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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical college of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

CPL-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： Peng Fan Li-Xuan Cai Xiao-Fang Duan Fan Yin Chen-Chen Li Zhong-Hua Deng Xiao-Zhen Li Qing-Fu Sun college of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China strait Institute of Flexible Electronics(Future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian college University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PLQY)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPL)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPL *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@L^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral L^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@L^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@L^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PLQY of 96.92%.Notably,[G@L^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WLEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

Recent development in biogeotechnology and its engineering applications

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Frontiers of Structural and Civil Engineering 2021年第5期15卷 1073-1096页

作者： Hanjiang LAI Shifan WU Mingjuan CUI Jian CHU Zijin School of Geology and Mining Fuzhou UniversityFuzhou 350108China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore college of Civil Engineering Fuzhou UniversityFuzhou 350108China

Microbial geotechnology or biogeotechnology is a new branch of geotechnical *** involves the use of microbiology for traditional geotechnical *** new innovative soil improvement methods have been developed in recent years based on this approach.A proper understanding of the various approaches and the performances of different methods can help researchers and engineers to develop the most appropriate geotechnical *** present,most of the methods can be categorized into three major types,biocementation,bioclogging,and biogas *** and differences of different approaches and their potential applications are *** affecting the different processes are also *** of up-scaled model tests and pilot trials are presented to show the emerging *** challenges and problems of biogeotechnology are also discussed.

关键词： biogeotechnology biocementation bioclogging biogas strength enhancement liquefaction mitigation seepage control

Rational designed microstructure pressure sensors with highly sensitive and wide detection range performance

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Journal of Materials Science & Technology 2022年第35期130卷 184-192页

作者： Yimeng Ni Lexin Liu Jianying Huang Shuhui Li Zhong Chen Weiying Zhang Yuekun Lai college of Chemical Engineering Fuzhou UniversityFuzhou 350116China Department of Chemistry University College LondonLondonUK School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore

Highly sensitive pressure sensors are often deployed in human-machine interaction area,touch screen and human motion ***,there are still great challenges to fabricating with high sensitivity pressure sensor with wide-range ***,we developed a new strategy to fabricate a highly sensitive pressure sensor using sandpaper and improve its detection range using a sacrificial *** was the fthatirst time to combine microstructure processing with the sacrificial template method to fabricate pressure *** microstructure of sandpaper endowed the sensor with high sensitivity,and the elastic substrate enhanced the sensor ability to resist high pressure without being *** fabricated sensor device exhibits a superior sensitivity of 39.077 kPa-1in the range from 50 kPa to 110 kPa with a broad linear ***,high pressure ceiling(<160 kPa) ensures that the sponge could be applied in different practical conditions to monitor a range of subtle human motions including finger,wrist bending,and *** applications,the sensor device can not only detect the foot stepping behavior(0.7 MPa) but also produce an obvious response to an extremely slight paper(9 mg,~0.9 Pa).The successful preparation of this micro-structured elastic sponge material provided new ideas for exploring its potential applications in pressure sensors and flexible wearable electronic devices.

关键词： Pressure sensor High sensitivity Conductive sponge Template Micro-structure

Surface patterning and modification of polyurethane biomaterials using silsesquioxane-gelatin additives for improved endothelial affinity

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Science China Chemistry 2014年第4期57卷 596-604页

作者： HOU LinXi PECK Yvonne WANG XiaoWen WANG DongAn college of Chemistry and Chemical Engineering Fuzhou University Division of Bioengineering School of Chemical and Biomedical Engineering Nanyang Technological University

Polyurethanes(PUs) are well-known for their biocompatibility but their intrinsic inert property hampers cell-matrix interactions. Surface modifications are thus necessary to widen their use for biomedical applications. In this work, surface modifications of PU were achieved first by incorporating polyhedral oligomeric silsesquioxane(POSS), followed by alteration of the surface topography via the breath figures method. Subsequently, surface chemistry was also modified by immobilization of gelatin molecules through grafting, for the enhancement of the surface cytocompatibility. Scanning electron microscopy(SEM) was used to verify the formation of highly ordered microstructures while static contact angle, FTIR and XPS confirmed the successful grafting of gelatin molecules onto the surfaces. In vitro culture of human umbilical vein endothelial cells(HUVECs) revealed that endothelial cell adhesion and proliferation were significantly enhanced on the gelatin-modified surfaces, as shown by live/dead staining and WST-1 proliferation assay. The results indicated that the combination of the strategies yielded an interface that improves cell attachment and subsequent growth. This enhancement is important for the development of higher quality biomedical implants such as vascular grafts.

关键词： biomaterials surface modification pattern polyurethane silsesquioxane gelatin endothelization

A quasi-solid-state electrolyte with high ionic conductivity for stable lithium-ion batteries

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Science China(technological Sciences) 2022年第10期65卷 2369-2379页

作者： ZHANG WenJing LI SenLin ZHANG YuRong WANG XingHui LIU JingDong ZHENG YuanHui college of Chemistry Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated MaterialsFuzhou UniversityFuzhou 350108China college of Physics and Information Engineering Fuzhou UniversityFuzhou 350108China

The practical applications of solid-state electrolytes in lithium-ion batteries(LIBs)are hindered by their low ionic conductivity and high interfacial ***,an ethoxylated trimethylolpropane triacrylate based quasi-solid-state electrolyte(ETPTAQSSE)with a three-dimensional(3D)network is prepared by a one-step in-situ photopolymerization *** 3D network is designed to overcome the contradiction between the plasticizer-related ionic conductivity and the thickness-dependent mechanical property of quasi-solid-state *** ETPTA-QSSE achieves superb room-temperature ionic conductivity up to 4.55×10^(−3)S cm^(−1),a high lithium ion transference number of 0.57,along with a wide electrochemical window of 5.3 V(***+/Li),which outperforms most ever of the reported solid-state *** to the robust network structure and the cathodeelectrolyte integrated electrode design,Li metal symmetrical cells show reduced interface resistance and reinforced electrode/electrolyte interface *** applying the ETPTA-QSSE in LiFePO_(4)||Li cells,the quasi-solid-state cell demonstrates an enhanced initial discharge capacity(155.5 mAh g^(−1)at 0.2 C)accompanied by a high average Coulombic efficiency of greater than 99.3%,offering capacity retention of 92%after 200 ***,this work sheds light on the strategy of enhancing ionic conductivity and reducing interfacial resistance of quasi-solid-state electrolytes,which is promising for high-voltage LIBs.

关键词： quasi-solid-state electrolyte ionic conductivity electrochemical window photopolymerization lithium-ion batteries

Namib desert beetle inspired special patterned fabric with programmable and gradient wettability for efficient fog harvesting

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Journal of Materials Science & Technology 2021年第2期61卷 85-92页

作者： Zhihua Yu Huimei Zhang Jianying Huang Shuhui Li Songnan Zhang Yan Cheng Jiajun Mao Xiuli Dong Shouwei Gao Shanchi Wang Zhong Chen Yaoxing Jiang Yuekun Lai college of Chemical Engineering Fuzhou UniversityFuzhou 350116China National Engineering Laboratory for Modem Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore

Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production.

关键词： Superwettability Fabric Copper Namib desert beetle Fog harvesting

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian Chen Yijuan Han Zhenhui Zhong Guodong Lu Yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

Advances in particulate matter filtration:Materials,performance,and application

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Green Energy & Environment 2023年第3期8卷 673-697页

作者： Xuzheng Ji Jianying Huang Lin Teng Shuhui Li Xiao Li Weilong Cai Zhong Chen Yuekun Lai college of Chemical Engineering Fuzhou UniversityFuzhou350116China b Qingyuan Innovation Laboratory Quanzhou362801China Department of Chemistry University College LondonLondonWC1H 0AJUK School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore

Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human *** during the current COVID-19 pandemic,effective filtration of the virus is an urgent matter *** this review,we first introduce some fundamentals about PM,including its source and classification,filtration mechanisms,and evaluation *** filtration materials and their functions are then summarized,among which polymers and MOFs are discussed in detail together with their antibacterial *** discussion on the application is divided into end-of-pipe treatment and source ***,we conclude this review with our prospective view on future research in this area.

关键词： Air filtration PM capture End-of-pipe treatment Source control COVID-19