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Journal of Rock Mechanics and geotechnical engineering 2024年第3期16卷 727-740页

作者： Chengkai Fan Na Zhang Bei Jiang Wei Victor Liu Department of Civil and environmental engineering University of AlbertaEdmontonAlbertaT6G 2E3Canada Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaT6G 2G1Canada

Ore production is usually affected by multiple influencing inputs at open-pit ***,the complex nonlinear relationships between these inputs and ore production remain *** becomes even more challenging when training data(*** haulage information and weather conditions)are *** machine learning(ML)algorithms,deep neural network(DNN)is a superior method for processing nonlinear and massive data by adjusting the amount of neurons and hidden *** study adopted DNN to forecast ore production using truck haulage information and weather conditions at open-pit mines as training *** the prediction models were built,principal component analysis(PCA)was employed to reduce the data dimensionality and eliminate the multicollinearity among highly correlated input *** verify the superiority of DNN,three ANNs containing only one hidden layer and six traditional ML models were established as benchmark *** DNN model with multiple hidden layers performed better than the ANN models with a single hidden *** DNN model outperformed the extensively applied benchmark models in predicting ore *** can provide engineers and researchers with an accurate method to forecast ore production,which helps make sound budgetary decisions and mine planning at open-pit mines.

关键词： Oil sands production Open-pit mining Deep learning Principal component analysis(PCA) Artificial neural network Mining engineering

Saffman–Taylor instability in eccentric cylinders at gaseous cavitation

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Friction 2024年第2期12卷 356-362页

作者： Anatoliy A.MONAKHOV Nikolay BUKHARIN Institute of Mechanics Moscow State UniversityMoscow 119899Russia ThermoFluid Solutions Ltd. CalgaryAlberta T3G4E8Canada

A flow of silicon fluid in the gap between eccentric cylinders was studied *** condition of gaseous cavitation inception during the rotation of internal cylinder was *** was shown that at reduction of the gap between cylinders Saffman–Taylor instability appeared on surface of the internal cylinder and then gaseous cavitation was *** of one uniform gas formation appearance under this type of instability was demonstrated.

关键词： gaseous cavitation Saffman-Taylor instability eccentric cylinders friction lubrication theory

A novel approach to the dynamic response analysis of euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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earthquake engineering and engineering Vibration 2024年第2期23卷 389-401页

作者： Adolfo Foriero Filippo Santucci de Magistris giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

Ca^(2+) binding to the C_(2)e domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerearLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany göttingen graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de genética e Biologia evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DeRDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of excellence(MBexC) University of Göttingen37075 GöttingenGermany Functional Auditory genomics group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing genomics group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human genetics University Medical Center Göttingen37075 GöttingenGermany

Dear editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

Pile foundation in alternate layered liquefiable and non-liquefiable soil deposits subjected to earthquake loading

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earthquake engineering and engineering Vibration 2024年第2期23卷 359-376页

作者： Praveen Huded M Suresh R Dash LeA associates South east Asia Pvt.Ltd. New Delhi 110044India Indian Institute of Technology Bhubaneswar Khurda 752050India

Pile foundations are still the preferred foundation system for high-rise structures in earthquake-prone *** foundations have experienced failures in past earthquakes due to *** on pile foundations in liquefiable soils has primarily focused on the pile foundation behavior in two or three-layered soil ***,in natural occurrence,it may occur in alternative layers of liquefiable and non-liquefiable ***,the experimental and/or numerical studies on the layered effect on pile foundations have not been widely addressed in the *** of the design codes across the world do not explicitly mention the effect of sandwiched non-liquefiable soil layers on the pile *** the present study,the behavior of an end-bearing pile in layered liquefiable and non-liquefiable soil deposit is studied *** study found that the kinematic bending moment is higher and governs the design when the effect of the sandwiched non-liquefied layer is considered in the analysis as opposed to when its effect is ***,ignoring the effect of the sandwiched non-liquefied layer in a liquefiable soil deposit might be a nonconservative design approach.

关键词： pile foundation liquefaction alternately layered soil fixity effect layered effect

A photogrammetric approach for quantifying the evolution of rock joint void geometry under varying contact states

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International Journal of Mining Science and Technology 2024年第4期34卷 461-477页

作者： Rui Yong Changshuo Wang Nick Barton Shigui Du Institute of Rock Mechanics Ningbo UniversityNingbo 315211China Nick Barton&associates Fjordveien 65cHøvik 1363Norway

Accurate measurement of the evolution of rock joint void geometry is essential for comprehending the distribution characteristics of asperities responsible for shear and seepage ***,existing techniques often require specialized equipment and skilled operators,posing practical *** this study,a cost-effective photogrammetric approach is ***,local coordinate systems are established to facilitate the alignment and precise quantification of the relative position between two halves of a rock ***/pull tests are conducted on rock joints with varying roughness levels to induce different contact states.A high-precision laser scanner serves as a benchmark for evaluating the photogrammetry *** certain deviations exist,the measured evolution of void geometry is generally consistent with the qualitative findings of previous *** photogrammetric measurements yield comparable accuracy to laser scanning,with maximum errors of 13.2%for aperture and 14.4%for void *** joint matching coefficient(JMC)measurement errors are below 20%.Larger measurement errors occur primarily in highly mismatched rock joints with JMC values below 0.2,but even in cases where measurement errors exceed 80%,the maximum JMC error is only ***,the proposed photogrammetric approach holds promise for widespread application in void geometry measurements in rock joints.

关键词： Rock joint Void geometry evolution Photogrammetry Aperture Void volume Joint matching coefficient

Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin eudragit RS 100 Nanoparticles Hyperlipidemia

Strain-dependent alpha-synuclein spreading in Parkinson's disease and multiple system atrophy

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Neural Regeneration Research 2024年第12期19卷 2581-2582页

作者： Shuyu Zhang Paul Lingor Department of Neurology School of MedicineUniversity Hospital rechts der IsarTechnical University of MunichMunichGermany Department of Neurology University Medical Center GöttingenGöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center GöttingenGöttingenGermany

Parkinson's disease(PD) and atypical Parkinsonian syndromes,such as multiple system atrophy(MSA) and Dementia with Lewy bodies,are neurodegenerative movement disorders characterized by the accumulation of alphasynuclein(a-syn) *** a-syn aggregates propagate throughout the brain in a prion-like manner,where pathological a-syn recruits endogenous a-syn to form insoluble *** forms representing intermediates on the way to insoluble aggregates result in the most pronounced neurotoxic effects.

关键词： atrophy endogenous atypical

Photoelectrochemical Iron-Catalyzed C(sp^(3))-H Borylation of Alkanes in a Position-Selective Manner

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CCS Chemistry 2024年第6期6卷 1430-1438页

作者： Wen Wei Bin Wang Simon L.Homölle Jinbin Zhu Yanjun Li Tristan von Münchow Isaac Maksso Lutz Ackermann Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen

Catalytic C-H borylation is of prime topical importance,since easily available feedstock chemicals can thereby be transformed into valuable transient functional groups in the absence of directing ***,we disclose an iron-catalyzed C(sp^(3))-H borylation of simple,non-prefunctionalized alkanes,providing access to value-added products in a single step by means of *** power of merging photo-and electrochemistry was mirrored by ample scope and exceedingly mild reaction ***,an outstanding position-selectivity in favor of primary C(sp^(3))-H proved viable within the photoelectrochemical borylation through a chemo-selective anodic overoxidation *** ferro-photoelectrochemistry strategy avoids toxic precious transition metals,enabling C(sp^(3))-H borylations in a site-selective fashion.

关键词： photoelectrocatalysis C(sp^(3))-H borylation iron catalysis position-selectivity chlorine radical

Sustainable management of campus fallen leaves through low-temperature pyrolysis and application in Pb immobilization

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Journal of environmental Sciences 2024年第5期139卷 281-292页

作者： Rongli Tan Ke Li Yue Sun Xiaoliang Fan Zhengtao Shen Lingyi Tang School of environment Nanjing UniversityNanjing 210023China School of Chemistry and Chemical engineering Nanjing UniversityNanjing 210023China School of earth and engineering Sciences Nanjing UniversityNanjing 210023China Department of earth and Atmospheric Sciences University of AlbertaEdmonton T6G 2E3Canada

Realizing campus sustainability requires the environmental-friendly and economical treatment of tremendous fallen *** fallen leaf biochar at a low temperature is a candidate *** this study,six common types of fallen leaves on the campus were pyrolyzed at 300℃.The obtained biochars were characterized and the adsorption mechanisms of lead(Pb)by the fallen leaf biochars were *** adsorption capacity of leaf biochar for Pb was relatively high,up to 209 mg/g(Yulania denudata leaf biochar).Adsorption of Pb onto active sites was the rate-limiting step for most leaf *** for Platanus leaf biochar,intraparticle diffusion of Pb^(2+)dominated owing to the lowest adsorption ***,the highest exchangeable Pb fraction(27%)indicated its potential for removing aqueous Pb^(2+).ginkgo and Prunus cerasifera leaf biochar immobilized Pb by surface complexation and precipitation as lead ***,they were suitable for soil heavy metal *** study shed the light on the sustainable utilization of campus fallen leaves and the application of fallen leaf biochars in heavy metal remediation.

关键词： Fallen leaves Waste management Biochar Lead removal Sorption Circular campus