检索结果-南通市图书馆

Review of dynamic contrast-enhanced ultrasound guidance in ablation therapy for hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2011年第45期17卷 4952-4959页

作者： Yasunori Minami Masatoshi Kudo department of gastroen-terology and Hepatology Kinki University School of Medicine

Local ablative techniques-percutaneous ethanol injection, microwave coagulation therapy and radiofrequency ablation (RFA)-have been developed to treat unresectable hepatocellular carcinoma (HCC). The success rate of percutaneous ablation therapy for HCC depends on correct targeting of the tumor via an imaging technique. However, probe insertion often is not completely accurate for small HCC nodules, which are poorly def ined on conventional B-mode ultrasound (US) alone. Thus, multiple sessions of ablation therapy are frequently required in diffi cult cases. By means of two breakthroughs in US technology, harmonic imaging and the development of second-generation contrast agents, dynamic contrast-enhanced harmonic US imaging with an intravenous contrast agent can depict tumor vascularity sensitively and accurately, and is able to evaluate small hypervascular HCCs even when B-mode US cannot adequately characterize the tumors. Therefore, dynamic contrast-enhanced US can facilitate RFA electrode placement in hypervascular HCC, which is poorly depicted by B-mode US. The use of dynamic contrast-enhanced US guidance in ablation therapy for liver cancer is an effi cient approach. Here, we present an overview of the current status of dynamic contrast-enhanced US-guided ablation therapy, and summarize the current indications and outcomes of reported clinical use in comparison with that of other modalities.

关键词： Dynamic contrast-enhanced ultrasound Hepatocellular carcinoma Percutaneous ethanol injection Radiofrequency ablation

Malignancy in adult celiac disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2009年第13期15卷 1581-1583页

作者： Hugh James Freeman department of Medicine (gastroen-terology) University of British Columbia Hospital

Prior studies have suggested that the incidence of some neoplastic disorders,particularly malignant lymphoma and small intestinal adenocarcinoma,are increased in celiac *** studies from the United Kingdom have also suggested a link between celiac disease and esophageal carcinoma,although this has not been confi rmed in North *** risk of other gastrointestinal cancers seems to be *** cancer does not appear to be detected more frequently,although direct endoscopic visualization of the upper gastrointestinal tract is now very common in patients with celiac *** cancer also appears to be limited in celiac disease,even in patients first diagnosed with celiac disease late in *** has led to the hypothesis that untreated celiac disease may be protective,possibly owing to impaired absorption of fat or fat-soluble agents,including hydrocarbons and putative co-carcinogens implicated in the pathogenesis of colon cancer,which may be poorly absorbed and rapidly excreted.

关键词： Adult Celiac disease Adenocarcinoma Lymphoma T cell enteropathy

Intraductal papillary mucinous neoplasms and other pancreatic cystic lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2008年第19期14卷 2977-2979页

作者： Hugh James Freeman department of Medicine (gastroen-terology) University of British Columbia

Pancreatic cystic neoplasms are being increasingly recognized, even in the absence of symptoms, in large part, due to markedly improved imaging modalities such as magnetic resonance imaging (MRI)/magnetic resonance cholangio pancreatography (MRCP) and computer tomography (CT) scanning. During the past 2 decades, better imaging of these cystic lesions has resulted in definition of different types, including pancreatic intraductal papillary mucinous neoplasms (IPMN). While IPMN represent only a distinct minority of all pancreatic cancers, they appear to be a relatively frequent neoplastic form of pancreatic cystic neoplasm. Moreover, IPMN have a much better outcome and prognosis compared to pancreatic ductal adenocarcinomas. Therefore, recognition of this entity is exceedingly important for the clinician involved in diagnosis and further evaluation of a potentially curable form of pancreatic cancer.

关键词： Pancreatic cancer Pancreatic intraductal papillary mucinous neoplasms Mucinous cystic neoplasm of pancreas Serous cystadenoma Pancreatic cysticlesions

Endocrine manifestations in celiac disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2016年第38期22卷 8472-8479页

作者： Hugh James Freeman department of Medicine (gastroen- terology) University of British Columbia

Celiac disease(CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulindependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist. In some with CD, multiple glandular endocrinopathies may also occur and complicate the initial presentation of the intestinal disease. In others presenting with an apparent isolated endocrine disorder, serological screening for underlying subclinical CD may prove to be positive, particularly if type 1 diabetes, autoimmune thyroid or other autoimmune endocrine diseases, such as Addison's disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.

关键词： Pituitary insufficiency Ovarian infertility Celiac disease Gluten-sensitive enteropathy Endocrine disorders Thyroiditis Hypothyroidism Diabetes Adrenal insufficiency

Venous thromboembolism with inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2008年第7期14卷 991-993页

作者： Hugh James Freeman department of Medicine (gastroen-terology) University of British ColumbiaVancouverBCCanada

Venous thrombosis and thromboembolism appear to be increased in patients with inflammatory bowel disease. Although several acquired and genetic risk factors are known, about half that develop a thromboembolic event have no identifiable risk factor. Control of the inflammatory process is thought to be the key factor in risk reduction for thrombotic events. Prophylactic use of anticoagulants is not universally recommended, but possible use should be reviewed in an individual patient after evaluation of the risks, such as hemorrhage, compared to potential benefits. Particular consideration should be given if there has been a prior thrombotic event, if hospitalization will require surgery, or if an underlying coagulation disorder is present.

关键词： Venous thrombosis Thromboembolism Inflammatory bowel disease Crohn's disease Ulcerative colitis

Acute recurrent pancreatitis:An autoimmune disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2008年第7期14卷 999-1006页

作者： Raffaele Pezzilli department of Internal Medicine and gastroen-terology Sant'Orsola-Malpighi Hospital. Bologna 40138Italy

In this review article, we will briefly describe the main characteristics of autoimmune pancreatitis and then we will concentrate on our aim, namely, evaluating the clinical characteristics of patients having recurrence of pain from the disease. In fact, the open question is to evaluate the possible presence of autoimmune pancreatitis in patients with an undefined etiology of acute pancreatitis and for this reason we carried out a search in the literature in order to explore this issue. In cases of recurrent attacks of pain in patients with "idiopathic" pancreatitis, we need to keep in mind the possibility that our patients may have autoimmune pancreatitis. Even though the frequency of this disease seems to be quite low, we believe that in the future, by increasing our knowledge on the subject, we will be able to diagnose an ever-increasing number of patients having acute recurrence of pain from autoimmune pancreatitis.

关键词： Pancreatitis Autoimmune pancreatitis Diagnosis Therapy Outcome

A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2008年第1期14卷 114-119页

作者： Hong-Liang Liang Qin Ouyang department of gastroen-terology West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM: To investigate the therapeutic effects of the combined use of rosiglitazone and aminosalicylate on mild or moderately active ulcerative colitis (UC).METHODS: According to the national guideline for diagnosis and treatment of inflammatory bowel disease (IBD) in China, patients with mild or moderately active UC in our hospital were selected from July to November, 2004. Patients with infectious colitis, amoebiasis, or cardiac, renal or hepatic failure and those who had received corticosteroid or immunosuppressant treatment within the last month were excluded. Following a quasi-randomization principle, patients were allocated alternatively into the treatment group (TG) with rosiglitazone 4 mg/d plus 5-ASA 2 g/d daily or the control group (CG) with 5-ASA 2 g/d alone, respectively, for 4 wk. Clinical changes were evaluated by Mayo scoring system and histological changes by Truelove-Richards' grading system at initial and final point of ***: Forty-two patients completed the trial, 21 each in TG and CG. The Mayo scores in TG at initial and final points were 5.87 (range: 4.29-7.43) and 1.86 (range: 1.03-2.69) and those in CG were 6.05 (range: 4.97-7.13) and 2.57 (range: 1.92-3.22) respectively. The decrements of Mayo scores were 4.01 in TG and 3.48 in CG, with a remission rate of 71.4% in TG and 57.1% in CG, respectively. Along with the improvement of disease activity index (DAI), the histological grade improvement was more significant in TG than in CG (P < 0.05).CONCLUSION: Combined treatment with rosiglitazone and 5-ASA achieved better therapeutic effect than 5-ASA alone without any side effects. Rosiglitazone can alleviate colonic inflammation which hopefully becomes a novel agent for UC treatment.

关键词： Peroxisome proliferators-activated receptor γ Rosiglitazone Ulcerative colitis

Etiopathogenesis of primary sclerosing cholangitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2008年第21期14卷 3350-3359页

作者： Roger Chapman Sue Cullen department of gastroen-terology John Radcliffe HospitalHeadingtonOxford OX3 9DUUnited Kingdom

Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this *** with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated *** immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the *** derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic *** may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response.

关键词： Autoantibody Immunogenetics Biliaryepithelial cells T cell receptor Lymphocytes

Narrow-band imaging endoscopy with and without magnification in diagnosis of colorectal neoplasia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2011年第5期17卷 666-670页

作者： Qing-Jie Zhou Jian-Min Yang Bao-Ying Fei Qi-Shun Xu wei-Quan wu Hong-Jun Ruan department of gastroen-terology Zhejiang Provincial People's Hospital Hangzhou310014 Zhejiang Province China

AIM:To evaluate the diagnostic efficacies of narrowband imaging(NBI) endoscopy with and without high magnification in distinguishing neoplasia from nonneoplasia colorectal ***:A total of 118 patients with 123 colorectal lesions examined by NBI endoscopy in the Zhejiang Provincial People's Hospital from September 2008 to April 2010 were enrolled in this *** lesions were classified by pit pattern and capillary pattern,and then assessed by ***:Ten lesions not meeting the diagnostic criteria were excuded,the overall diagnostic accuracy of NBI endoscopy in distinguishing neoplasia from non-neoplasia colorectal lesions was 91.2%(103/113),and that of NBI endoscopy with and without high magnification was 93.0%(40/43) and 90.0%(63/70),*** were significantly higher than that of conventional colonoscopy reported in the literature(P 0.05).CONCLUSION:Besides NBI magnifying endoscopy,NBI endoscopy without magnification may also be used to distinguish neoplasia from non-neoplasia colorectal lesions.

关键词： Narrow-band imaging Colorectal neoplasia Magnifying endoscopy Non-magnifying endoscopy Di-agnosis