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Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

Journal of Diabetes Mellitus 2020年第3期10卷 154-168页

作者： Comlan Jules Gninkoun Sylvie A. Ahn K. Daniel Amoussou-Guenou Evariste Bouenizabila Michel F. Rousseau Michel P. Hermans service d’Endocrinologie & Diabétologie Faculté des Sciences de la Santé Cotonou Bénin Division of Cardiology Cliniques Universitaires St-Luc and P&#244 le de Recherche Cardiovasculaire Institut de Recherche Expérimentale et Clinique (IREC) Université catholique de Louvain Brussels Belgium Departmental hospital and university Centre Service de Médecine interne-Endocrinologie CHUD/OP Porto-Novo Université d’Abomey-Calavi Abomey-Calavi Bénin service de Maladies Métaboliques et Endocriniennes Centre Hospitalier et Universitaire de Brazzaville Brazzaville Congo Division of Endocrinology & Nutrition Cliniques universitaires St-Luc and Institut de Recherche Expérimentale et Clinique (IREC) Université catholique de Louvain Brussels Belgium

Purpose: Non-alcoholic fatty liver (NAFL) is comorbid to obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM). It is unclear whether NAFLD constitutes a direct risk factor for macrovascular disease in T2DM. This study aimed at revisiting the cardiometabolic traits linked to NADL and micro-/ macrovascular complications in a biethnic Caucasian and African cohort. Methods: Cross-sectional analysis of 568 of T2DM patients (515 Caucasians;53 Africans) in whom the presence of NAFL was identified by ultrasonography and the cardiometabolic phenotype was exhaustively characterized, including carbohydrate homeostasis, comprehensive lipidogram including Lp(a), cumulative exposure to hyperglycemia, and prevalent micro/macrovascular complications. Results: FL was present in 73% of Caucasians and 36% of Africans (p − in both groups. A marked reduction in diabetic retinopathy (DR), ocular hypertonia and cataracts were found in FL+ of the two ethnicities. In FL+ Caucasians, relative risk of DR was −38%, cataracts −35%, and ocular hypertonia −42%. In FL+ Africans, risk of overall microangiopathy was −66% and that of DR −86%. Conclusions: An inverse association was observed between NAFL and the presence of diabetic retinopathy, cataract and ocular hypertonia. The ophthalmoprotection conferred by liver steatosis was found in Caucasians and Africans. Among the latter, hepatic steatosis was linked to lower lipopro

关键词： Fatty Liver Type 2 Diabetes Microangiopathy Retinopathy Coronary Artery Disease Lipoprotein(a)

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Prevalence, Resistance to Quinolones/Fluoroquinolones of <i>Staphylococcus aureus</i>Strains Isolated in the hospital and university Center of brazzaville, Republic of Congo

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Advances in Microbiology 2021年第11期11卷 607-615页

作者： Léa Gwladys Gangoue Etienne Nguimbi Faust René Okamba Ondzia Briceline Princesse Banzouzi Mahoukou Tantique Moutali Lingouagou Tarcisse Baloki Ngoulou Isaac Samuel Onyankouang Rachel Moyen Laboratoire de Biologie Cellulaire et Moléculaire (BCM) Faculté des Sciences et Techniques Université Marien NGOUABI Brazzaville Congo Unité de Microbiologie moléculaire et Bioinformatique Faculté des Sciences et Techniques Université Marien NGOUABI Brazzaville Congo Institut National de Recherche en Sciences Exactes et Naturelles (IRSEN) Avenue de l’Auberge Gascogne Scientific City (Ex. OROSTOM) Brazzaville Congo

Staphylococcus aureus is a gram-positive pathogenic bacterium responsible for various infections including skin suppurations. Quinolones are sometimes used last in infections. The Staphylococcus aureus objective of this study was to determine the prevalence and assess the level of resistance to quinolones of Staphylococcus aureus trains isolated in the hospital and university Center of brazzaville (CHU-B). 40 strains of Staphylococcus aureus from various biological products were isolated and identified by bacteriological methods. The study of the resistance of these different strains to antibiotics (Quinolones/Fluoroquinolones) was carried out by the phenotypic method, by antibiogram. A total of 40 Staphylococcus aureus strains were isolated including 13 (32.50%) community strains, 27 (67.5%) clinical strains distributed as follows: neonatal and pediatric service 29.62% and 25.92%, surgery 18.51%, contagious 14.81%, emergencies 7.4% and delivery block 3.7%. 60% of strains were isolated in women and 40% in men. The average age of those infected was 16 years and older. 90% strains were resistant to Nalidixic acid (AN), 72.5% to Ofloxacin (OFL), 67.5% to Ciprofloxacin (CIP), 70% to Norfloxacin (NOR), 62.5% to Levofloxacin (LEV), 47.5% to Moxifloxacin (MXF), and 40% strains were resistant to all antibiotics tested.

关键词： Prevalence Staphylococcus aureus Antibiotics Resistance

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