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Qishen granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway

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Chinese Herbal medicines 2025年第1期17卷 139-147页

作者： Yiqin Hong Hui Wang Hanyan Xie Xinyi Zhong Xu Chen Lishuang Yu Yawen Zhang Jingmei Zhang Qiyan Wang Binghua Tang Linghui Lu Dongqing guo School of Life Sciences Beijing University of Chinese Medicine School of Traditional Chinese medicine Beijing University of Chinese Medicine

Objective:Therapeutic angiogenesis has become a promising approach for treating ischemic heart disease(IHD).The present study aims to investigate the effects of Qishen granule(QSg) on angiogenesis in myocardial ischemia(MI) and the potential ***:In vivo study was conducted on rat model of myocardial *** was performed daily at a dose of 2.352 g/kg for four *** function was assessed by echocardiogram and pro-angiogenic effects were evaluated by Laser Doppler and CD31 ***-glucose deprivation(OgD) was applied in cultured human umbilical vein endothelial cells(HUVeCs).Cell viability,wound healing and tube formation assay were used to test functions of *** and Western blots were used to assess protein expressions of bone morphogenetic protein 2-delta-like 4-notch homolog 1(BMP2-Dll4-Notchl)signaling ***:The results showed that QSg improved heart function,cardiac blood flow and microvessel density in myocardial ischemic *** vitro,QSg protected HUVeCs by promoting the cell viability and tube *** upregulated bone morphogenetic protein-2(BMP2) and downregulated delta-like 4(Dll4) and notch homolog 1(Notch1) expressions both in rats and ***:QSg protected against MI by promoting angiogenesis through BMP2-Dll4-Notch1 ***2 might be a promising therapeutic target for IHD.

关键词： angiogenesis bone morphogenetic protein-2 delta-like 4 myocardial ischemia notch homolog 1 Qishen granule

Pharmacological Mechanism of Chinese medicine in Systemic Lupus erythematosus:A Narrative Review

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Chinese Journal of Integrative medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANg Hui-ping ZHANg Na XIA Jia CHeN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLe)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLe from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLe.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impairment through sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) pathway

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Chinese Journal of Natural medicines 2025年第1期23卷 77-89页

作者： Wenqin Yang Wen Wen Hao Chen Haijun Zhang Yun Lu Ping Wang Shijun Xu State Key Laboratory of Southwestern Chinese medicine Resources Chengdu University of Traditional Chinese Medicine Institute of Material Medica Integration and Transformation for Brain Disorders Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine emergency Department Hospital of Chengdu University of Traditional Chinese Medicine

The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS) levels. Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN) ameliorates post-stroke cognitive impairment(PSCI). However, the underlying mechanism, particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway, remains unclear. This study employed an oxygen-glucose deprivation(OgD) cell model using SHSY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory, neuroprotective activity, mitochondrial function, oxidative stress, and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro. Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax) ratio, reduced terminal deoxynucleotidyl transferase-mediated d UTP nickend-labeling(TUNeL)+ cells, and markedly improved cognition, synaptic plasticity, and neuronal function in the hippocampus and cortex. Furthermore, ZFXN exhibited potent antioxidant activity, evidenced by decreased ROS and malondialdehyde(MDA) content and increased superoxide dismutase(SOD), catalase(CAT), and glutathione(gSH) levels. ZFXN also demonstrated considerable enhancement of mitochondrial membrane potential(MMP), Tom 20 fluorescence intensity, adenosine triphosphate(ATP) and energy charge(eC) levels, and mitochondrial complex Ⅰ and Ⅲ activity, thereby inhibiting mitochondrial damage. Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1, nuclear Nrf2, and HO-1 ***, these effects were substantially counteracted when SIRT1 was suppressed by the inhibitor eX-527 in vitro. In conclusion, ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochond

关键词： Apoptosis Mitochondrial function Oxidative stress Post-stroke cognitive impairment Sirtuin1/nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway Zhongfeng Xingnao Liquid

effect of electroacupuncture on pain after periodontal flap surgery:a randomized controlled trial

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Journal of Traditional Chinese medicine 2025年第1期45卷 184-191页

作者： emre Bulut Didem ?zkal emino?lu Yasemin ?ay?r Department of Periodontology Faculty of DentistryAtatürk University Department of Family medicine Faculty of MedicineAtatürk University

OBJeCTIVe: To examine the effect of electroacupuncture(eA) application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery. MeTHODS: In this prospective, randomized and controlled study, patients planned for periodontal surgery were divided into two groups [eA group(n = 22): patients who received electroacupuncture and control group(n = 22): patients who did not receive electroacupuncture]. electroacupuncture was applied bilaterally to the Hegu(LI4), Daying(ST5), and Jiache(ST5) points of the patients in the eA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate. The patients in the control group underwent flap surgery without applying electroacupuncture. Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form. ReSULTS: The total mean score of pain felt in the eA group(16.60 ± 2.78) was found to be significantly lower than that in the control group(31.37 ± 2.78)(P = 0.001). No significant difference was found between the groups regarding the amount of analgesics taken(4.77 ± 4.72, 5.82 ± 3.11)(P = 0.111). CONCLUSIONS: Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery. Overall, more research is needed to fully understand the effects of electroacupuncture on postoperative pain.

关键词： analgesics electroacupuncture pain, postoperative periodontitis randomized controlled trial

Chinese medicine for Treatment of COVID-19:A Review of Potential Pharmacological Components and Mechanisms

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Chinese Journal of Integrative medicine 2025年第1期31卷 83-95页

作者： XU Qian-qian YU Dong-dong FAN Xiao-dan CUI He-rong DAI Qian-qian ZHONg Xiao-ying ZHANg Xin-yi ZHAO Chen YOU Liang-zhen SHANg Hong-cai Key Laboratory of Chinese Internal medicine of Ministry of education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China The geriatrics Center First Affiliated HospitalAnhui University of Chinese MedicineHefei230031China School of Medical Information engineering Guangzhou University of Chinese MedicineGuangzhou51006China Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing100700China

Coronavirus disease 2019(COVID-19)is an acute infectious respiratory disease that has been prevalent since December *** medicine(CM)has demonstrated its unique advantages in the fight against COVID-19 in the areas of disease prevention,improvement of clinical symptoms,and control of disease *** review summarized the relevant material components of CM in the treatment of COVID-19 by searching the relevant literature and reports on CM in the treatment of COVID-19 and combining with the physiological and pathological characteristics of the novel *** the basis of sorting out experimental methods in vivo and in vitro,the mechanism of herb action was further clarified in terms of inhibiting virus invasion and replication and improving related *** aim of the article is to explore the strengths and characteristics of CM in the treatment of COVID-19,and to provide a basis for the research and scientific,standardized treatment of COVID-19 with CM.

关键词： Chinese medicine COVID-19 SARS-CoV-2 substance component mechanism experimental method

Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung Kim gye Ryeol Park Jae eun Ryu Ji eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh eileen L Yoon Dae Won Jun Department of Internal medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKgROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

evaluation of a user-friendly CSDS cage apparatus for studying depressive-like behaviors in rodents

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Animal Models and experimental medicine 2025年第1期8卷 179-186页

作者： Hao Zhang Dongmei gao Minghu Hu Wanqing Zhou Muxuan Han Ya Sun Yang Zhang Jieqiong Wang Mingzhou gao High-Level Key Disciplines of Traditional Chinese medicine:Basic Theory of Traditional Chinese medicine National Administration of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Key Laboratory of Traditional Chinese medicine Classical Theory Ministry of EducationShandong University of Traditional Chinese MedicineJinanChina experimental Center Shandong University of Traditional Chinese MedicineJinanShandongChina College of Traditional Chinese medicine Shandong University of Traditional Chinese MedicineJinanShandongChina Innovative Institute of Chinese medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanShandongChina Social Cooperation and Achievement Transformation Department Shandong University of Traditional Chinese MedicineJinanShandongChina

Background:Previously,a chronic social defeat stress(CSDS)model has been widely-adopted for assessing depressive-like behaviors in ***,there is still room for improvement in the CSDS model to safeguard study accuracy and the wel-fare of lab *** study team developed a novel,standardized apparatus to induce CSDS in rodents and assessed the model's practical ***:An innovative CSDS cage apparatus and water bottle was *** evaluate the effectiveness of the newly developed tools,a variety of animal models,including the tail suspension test(TST),sucrose preference test,forced swimming test(FST),novelty-suppressed feeding test,female urine sniffing test,and open field test(OFT),were adopted to assess depressive-like behaviors in *** treat-ment was also administered to observe the reversal effect,as part of the ***:The CSDS cage apparatus resulted in the manifestation of depressive-like behaviors in the model *** reductions in sucrose preference and urine sniffing time were observed,while the OFT revealed decreased central zone total distance,residence time,and frequency of ***,increased immobility was found in the FST and *** treatment was found to successfully reverse the modeling ***:The CSDS cage apparatus was validated for enhanced usability and ad-dressed the previous challenges of water bottle leakage and lab rodent welfare *** consistent results from multiple behavioral tests also supported real-world application of the apparatus,offering researchers a promising alternative to conven-tional rodent cages.

关键词： CSDS depression experimental cage leak-proof water bottle methodology

Regulator of g protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary graduate Program in Molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of g protein signaling 6(RgS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RgS6fl/fl;APP_(SWe) mice and used retroviral approaches to examine the impact of RgS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWe) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RgS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWe) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RgS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RgS6-expressing ***,RgS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWe) mice,identifying RgS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of g protein signaling 6(RgS6)

Productive and metabolomic consequences of arginine supplementation in sows during different gestation periods in two different seasons

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Journal of Animal Science and Biotechnology 2025年第1期16卷 218-237页

作者： Sara Virdis Diana Luise Federico Correa Luca Laghi Norma Arrigoni Roxana elena Amarie Andrea Serra giacomo Biagi Clara Negrini Francesco Palumbo Paolo Trevisi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4440127 BolognaItaly Istituto Zooprofilattico Sperimentale Della Lombardia e Dell’emilia Romagna(IZSLeR)“Bruno Ubertini” Via Bianchi925124 BresciaItaly Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8056124 PisaItaly Department of Veterinary medicine University of BolognaVia Tolara Di Sopra 5040064 Ozzano Dell’Emilia(BO)Italy.

Background The prolificacy of sows(litter size at birth)has markedly increased,leading to higher post-natal *** stress can exacerbate this *** plays an important role in several physiological pathways;its effect on gestating sows can depend on the period of *** study evaluated the effects of arginine supplementation on the productive performance and physiological status of sows during different gestation periods and seasons,using a multi-omics *** A total of 320 sows were divided into 4 groups over 2 seasons(warm/cold);a control group(CO)received a standard diet(including 16.5 g/d of arginine)and 3 other groups received the standard diet supplemented with 21.8 g/d of arginine(38.3 g/d of arginine)either during the first 35 d(early35),the last 45 d(Late45)or through-out the entire gestation period(COM).The colostrum was analyzed for nutritional composition,immunoglobulins and metabolomic *** and feces were analyzed on d 35 and 106 for the metabolomic and microbial *** body weight and mortality were recorded at birth,d 6,d 26,and on d 14 *** Interactions between arginine and season were never *** early35 group had a lower percent-age of stillborn(Ped(P=0.002)and low birthweight(LBW)piglets(P=0.02)than the CO *** Late45 group had a lower percentage of stillborn piglets(P=0.029)and a higher percentage of high birthweight piglets(HBW;Pe CO *** COM group had a higher percentage of LBW(P=0.004)and crushed piglets(Pe CO *** supplementation modifies the metabolome characterization of colos-trum,urine,and *** and nitric oxide pathways,as well as metabolites related to microbial activity,were influenced in all matrices.A slight trend in the beta diversity index was observed in the microbiome profile on d 35(P=0.064).Conclusions Arginine supplementation during early gestation reduced the percentage o

关键词： Colostrum Feces Microbiota Piglets’birth weight Stillborn Urine