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Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-Chen Zhang Chun-Mei Lai Bang-Yue Luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

THE LOGARITHMIC SOBOLEV INEQUALITY FOR A SUBMANIFOLD IN MANIFOLDS WITH ASYMPTOTICALLY NONNEGATIVE SECTIONAL CURVATURE

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Acta Mathematica Scientia 2024年第1期44卷 189-194页

作者：东瑜昕林和子陆琳根 School of Mathematical Sciences Fudan UniversityShanghai20043China School of Mathematics and Statistics&Laboratory of Analytical Mathematics and Applications(Ministry of education)&FJKLMAA Fujian Normal UniversityFuzhou350108China

In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional *** the Michale-Simon Sobolev inequality,this inequ... 详细信息

关键词： asymptotically nonnegative sectional curvature logarithmic Sobolev inequality ABP method

Transcription factor OsSPL10 interacts with OsJAmyb to regulate blast resistance in rice

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The Crop Journal 2024年第1期12卷 301-307页

作者： Zaofa Zhong Lijing Zhong Xiang Zhu Yimin Jiang Yihong Zheng Tao Lan Haitao Cui College of Life Science Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Plant Protection Shandong Agricultural UniversityTai’an 271018ShandongChina

Transcription factors(TFs)play essential roles in transcriptional reprogramming during activation of plant immune responses to ***10(SQUAMOSA promoter binding protein-like10)is an important TF regulating trichome development and salt tolerance in *** we report that knockout of OsSPL10 reduces whereas its overexpression enhances rice resistance to blast ***10 positively regulates chitin-induced immune responses including reactive oxygen species(ROS)burst and callose *** show that OsSPL10 physically associates with OsJAmyb,an important TF involved in jasmonic acid(JA)signaling,and positively regulates its protein *** then prove that OsJAmyb positively regulates resistance to *** results reveal a molecular module consisting of OsSPL10 and OsJAmyb that positively regulates blast resistance.

关键词： Immunity Jasmonate Oryza sativa OsSPL10 Transcription factor

The role of Piezo1 and Piezo2 proteins in tissue engineering:A Comprehensive review

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Engineered Regeneration 2024年第2期5卷 170-185页

作者： Tejaswini Tadge Ashwini Pattewar Namdev More Srivalliputtur Sarath Babu Ravichandiran Velyutham Govinda Kapusetti National institute of Pharmaceutical education and Research KolkataWest Bengal 700054India National institute of Pharmaceutical education and Research AhmedabadGujarat 382355India

Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric *** largely relies on ion channels that respond to mechanical forces,such as the epithelial sodium channels/degenerins,tran-sient receptor potential channel,and the two-pore domain potassium ***1 and Piezo2 proteins were discovered to be the biggest non-selective mechanosensitive cation channels in the cell membrane.A substantial amount of research has previously been published on the Piezo channel’s function in touch sensation,balance,and cardiovascular ***,the mechanistic perspective must be refined to fully understand the role of Piezo proteins in tissue *** review centers on the latest insights into the structure of Piezo chan-nels,activation mechanisms,and its interactions with cytoskeletal components,by emphasizing the physiological activities of Piezo channels in different *** study also places focus on the possibilities of targeting this cation channel family as a tissue regeneration aid.

关键词： Piezo1 Piezo2 Mechanotransduction Tissue regeneration Mechanoreceptors

Efficient and Fast X-Ray Luminescence in Organic Phosphors Through High-Level Triplet-Singlet Reverse Intersystem Crossing

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CCS Chemistry 2024年第2期6卷 334-341页

作者： Yang Zhang Minghong Chen Xiaoze Wang Miao Lin Hongyu Wang Weihong Li Fuhai Chen Qing Liao Hongming Chen Qiushui Chen Meijin Lin Huanghao Yang Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116 New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhouFujian 350108 College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116

Organic scintillators that efficiently generate bright triplet excitons are of critical importance for highperformance X-ray-excited luminescence in radiation ***,the nature of triplet-singlet spinforbidden transitions in these materials often result in long-lived phosphorescence,which is undesirable for ultrafast X-ray detection and *** we demonstrate that the effect of hybridized local and charge-transfer(HLCT)excited states enables organic scintillators to exhibit highly efficient and fast radioluminescence(RL)in response to X-ray *** experimental and theoretical investigation shows that the oxidized 1,8-naphthalimide-phenothiazine dyad(OMNI-PTZ 2)with HLCT-excited states has an enhanced overlap integral of the highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)on MNIπ-orbitals,and moderate donor–acceptor electron *** a result,the RL of these crystals exhibits a 61-fold increase and its monoexponential decay lifetime is three orders of magnitude faster compared to its corresponding thermally activated delayed fluorescence(TADF)molecule MNI-PTZ *** further demonstrate the practical utility of the OMNI-PTZ 2(G)in high-performance X-ray detection and imaging,achieving an X-ray dose sensitivity of 97 nGy s−1 and an exceptional spatial resolution of 20 lp/*** study provides a promising molecular design principle for utilizing triplet excitons to develop high-efficiency and fast X-ray scintillators for the development of next-generation flexible and stretchable X-ray imaging detectors.

关键词： organic scintillators X-ray imaging hybridized local and charge transfer excited state triplet-singlet reverse intersystem crossing high exciton utilization

Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

Cu-catalyzed regioselective diborylation of 1,3-enynes for the efficient synthesis of 1,4-diborylated allenes

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Chinese Chemical Letters 2024年第5期35卷 141-144页

作者： Wujun Jian Mong-Feng Chiou Yajun Li Hongli Bao Song Yang National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China Strait institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal UniversityFuzhou 350117China Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterUniversity of Chinese Academy of SciencesFuzhou 350002China

Borylation of 1,3-enynes with bis(boronate)compounds often ends up with the formation of hydroborylated products,leaving the diborylation of 1,3-enynes for the formation of 1,4-diborylated allenes to be ***,a copper-catalyzed chemo-,regio-,and stereo-selective diborylation of 1,3-enynes for the efficient construction of 1,4-diborylated allenes under base-free conditions was reported.A wide range of 1,3-enynes bearing various functional groups can participant in the reaction and afforded the corresponding 1,4-diborylated allenes in good to excellent yields,which was enabled by the protocol of Bpin to BF3K *** borylcopper species was supposed to selectively attack the C-C triple bond of the 1,3-enynes.

关键词： Copper catalysis Regioselective 1,3-Enynes Borylation Allenes

Tunnel bottleneck management with high-occupancy vehicle priority on intelligent freeways

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Transportation Safety and Environment 2024年第2期6卷 87-95页

作者： Jinyong Gao Juncheng Zeng Xinyuan Wang Cheng Zhou Hailin Zhang Jintao Lai Fujian Express way Group Co. LtdFuzhou 350000FujianChina Fujian Express way Science&Technology Innovation Research institute Co. LtdFuzhou 350000FujianChina Beijing Baidu Netcom Science Technology Co. LtdBeijing 100000China Key Laboratory of Road and Traffic Engineering of the Ministry of education Tongji UniversityShanghai 201804China

Tunnels on freeways,as one of the critical bottlenecks,frequently cause severe congestion and passenger *** solve the tunnel bottleneck problem,most of the existing research can be divided into two *** is to adopt variable speed limits(VSLs)to regulate a predetermined speed for vehicles to get through a bottleneck *** other is to adopt high-occupancy vehicle(HOV)lane *** HOV lane management strategies,all traffic is divided into HOVs and low-occupancy vehicles(LOVs).HOVs are vehicles with a driver and one or more *** are vehicles with only a *** kind of research can grant priority to HOVs by providing a dedicated HOV ***,the existing research cannot both mitigate congestion and maximize passenger-oriented *** address the research gap,this paper leverages connected and automated vehicle(CAV)technologies on intelligent freeways and develops a tunnel bottleneck management strategy with a dynamic HOV lane(DHL).The strategy bears the following features:1)enables tunnel bottleneck management at a microscopic level;2)maximizes passenger-oriented benefits;3)grants priority to HOVs even when the HOV lane is open to LOVs;4)allocates right-of-way segments for HOVs and LOVs in real time;and 5)performs well in a mixed-traffic *** proposed strategy is evaluated through comparison against the non-control baseline and a VSL *** analysis is conducted under different congestion levels and penetration *** results demonstrate that the proposed strategy outperforms in terms of passenger-oriented delay reduction and HOVs’priority level improvement.

关键词： tunnel bottleneck high-occupancy vehicle(HOV) intelligent freeways right-of-way segment

The OsBSK1-2-MAPK module regulates blast resistance in rice

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The Crop Journal 2024年第1期12卷 110-120页

作者： Shengping Li Xinquan Xiang Zhijuan Diao Na Xia Ling Lu Jing Zhang Zhiwei Chen Dingzhong Tang State Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Life Science Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Receptor-like cytoplasmic kinase OsBSK1-2 was reported to play an important role in regulation of response to rice blast,but the signaling pathway remained *** this study,we identified OsMAPKKK18 and previously uncharacterized MAPKKKs OsMAPKKK16 and OsMAPKKK19 that interact with *** of all three MAPKKKs was induced by Magnaporthe oryzae infection,and all three induced cell death when transiently expressed in Nicotiana benthamiana *** of OsMAPKKK16 and OsMAPKKK18 compromised blast resistance and overexpression of OsMAPKKK19 increased blast resistance,indicating that all three MAPKKKs are involved in regulation of rice blast ***,both OsMAPKKK16 and OsMAPKKK19 interacted with and phosphorylated OsMKK4 and OsMKK5,and chitin-induced MAPK activation was suppressed in osmapkkk16 and osbsk1-2 ***18 was earlier reported to interact with and phosphorylate OsMKK4 and affect chitin-induced MAPK activation,suggesting that OsBSK1-2 is involved in regulation of immunity through multiple MAPK signaling *** BSK1 in Arabidopsis,OsBSK1-2 was not involved in response to avirulent *** *** together,our results revealed important roles of OsMAPKKK16/18/19 and a OsBSK1-2-OsMAPKKK16/18/19-OsMKK4/5 module in regulating response to rice blast.

关键词： Disease resistance Magnaporthe oryzae Oriza sativa Rice blast