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Long‑term outcomes of two first‑generation trabecular micro‑bypass stents(iStent)with phacoemulsification in primary open‑angle glaucoma:eight‑year results

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Eye and Vision 2021年第4期8卷 431-442页

作者： Ali Salimi Harrison Watt Paul Harasymowycz Department of Ophthalmology Faculty of MedicineMcGill UniversityMontrealQCCanada Montreal Glaucoma Institute MontrealQCCanada Faculty of Medicine McGill UniversityMontrealQCCanada Department of Ophthalmology University of Montreal4135 de RouenMontrealQC H1V1G5Canada

Background:The short-and medium-term outcomes of iStent have been extensively studied;however,only few studies have investigated its long-term ***,we assessed the long-term efficacy and safety of two iStents with concomitant cataract surgery in glaucomatous eyes while also evaluating measures of disease stability using visual field and optical coherence tomography(OCT)of the optic nerve and the macula throughout 8 years of ***:This longitudinal,single-center consecutive case series included glaucomatous eyes that underwent implantation of two first-generation trabecular micro-bypass stents(iStent)with concomitant cataract ***-year efficacy outcomes included mean intraocular pressure(IOP)and medications,as well as surgical ***-year safety outcomes included best-corrected visual acuity(BCVA),visual field mean deviation(VF-MD),cup-todisc ratio(CDR),retinal nerve fiber layer(RNFL)thickness,ganglion cell-inner plexiform layer(GC-IPL)thickness,and adverse ***:A total of 62 eyes with primary open-angle glaucoma(POAG)were *** 8 years postoperative,IOP reduced by 26%from 19.2±3.9 mmHg preoperatively to 14.2±2.4 mmHg(P<0.001),91.1%of eyes achieved IOP≤18 mmHg(vs.51.6%preoperatively),69.6%of eyes achieved IOP≤15 mmHg(vs.14.5%preoperatively),and 25%of eyes achieved IOP≤12 mmHg(vs.1.6%preoperatively).Medication use decreased by 17.9%from 2.8±1.1 preoperatively to 2.3±1.2(P=0.018).Surgical success was 90%,as six eyes underwent subsequent glaucoma *** measures of BCVA,CDR,RNFL thickness and GC-IPL thickness remained stable through 8 years ***-MD remained stable until postoperative year 5 and subsequently progressed according to the natural history of glaucomatous ***:Implantation of two iStents with concomitant cataract surgery is an effective and safe treatment option for surgery-naïve POAG eyes,evidenced by significant IOP and medication reductions,reasonable surgical success

关键词： Minimally invasive glaucoma surgery MIGS Trabecular micro-bypass stent iStent Glaucoma Cataract surgery Long-term outcomes

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Longitudinal trajectories of athlete burnout among young table tennis players: A 3-wave study

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Journal of Sport and Health Science 2020年第4期9卷 367-375页

作者： Guillaume Martinent Benoıt Louvet Jean-Claude Decret Laboratory of Vulnerabilities and Innovation in Sport Claude Bernard University Lyon 1Villeurbanne 69622France Center of Research of Transformations of Sports and Physical Activities(CETAPS) University of RouenMont-Saint-Aignan 76821France French Federation of Table Tennis Paris 75625France

Purpose:The purposes of this study were to examine the trajectories of athlete burnout across a 2-month period characterized by high physical,psychological,and social demands to explore(1)whether several subgroups of athletes representing distinct burnout trajectories emerged from the analyses and(2)whether athlete burnout symptoms(reduced accomplishment,sport devaluation,and exhaustion)developed in tandem or whether some burnout dimensions predicted downstream changes in other dimensions(causal ordering model).Methods:One hundred and fifty-nine table tennis players in intensive training centers completed a self-reported athlete burnout measure across 3 time points within a 2-month period characterized by high *** were analyzed through latent class growth ***:Results of latent class growth analysis showed 3 distinct trajectories for each athlete burnout dimension,indicating not only linear or quadratic change but also stability in longitudinal athlete burnout *** also suggested that the 3 dimensions of athlete burnout did not develop in ***,the likelihood of belonging to particular emerging trajectories of sport devaluation and physical/emotional exhaustion was significantly influenced by the athletes’perception of reduced accomplishment assessed at Time ***,reduced accomplishment predicted downstream changes in the 2 other athlete burnout ***:As a whole,these results highlighted that the multinomial heterogeneity in longitudinal athlete burnout symptoms needs to be accounted for in future research.

关键词： Athlete burnout Intensive training Latent class growth analyses Person-centered approach Table tennis Youth elite athletes

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Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER （-） and ER （＋） breast cancer cell lines in vitro

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Chinese Medical Journal 2009年第11期122卷 1300-1304页

作者： WANG Xiao-yi TAN Jin-xiang Marc Vasse Bertrand Delpech REN Guo-sheng Department of Endocrine Surgery First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Groupe MERCI Faculte de Medecine-Pharmacie 22 boulevard Gambetta 76183 Rouen cedex France Laboratoire d'Oncologie Moleculaire Centre Henri-Becquerel rue d'Amiens 76000 Rouen France

Background Hyaluronidase （Hyase） is an enzyme which hydrolyses hyaluronan （HA）, a large nonsulfated glycosaminoglycan. Several genes have been identified to code for hyaluronidases in humans. Its role has only recently been underlined in the invasion of prostate cancer, colonic cancer, and breast cancer. Moreover, the findings were in agreement with some experimental results which showed that HA-derived oligosaccharides had angiogenesis-promoting activity. All these findings prompted us to investigate factors that had been characterized as putative invasive factors in different human breast cancer-derived cell lines. Methods We selected two series of human breast cancer-derived cell lines whose expression of estrogen receptors （ER） was previously published. Hyaluronidase secretion in culture medium and expression of matrix metallo-proteinase （MMP）-9, cathepsin-D （cath-D） and vascular endothelial growth factor （VEGF） by cells were determined. We also investigated cell invasiveness in the Matrigel invasion assay, and studied the capability of cancer cells to promote in vitro formation of tubules by endothelial cells. Results ER（-） cells secreted significantly more hyaluronidase （P 〈0.001） and expressed significantly more VEGF （P 〈0.01）, MMP-9 （P 〈0.05） and cath-D （P 〈0.0001） than ER（＋） cells. Invasion through Matrigel by ER（-） Hyase（＋） cells was significantly higher than that by ER（＋） Hyase（-） cells （P 〈0.05）. In both cases, invasion was decreased by heparin （P 〈0.05）. When ECV-304 endothelial cells were co-cultivated in millicell chambers with cancer cells, ECV-304 cells were induced to form tubules. Tubule formation was demonstrated to be more prominent with ER（-） Hyase（＋） cells than with ER（＋） Hyase（-） cells （P 〈0.05）. Conclusion Invasive features of ER（-） breast cancer cells can be characterized in vitro by an invasive Matrigel assay, as the induction of tubule formation by ECV-304 endothelial cells, higher secretion of hyaluronidase, and higher expression of prot

关键词： angiogenesis breast neoplasms receptors, estrogen hyaluronidase invasion peptide hydrolases

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RENORMALIZED SOLUTIONS OF ELLIPTIC EQUATIONS WITH ROBIN BOUNDARY CONDITIONS

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Acta Mathematica Scientia 2017年第4期37卷 889-910页

作者： Olivier GUIBE Alip OROPEZA Laboratoire de Mathématiques Raphaёl Salem CNRSUMR 6085Universitéde RouenAvenue de l'UniversiteBP 1276801 Saint-Etienne du Rouvray cedexFrance University of the Philippines Diliman Institute of Mathematics1101 DilimanQuezon CityPhilippines

In the present paper, we consider elliptic equations with nonlinear and nonlao mogeneous Robin boundary conditions of the type {-div（B（x,u）△u） = f in Ω,u=0 on Гo, B（x,u）Vu·n^-＋γ（x）h（u） = 9 on Г1,where f and g are the element of L^1（Ω） and L^1（Г1）, respectively. We define a notion of renormalized solution and we prove the existence of a solution. Under additionM assumptions on the matrix field B we show that the renormalized solution is unique.

关键词： elliptic equations renormalized solution uniqueness Robin boundary conditions L^1 data

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CCD互相关粒子图像测速及其在对抗流流场测量中的应用

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推进技术 2000年第6期21卷 83-88页

作者：郑日恒 Bray K N C Rogg B Lecordier B 英国剑桥大学工程系鲁尔大学流体热力学研究所 CORIA Rouen大学

在常规自相关粒子图像测速 (PIV)系统的基础上 ,发展了一个采用CCD像机的互相关粒子图像测速系统。用这一新系统测量了对抗流流场的结果表明 ,这一技术克服了自相关粒子图像测速技术在测量具有滞止点的流场中的困难。实验说明 ,与自相... 详细信息

在常规自相关粒子图像测速 (PIV)系统的基础上 ,发展了一个采用CCD像机的互相关粒子图像测速系统。用这一新系统测量了对抗流流场的结果表明 ,这一技术克服了自相关粒子图像测速技术在测量具有滞止点的流场中的困难。实验说明 ,与自相关粒子图像测速技术相比。

关键词：粒子速度成像对抗流互相关自相关速度分布流动测量

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Comparative Study of Three High Order Schemes for LES of Temporally Evolving Mixing Layers

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Communications in Computational Physics 2012年第10期12卷 1603-1622页

作者： Helen C.Yee Bjorn Sjögreen Abdellah Hadjadj NASA-Ames Research Center Moffett FieldCA94035USA Lawrence Livermore National Laboratory LivermoreCA94551USA CORIA UMR 6614&INSA de rouen 76800 St-Etienne du RouvrayFrance

Three high order shock-capturing schemes are compared for large eddy simulations(LES)of temporally evolving mixing layers for different convective Mach numbers ranging from the quasi-incompressible regime to highly compressible supersonic *** considered high order schemes are fifth-order WENO(WENO5),seventh-order WENO(WENO7)and the associated eighth-order central spatial base scheme with the dissipative portion of WENO7 as a nonlinear post-processing filter step(WENO7fi).This high order nonlinear filter method of Yee&Sjogreen is designed for accurate and efficient simulations of shock-free compressible turbulence,turbulence with shocklets and turbulence with strong shocks with minimum tuning of scheme *** LES results by WENO7fi using the same scheme parameter agree well with experimental results compiled by Barone et al.,and published direct numerical simulations(DNS)work of Rogers&Moser and Pantano&Sarkar,whereas results by WENO5 andWENO7 compare poorly with experimental data and DNS computations.

关键词： High order numerical methods numerical methods for turbulencewith shocks DNS LES mixing layer

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Using Microscopy to Help with the Understanding of Degradation Mechanisms Observed in Materials of Pressurized Water Reactors

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材料科学与工程（中英文B版） 2017年第5期7卷 187-220页

作者： Laurent Legras Alexandre Volgin Bertrand Radiguet Philippe Pareige Cedric Pokor Brigitte Decamps Thierry Couvant Nicolas Huin Romain Soulas EDF R&D-EDF Lab Les Renardieres Moret sur Loing cedex 77818 France gpm rouen Avenue de l'Universite Saint-F.tienne-du-Rouvray 76800 France CSNSM IN2P3 Universite de Paris Sud Orsay 91400 France Institut PPrime Universite de Poitiers ISAE-ENSMA UPR 3346 BP 30179 F86962 Futuroscope Chasseneuil France INP Grenoble SIMAP Saint-Martin-d'Heres 38402 France

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Remarks on the rank properties of formal CR maps Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1477-1490页

作者： LAMEL Bernhard MIR Nordine Universitt Wien Fakultt für Mathematik Nordbergstrasse 15A-1090 Wiensterreich Université de rouen Laboratoire de Mathématiques Rapha■l Salem UMR 6085 CNRSAvenue de I'UniversitéB.P. 1276801 Saint Etienne du RouvrayFrance

We prove several new transversality results for formal CR maps between formal real hypersurfaces in complex space. Both cases of finite and infinite type hypersurfaces are tackled in this note.

关键词： formal CR map, CR-transversality.

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Contribution to Development of Reliability and Optimization Methods Applied to Mechanical Structures

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Applied Mathematics 2013年第1期4卷 19-24页

作者： Siham Ouhimmou Abdelkhalak El Hami Rachid Ellaia Mohamed Tkiouat Laboratory of Mechanics of rouen National Institute of Applied Sciences Rouen France Laboratory of Mechanics University Hassan II Casablanca Morocco Laboratory of Study and Research in Mathematics Applied Mohammedia School of Laboratory of Study and Research in Mathematics Applied Mohammedia School of Engineers Agdal-Rabat Morocco

In order to take into account the uncertainties linked to the variables in the evaluation of the statistical properties of structural response, a reliability approach with probabilistic aspect was considered. This is called the Probabilistic Transformation Method (PTM). This method is readily applicable when the function between the input and the output of the system is explicit. However, the situation is much more involved when it is necessary to perform the evaluation of implicit function between the input and the output of the system through numerical models. In this work, we propose a technique that combines Finite Element Analysis (FEA) and Probabilistic Transformation Method (PTM) to evaluate the Probability Density Function (PDF) of response where the function between the input and the output of the system is implicit. This technique is based on the numerical simulations of the Finite Element Analysis (FEA) and the Probabilistic Transformation Method (PTM) using an interface between Finite Element software and Matlab. Some problems of structures are treated in order to prove the applicability of the proposed technique. Moreover, the obtained results are compared to those obtained by the reference method of Monte Carlo. A second aim of this work is to develop an algorithm of global optimization using the local method SQP, because of its effectiveness and its rapidity of convergence. For this reason, we have combined the method SQP with the Multi start method. This developed algorithm is tested on test functions comparing with other methods such as the method of Particle Swarm Optimization (PSO). In order to test the applicability of the proposed approach, a structure is optimized under reliability constraints.

关键词： Reliability Methods Probabilistic Transformation Method Finite Element Analysis FEACPTM The Method SQP The Multi Start Method Algorithm MSQP Structural Optimization

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Composition, Stability and Probable Structure of a Colourless Organometallic Complex (Gd(III)-Malic Acid)

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Open Journal of Physical Chemistry 2013年第1期3卷 49-58页

作者： Mohammed Riri Oussama Kamal Abdelkhalek Benjjar Farid Serdaoui Miloudi Hlaibi Laboratoire d’Interface Matériaux et Chimie de l’Environnement UniversitéHassan II Facultédes Sciences Ain ChockCasablancaMaroc Laboratoire des Polymères BiopolymèresSurfacesFacultédes SciencesUniversitéde RouenRouenFrance

The formation of colourless gadolinium complexes (x,y,z), between x gadolinium ions, y ligands and z protons, of some organic acids, has been studied in aqueous solution. In this work we present the results of investigations on the interaction of the gadolinium ion (Gd3+) with malic acid (C4H6O5, a-hydroxyl dicarboxylic acid), in dilute aqueous solution for pH values between 5.5 and 7.5. Colourless gadolinium complexes of malate ions have no absorption band UV-visible, the indirect photometric detection (IPD) technique was used and studies have identified a major tri-nuclear complex of malate ion (﹣OOC-CH2-CHOH-COO﹣). The formation of this new colourless complex is derived from three Gd(III) ions that react with two malate ions and two hydronium ions (H3O+), giving for this colourless complex, a (3,2,2) composition and apparent stability constant depends on the acidity of the medium, with logK'322 = 18.88 ± 0.05 at pH = 6.30. To complement previous results and to propose a probable structure for this new complex detected in solution, studies of IR spectroscopy have been conducted to identify the chelation sites for both ligands. The results were analysed and show that this organometallic gadolinium complex, contains two different sites, respectively, two lateral tetradentate mono-nuclear sites and a single central bidentate mono-nuclear site. From these results, the reaction of formation, the stability constant and the probable structure of this new colourless organometallic gadolinium complex are proposed.

关键词： Gadolinium Complexes Malate Ions Indirect Photometric Detection(IPD) Apparent Stability Constant Chelation Sites Bidentate Mono-Nuclear Tetradentate Mono-Nuclear

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