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Microarchitecture of titanium cylinders obtained by additive manufacturing does not influence osseointegration in the sheep

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Regenerative Biomaterials 2021年第4期8卷 11-20页

作者： Louis Rony Eric Aguado Bruno Verlee Florence Pascaretti-Grizon Daniel Chappard gerom-Groupe Etudes Remodelage Osseux et bioMate´riaux LabCom NextBoneUniv-AngersIRIS-IBS Institut de Biologie en Sante´49933 AngersFrance ONIRIS Ecole Ve´te´rinaire de Nantes44307Nantes Cedex 3France SIRRIS Lie`ge Science Park Rue du bois St Jean 12Seraing 4102Belgium SCIAM Service Commun d’Imagerie et Analyses MicroscopiquesIRIS-IBS Institut de Biologie en Sante´Univ-AngersAngers Cedex 49933France

Large bone defects are a challenge for orthopedic ***(bone grafts)and synthetic biomaterials have been proposed but several problems arise such as biomechanical resistance or viral/bacterial *** use of metallic foams could be a solution to improve mechanical resistance and promote osseointegration of large porous metal *** cylinders have been prepared by additive manufacturing(3D printing/rapid prototyping)with a geometric or trabecular *** were implanted in the femoral condyles of aged ewes;the animals were left in stabling for 90 and 270 days.A double calcein labeling was done before sacrifice;bones were analyzed by *** bone volume,bone/titanium interface nor mineralization rate were influenced by the cylinder’s microarchitecture;the morphometric parameters did not significantly increase over *** anchoring occurred on the margins of the cylinders and some trabeculae extended in the core of the cylinders but the amount of bone inside the cylinders remained *** rigid titanium cylinders preserved bone cells from strains in the core of the *** manufacturing is an interesting tool to prepare 3D metallic scaffolds,but microarchitecture does not seem as crucial as expected and anchoring seems limited to the first millimeters of the graft.

关键词： titanium trabecular scaffold osseointegration geometric architecture histomorphometry

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Donkey pericardium as a select sourcing to manufacture percutaneous heart valves:Decellularization has not yet demonstrated any clear cut advantage to glutaraldehyde treatment

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Medicine in Novel Technology and Devices 2019年第4期4卷 38-46页

作者： Aisa Rassoli Yiming Li Xianhao Bao Fabien Kawecki Xinzhe Zhao Daniel Chappard Gaetan Le-Bel Jiaxuan Feng Benedikt Weber Nasser Fatouraee Ze Zhang Zaiping Jing Lucie Germain Lu Wang Robert Guidoin Department of Surgery Faculty of MedicineUniversite Laval and Regenerative Medicine AxisCHU de Quebec Research CenterQuebecCanada Department of Biomedical Engineering Amirkabir University of TechnologyTehranIran Departnent of Vascular Surgery Changhai Hospital of Naval Military Medical UniversityShanghaiChina Key Laboratory of Textile Sciences and Technology Ministry of EducationColle of TextilesDonghua UniversityShanghaiChina gerom Institut de Biologie en SanteCHU D'AngersAngersFrance Department of Dermatology Medical University of ViennaViennaAustria

Background:The donkey pericardium is considered a good candidate to manufacture percutaneous heart valves based upon its thinness,low cellularity and undulating collagen bundles and *** represents an avenue worth exploring,should its superiority to glutaraldehyde-treated pericardium be *** and methods:Donkey pericardium was divided into two groups:regular glutaraldehyde fixation and mild *** treated pericardia were observed using scanning electron microscopy,histology and transmission electron *** tests were performed along the axial and perpendicular directions,with the data fitted into both the Gasser–Ogden–Holzapfel(GOH)material model and the Fung’s anisotropic ***:The microstructures of the pericardia processed by the two protocols were similar,showing collagen bundles and laminates free of *** decellularization eliminated most of the cells,however leaving the structure somehow *** collagen filaments in bundles were slightly *** anisotropy rates of the non-decellularized specimens were almost identical to the decellularized *** decellularized pericardium appeared ***:The decellularization proved to be ***,it makes the tissue stiffer,which may lead to higher shear concentration during cardiac cycles and reduce its wavy ***,it appears premature to select decellularized donkey pericardium to manufacture heart valves.

关键词： Donkey pericardium Decellularization Valve leaflet Transcatheter aortic valve implantation Wavy microstructure

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