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Glial response in the midcingulate cortex in Huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

The role of the unfolded protein response in myelination

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Neural Regeneration Research 2016年第3期11卷 394-395页

作者： Michelle C.Naughton Jill M.McMahon Una F.FitzGerald NCBES Galway Neuroscience CentreNational University of Ireland Galway

The production,transport and integration of myelin components into the membrane during development is a highly coordinated and regulated process that relies heavily on the endoplasmic reticulum（ER）,a sub-cellular organelle that is the principal site of membrane *** on the rough ER allow translation of proteins such as proteolipid protein（PLP）prior to correct folding,

关键词： endoplasmic translational reticulum prior folding assembly coordinated myelin correct tracts

Central CB2 receptors in inflammation-driven neurodegeneration： dysregulation and therapeutic potential

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Neural Regeneration Research 2016年第9期11卷 1409-1410页

作者： Ruth M. Concannon Eilis Dowd Pharmacology & Therapeutics and galway neuroscience centre National University of Ireland Galway Ireland

In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease. Neuroprotective strategies to slow, halt or reverse neuro- degeneration have not proven fruitful clinically, and the notion of a multi-hit hypothesis in the progression of neurodegenerative disease has steered focus towards other contributory pathological factors, particularly neuroinflammation. Neuroinflammation is believed to sustain the neurodegenerative pathology, forming a cy- clical and self-sustaining pathological process, with dying neurons activating microglia, which, once activated, can release several fac- tors that kill further neurons （reviewed in Blandini, 2013）.

关键词： Central CB2 receptors in inflammation-driven neurodegeneration CB

Seeing the wood for the trees:towards improved quantification of glial cells in central nervous system tissue

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Neural Regeneration Research 2018年第9期13卷 1520-1523页

作者： Sinéad Healy Jill McMahon Una FitzGerald galway neuroscience centre School of Natural SciencesNational University of Ireland

The following mini-review attempts to guide researchers in the quantification of fluorescently-labelled proteins within cultured thick or chromogenically-stained proteins within thin sections of brain *** follows from our examination of the utility of Fiji Image J thresholding and binarization *** how we identified the maximum intensity projection as the best of six tested for two dimensional（2 D）-rendering of three-dimensional（3 D） images derived from a series of z-stacked micrographs,the review summarises our comparison of 16 global and 9 local algorithms for their ability to accurately quantify the expression of astrocytic glial fibrillary acidic protein（GFAP）,microglial ionized calcium binding adapter molecule 1（IBA1） and oligodendrocyte lineage Olig2 within fixed cultured rat hippocampal brain *** application of these algorithms to chromogenically-stained GFAP and IBA1 within thin tissue sections,is also ***’s Bio Voxxel plugin allowed categorisation of algorithms according to their sensitivity,specificity accuracy and relative *** Percentile algorithm was deemed best for quantifying levels of GFAP,the Li algorithm was best when quantifying IBA expression,while the Otsu algorithm was optimum for Olig2 staining,albeit with over-quantification of oligodendrocyte number when compared to a stereological ***,GFAP and IBA expression in 3,3′-diaminobenzidine（DAB）/haematoxylin-stained cerebellar tissue was best quantified with Default,Isodata and Moments *** workflow presented in Figure 1 could help to improve the quality of research outcomes that are based on the quantification of protein with brain tissue.

关键词： organotypic brain slice culture glial cell quantification thresholding algorithms Fiji Image J Bio Voxxel plug-in stereology

Brain repair for Parkinson's disease:is the answer in the matrix?

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Neural Regeneration Research 2018年第7期13卷 1187-1188页

作者： Niamh Moriarty Eilís Dowd Pharmacology & Therapeutics and galway neuroscience centre National University of Ireland

Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophys... 详细信息

关键词： Brain repair for Parkinson’s disease:is the answer in the matrix

Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?

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Neural Regeneration Research 2023年第8期18卷 1721-1722页

作者： Oliver WG Wood Jason HY Yeung Andrea Kwakowsky centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer's disease(AD)is the most common form of dementia worldwide,impairing memory and cognitive functions due to widespread neuronal *** global incidence of this neurodegenerative disorder is predicted to increase... 详细信息

关键词： Alzheimer death EAAT2

Metabotropic glutamate receptor 1 alpha:a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2023年第10期18卷 2196-2197页

作者： Jason HY Yeung Andrea Kwakowsky centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer’s disease (AD) is the leading neurodegenerative disorder *** this,there is minimal effective therapeutics proven to reduce or prevent the progression of this *** is the main excitatory neurotransmitter with... 详细信息

关键词： Alzheimer Metab pathogenesis