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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina key laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

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Characterizing extreme drought and wetness in Guangdong,China using global navigation satellite system and precipitation data

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Satellite Navigation 2024年第1期5卷 258-274页

作者： Hai Zhu Kejie Chen Haishan Chai Yuanbin Ye Wenjian Liu Department of Earth and Space sciences Southern University of Science and TechnologyShenzhen518055China Lands and Resource Department of Guangdong Province Surveying and Mapping InstituteGuangzhou510500China

As global temperature rises,the frequency of extreme climate events,e.g.,severe droughts and floods,has increased significantly and caused severe damage over the past *** this regard,precipitation efficiency,a crucial meteorological parameter,could provide valuable insights for a better understanding of the patterns and characteristics of these extreme *** this study,taking Guangdong province as an exemplary region,we first obtained long-term and high-resolution historical records of precipitation efficiency by integrating the observations from a dense network of Global Navigation Satellite System(GNSS)stations with precipitation data,and then characterized the extreme drought and wetness through climate *** found a distinct seasonal trend in precipitation efficiency in Guangdong,with annual fluctuations ranging from 10 to 25%.Notably,precipitation efficiency is higher in proximity to the Pearl River Delta Plain and gradually decreases towards the east and *** occurrence of anomalous peaks and valleys in precipitation efficiency generally corresponds to dry and wet conditions,respectively.A total of 9 extreme wet events and 6 dry events occurred from January 2007 to May 2022,with durations from 3 to 6 *** results also demonstrated that both wet and dry frequencies exhibit an increasing trend with the expansion of the time scale,and the frequency of extreme events near the Pearl River Delta Plain surpasses that of other ***,the propagation time from meteorological anomalies to agricultural and hydrological anomalies is about 3 *** periodic characteristics of meteorological anomalies are identified as the primary driver for other anomalous periodic *** work unveils the long-term dynamic behavior of precipitation efficiency,as well as the characteristics of extreme drought and wetness events in the regions characterized by intricate land–atmosphere interactions.

关键词： GNSS Precipitation efficiency Extreme drought and wetness

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Present situation of minimally invasive surgical treatment for early gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1154-1165页

作者： Chun-Yan Li Yi-Feng Wang Li-Kang Luo Xiao-Jun Yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina gansu key laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical *** addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer *** minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so *** new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

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Defining the We-map Reference Frames and Providing Mathematical Expressions for Transformation Relations

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Journal of Geodesy and Geoinformation science 2024年第3期7卷 76-88页

作者： WANG Xiaolong YAN Haowen WANG Zhuo MA Wenjun YU Yitao College of Earth and Environmental sciences Lanzhou UniversityLanzhou 730000China key laboratory of Western China’s Environmental Systems Ministry of EducationLanzhou 730000China Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China National-Local Joint Engineering Research Center of Technologies and Applications for National Geographic State Monitoring Lanzhou 730070China gansu provincial key laboratory of science and technology in surveying&mapping Lanzhou 730070China School of Resource and Environmental sciences Wuhan UniversityWuhan 430072China

We-map is an interactive mobile map that can be easily communicated and applied on personal electronic devices,such as personal computers and mobile ***,the study of direction systems and coordinate systems is critical,and exploring reference frames is essential in direction and coordinate *** its significance,existing research on We-map lacks specific solutions for the exploration of reference frames is indispensable for the establishment of accurate direction and coordinate *** this paper,we endeavor to address this gap by elucidating the significance of We-map reference frames,defining them with mathematical constraints,summarizing their nature and characteristics,deriving their transformation relationships and representing them through mathematical formulars and *** work contributes to the fundamental theory of We-map and provides valuable systems and support for the mathematical foundation of We-map,map production,and platform ***,this research serves to advance the development of We-map.

关键词： We-map reference frames spatial direction relation coordinate system

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Effects of Enclosure on Grassland Ecological and Economic Benefits in Northern China

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Chinese Geographical science 2024年第1期34卷 67-78页

作者： HU Bo WEN Qingke XI Fengjiang LI Mengyao WANG Libing REN Yuejuan Aerospace Information Research Institute Chinese Academy of SciencesBeijing100094China University of Chinese Academy of sciences Beijing100049China Inner Mongolia Remote Sensing Center Co. Ltd.Huhhot010000China Xilinhot the Maodeng pasture Xilinhot026000China China University of Mining and technology Xuzhou221116China Shanxi provincial key Lab of Resources Environment and Disaster MonitoringCoal Geological Geophysical Exploration Surveying&Mapping Institute of Shanxi ProvinceJinzhong030600China

Grasslands in northern China serve the country as both an ecological barrier and a livestock production ***,installing enclosures has been becoming the major grassland restoration measure adopted by many local ***,the effects of restoration on both ecological and production benefits of grassland remain unclear for implemented grassland restoration ***,a representative rangeland in northern China,the Maodeng pasture in Inner Mongolia Autonomous Region was selected as the study area,and remote sensing monitoring analyses were carried out to quantify the ecological benefits and economic benefits from 2015 to *** results showed that:1) in terms of ecological benefits,the grassland area with a grassland coverage rate of more than 60% accounts for 32.3% of the regional area,and 86.4% of its grassland grew significantly better than the same period in2015,showing a significant improvement in grassland *** the average amount of carbon per unit area as the ecological benefit evaluation index,it increased by 27.1% to 32.48Tg C/yr from 2015 to 2021.2) In terms of economic benefits,both theoretical grass production and livestock carrying capacity increased from 2015 to *** to 2015,the theoretical grass production in 2021 increased by 24.8% to 71 900 *** livestock carrying capacity reached 52 100 sheep units in 2021,nearly 11 000 sheep units more than that in *** the study period,multiple economic indicators(on a per capita basis of permanent residents) for the pastoral area of Xilinhot City to which the Maodeng pasture belongs,have grown *** capita total income rose from 29 630 yuan(RMB) in2015 to 62 859 yuan(RMB) in *** on grassland resources to develop the pastoral ecology also broadens the potential economic development ***,the establishment of the reserve and the experiment of implanting an enclosure policy have had a significant and positive impact on Maodeng pasture’s develo

关键词： enclosure grassland ecological benefit economic benefit Maodeng pasture Inner Mongolia northern China

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Numerical and experimental study of the effects of wind turbine operation on sand-dust transport characteristics

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science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 97-113页

作者： Gaosheng Ma Hong Han Ye Li Deshun Li Yan Wang Ning Fu Quan Zheng Rennian Li School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China gansu provincial technology Center for Wind Turbines Lanzhou 730050China key laboratory of Fluid Machinery and Systems Lanzhou 730050China Multiple Function Towing Tank laboratory State Key Laboratory of Ocean EngineeringSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Given factors such as reduced land availability for onshore wind farms,wind resource enrichment levels,and costs,there is a growing trend of establishing wind farms in deserts,the Gobi,and other arid ***,the relationship between sanddust weather environments and wind turbine operations has garnered significant *** investigate the impact of wind turbine wakes on sand-dust transportation,this study employs large eddy simulation to model flow fields,coupled with an actuator line model for simulating rotating blades and a multiphase particle in cell model for simulating sand *** research focuses on a horizontal axis wind turbine model and examines the motion and spatiotemporal distribution characteristics of four typical sizes of sand particles in the turbine *** findings reveal that sand particles of varying sizes exhibit a spiral settling pattern after traversing the rotating plane of wind turbine blades,influenced by blade shedding vortex and *** particles tend to cluster in the peripheries of the vortex cores of low vorticity in the wind turbine *** rotation of wind turbines generates a wake vortex structure that causes a significant clustering of sand particles at the tip *** the wake distance increases,the particles that cluster at the turbine's tip gradually spread outward to approximately twice the rotor diameter and then begin to mix with the incoming flow *** turbines have a noticeable impact on sand-dust transportation,hindering their movement to a significant *** average sand-blocking rate exhibits a trend of initially increasing and then decreasing as the wake distance *** its peak,the sand-blocking rate reaches an impressive 67.55%.The presence of wind turbines induces the advanced settling of sand particles,resulting in a“triangular”distribution of the deposition within the ground projection area of the wake.

关键词： wind turbine particle transportation actuator line model dry deposition particle clustering

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The GNSS PWV retrieval using non-observation meteorological parameters based on ERA5 and its relation with precipitation

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Geodesy and Geodynamics 2024年第3期15卷 302-313页

作者： Weifeng Yang Zhiping Chen Kaiyun Lv Pengfei Xia Tieding Lu School of surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China key laboratory of Mine Environmental Monitoring and Improving around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China State key laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China Jiangxi Province Engineering Research Center of surveying Mapping and Geographic InformationNanchang 330025China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China

The pressure and temperature significantly influence precipitable water vapor(PWV) retrieval. Global Navigation Satellite System(GNSS) PWV retrieval is limited because the GNSS stations lack meteorological sensors. First, this article evaluated the accuracy of pressure and temperature in 68 radiosonde stations in China based on ERA5 Reanalysis data from 2015 to 2019 and compared them with GPT3model. Then, the accuracy of pressure and temperature calculated by ERA5 were estimated in 5 representative IGS stations in China. And the PWV calculated by these meteorological parameters from ERA5(ERA5-PWV) were analyzed. Finally, the relation between ERA5-PWV and precipitation was deeply explored using wavelet coherence analysis in IGS stations. These results indicate that the accuracy of pressure and temperature of ERA5 is better than the GPT3 model. In radiosonde stations, the mean BIAS and MAE of pressure and temperature in ERA5 are-0.41/1.15 hpa and-0.97/2.12 K. And the mean RMSEs are 1.35 hpa and 2.87 K, which improve 74.77% and 40.58% compared with GPT3 model. The errors of pressure and temperature of ERA5 are smaller than the GPT3 model in bjfs, hksl and wuh2, and the accuracy of ERA5-PWV is improved by 18.77% compared with the GPT3 model. In addition, there is a significant positive correlation between ERA5-PWV and precipitation. And precipitation is always associated with the sharp rise of ERA5-PWV, which provides important references for rainfall prediction.

关键词： ERA5 GNSS Precipitable water vapor Precipitation Wavelet coherence analysis

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UDT:U-shaped deformable transformer for subarachnoid haemorrhage image segmentation

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CAAI Transactions on Intelligence technology 2024年第3期9卷 756-768页

作者： Wei Xie Lianghao Jin Shiqi Hua Hao Sun Bo Sun Zhigang Tu Jun Liu Hubei provincial key laboratory of Artificial Intelligence and Smart Learning Central China Normal UniversityWuhanChina School of Computer science Central China Normal UniversityWuhanChina National Language Resources Monitoring and Research Center for Network Media Central China Normal UniversityWuhanChina The First Affiliated Hospital of Dalian Medical University DalianChina State key laboratory of Information Engineering in surveying Mapping and Remote SensingWuhan UniversityWuhanChina Information Systems technology and Design Pillar Singapore University of Technology and DesignSingaporeSingapore

Subarachnoid haemorrhage(SAH),mostly caused by the rupture of intracranial aneu-rysm,is a common disease with a high fatality *** lesions are generally diffusely distributed,showing a variety of scales with irregular *** complex characteristics of lesions make SAH segmentation a challenging *** cope with these difficulties,a u-shaped deformable transformer(UDT)is proposed for SAH ***,first,a multi-scale deformable attention(MSDA)module is exploited to model the diffuseness and scale-variant characteristics of SAH lesions,where the MSDA module can fuse features in different scales and adjust the attention field of each element dynamically to generate discriminative multi-scale ***,the cross deformable attention-based skip connection(CDASC)module is designed to model the irregular edge char-acteristic of SAH lesions,where the CDASC module can utilise the spatial details from encoder features to refine the spatial information of decoder ***,the MSDA and CDASC modules are embedded into the backbone Res-UNet to construct the proposed *** experiments are conducted on the self-built SAH-CT dataset and two public medical datasets(GlaS and MoNuSeg).Experimental results show that the presented UDT achieves the state-of-the-art performance.

关键词： image segmentation medical image processing

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Case study on the mechanics of NPR anchor cable compensation for large deformation tunnel in soft rock in the Transverse Mountain area,China

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Journal of Central South University 2024年第6期31卷 2054-2069页

作者： LI Yong ZHENG Jing HUO Shu-sen WANG Feng-nian HE Man-chao TAO Zhi-gang College of Geoscience and surveying Engineering China University of Mining and Technology(Beijing)Beijing 100083China State key Labortaory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and Technology(Beijing)Beijing 100083China State key laboratory for Tunnel Engineering China University of Mining and Technology(Beijing)Beijing 100083China Shanxi provincial Transportation technology Research and Development Co.Ltd. Key Laboratory of Highway Construction and Maintenance Technology in Loess AreaTransportation IndustryTaiyuan 030000China

A study was conducted to analyze the deformation mechanism of strongly weathered quartz schist in the Daliangshan Tunnel,located in the western Transverse Mountain area.A large deformation problem was experienced during the tunnel *** mitigate this problem,a support system was designed incorporating negative Poisson ratio(NPR)anchor cables with negative Poisson ratio *** model experiments,field experiments,and numerical simulation experiments were conducted to investigate the compensation mechanical behavior of NPR anchor *** large deformations of soft rocks in the Daliangshan Tunnel are caused by a high ground stress,a high degree of joint fracture development,and a high degree of surrounding rock fragmentation.A compensation mechanics support system combining long and short NPR anchor cables was suggested to provide sufficient counter-support force(approximately 350 kN)for the surrounding rock inside the *** the NPR anchor cable support system with the original support system used in the Daliangshan tunnel showed that an NPR anchor cable support system,combining cables of 6.3 m and 10.3 m in length,effectively prevented convergence of surrounding rock deformation,and the integrated settlement convergence value remained below 300 *** study provides an effective scientific basis for resolving large deformation problems in deeply buried soft rocks in western transverse mountain areas.

关键词： soft rock large deformation NPR anchor cable physical model numerical simulation compensation mechanics

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Thermal Property Enhancement of a Novel Shape-Stabilized Sodium Acetate Trihydrate-Acetamide/Expanded Graphite-Based Composite Phase Change Material

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Journal of Thermal science 2024年第4期33卷 1564-1576页

作者： AN Zhoujian HOU Wenjie DU Xiaoze HUANG Zhongzheng MOMBEKI PEA Hamir Johan ZHANG Dong LIU Xiaomin College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou730050China key laboratory of Multi-supply System with Solar Energy and Biomass of gansu Province Lanzhou730050China gansu Natural Energy Research Institute Lanzhou730046China

Phase change materials(PCMs)are a kind of highly efficient thermal storage materials which have a bright application prospect in many fields such as energy conservation in buildings,waste heat recovery,battery thermal management and so *** inorganic hydrated salt PCMs have received increasing attention from researchers due to their advantages of being inexpensive and ***,inorganic hydrated salt PCMs are still limited by the aspects of inappropriate phase change temperature,liquid phase leakage,large supercooling and severe phase separation in the application *** this work,sodium acetate trihydrate was selected as the basic inorganic PCM,and a novel shape-stabilized composite phase change material(CPCM)with good thermal properties was prepared by adding various functional *** first,the sodium acetate trihydrate-acetamide binary mixture was prepared and the melting point was adjusted using *** the binary mixture was incorporated into expanded graphite to synthesize a novel shape-stabilized *** thermophysical properties of the resultant shape-stabilized CPCM were systematically *** microscopic morphology and chemical structure of the obtained shape-stabilized CPCM were characterized and *** experiment results pointed out that acetamide could effectively lower the melting point of sodium acetate *** obtained shape-stabilized CPCM modified with additional 18%(mass fraction)acetamide and 12%(mass fraction)expanded graphite exhibited good shape stability and thermophysical characteristics:a low supercooling degree of 1.75℃and an appropriate melting temperature of 40.77℃were obtained;the latent heat of 151.64 kJ/kg and thermal conductivity of 1.411 W/(m·K)were also ***,after 50accelerated melting-freezing cycles,the obtained shape-stabilized CPCM represented good thermal reliability.

关键词： sodium acetate trihydrate melting point modification agent expanded graphite shape stability thermal conductivity enhancement

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