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利妥昔单抗治疗IgM单克隆自发感觉神经病

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 51-51页

作者： Goldfarb A.R. Weimer L.H. Brannagan III T.H. 李一明 Peripheral Neuropathy Center Dept. of Neurology and Neuroscience Weill Med. Coll. of CornellUniv. 635 Madison Avenue New York NY 10022 UnitedStates Dr.

Rituximab, a monoclonal antibody against B-cell membrane marker CD-20, is an effective treatment for immunoglobulinM (IgM) monoclonal anti-myelin-associat ed glycoprotein(MAG) neuropathies. We report a patient with an autonomicand pain ful sensory neuropathy associated with an IgM lambda monoclonal gammopathy, resp onsive to rituximab. Treatment resulted in a decline in total IgM and improvemen t in the patient’s painful neuropathy and dysautonomia. Rituximab maybe an effe ctive and tolerable treatment for autonomic and sensory neuropathy associated wi th IgM monoclonal gammopathy.

关键词：利妥昔单抗 IgM 疼痛性族性髓磷脂

两个不同部位长期留置外科中央静脉导管的新生儿病例的预后差异:颈部和腹股沟区

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 30-30页

作者： Vegunta R.K. Loethen P. Wallace L.J. 朱新菊 Depts. of Surgery and Pediatrics Univ. Illinois Coll. Med. at Peoria Children' s Hosp. Illinois OSF S. F. Peoria IL 61603 United States

Long-term tunneled central venous catheters (CVC) are frequently used in the neonatal intensive care unit (NICU) babies. They are placed either in the neck or groin based primarily upon the surgeon’ s preference. There is meager published in-formation available about the relative risks of these lines. This is a retrospective analysis of all the tunneled central venous catheters placed in NICU babies at a children’ s hospital over a nearly 5-year period. Single lumen Broviac catheters were used in all cases. A total of 137 catheters were placed in 126 patients. There were 88 neck lines and 49 groin lines. Age, gestational maturity, and body weight were significantly lower for babies who underwent groin line placement. There was no significant difference in the number of days the catheters were live between the 2 groups. Total complication rates and catheter infection rates were significantly higher with neck lines. The accidental removal rate was higher with neck lines but did not reach statistical significance. Broviac catheters placed in the groin of NICU babies are associated with significantly fewer complications compared with those placed in the neck.

关键词：新生儿病中央静脉导管腹股沟区静脉留置导管儿童医院手术医师统计学显著性风险值单腔个人习惯

慢性高血压患者妊娠期并发先兆子痫的预测模型

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 16-16页

作者： August P. Helseth G. Cook E.F. Sison C. 高雪莲 Div. of Nephrology and Hypertension Weill Med. Coll. of Cornell Univ. New York NY Biostatist. U. N. S. Boston MA United States

Objective Women with chronic hypertension are at increased risk for superimposed preeclampsia. We developed a prediction algorithm for superimposed preeclampsia using clinical and laboratory information that were measured early in pregnancy. Study design A secondary analysis of data that were collected from 110 women with chronic hypertension who were enrolled in a trial of calcium supplementation was performed. Blood pressure, the reninangiotensin system, and calcium metabolism were assessed at 12, 20, 28, and 36 weeks of gestation and 6 weeks after delivery. Multivariable logistic regression was used to develop the predictive model. Results Thirtyseven women had superimposed preeclampsia. The final model included systolic blood pressure, serum uric acid, and plasma renin activity, which were all measured at 20 weeks of gestation. Women with high systolic blood pressure (>140 mm Hg), elevated uric acid (>3.6 mg/dL), and low plasma renin activity (< 4 ng/mL/hr) had an 86%probability of having superimposed preeclampsia. Women with 2 risk factors had a 62%probability of superimposed preeclampsia, and women with only 1 risk factor had a 30%to 40%probability of superimposed preeclampsia. Conclusion We developed a prediction algorithm that can be validated in future studies for superimposed preeclampsia for women with chronic hypertension.

关键词：慢性高血压先兆子痫预测模型血浆肾素活性血尿酸水平妊娠早期钙代谢预测方法临床试验实验室资料

新生儿严重甲状旁腺功能亢进症:基因型/表现型间相关性和应用pamidronate作为抢救措施

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 31-31页

作者： Waller S. Kurzawinski T. Spitz L. W.G.Van’t Hoff 高蕊 Nephro-Urology Unit Univ. Coll. of London Med. Schools Hospital for Children NHS Trust Great Ormond Street WC1N 3JH London United Kingdom

家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSH... 详细信息

家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSHPT 者如果不进行甲状旁腺切除则有生命危险。笔者报道了3例NSHPT病例。

关键词： pamidronate 高钙血症甲状旁腺切除钙敏感受体生命危险表现型纯合性无症状杂合性遗传性疾病

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Preface

Science China Chemistry 2013年第3期56卷 271-272页

作者： WANG Qian HUANG Zhen PU Lin Univ Lausanne CH-1015 Lausanne Switzerland Scripps Res Inst La Jolla CA USA Harvard Univ Sch Med Cambridge MA 02138 USA CUNY Brooklyn coll Brooklyn NY 11210 USA Georgia State Univ Atlanta GA 30303 USA CALTECH Prof Robert H Grubbs Res Grp Pasadena CA 91125 USA N Dakota State Univ Dept Chem Fargo ND USA Univ Virginia Dept Chem Charlottesville VA 22903 USA Sichuan Univ Minist Educ Chengdu Peoples R China

The Eighth Sino-US Chemistry Professors Conference: A Forum for Chemistry and Chemical Biology The Eighth Sino-US Chemistry Professors Conference,co-organized by Kunming Institute of Botany of Chinese Academy of Sciences (Professor Ninghua Tan as the Chairwoman), Yunan University (Professor Hongbin Zhanga s the co-Chairman) and CAPA (The Chinese-American Chemistry & Chemical Biology Professors Association,

关键词： CAPA US Preface

Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda Univ Texas MD Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor coll med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich Alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St Jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St Jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化