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Blade-Coated Porous 3D Carbon Composite Electrodes Coupled with Multiscale Interfaces for Highly Sensitive All-Paper Pressure Sensors

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Nano-Micro Letters 2024年第12期 225-240页

作者： Bowen Zheng Ruisheng Guo Xiaoqiang Dou Yueqing Fu Bingjun Yang Xuqing Liu Feng Zhou State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering Northwestern Polytechnical University research center of Resource Chemistry and Energy Materials State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese of Academy of Sciences Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences

Flexible and wearable pressure sensors hold immense promise for health monitoring, covering disease detection and postoperative rehabilitation. Developing pressure sensors with high sensitivity, wide detection range, and cost-effectiveness is paramount. By leveraging paper for its sustainability, biocompatibility, and inherent porous structure, herein, a solution-processed all-paper resistive pressure sensor is designed with outstanding performance. A ternary composite paste, comprising a compressible 3D carbon skeleton, conductive polymer poly（3,4-ethylene dioxythiophene）:poly（styrenesulfonate）, and cohesive carbon nanotubes, is blade-coated on paper and naturally dried to form the porous composite electrode with hierachical micro-and nano-structured surface. Combined with screen-printed Cu electrodes in submillimeter finger widths on rough paper, this creates a multiscale hierarchical contact interface between electrodes, significantly enhancing sensitivity(1014 k Pa-1) and expanding the detection range（up to 300 k Pa） of as-resulted all-paper pressure sensor with low detection limit and power consumption. Its versatility ranges from subtle wrist pulses, robust finger taps, to large-area spatial force detection, highlighting its intricate submillimetermicrometer-nanometer hierarchical interface and nanometer porosity in the composite electrode. Ultimately, this all-paper resistive pressure sensor, with its superior sensing capabilities, large-scale fabrication potential, and cost-effectiveness, paves the way for next-generation wearable electronics, ushering in an era of advanced, sustainable technological solutions.

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Computational Screening of Pt1@Ti_(3)C_(2)T_(2)(T=O,S)MXene Catalysts for Water-Gas Shift Reaction

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Precision Chemistry 2024年第2期2卷 70-80页

作者： Yang Meng Haiyan Wang Jin-Xia Liang Chun Zhu Jun Li School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China Department of Chemistry and Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry and Engineering research center of Advanced Rare-Earth Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

Single-atom catalysts(SACs)provide an oppor-tunity to elucidate the catalytic mechanism of complex reactions in heterogeneous *** low-temperature water-gas shift(WGS)reaction is an important industrial technology to obtain high purity ***,we study the catalytic activity of Pt1@Ti_(3)C_(2)T_(2)(T=O,S)SACs,where one subsurface Ti atom with three T vacancies in the functionalized Ti_(3)C_(2)T_(2)(T=O,S)MXene is substituted by one Pt atom,for the low-temperature show that Pt1@Ti_(3)C_(2)T_(2)provides an excellent platform for the WGS reaction by its bowl-shaped vacancy derived from the Pt1 single atom and three T defects surrounding ***,Pt1@Ti_(3)C_(2)S_(2)SAC has higher catalytic performance for the WGS reaction,due to the weaker electronegativity of the S atom than the O atom,which significantly reduces the energy barrier of H*migration in the WGS reaction,which is often the rate-determining *** the most favorable redox mechanism of the WGS reaction on Pt1@Ti_(3)C_(2)S_(2),the rate-determining step is the dissociation of OH*into O*and H*with the energy barrier as low as 1.12 *** results demonstrate that Pt1@Ti_(3)C_(2)S_(2)is promising in the application of MXenes for low-temperature WGS reactions.

关键词： single-atom catalyst(SAC) density functional theory(DFT) water gas shift(WGS)reaction defective MXene thermocatalysis

基于神经网络势能函数实现多组分金属液体玻璃化转变过程的精确高效模拟（英文）

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Science China Materials 2024年第10期67卷 3298-3308页

作者：苏锐余洁意管鹏飞汪卫华 College of Materials&Environmental Engineering Hangzhou Dianzi University Beijing Computational Science research center Songshan Lake Materials Laboratory

多组元金属液体中玻璃化转变的计算模拟面临精确势能函数构建及玻璃转变温度附近指数增长的结构弛豫时间这两大关键问题.通过高效的神经网络势训练算法和程序实现,以及基于原子交换的杂化蒙特卡洛方法,我们提出了一套高效且精确的处理... 详细信息

多组元金属液体中玻璃化转变的计算模拟面临精确势能函数构建及玻璃转变温度附近指数增长的结构弛豫时间这两大关键问题.通过高效的神经网络势训练算法和程序实现,以及基于原子交换的杂化蒙特卡洛方法,我们提出了一套高效且精确的处理多组元金属液体玻璃化转变模拟问题的通用算法并在Zr-Cu-Al三元金属玻璃体系中进行了验证.验证结果表明,该算法可以准确地再现第一性原理计算和实验中所获得的合金相稳定性和结构关联函数,并将深过冷温度下的结构弛豫时间缩短至少五个数量级同时得到了接近实验冷却速率范围的玻璃结构样品.该研究为进一步研究多组元金属液体中的玻璃化过程特别是成分依赖的玻璃形成能力和物理性能奠定了理论基础.

关键词： metallic glass computational methods glass transition

Algorithm for Solving Traveling Salesman Problem Based on Self-Organizing Mapping Network

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 463-470页

作者：朱江辉叶航航姚莉秀蔡云泽 Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China Shanghai Engineering research center of Intelligent Control and Management Shanghai 200240China Key Laboratory of Marine Intelligent Equipment and System Ministry of EducationShanghai 200240China Huawei Technologies Co. Ltd.Shanghai 201206China

Traveling salesman problem(TSP)is a classic non-deterministic polynomial-hard optimization *** on the characteristics of self-organizing mapping(SOM)network,this paper proposes an improved SOM network from the perspectives of network update strategy,initialization method,and parameter *** paper compares the performance of the proposed algorithms with the performance of existing SOM network algorithms on the TSP and compares them with several heuristic *** show that compared with existing SOM networks,the improved SOM network proposed in this paper improves the convergence rate and algorithm *** with iterated local search and heuristic algorithms,the improved SOM net-work algorithms proposed in this paper have the advantage of fast calculation speed on medium-scale TSP.

关键词： traveling salesman problem(TSP) self-organizing mapping(SOM) combinatorial optimization neu-ral network

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

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Oncology research 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUMERA-CIEĆKIEWICZ BARTŁOMIEJ SZOSTAKOWSKI MATEUSZ J.SPAŁEK TOMASZŚWITAJ PIOTR RUTKOWSKI ANNA M.CZARNECKA Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(IMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,IMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat IMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on IMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)

A live birth resulting from a fourth cesarean scar pregnancy after combined hysteroscopic and laparoscopic uterine repair: A case report and literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 136-139页

作者： Jie Yang Jianmin Chen Dong Huang Assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility Hangzhou 310016China Zhejiang Provincial Clinical research center for Obstetrics and Gynecology Hangzhou 310016China

Cesarean scar pregnancy(CSP)is a rare form of ectopic pregnancy that is defined as a pregnancy sac located within the scar of a previous cesarean *** cesarean scar pregnancy(RCSP)is even more uncommon,1 with Hasegawa et al reporting the first RCSP in 2005.2 RCSP is a high-risk pregnancy condition with potential complications that include heavy bleeding,uterine rupture,and maternal *** exact incidence rates for CSP and RCSP are unknown,although the incidence of CSP is 1/2656–1/1800 of the total number of cesarean sections,and the incidence of RCSP can reach 6.9%–34.3%.3,4,5 With the promulgation of the second and third child policies in China,an increasing number of patients now manifest fertility needs after cesarean *** improvements in examination methods and awareness of CSP,we also suspect that the rates of CSP and RCSP may be even ***,there is no standard treatment for *** herein report a case in which the patient was treated by combined hysteroscopic and laparoscopic uterine repair without scar resection during the third RCSP,and the fourth RCSP occurred 6 months later;the patient then selected expectant *** outcome was a successful cesarean section delivery of a live baby at 34 weeks of gestation,and the uterus was successfully *** pathology was examined after delivery and revealed that the chorionic villi penetrated deeply into the myometrium.

关键词： pregnancy cesarean repair

Microenvironment and electronic state modulation of Pd nanoparticles within MOFs for enhancing low-temperature activity towards DCPD hydrogenation

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Chinese Journal of Catalysis 2024年第9期64卷 112-122页

作者： Zhiyuan Liu Changan Wang Ping Yang Wei Wang Hongyi Gao Guoqing An Siqi Liu Juan Chen Tingting Guo Xinmeng Xu Ge Wang Beijing Advanced Innovation center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingShunde 528399GuangdongChina Sinopec research Institute of Petroleum Processing Co. LtdSINOPECBeijing 100083China

Precise control of the local environment and electronic state of the guest is an important method of controlling catalytic activity and reaction *** this paper,guest Pd NPs were introduced into a series of host UiO-67 MOFs with different functional ligands and metal nodes,the microenvironment and local electronic structure of Pd is modulated by introducing bipyridine groups and changing metal nodes(Ce6O6 or Zr6O6).The bipyridine groups not only promoted the dispersion Pd NPs,but also facilitated electron transfer between Pd and UiO-67 MOFs through the formation of Pd-N *** with Zr6 clusters,the tunability and orbital hybridisation of the 4f electronic structure in the Ce6 clusters modulate the electronic structure of Pd through the construction of the Ce-O-Pd *** optimal catalyst Pd/UiO-67(Ce)-bpy presented excellent low-temperature activity towards dicyclopentadiene hydrogenation with a conversion of>99%and a selectivity of>99%(50℃,10 bar).The results show that the synergy of Ce-O-Pd and Pd-N promotes the formation of active Pdδ+,which not only enhances the adsorption of H2 and electron-rich C=C bonds,but also contributes to the reduction of proton migration distance and improves proton utilization *** results provide valuable insights for investigating the regulatory role of the host MOFs,the nature of host-guest interactions,and their correlation with catalytic performance.

关键词： Interface regulation Pdδ+ Microenvironment Electronic state Hydrogenation

Chemokine-like factor 1 (CKLF1) is expressed in myocardial ischemia injury in vivo and in vitro

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BIOCELL 2024年第6期48卷 981-990页

作者： JULING FENG HAODONG CHEN YANGBO LIU QIDI AI YANTAO YANG LEI ZHAO SHIFENG CHU NAIHONG CHEN School of Pharmacy Department of PharmacyHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction PiecesHunan University of Chinese MedicineChangsha410208China Department of Pharmacology State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica&Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of Diagnostics research Lab of Translational Medicine Hengyang Medical CollegeUniversity of South ChinaHengyang421001China Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyang421001China

Introduction:Chemokine-like factor 1(CKLF1)is a chemokine that is overexpressed in several *** previousﬁndings revealed a signiﬁcant increase in CKLF1 expression in the ischemic brain,suggesting its potential as a therapeutic target for ischemic ***:In this study,we examined the expression dynamics of CKLF1 in both in vivo and in vitro models of ischemic cardiac *** infarction(MI)was induced in vivo by ligation of the left anterior descending artery(LAD)of the rat *** levels of CKLF1,Creatine Kinase MB Isoenzyme(CK-MB),and Lactate dehydrogenase(LDH)in the serum were detected using Enzyme-linked immunosorbent assay(ELISA).The expression of CKLF1 in the infarcted area was detected by immunohistochemistry,immunoﬂuorescence,quantitative PCR(qPCR),and Western blotting(WB).H9C2 and AC16 cardiomyocytes cultured in vitro were subjected to oxygen and glucose deprivation(OGD).LDH was used to detect cell damage,and CKLF1 expression was detected by qPCR and ***:CKLF1 mRNA and protein expression were signiﬁcantly increased in h9c2 cells at 1.5 h and in AC16 cells at 4 h after *** serum CK-MB in rats increased signiﬁcantly on theﬁrst day after infarction,while the LDH concentration increased signiﬁcantly on the third day after ***1 blood levels signiﬁcantly increased on theﬁrst day following MI in ***1 expression notably increased in the infarct area on days 1,3,and 7 *** MI tissue,CKLF1 colocalizes with cardiomyocytes,macrophages,and ***:CKLF1 was substantially expressed during myocardial ischemia injury both in vivo and in vitro and was colocalized with macrophages and neutrophils,indicating that CKLF1 is expected to be a biomarker and a drug target for the treatment of myocardial infarction.

关键词： Chemokine-like factor 1 Overexpression Myocardial infarction

3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

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BIOCELL 2024年第5期48卷 861-872页

作者： XIAOQI WU YECHUAN HE YEQIN YUAN XIAN TAN LIN ZHU DANLING WANG BINYUAN JIANG Hengyang Medical School University of South ChinaHengyang421001China Institute for Future Sciences University of South ChinaChangsha410008China Medical research center The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China Department of Clinical Laboratory The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China

Background:Nasopharyngeal carcinoma(NPC)exhibits a significant prevalence in the southern regions of China,and paclitaxel(PTX)is frequently employed as a medication for managing advanced ***,drug resistance is typically accompanied by a poor *** the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment ***:This study investigated whether 3-Methyladenine(3-MA)could potentiated the effect of PTX and its potential molecular *** were divided into the following categories:Negative control(NC)with the solvent dimethyl sulfoxide(DMSO,0.5%v/v),PTX(400 nM),3-MA(4 mM),and PTX(400 nM)+3-MA(4 mM).The viability of NPC cells was assessed using both the cell counting kit-8(CCK-8)assay and the colony formation *** observation was performed to identify morphological cell *** cytometry was used to assess cell cycle status,mitochondrial membrane potential(MMP),and apoptotic *** blotting was conducted to quantify the protein ***:3-MA enhanced PTX-specific inhibition of NPC cell ***,either alone or in combination with 3-MA,caused cell cycle halt at the G2/M phase in the majority of NPC cells,and the combination treatment of PTX with 3-MA induced a higher rate of NPC cell death compared to PTX *** blotting results revealed the combination of PTX with 3-MA heightened activation of cyclin-dependent kinase 1(CDK1),a key molecule in shifting cells from mitotic arrest to apoptosis,led to a reduction in Myeloid Cell Leukemia 1(MCL-1)expression and an increase in Poly(ADP-ribose)polymerase(PARP)***:The concurrent administration of PTX with 3-MA effectively enhances PTX’s inhibitory impact on NPC and activates the apoptosis signal regulated by CDK1.

关键词： Nasopharyngeal carcinoma Paclitaxel 3-Methyladenine Cell cycle Apoptosis