PauloSão PauloSP 01000-000Brazil Laboratório de gastroenterologia Clínica e Experimental(LIM-07)do Departamento de gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo São PauloSP 01000-000Brazil Internal Medicine Gastroenterology and Hepatology ServicesBrooke Army Medical CenterSan AntonioTX 78234USA Div.of Gastroenterology Hepatology and NutritionDept.of Internal MedicineVirginia Commonwealth University School of MedicineRichmondVA 23298-0341USA Viral and Metabolic Liver Unit Department of HepatologySaint-Antoine Hospital75012 ParisParis Department of Hepatology School of Digestive and Liver DiseaseInstitute of Post Graduate Medical Education&ResearchKolkata 700020India Disease Biology John C Martin Centre for Liver Research and Innovations SonarpurKolkata 7000150India

Aim:To compare the phenotype of lean versus overweight(OW)and obese(OB)subjects with non-alcoholic fatty liver disease(NAFLD)across multiple continents.Methods:A retrospective study of histologically defined subjects from a single center each in France(Fr),Brazil(Br),India(In)and United States(US)was performed.Results:A total of 70 lean[body mass index(BMI)25 kg/m2]subjects(Fr:Br:In:US:16:19:22:13)with NAFLD were compared to 136 OW(BMI>25 kg/m2,BMI29 kg/m2)(n=28:33:52:23)and 224 OB subjects(BMI>29 kg/m2)(n=81:11:22:103).Lean French subjects had the lowest incidence of type 2 diabetes while those from Brazil(P<0.01)had the highest.Lean subjects had similar low-density lipoprotein-cholesterol,but higher high-density lipoprotein-cholesterol compared to obese subjects in all regions.In both lean and obese subjects,there were both insulin-sensitive and insulin-resistant subjects.Lean French subjects were most insulin-sensitive while those from Brazil were mostly insulin-resistant.For each weight category,subjects from India were more insulin-sensitive than those from other regions.Disease activity increased from lean to overweight to obese in France but was similar across weight categories in other regions.Conclusion:The phenotype of NAFLD in lean subjects varies by region.Some obese subjects with NAFLD are insulin-sensitive.We hypothesize that genetics and region-specific disease modifiers account for these differences.

关键词： Non-alcoholic fatty liver disease phenotype epidemiology demographics

Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

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World Journal of Gastroenterology 2013年第20期19卷 3043-3051页

作者： Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur LC da Silva Isabel CA Scaletsky José Pedrazzoli Jr Marcelo L Ribeiro Unidade Integrada de Farmacologia e gastroenterologia Universidade So FranciscoBragan a Paulista 12916-900SPBrazil Programa de Pós Gradua o em Genética e Biologia Molecular State University of CampinasCampinas 13083-970SPBrazil Departamento de Clínica Médica UNESPBotucatu 18618-970SPBrazil Departamento de Genética Universidade Federal do ParáBelém 68400-000PABrazil Departamento de Microbiologia Imunologia e ParasitologiaUniversidade Federal de So PauloSo Paulo 04021-001SPBrazil

AIM:To evaluate the association between Helicobacter pylori(H.pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or H.pylori-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver staining.Statistical analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's t-test.RESULTS:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of H.pylori infection status.The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H.pylori infection(P < 0.05);this region was methylated in 66% of gastric cancer patients,and the difference in the percentage of methylated samples between these patients and those from H.pylori-infected chronic gastritis patients was statistically significant(P < 0.05).MLH1 methylation frequencies among H.pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%,respectively.We observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from H.pylori-infected adult chronic gastritis patients(P < 0.001 and P < 0.01,respectively).The frequency of promoter methylation for both genes was higher in gastric cancer samples than in H.pylori-positive chronic gastritis

关键词： Helicobacter pylori Microsatellite instability Promoter methylation MLH1 MGMT Gastric cancer

Neoadjuvant treatment:A window of opportunity for nutritional prehabilitation in patients with pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 885-903页

作者： Ilaria Trestini Marco Cintoni Emanuele Rinninella Futura Grassi Salvatore Paiella Roberto Salvia Emilio Bria Carmelo Pozzo Sergio Alfieri Antonio Gasbarrini Giampaolo Tortora Michele Milella Maria Cristina Mele Section of Oncology Department of MedicinePancreas InstituteUniversity of Verona Hospital TrustVerona 37126Italy Scuola di Specializzazione in Scienza dell’Alimentazione Universitàdi Roma Tor VergataRoma 00133Italy UOC Nutrizione Clinica Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico A.Gemelli IRCCSRoma 00168Italy Dipartimento di Medicina e Chirurgia Traslazionale UniversitàCattolica del Sacro CuoreRoma 00168Italy General and Pancreatic Surgery Unit Pancreas InstituteUniversity of Verona Hospital TrustVerona 37126Italy Oncologia Medica Unit Comprehensive Cancer CenterFondazione Policlinico Universitario A Gemelli IRCCSRoma 00167Italy Oncologia Medica Unit UniversitàCattolica del Sacro CuoreRoma 00168Italy Digestive Surgery Unit and Pancreatic Surgery Gemelli Center Director Fondazione Policlinico Universitario A Gemelli IRCCSRoma 00167Italy UOC di Medicina Interna e gastroenterologia Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario A Gemelli IRCCSRoma 00167Italy UOSD Nutrizione Avanzata in Oncologia Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario A Gemelli IRCCSRoma 00167Italy

Patients affected by pancreatic ductal adenocarcinoma(PDAC)frequently present with advanced disease at the time of diagnosis,limiting an upfront surgical approach.Neoadjuvant treatment(NAT)has become the standard of care to downstage non-metastatic locally advanced PDAC.However,this treatment increases the risk of a nutritional status decline,which in turn,may impact therapeutic tolerance,postoperative outcomes,or even prevent the possibility of surgery.Literature on prehabilitation programs on surgical PDAC patients show a reduction of postoperative complications,length of hospital stay,and readmission rate,while data on prehabilitation in NAT patients are scarce and randomized controlled trials are still missing.Particularly,appropriate nutritional management represents an important therapeutic strategy to promote tissue healing and to enhance patient recovery after surgical trauma.In this regard,NAT may represent a new interesting window of opportunity to implement a nutritional prehabilitation program,aiming to increase the PDAC patient’s capacity to complete the planned therapy and potentially improve clinical and survival outcomes.Given these perspectives,this review attempts to provide an in-depth view of the nutritional derangements during NAT and nutritional prehabilitation program as well as their impact on PDAC patient outcomes.

关键词： Pancreatic cancer Neoadjuvant treatment Pancreatic cancer surgery Nutritional status Nutritional prehabilitation Malnutrition

Relaxin prevents the development of severe acute pancreatitis

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World Journal of Gastroenterology 2006年第10期12卷 1558-1568页

作者： Laura Iris Cosen-Binker Marcelo Gustavo Binker Rodica Cosen Gustavo Negri Osvaldo Tiscornia RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clinicas Universidad de Buenos AiresArgentina Cátedra de Gastroenterologia y Enzimologia Clinica-Departamento de Bioquimica ClinicaFacultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Cátedra de Gastroenterología y Enzimología Clínica-Departamento de Bioquímica Clínica Facultad de Farmacia y Bioquimica Universidad de Buenos AiresArgentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos Aires Argentina

瞄准：为了调查尖锐胰腺炎(AP ) 的严厉，被联系到白血球激活，煽动性的起来规定和联系到 ischemia-reperfusion 损害的微循环混乱的紧张。支持 inflammatory 调停人的 Microvascular 完整和抑制在 AP 的进化是关键因素的。松弛激素是... 详细信息

瞄准：为了调查尖锐胰腺炎(AP ) 的严厉，被联系到白血球激活，煽动性的起来规定和联系到 ischemia-reperfusion 损害的微循环混乱的紧张。支持 inflammatory 调停人的 Microvascular 完整和抑制在 AP 的进化是关键因素的。松弛激素是被归因的像胰岛素的荷尔蒙经由氮的氧化物小径的 vasorelaxant 性质当作为糖皮质激素受体收缩筋表现时。方法：AP 被 bilio 胰腺的 duct-outlet-exclusion closed-duodenal-loops 模型导致。有松弛激素的处理在不同时间点被做。由由 mifepristone 的阻塞被考虑的 L 名字和糖皮质激素受体(GR ) 的氮的氧化物 synthase 抑制。AP 严厉被生物化学、组织病理学说的分析估计。结果：有松弛激素的处理减少了浆液淀粉酶，脂肪分解酵素， C 反应的蛋白质， IL-6， IL-10， hsp72， LDH 和 8-isoprostane 象一样胰腺并且肺 myeloperoxidase。腺泡和脂肪坏死，出血和 neutrophil 渗透也被减少。当 caspases 2-3-8 和 9 项活动被增加时， ATP 弄空和 ADP/ATP 比率被减少。L 名字和 mifepristone 减少了松弛激素的效率。结论：松弛激素结果在当保存微发行量并且在坏死上赞成 apoptosis 时，联合 GR 收缩筋的性质的 AP 的处理有益。

关键词：松弛素急性胰腺炎药物治疗病理机制