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ribonucleotide reductase M2 (rrM2): regulation, function and targeting strategy in human cancer

Genes & diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang Innovative drug r&d center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"center for Cellular regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

ribonucleotide reductase M2(rrM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for dNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of rrM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of rrM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of rrM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,rrM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition regulation resistance rrM2

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Optimization of LPS-Induced Inflammation Model and Its Feasibility as a Fast Screening Model for Cosmetics

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Journal of Cosmetics, dermatological Sciences and Applications 2024年第1期14卷 84-97页

作者： Fanghui Sun Xiaojie Song Nannan Liu Gang Huo r & d center OSM Biology Co. Ltd. Huzhou China

Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced inflammation model is less conducive to the study of skin inflammation. The aim of this research is to enhance the existing LPS-induced inflammation model and establish a skin inflammation model that is suitable for the swift screening of anti-inflammatory agents in the cosmetics industry. Methods: LPS was used to induce inflammatory responses in KC and THP-1 cells. Enzyme-linked immunosorbent assay (ELISA) was employed to assess the levels of IL-1α, IL-8, and TNF-α in the two cell types, while the dCFH-dA probe was utilized to label the levels of reactive oxygen species (rOS) in both cell types. results: In KC cells, 10 μg/mL of LPS induced a significant upregulation of IL-8 but did not result in elevated expression of IL-1α. However, at 100 μg/mL of LPS, both IL-8 and IL-1α were highly expressed in KC cells. LPS concentrations ranging from 0.01 to 100 μg/mL failed to stimulate TNF-α production in KC cells but induced a gradient increase in rOS levels. In THP-1 cells, LPS concentrations from 0.01 to 100 μg/mL did not induce IL-1α production but significantly elevated IL-8 and led to a gradient increase in TNF-α and rOS. After treatment with 100 μg/mL of LPS, the cosmetic ingredient rucika KGM mitigated the elevated levels of IL-1α, IL-8, and rOS in LPS-induced KC cells and IL-8 and rOS in THP-1 cells. Conclusion: This study has successfully developed an application-oriented model suitable for investigating skin inflammation, enabling the rapid and comprehensive screening of cosmetic ingredients with anti-inflammatory activity. .

关键词： Cell Culture Anti-Inflammatory Lipopolysaccharide Keratinocytes THP-1 Inflammatory Factors

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dysfunction of the adhesion G protein-coupled receptor latrophilin 1(AdGrL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf diana Le duc Laura Lehmann Stefan Lehr Stephanie Pick Albert ricken rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg doreen Thor Simone Prömel rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German center for diabetes research(dZd e.V.) Munich-NeuherbergGermany Cardiovascular degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular research Institute(CArId) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany center for Pediatric research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCrs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCrs,such as the melanocortin receptor type 4(MC4r),have been associated with early-onset ***,we identified the adhesion GPCr latrophilin 1(AdGrL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human AdGrL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Analysis of quality-related proteins in golden pompano(Trachinotus ovatus)fillets with modified atmosphere packaging under superchilling storage

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Food Science and Human Wellness 2024年第4期13卷 2253-2265页

作者： Chuang Pan Xiaofan Zhang Shengjun Chen Yong Xue Yanyan Wu Yueqi Wang di Wang South China Sea Fisheries research Institute Chinese Academy of Fishery SciencesKey Laboratory of Aquatic Product ProcessingMinistry of Agriculture and Rural AffairsNational R&D Centre for Aquatic Product ProcessingGuangzhou 510300China Co-Innovation center of Jiangsu Marine Bio-industry Technology Jiangsu Ocean UniversityLianyungang 222005China Collaborative Innovation center of Seafood deep Processing Dalian Polytechnic UniversityDalian 116034China Key Laboratory of Efficient Utilization and Processing of Marine Fishery resources of Hainan Province Sanya Tropical Fisheries Research InstituteSanya 572018China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

Here,we aimed to study the changes in proteome of golden pompano fillets during post-mortem *** mass tags(TMT)-labeled quantitative proteomic strategy was applied to investigate the relationships between protein changes and quality characteristics of modified atmosphere packaging(MAP)fillets during superchilling(-3°C)*** electron microscopy was used to show that the muscle histology microstructure of fillets was damaged to varying degrees,and low-field nuclear magnetic resonance was used to find that the immobilized water and free water in the muscle of fillets changed *** sulfhydryl content,TCA-soluble peptides and Ca2+-ATPase activity also showed that the fillet protein had a deterioration by oxidation and *** Fresh(FS),MAP,and air packaging(AP)groups were *** of 150 proteins were identified as differential abundant proteins(dAPs)in MAP/FS,while 209 dAPs were in AP/FS *** KEGG pathway analysis indicated that most dAPs were involved in binding proteins and protein *** analysis found that 52 dAPs were correlated with quality *** them,8 highly correlated dAPs are expected to be used as potential quality markers for protein oxidation and water-holding *** results provide a further understanding of the muscle deterioration mechanism of packaging golden pompano fillets during superchilling.

关键词： Tandem mass tags(TMT)proteomics Trachinotus ovatus Modified atmosphere packaging Superchilling storage Low-field nuclear magnetic resonance Protein deterioration

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The appearance of cytoplasmic cytochrome C precedes apoptosis during drosophila salivary gland degradation

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Insect Science 2024年第1期31卷 157-172页

作者： Shihui Long Wenxin Cao Yongyu Qiu ruohan deng Jiali Liu Lidan Zhang renke dong Fengxin Liu Sheng Li Haigang Zhao Na Li Kang Li Guangdong Provincial Key Laboratory of Insect developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Guangmeiyuan r&d center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina ChemPartner PharmaTech Co. LtdJiangmenGuangdong ProvinceChina

Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during *** mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the ***,whether this process is conserved in the fruit fly,drosophila melanogaster,remains *** this study,we discovered that during the degradation of drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding *** proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland ***,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the ***,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,*** research provides evidence that cytoplasmic Cyt-c appears before apoptosis during drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals.

关键词： active caspase 3 apoptosis Cyt-c drosophila salivary gland

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Lipidomics and whole-genome sequencing identify lipid profiles in fermented golden pompano(Trachinotus ovatus) inoculated with Bacillus subtilis: Influence of indigenous strains on lipid changes

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Food Science and Human Wellness 2024年

作者： Yanyan Wu Huifang Wang Huan Xiang di Wang Chunsheng Li Shengjun Chen Yongqiang Zhao Yueqi Wang Key Laboratory of Aquatic Product Processing Ministry of Agriculture and rural Affairs National r&d center for Aquatic Product Processing South China Sea Fisheries research Institute Chinese Academy of Fishery Sciences Guangxi Colleges and Univerisities Key Laboratory development and High-value Utilization of Buibu Gulf Seafood resources College of Food Engineering Beibu Gulf University Co-Innovation center of Jiangsu Marine Bio-industry Technology Jiangsu Ocean University Collaborative Innovation center of Seafood deep Processing dalian Polytechnic University

Inoculated fermentation enables rapid fermentation of aquatic products. No studies have been conducted on the lipid profiles of inoculated fermented golden pompano (Trachinotus ovatus). In this study， a lipase-producing Bacillus subtilis with salt tolerance was screened from traditionally fermented golden pompano (TF) and used as a starter culture. Whole-genome sequencing analysis revealed it carries four CrISPr structures and two genes encoding triacylglycerol lipase. Untargeted lipidomics identified lipid molecules (833) in six major classes from B. subtilis SCSMX-2 fermented golden pompano (IF). Twenty-eight lipid molecules were upregulated in IF， including phosphatidylcholines (PCs)， triacylglycerols (TAGs)， and lysophosphatidylcholine. B. subtilis supplementation enhanced the production of polyenyl phosphatidylcholines and medium- and long-chain triacylglycerols. The IF rich in linoleic， docosahexaenoic acids， and eicosapentaenoic acid were primarily distributed in the sn-2 position of dHA， PC and PE. This research revealed the lipid profiles of IF， providing theoretical basis for the application of B. subtilis in the fermented fish industry.

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The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

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Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng Jin ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang National r&d center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China department of Food Science rutgers University New BrunswickNJ 08901USA Joint International research Laboratory of Food&Medicine resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic ***,in this study,the quality standard and the hypoglycemic effect of CCAE were *** and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)*** results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,*** investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)*** results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： Cinnamomi Cortex Cinnamaldehyde Coumarin Hypoglycemic effect

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Emerging mechanisms of ferroptosis and its implications in lung cancer

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Chinese Medical Journal 2024年第7期137卷 818-829页

作者： Qian Li Qibin Song Huadong Pei Yali Chen Cancer center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashington D.C.20057USA State Key Laboratory of Medical Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Lung cancer is one of the most common malignancies and has the highest number of deaths among all *** continuous advances in medical strategies,the overall survival of lung cancer patients is still low,probably due to disease progression or drug *** is an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides,and its dysregulation is implicated in cancer *** evidence has shown that targeting the ferroptosis pathway could be a potential strategy for improving lung cancer treatment *** this review,we summarize the underlying mechanisms and regulatory networks of ferroptosis in lung cancer and highlight ferroptosis-targeting preclinical attempts to provide new insights for lung cancer treatment.

关键词： Lung cancer Ferroptosis Ferroptosis regulators Ferroptosis inducers Cancer treatment

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Stable,intense supercontinuum light generation at 1 kHz by electric field assisted femtosecond laser filamentation in air

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Light(Science & Applications) 2024年第2期13卷 354-365页

作者： Yaoxiang Liu Fukang Yin Tie-Jun Wang Yuxin Leng ruxin Li Zhizhan Xu See Leang Chin State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)light source has advanced ultrafast laser spectroscopy in condensed matter science,biology,physics,and *** to the frequently used photonic crystal fibers and bulk materials,femtosecond laser filamentation in gases is damage-immune for supercontinuum generation.A bottleneck problem is the strong jitters from filament induced self-heating at kHz repetition rate *** demonstrated stable kHz supercontinuum generation directly in air with multiple mJ level pulse *** was achieved by applying an external dC electric field to the air plasma *** pointing jitters of the 1 kHz air filament induced SC light were reduced by more than 2 *** stabilized high repetition rate laser filament offers the opportunity for stable intense SC generation and its applications in air.

关键词： intense repetition light

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Acetyl coenzyme A carboxylase modulates lipogenesis and sugar homeostasis in Blattella germanica

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Insect Science 2024年第2期31卷 387-404页

作者： Xiaojin Pei Tiantian Bai Yuan Luo Zhanfeng Zhang Sheng Li Yongliang Fan Tong-Xian Liu Guangdong Provincial Key Laboratory of Insect developmental Biology and Applied Technology and Institute of Insect Science and Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShaanxiChina Guangmeiyuan r&d center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina Institute of Entomology Guizhou UniversityGuiyangChina

Lipid and sugar homeostasis is critical for insect development and *** this study,we characterized an acetyl coenzyme A carboxylase gene in Blattella germanica(BgacC)that is involved in both lipogenesis and sugar *** found that BgacC was dominantly expressed in the fat body and integument,and was significantly upregulated after *** of BgacC in 5th-instar nymphs did not affect their normal molting to the next nymphal stage,but it caused a lethal phenotype during adult ***-rNA interference(rNAi)significantly downregulated total free fatty acid(FFA)and triacylglycerol(TAG)levels,and also caused a significant decrease of cuticular hydrocarbons(CHCs).repression of BgacC in adult females affected the development of oocytes and resulted in sterile females,but BgacC-rNAi did not affect the reproductive ability of ***,knockdown of BgacC also changed the expression of insulin-like peptide genes(BglLPs),which mimicked a physiological state of high sugar *** addition,BgacC was upregulated when *** were fed on a high sucrose diet,and repression of BgacC upregulated the expression of the glycogen synthase gene(BgGlyS).Moreover,BgacC-rNAi increased the circulating sugar levels and glycogen storage,and a longevity assay suggested that BgacC was important for the survival of *** under conditions of high sucrose *** results confirm that BgacC is involved in multiple lipid biogenesis and sugar homeostasis processes,which further modulates insect reproduction and sugar *** study benefits our understanding of the crosstalk between lipid and sugar metabolism.

关键词： acetyl-CoA carboxylase German cockroach lipid biosynthesis sugar tolerance

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